Pediatrics and Neonatal Medicine最新文献

{"title":"Determinants of Neonatal Morbidity And Mortality In The Suburbs of Dakar in Senegal","authors":"F. Ly, D. Ndiaye, A. Sakho Kane, F. Sarr","doi":"10.33425/2768-0363.1013","DOIUrl":"https://doi.org/10.33425/2768-0363.1013","url":null,"abstract":"Introduction: Neonatal morbidity and mortality is a major public health problem in developing countries such as Senegal. The objective of our study was to study the determinants of neonatal morbidity and mortality in a hospital located in the suburbs of Dakar in Senegal. Materials and methods: We conducted a retrospective, descriptive and analytical study over the period from 1 January to 31 December 2019 (1 year). Results: Of the 1198 children hospitalized in the ward, all 500 were newborns. (incidence=41.7%). The sex ratio was 1.29. The most common maternal pathologies were hypertension, preeclampsia and diabetes. The notion of urogenital infection was reported in 21% of cases MPR was greater than 12 hours in 60% of cases. More than a quarter (27%) of newborns had not screamed at birth and 74% were resuscitated. Almost half of newborns (43%) were preterm infants. Hypotrophs accounted for 48% (n=202). Diagnoses on admission were dominated by infections neonatal, inhalation of amniotic fluid, hyaline membrane disease and perinatal asphyxia. The mortality rate was 19% (n=95). The most frequently found causes of death were related to prematurity (48.4%), respiratory distress (82%) and nosocomial infections (20%). Conclusion: Despite initiatives undertaken at the national level, statistics remain alarming and call for more efforts to be made to achieve the Sustainable Development Goals (SDGs) by 2030.","PeriodicalId":297300,"journal":{"name":"Pediatrics and Neonatal Medicine","volume":"25 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131882441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Successful Treatment of Severe Lead Poisoning Children with Low Dosage of CaNa2EDTA -A Retrospective Study of 8 Cases from China","authors":"Peng Li, Shuxia Huang","doi":"10.33425/2768-0363.1012","DOIUrl":"https://doi.org/10.33425/2768-0363.1012","url":null,"abstract":"Background: To analyze the clinical features, treatment and prognosis of 8 Chinese children with severe lead poisoning. Methods: 8 children with blood lead levels (BLLs) over 45ug/dL hospitalized at Beijing Chaoyang Hospital of Capital Medical University from January 2015 to December 2019 were diagnosed as severe lead poisoning. Detailed medical data were retrospectively studied. All patients accepted the chelation therapy with calcium disodium ethyleneaminetetraacetate (CaNa2 EDTA). Results: The onset age ranged from 3 months to 12 years old. BLLs ranged from 46.6ug/dL to 120.2ug/dL. The sources of lead exposure were different while 3 cases had taken Chinese herbs. 3 cases had symptoms of nervous system. 3 cases had anemia. 2 cases had abnormal liver function. All patients had normal renal function. All cases accepted the repeated treatment of consecutive intravenous CaNa2 EDTA (20mg/kg/d, 5 days every month), until BLLs remained below 40ug/dL. 1 case One case got rash and one patient got transient elevated serum transaminase during the courses. All cases had BLLs under 45ug/dL on followup. Conclusion: Chinese herbs containing lead might be one of the attributing factors of lead poisoning in children. Low dosage of CaNa2 EDTA was relatively safe and effective in dealing with lead poisoning in children.","PeriodicalId":297300,"journal":{"name":"Pediatrics and Neonatal Medicine","volume":"61 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132427044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bacterial and prognostic profile of nosocomial meningitis in newborns","authors":"FZ Elhanafi, F. Bennaoui, N. Mahir, NE Slitine, Maoulainine Fmr","doi":"10.33425/2768-0363.1011","DOIUrl":"https://doi.org/10.33425/2768-0363.1011","url":null,"abstract":"Introduction: Nosocomial neonatal meningitis is particularly dreadful because it occurs in patients of immature immunity and a developing brain. It is always a challenge for the clinician due to its clinical polymorphism making the diagnosis often difficult Aim: To study the epidemiological, clinical, bacteriological, therapeutic and evolutionary