International Journal of Medical Sciences And Clinical Research最新文献

{"title":"STUDYING THE ACUTE TOXICITY AND ANTI-TUMOR ACTIVITY OF THE NEW DRUG COLHAMETIN","authors":"Yuldashev Javlonabduraimovich, Ibragimov Shavkat Narzikulovich, Shakhanova Shakhnoza Shavkatovna, Esankulova Bustonoy Sobirovna","doi":"10.37547/ijmscr/volume03issue03-06","DOIUrl":"https://doi.org/10.37547/ijmscr/volume03issue03-06","url":null,"abstract":"The aim of the study was to study acute toxicity during intraperitoneal administration of a new antitumor drug \"colhametin\" (K-2) in mice and rats and its antitumor activity on 2 strains of tumors, including with a smaller number of injections. Material and research methods. Acute toxicity of the K-2 preparation after a single intraperitoneal injection was carried out according to the Litchfield and Wilcoxon method on 30 white outbred mice weighing 20±2g of both sexes and 30 male and female rats weighing 140±10g, 5 animals in each group. The study of antitumor activity was performed on 12 outbred mice and 16 outbred rats with transplanted tumors S-180 (Sarcoma-180) and WC (Walker's sarcoma) which were administered drugs on the 4th day after tumor inoculation 10- and 5-fold. The results were evaluated according to standard criteria: tumor growth inhibition (TGI), body weight and spleen of animals Differences were considered significant at p<0.05. Results. The following data were obtained with a single intraperitoneal injection to mice: the average lethal dose of LD50 is 890 (-150 + 172) mg/kg, LD50 with a single intraperitoneal dose of K-2 preparation in rats, LD50 is 410 (-56 + 61) mg/kg, the values are also determined LD10, LD16 and LD84. The antitumor activity of the drug K-2 on the tumor strain Sarcoma - 180 was high, 99/90%. On WC tumors the effect of K-2 reached 90/91% with 10-fold administration, and 89/89% with 5-fold administration, however, its effect was accompanied by a decrease in hematopoietic parameters. Conclusions. The study of the acute toxicity of the substance of the preparation K-2 showed that this preparation belongs to the IV class of low-toxic compounds. On 2 tumors, the effect of the new drug was high, which did not decrease with a decrease in the number of injections.","PeriodicalId":297181,"journal":{"name":"International Journal of Medical Sciences And Clinical Research","volume":"19 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121700697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"STRATEGIES FOR VACCINE DEVELOPMENT OF COVID-19 IN THE WORLD","authors":"Mirkhamidova Sevara Mirmakhmudovna, Abrarul Haq, Ilyasova Munisa Mirvaliyevna, Khudaykulova Gulnara Karimovna","doi":"10.37547/ijmscr/volume03issue03-02","DOIUrl":"https://doi.org/10.37547/ijmscr/volume03issue03-02","url":null,"abstract":"The purpose of this phase is to study the best doses to use, the most common side effects and how many doses are needed and protect individuals at highest risk from serious illness or death.","PeriodicalId":297181,"journal":{"name":"International Journal of Medical Sciences And Clinical Research","volume":"174 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127583717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"IMPLEMENTATION AND RESULTS OF SURVEY HELD IN THE AWARENESS OF PUBLIC ON ALLERGIC CONTACT DERMATITIS","authors":"Mirkhamidova Sevara Mirmakhmudovna, Jenifer Alat Stephen, Karimbayev Shakhrambay Dexkanbayevich, Abdurashitova Sharafat Abdumajidovna","doi":"10.37547/ijmscr/volume03issue03-11","DOIUrl":"https://doi.org/10.37547/ijmscr/volume03issue03-11","url":null,"abstract":"Allergic Contact Dermatitis due to cosmetic products is a common dermatologic complaint that considerably affects the quality of life. Most cases are caused by skin hygiene and moisturizing products followed by cosmetic hair and nail products. Fragrances are the most cause of allergy to cosmetics, followed by hair dyes and preservative [1]. Patch Testing remains the gold standard for identification of causative allergens [5]. Careful determination of allergen avoidance can result in dramatic clinical improvement.","PeriodicalId":297181,"journal":{"name":"International Journal of Medical Sciences And