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Cartoon by Simon Champ, ink on paper Simon Champ的漫画，纸上的墨水
IF 0.3
Health and History Pub Date : 2023-02-19 DOI: 10.1353/hah.2022.0025
S. Champ
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引用次数: 0
Edith Blake’s War: The Only Australian Nurse Killed in Action During the First World War by Krista Vane-Tempest (review) 《伊迪丝·布莱克的战争：第一次世界大战期间唯一一名在行动中丧生的澳大利亚护士》，作者：Krista Vane Tempest（评论）
IF 0.3
Health and History Pub Date : 2023-02-19 DOI: 10.1353/hah.2022.0033
Kirsty Harris
{"title":"Edith Blake’s War: The Only Australian Nurse Killed in Action During the First World War by Krista Vane-Tempest (review)","authors":"Kirsty Harris","doi":"10.1353/hah.2022.0033","DOIUrl":"https://doi.org/10.1353/hah.2022.0033","url":null,"abstract":"","PeriodicalId":29747,"journal":{"name":"Health and History","volume":"24 1","pages":"199 - 201"},"PeriodicalIF":0.3,"publicationDate":"2023-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47558102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Visions of Future Past 未来与过去的愿景
IF 0.3
Health and History Pub Date : 2023-02-19 DOI: 10.1353/hah.2022.0019
R. Ramjan
{"title":"Visions of Future Past","authors":"R. Ramjan","doi":"10.1353/hah.2022.0019","DOIUrl":"https://doi.org/10.1353/hah.2022.0019","url":null,"abstract":"","PeriodicalId":29747,"journal":{"name":"Health and History","volume":"24 1","pages":"131 - 134"},"PeriodicalIF":0.3,"publicationDate":"2023-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47571193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Frontmatter 头版头条
Health and History Pub Date : 2023-01-01 DOI: 10.1353/hah.2023.a904705
{"title":"Frontmatter","authors":"","doi":"10.1353/hah.2023.a904705","DOIUrl":"https://doi.org/10.1353/hah.2023.a904705","url":null,"abstract":"","PeriodicalId":29747,"journal":{"name":"Health and History","volume":"36 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136258453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Contributors 贡献者
Health and History Pub Date : 2023-01-01 DOI: 10.1353/hah.2023.a904723
{"title":"Contributors","authors":"","doi":"10.1353/hah.2023.a904723","DOIUrl":"https://doi.org/10.1353/hah.2023.a904723","url":null,"abstract":"","PeriodicalId":29747,"journal":{"name":"Health and History","volume":"20 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136258091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pancreatic cancer cell-derived exosomes induce epithelial-mesenchymal transition in human pancreatic cancer cells themselves partially via transforming growth factor β1. 胰腺癌细胞衍生的外泌体部分通过转化生长因子β1诱导人胰腺癌细胞的上皮-间质转化。
IF 1.8
Health and History Pub Date : 2022-09-01 Epub Date: 2022-04-27 DOI: 10.1007/s00795-022-00321-0
Fumiya Nakayama, Makoto Miyoshi, Ai Kimoto, Akari Kawano, Kumiko Miyashita, Shingo Kamoshida, Kazuya Shimizu, Yuichi Hori
{"title":"Pancreatic cancer cell-derived exosomes induce epithelial-mesenchymal transition in human pancreatic cancer cells themselves partially via transforming growth factor β1.","authors":"Fumiya Nakayama, Makoto Miyoshi, Ai Kimoto, Akari Kawano, Kumiko Miyashita, Shingo Kamoshida, Kazuya Shimizu, Yuichi Hori","doi":"10.1007/s00795-022-00321-0","DOIUrl":"10.1007/s00795-022-00321-0","url":null,"abstract":"<p><p>Distant metastasis is a dismal prognostic factor of pancreatic cancer. Metastasis is established in several steps, but the mechanism underlying the very early stages remains unclear. Epithelial-mesenchymal transition (EMT) is involved in these stages. Although signaling molecules have been reported to induce EMT, the mechanism underlying their origin is unclear. In this study, we hypothesized that pancreatic cancer cell-derived exosomes induce EMT in cancer cells themselves, a notion we entertained because we found EMT in in vitro three-dimensional colonies of cancer cells, with vimentin-positive cells observed in some of the budding pancreatic cancer cells and in single cells outside the colony as well. First, we clarified that pancreatic cancer cell-derived exosomes induce EMT in cancer cells themselves. Next, we examined the involvement of transforming growth factor-β1 (TGF-β1), and TGF-β1 knock-down in pancreatic cancer cells with TGF-β1 siRNA significantly suppressed TGF-β1 gene expression in cancer cells, and exosomal TGF-β1 was significantly reduced in the secretory exosomes. Exosomes from TGF-β1 knock-down cells suppressed EMT induction in cancer cells themselves and TGF-β1 protein expression in target cells. Taken together, these findings suggest that TGF-β1 is involved in EMT induction via exosomes, results that may support the production of effective metastasis inhibitors.