aspects of neonatal nosocomial bacterial meningitis. Results: Through our series, we reported fourteen cases of nosocomial meningitis, ie 43% of meningitis recorded over the study period. A male predominance was observed in 57.1%. The newborns were preterm in 28% of cases and had low birth weight in 42% of cases. The germ isolated was Klebsiella pneumoniae in 28.4% of cases. The blood culture was positive in 64% of cases. The same germ was isolated in both blood and the cerebrospinal fluid in 42% of cases. The complications found were: ventriculitis (28.5%), triventricular and tetraventricular hydrocephalus (14.2%) and multiple cerebral abscesses (14.2%). The mortality rate recorded in our series was 28.5%. Conclusion: Nosocomial meningitis is a serious or even fatal condition requiring early diagnosis and adequate antimacrobial therapy. Prevention remains the best strategy for the battle against this infection","PeriodicalId":297300,"journal":{"name":"Pediatrics and Neonatal Medicine","volume":"9 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115240667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Variations Analysis of Mitochondrial Cytochrome b (MT-CYB) Gene in Malnourished Children from Senegal","authors":"Jessika Issa, F. Mbaye, Ly Fatou, A. Diallo, Pape Mbacké Sembène","doi":"10.33425/2768-0363.1014","DOIUrl":"https://doi.org/10.33425/2768-0363.1014","url":null,"abstract":"Introduction: Child malnutrition is a major cause of infant morbidity and mortality worldwide and thus a major public health problem. The study of interactions between nutrition and genes— nutritional genomics—encompasses two domains: nutrigenetics and nutrigenomics. Malnutrition (deficiency or excess) can thus affect gene expression and genome stability. Objective: The objective of this work is to investigate mutations of interest of Mitochondrial Cytochrome b (MT-CYB) that may be related to child malnutrition and to study the genetic diversity of MT-CYB. Materials and methods: We analyzed the variability of MT-CYB in 23 malnourished children and six healthy children via PCR-sequencing. The search of mutations in the MT-CYB gene was conducted using Surveyor Mutation software. Nine prediction software programs (i.e., SIFT, PROVEAN, POLYPHEN-2, DEOGEN, SNPs & go, PREDICTSNP, MUTATIONTASTER, PANTHER, and FATHMM) were used to determine the functional impact of mutations. The various parameters of the genetic variety as well as the genetic differentiation of MT-CYB were obtained using DNAsp Version 5.1001, Harlequin Version 3.1 and Mega X. Results: A total of 24 mutations (Z-score ≥ 20) were identified in malnourished and healthy children. Among the non-synonym mutations present in malnourished children, mutations p.N206N/I, p.T336H, p.Y345A, p.T348T/N, and p.L357L/V were predicted pathogenic by at least five predictive software programs. The amino acids Ile, Lys, Arg and Asn demonstrate significant differences between normal and malnourished children. There is a predominance of T+A (53.72%) compared to C+G (46.28%). Our results show high haplotypic diversity (1.000+/-0.013) and low nucleotide diversity (0.10545+/- 0.00488). Conclusion: Our results allowed us to detect mutations in the MT-CYB gene that could be linked to childhood malnutrition. A decrease in isoleucine (Ile), asparagine (Asn), and arginine (Arg) may be correlated with the risk of malnutrition. This study will allow to readjust the strategies to fight against malnutrition.","PeriodicalId":297300,"journal":{"name":"Pediatrics and Neonatal Medicine","volume":"149 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130646175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fetal Macrosomia And Associated Factors at The National Hospital Center of Pikine (CHNP) Dakar/ Senegal","authors":"F. Ly, B. Fall, A. Sakho Kane, F. Sarr, AA Diouf, Cissé Df, D. A","doi":"10.33425/2768-0363.1015","DOIUrl":"https://doi.org/10.33425/2768-0363.1015","url":null,"abstract":"Introduction: Fetal macrosomia is a major risk factor for perinatal and maternal morbidity and mortality in developing countries such as Senegal. With this in mind, the objectives of our study were to describe the epidemiological, clinical, paraclinical and evolutionary characteristics of macrosomic newborns admitted to the Pikine National