Clinical Research","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130256075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ESTIMATION OF PETRIFYING TRENDSETTING TWINGE BY VIBRATION PARAPHRASE","authors":"Dr. Ritu Mishra","doi":"10.37547/ijmscr/volume03issue03-01","DOIUrl":"https://doi.org/10.37547/ijmscr/volume03issue03-01","url":null,"abstract":"Introduction- Petrifying trendsetting twinge may be a common problem with varied aetiologies. MRI has excellent soft tissue resolution and sensitive for detecting osseous, chondral, marrow abnormality and will be the simplest modality for various intra-articular and extra-articular causes of trendsetting twinge. Material and method- this study was done at our tertiary health care centre for 2 years during which 125 patients with a history of petrifying trendsetting twinge were included. Clinical history, laboratory parameters with proper MRI protocol with contrast administration wherever indicated was under taken to guage various causes of trendsetting twinge and to assess MRI appearances of trendsetting pathologies. the main target of our study was to seek out MR characteristics of the varied disease and to guage the simplest sequence for various trendsetting pathologies. We also evaluated various clinical and radiological parameters related to future femoral head collapse. Results- Amongst 125 patient evaluated commonest pathology for the explanation for petrifying trendsetting twinge was avascular necrosis of femoral head. red blood cell disease, chronic alcohol and steroid use were common causes for AVN. Site and percentage of femoral head involvement are essential predictors for future collapse of the femoral head. Amongst paediatric age bracket, transient synovitis followed by osteomyelitis may be a commonest cause for trendsetting twinge. Contrast-enhanced MRI can help within the differentiation of Pyogenic vs Tubercular arthritis. Gadolinium administration should be wiped out all cases of inflammatory arthritis to detect associated synovitis, enthesitis, bursitis. Conclusion- Various trendsetting pathologies cause progressive destruction of trendsetting where early diagnosis help in arresting the disease progression and prompt management of the patient.MRI is non-invasive, accurate and sensitive for trendsetting pathologies and proves to be the modality of choice within the guesstimation of trendsetting twinge altogether the age groups.","PeriodicalId":297181,"journal":{"name":"International Journal of Medical Sciences And Clinical Research","volume":"5 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115407871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ANALYSIS OF EARLY DIAGNOSIS AND TREATMENT OF MUCORMYCOSIS IN PATIENTS WITH COVID-19","authors":"Mirzaqandov Elyor Erkinjon Ogli, Moydinov Ravshanjon Rakhimjonovich, Usmonov Sanjar Bahromjon Ogli","doi":"10.37547/ijmscr/volume03issue02-11","DOIUrl":"https://doi.org/10.37547/ijmscr/volume03issue02-11","url":null,"abstract":"The development of mucormycosis is also caused by the lack of timely diagnosis and treatment of patients with chronic hemisinusitis after suffering from Covid-19, as well as the omission of intraocular and intracerebral complications. Timely diagnosis and treatment of mucormycosis during a pandemic are of great importance in the rapid recovery of the general condition of patients, and prevention of sinus thrombosis and other complications.","PeriodicalId":297181,"journal":{"name":"International Journal of Medical Sciences And Clinical Research","volume":"159 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116741271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PECULIARITIES OF FORENSIC MEDICAL ASSESSMENT OF LIVER, SPLEEN AND KIDNEY DAMAGE DURING A FALL FROM HEIGHT","authors":"O. I. Khvan, A. Don, K. Yakubov, T.K. Nasyrov","doi":"10.37547/ijmscr/volume03issue02-06","DOIUrl":"https://doi.org/10.37547/ijmscr/volume03issue02-06","url":null,"abstract":"The article reflects the data of an expert assessment of blunt abdominal trauma in a fall from a height. It is especially important to find out the circumstances of the injury in order to have an idea of possible damage to the hollow and