Vascular Biology - Selection of Mechanisms and Clinical Applications最新文献

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Nitric Oxide and Oxidative Stress-Mediated Cardiovascular Functionality: From Molecular Mechanism to Cardiovascular Disease 一氧化氮和氧化应激介导的心血管功能:从分子机制到心血管疾病

Vascular Biology - Selection of Mechanisms and Clinical Applications Pub Date : 2019-02-13 DOI: 10.5772/INTECHOPEN.82556

Weilue He, M. Kwesiga, Eyerusalem A Gebreyesus, Sijia Liu

{"title":"Nitric Oxide and Oxidative Stress-Mediated Cardiovascular Functionality: From Molecular Mechanism to Cardiovascular Disease","authors":"Weilue He, M. Kwesiga, Eyerusalem A Gebreyesus, Sijia Liu","doi":"10.5772/INTECHOPEN.82556","DOIUrl":"https://doi.org/10.5772/INTECHOPEN.82556","url":null,"abstract":"The underlying pathology of most cardiovascular diseases (CVDs) such as coronary artery disease, high blood pressure, and stroke involves decreased cardiovascular contractility and anatomic alterations in cardiovascular structures. Nitric oxide (NO) regulates vascular tone and contractile function of myocardium and maintains blood vessel homeostasis. Interestingly, the effect of NO is like a double-edged sword in the body. Insufficient NO causes hypertension and atherosclerosis, while an overproduction of NO may foster inflammation and cause heart infarction and shock. In addition, growing evidences have shown that oxidative stress plays pivotal roles in the initiation and progression of CVDs. This chapter will discuss in detail the roles NO plays in the cardiovascular system under both physiological and pathological conditions. We will focus on: (1) the molecular mechanism of cardiovascular contraction, (2) NO/Ca2+-induced muscle relaxation, (3) NO-related structural change in blood vessels, and (4) redox balance in the cardiovascular system. The relationships between these molecular mechanisms and the characteristics of CVDs will be highlighted.","PeriodicalId":294085,"journal":{"name":"Vascular Biology - Selection of Mechanisms and Clinical Applications","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122487022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 10

Potassium Channels in the Vascular Diseases 血管疾病中的钾通道

Vascular Biology - Selection of Mechanisms and Clinical Applications Pub Date : 2018-12-14 DOI: 10.5772/INTECHOPEN.82474

Yanrong Zhu, Xiao-Xin Jiang, Peng Ye, Shaoliang Chen, Dai-Min Zhang

引用次数: 3

Anomalous Origin of Coronary Arteries 冠状动脉异常起源

Vascular Biology - Selection of Mechanisms and Clinical Applications Pub Date : 2018-11-05 DOI: 10.5772/INTECHOPEN.76912

X. Krasniqi, Hajdin Çitaku

{"title":"Anomalous Origin of Coronary Arteries","authors":"X. Krasniqi, Hajdin Çitaku","doi":"10.5772/INTECHOPEN.76912","DOIUrl":"https://doi.org/10.5772/INTECHOPEN.76912","url":null,"abstract":"Coronary arteries supply the heart muscle with blood maintaining myocardial hemostasis and function. Coronary artery anomalies may persist after birth affecting cardiovascular system through haemodynamic impairment caused from shunting, ischaemia, especially in young children or adolescents and young adults. In patients undergoing coronary angiography the incidence of anomalous origination of the left coronary artery from right sinus is 0.15% and the right coronary artery from the left sinus is 0.92%. A recent classification of the coronary anomalies is based on anatomical considerations, recognizing three categories: anomalies of the origin and course, anomalies of the intrinsic coronary artery anatomy, and anomalies of the termination. In the setting of anomalous coronary artery from the opposite sinus, the proximal anomalous CA may run anterior to the pulmonary trunk (prepulmonic), posterior to the aorta (retroaortic), septal (subpulmonic), or between the pulmonary artery and the aorta itself (interarterial). Among them, only those with an interarterial aorta-pulmonary course are regarded as hidden conditions at risk of ischaemia and even sudden death. We presented two cases with anomalous origin of coronary arteries from opposite sinus, and two other cases with anomalous origin of left circumflex artery. The atherosclerotic coronary artery disease leads to the need of coronarography which can find out the presence of coronary artery anomalies. Anomalous origin of coronary artery that is present with atherosclerotic changes continues to exist as a challenge during treatment in interventional cardiology.","PeriodicalId":294085,"journal":{"name":"Vascular Biology - Selection of Mechanisms and Clinical Applications","volume":"25 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133869554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 17

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