Hospital Center and to study the factors associated with macrosomia. Materials and methods: This was a prospective study conducted over a period of 6 months, from 1 December 2021 to 30 June 2022 at the CHN of Pikine. Results: The hospital prevalence was 4.79%. The most represented maternal age group was between 25 and 35 years. The medical-obstetric pathologies during pregnancy were dominated by gestational diabetes (46.1%). The average maternal body mass index (BMI) during pregnancy was 28.47 ± 4.7 kg/m². The majority of macrosomic babies were born at term. Macrosomia was Grade 1 in 75.65% of cases. The main complications were hypoglycaemia and obstetric trauma. Cardiac abnormalities were found in newborns of diabetic mothers. Mortality was 2.61%. Factors that were significantly associated with macrosomia were: multiple gestations, multiple pregnancies and a history of macrosomia. Conclusion and recommendations: Even if its incidence seems low compared to LBW, fetal macrosomia can lead to obstetrical and neonatal complications that can be dramatic for the mother and/or the newborn; hence the need to ensure their prevention through better monitoring of pregnancy and delivery in all pregnant women at risk.","PeriodicalId":297300,"journal":{"name":"Pediatrics and Neonatal Medicine","volume":"31 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132009408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Pilot Randomized Control Trial of Safety and Feasibility of a Delayed Rewarming Intervention for Infants Following Cardiopulmonary Bypass Surgery","authors":"A. Craig, K. Deerwester, Lauren McAllister, F. Noubary, Mary E. Hourihan","doi":"10.33425/2768-0363.1009","DOIUrl":"https://doi.org/10.33425/2768-0363.1009","url":null,"abstract":"Objective: Investigate safety and feasibility of a 12-hour delayed rewarming intervention on infants following congenital heart disease (CHD) surgery. Study Design: Pilot randomized control trial of infants <6 months old with CHD undergoing cardiopulmonary bypass surgery. Infants were randomized 1:1 to standard of care (SOC) or to delayed rewarming intervention, accomplished by using a commercially available temperature regulating blanket set to gradually rewarm from 35°C to 36.5°C in the 12-hours following surgery. Safety was assessed by comparing the frequency of severe adverse events (SAE) for 48 hours after surgery. Feasibility was assessed by analysis of temperature data. Results: Twelve infants were randomized to SOC and 10 to the intervention group. Eight infants (36%) were female, 6 (27%) had Trisomy 21 and 7 (32%) had surgery in the first two weeks of life. Two SOC and one intervention infant had at least one SAE (p=0.57). Feasibility of the delayed rewarming intervention was demonstrated by a statistically significant difference in temperature over time between groups (p<0.001). Heart rates for infants in the intervention group were slower during and after the intervention, without significant changes in blood pressure. Infants in the intervention group had no evidence of coagulopathy with lower, but not statistically significantly lower, chest tube output at alltime points. Conclusions: There were no differences in the number of SAEs for the delayed rewarming group and the temperature curve indicates that the intervention is feasible. The results of this small study, from a single, small volume center must be interpreted cautiously. (NCT03036072).","PeriodicalId":297300,"journal":{"name":"Pediatrics and Neonatal Medicine","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130941999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The management of newborns of mothers who are COVID-19 positive in a \"COVID-free\" hospital in Italy","authors":"Migliori Claudio,, Braga Marta, Villa Maria Cristina,, Cotta-Ramusino Aristide, Bianchi Stefano","doi":"10.33425/2768-0363.1006","DOIUrl":"https://doi.org/10.33425/2768-0363.1006","url":null,"abstract":"The strategies planned by the Italian Ministry of Health to manage the COVID-19 pandemic include the centralisation of positive subjects in specific centres (Hubs) as well keeping others \"COVID free\". However due to the large number of positive subjects, the beds available have sometimes been inadequate. All pregnant women, at admission to the hospital, are