</p>","PeriodicalId":29747,"journal":{"name":"Health and History","volume":"16 1","pages":"227-235"},"PeriodicalIF":1.8,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9043512/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81716479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
Medicalising Borders: Selection, Containment and Quarantine since 1800 ed. by Sevasti Trubeta, Christian Promitzer, and Paul Weindling (review) 医学边界:1800年以来的选择、遏制和隔离，塞瓦斯蒂·特鲁贝塔、克里斯蒂安·普罗米策和保罗·温德林主编(书评)
IF 0.3
Health and History Pub Date : 2022-08-24 DOI: 10.1353/hah.2022.0009
Jenny Kain
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引用次数: 0
The Woman Who Cracked the Anxiety Code: The Extraordinary Life of Dr Claire Weekes by Judith Hoare (review) 《破解焦虑密码的女人:克莱尔·维克斯博士的非凡人生》朱迪思·霍尔著(书评)
IF 0.3
Health and History Pub Date : 2022-08-24 DOI: 10.1353/hah.2022.0011
J. Leckie
{"title":"The Woman Who Cracked the Anxiety Code: The Extraordinary Life of Dr Claire Weekes by Judith Hoare (review)","authors":"J. Leckie","doi":"10.1353/hah.2022.0011","DOIUrl":"https://doi.org/10.1353/hah.2022.0011","url":null,"abstract":"","PeriodicalId":29747,"journal":{"name":"Health and History","volume":"24 1","pages":"142 - 144"},"PeriodicalIF":0.3,"publicationDate":"2022-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66417998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Patient Voices in Britain, 1840–1948 ed. by Anne Hanley and Jessica Meyer (review) 《英国病人的声音，1840-1948》，作者:安妮·汉利和杰西卡·迈耶
IF 0.3
Health and History Pub Date : 2022-08-24 DOI: 10.1353/hah.2022.0010
Effie Karageorgos
{"title":"Patient Voices in Britain, 1840–1948 ed. by Anne Hanley and Jessica Meyer (review)","authors":"Effie Karageorgos","doi":"10.1353/hah.2022.0010","DOIUrl":"https://doi.org/10.1353/hah.2022.0010","url":null,"abstract":"","PeriodicalId":29747,"journal":{"name":"Health and History","volume":"24 1","pages":"139 - 142"},"PeriodicalIF":0.3,"publicationDate":"2022-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41525881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Royal Prince Alfred Hospital as the Birthplace of General Hospital Psychiatry in New South Wales 皇家阿尔弗雷德王子医院是新南威尔士州综合医院精神病学的发源地
IF 0.3
Health and History Pub Date : 2022-08-24 DOI: 10.1353/hah.2022.0003
Richard T. White
{"title":"Royal Prince Alfred Hospital as the Birthplace of General Hospital Psychiatry in New South Wales","authors":"Richard T. White","doi":"10.1353/hah.2022.0003","DOIUrl":"https://doi.org/10.1353/hah.2022.0003","url":null,"abstract":"Abstract:This narrative account of first occasions of the entry of psychiatric services into a general hospital in New South Wales commences by explaining why, in the early 1900s, general hospitals, which had previously refused any role in the management of insanity, began to accept responsibility for the assessment and management of cases of incipient mental disorder. The first hospital in New South Wales to do so was the Royal Prince Alfred Hospital (RPAH), which was then the sole teaching hospital of the University of Sydney. RPAH acquired the first significant outpatient and inpatient services in a general hospital in NSW and was the epicentre of general hospital psychiatry in NSW between 1900 and 1938.","PeriodicalId":29747,"journal":{"name":"Health and History","volume":"24 1","pages":"65 - 85"},"PeriodicalIF":0.3,"publicationDate":"2022-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43936166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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