parenchymal organs of the abdominal cavity. According to the conducted studies, when falling from a height, characteristic damage was established, depending on the height of the fall.","PeriodicalId":297181,"journal":{"name":"International Journal of Medical Sciences And Clinical Research","volume":"40 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134509610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CLINIC, DIAGNOSIS AND TREATMENT OF OCCLUSIVE HYDROCEPHALUS IN CHILDREN","authors":"Saidumarov Dilshod Mirzaakhmatovich, Saidumarova Marguba Tulanovna","doi":"10.37547/ijmscr/volume03issue02-07","DOIUrl":"https://doi.org/10.37547/ijmscr/volume03issue02-07","url":null,"abstract":"This article deals with the clinic, diagnosis and methods of treatment of occlusive hydrocephalus in children. The authors of the article consider that surgical intervention in the treatment of occlusive hydrocephalus in children is the only method to combat the disease. In most cases, medication can only slow down the course of the disease, but does not eliminate the underlying cause of the disease. In the case of a successful operation, almost complete recovery and a return to a normal life is possible","PeriodicalId":297181,"journal":{"name":"International Journal of Medical Sciences And Clinical Research","volume":"33 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123387303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MODERN METHODS OF TREATMENT OF VIRAL HEPATITIS","authors":"J. Djuraev, Sh. Khodjanov, A. Shaumarov, U. Abdullaev, A. J. Botirov, Safura M. Mingboboeva, Solikha O. Dadakhanov, Lola T. Kuzieva","doi":"10.37547/ijmscr/volume03issue02-14","DOIUrl":"https://doi.org/10.37547/ijmscr/volume03issue02-14","url":null,"abstract":"This scientific article discusses the causes of viral hepatitis, classification of hepatitis, symptoms, diagnosis of the disease, treatment and prevention of viral hepatitis.","PeriodicalId":297181,"journal":{"name":"International Journal of Medical Sciences And Clinical Research","volume":"30 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132908049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CURRENT STATUS OF DIAGNOSTICS OF NOCTURAL ENUREZIS IN CHILDREN AND ADOLESCENTS”","authors":"J. Djuraev, N. Akhundjanov, B. Narmurotov, P.B. Aibatova, A.T. Esbergenova, Sh.A. Zakirova, D. Ismoilova, D. Khakimova","doi":"10.37547/ijmscr/volume03issue02-13","DOIUrl":"https://doi.org/10.37547/ijmscr/volume03issue02-13","url":null,"abstract":"These analyzes of the study on the methodology for diagnosing nocturnal enuresis in children and adolescents are given and the causes and circumstances diagnosed by modern technologies are considered. Nocturnal enuresis, involuntary urination during sleep in a child who is already able to control his physiological needs for it, occurs frequently 5-17% depending on age.[1]","PeriodicalId":297181,"journal":{"name":"International Journal of Medical Sciences And Clinical Research","volume":"6 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133860771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PHYSIOTHERAPEUTIC TREATMENT METHODS AND URINARY INCONTINENCE","authors":"Tilavova Sitora Amirzoda, Khudoyarova Dildora Rakhimovna","doi":"10.37547/ijmscr/volume03issue02-02","DOIUrl":"https://doi.org/10.37547/ijmscr/volume03issue02-02","url":null,"abstract":"This article presents the results of scientific work on the effectiveness of complex treatment methods for premenopausal women with urinary incontinence at the Department of Obstetrics and Gynecology No. 1 of Samarkand State Medical University. The study was conducted on women who applied to the gynecology department during 2019-2020. According to the method of treatment, women were divided into 2 groups: the main group was prescribed complex treatment, and the comparison group was prescribed only medical treatment. As a result, the effectiveness of the complex treatment method was determined.","PeriodicalId":297181,"journal":{"name":"International Journal of Medical Sciences And Clinical Research","volume":"16 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127214189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}