screened and, if positive, sent to an Hub, but in the case of known positivity after birth, without bed availability, we structured a plan to complete the hospitalisation in our department of asymptomatic mothers with negative newborns. From October to December 2020, eleven babies were born to mothers who tested COVID-19-positive after delivery. Seven of them completed hospitalisation in our department. No complications in mother-baby dyads and no contagion among hospital staff were found. This strategy, even in a limited number of cases, allowed the management without complications for both patients and healthcare professionals.","PeriodicalId":297300,"journal":{"name":"Pediatrics and Neonatal Medicine","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130153178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Breastfeeding Techniques in Breast Milk Dams of Primipara Mothers at Gynecology Room","authors":"Jenita Dt Donsu, A. Pont, Herman Tandilimbong,, A. Rahman, Syam sir, Syarifuddin, Agussalim","doi":"10.33425/2768-0363.1007","DOIUrl":"https://doi.org/10.33425/2768-0363.1007","url":null,"abstract":"","PeriodicalId":297300,"journal":{"name":"Pediatrics and Neonatal Medicine","volume":"17 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122036568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diffuse Intrinsic Pontine Glioma in an 11-Year- Old Female Treated with Antineoplastons: Complete Response and >25 Years Survival","authors":"Burzynski Stanislaw, Burzynski Gregory, Janicki Tomasz, Beenken Samuel","doi":"10.33425/2768-0363.1010","DOIUrl":"https://doi.org/10.33425/2768-0363.1010","url":null,"abstract":"Rationale: Diffuse intrinsic pontine glioma (DIPG), a lethal brain tumor, is the leading cause of brain tumor–related death in children. Over the past few decades clinical trials have shown no improvement in outcome. The purpose of this case study is to detail and discuss the use of Antineoplastons A-10 (Atengenal) and AS2-1 (Astugenal) in the treatment of an eleven-year-old female with a newly diagnosed DIPG. Objectives: The patient described here was enrolled into BT-11, a Phase II protocol utilizing Antineoplastons A-10 and AS2-1 in the treatment of brainstem gliomas. The patient’s tumor response to therapy was measured by sequential MRIs of the brain, with and without gadolinium contrast. Findings: At her presentation to the Burzynski Clinic (BC), the patient was alert, and weighed 42.1 Kg. Physical examination showed dysfunction of the 6th and 7th cranial nerves, with lateral movement of the left eye being decreased by approximately 30% and with left-sided facial weakness being present. The patient obtained a baseline MRI, with and without gadolinium. Post-gadolinium T1-weighted axial images showed a 0.80 cm2 enhancing pontine mass and a 2.70 cm2 non-enhancing left-sided brainstem mass. Following Antineoplastons (ANP), the patient achieved a complete response (CR) of the enhancing pontine mass. At that time, physical examination, especially neurologic examination, showed no abnormalities. The patient was last seen at the BC on October 15, 2004 and she was in excellent health with no evidence of new/recurrent disease. On August 10, 2021, correspondence with the patient indicated that she continued in excellent health (>25 years survival). Conclusions: ANP is an effective treatment for DIPG and for a variety of low- and high-grade brain tumors. Multiple Phase II protocols utilizing ANP have now been completed and its impact on the treatment of brain tumors has been widely published.","PeriodicalId":297300,"journal":{"name":"Pediatrics and Neonatal Medicine","volume":"84 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133299226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unusual Presentation of Herpes Simplex Virus Hepatitis in Pregnancy leading to severe Maternal Morbidity and Sadly Neonatal Death: A Case Report and Review","authors":"Shaista Zubair, S. Patni, Sonali Gupta, Idoracaera Ikhwan","doi":"10.33425/2768-0363.1008","DOIUrl":"https://doi.org/10.33425/2768-0363.1008","url":null,"abstract":"","PeriodicalId":297300,"journal":{"name":"Pediatrics and Neonatal Medicine","volume":"54 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"120924939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}