{"title":"Pathogenesis and complications of non-alcoholic steatohepatitis and its management by nutraceuticals","authors":"Al-Okbi Sahar Y","doi":"10.17352/ojh.000010","DOIUrl":"https://doi.org/10.17352/ojh.000010","url":null,"abstract":"Non-Alcoholic Steatohepatitis (NASH) is a real health problem that is commonly associated with obesity and diabetes. Cardiovascular diseases, liver carcinoma, and liver failure might develop from NASH if not well managed. The present article deals with the pathogenesis of non-alcoholic steatohepatitis and its complications in addition to exploring the importance of using nutraceuticals in its prevention and treatment.","PeriodicalId":288820,"journal":{"name":"Open Journal of Hepatology","volume":"35 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140427521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The effect of physical load of varying intensity on the activity of liver enzymes and hepatocytes’ proliferation","authors":"Malyshev Ii, Romanova Lp, Vorob'eva Ov","doi":"10.17352/ojh.000008","DOIUrl":"https://doi.org/10.17352/ojh.000008","url":null,"abstract":"The paper establishes the relationship between enzymatic activity and the proliferation of hepatocytes. Low-intensity physical activity is shown not to influence the activity of hepatocytes’ enzymes and their proliferation. Hard work results in decreased activity of redox enzymes; at the same time, the proliferation of hepatocytes is inhibited for a long time. The most favorable is moderate load, which leads to the activation of oxidative-reducing enzymes and increases the number of binucleated hepatocytes, which persist for a long time after the end of the experiment.","PeriodicalId":288820,"journal":{"name":"Open Journal of Hepatology","volume":"41 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131402148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Examination of Paraffin Sections of Different Rainbow Trout (Oncorhynchus mykiss) Tissues by Light and Scanning Electron Microscope","authors":"Demirci Beste, Terzi Funda, Kesbiç Osman Sabri","doi":"10.17352/ojh.000007","DOIUrl":"https://doi.org/10.17352/ojh.000007","url":null,"abstract":"The current study aimed to highlight histopathological findings in paraffin block sections of the liver, gill kidney, and pyloric cecum of rainbow trout (Oncorhynchus mykiss) by different imagining devices such as Scanning Electron (SEM) and Light Microscope (LM). To determine the performance of different imagining methods two different thickness paraffin sections such as 5 and 15 µm about various rainbow trout tissue were prepared for imagining different devices. That sections were imagined by SEM and LM, both sections including 5 and 15 µm were imagined by SEM while just 5 µm was an image by LM. In LM imagining, it was detected that hydropic degeneration and vacuole formations in the liver hepatocytes of fish, as well as hyperplasia in bile ducts. Lamellar epithelial cell hyperplasia/hypertrophy was mild and histopathological findings such as secondary lamellar elevation and edema were more severe in rainbow trout gills. Glomerular atrophy/hypertrophy was moderately detected in the kidneys and hydropic degeneration of tubular epithelium was more severe. No degeneration or necrosis was observed in the lamina epithelium of the pyloric cecum. In SEM imagining of different thickness paraffin sections, cartilage and secondary lamellar structure in the gills, glomerulus, and Bowman’s capsule structure in the kidneys, and the structure of the pyloric cecum was observed. In the SEM imaging of the paraffin block sections of hepatocytes of the liver, the cell nuclei were determined, and also the grooves in the cytoplasm were thought to be vacuoles. As a consequence, the structural elements of the organ had higher clarity in SEM imaging from paraffin block sections, but the histopathological alterations remained unclear. As a result, SEM imaging of fish tissue is more suited for seeing tissue architecture, although LM imaging is better suited for determining and scoring histopathological variations.","PeriodicalId":288820,"journal":{"name":"Open Journal of Hepatology","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131090394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
K. Dvir, G. G. Fortuna, Nathaly Cortez, V. Guerra, M. Cusnir
{"title":"Advances in Cholangiocarcinoma Treatment in the Personalized Medicine Era","authors":"K. Dvir, G. G. Fortuna, Nathaly Cortez, V. Guerra, M. Cusnir","doi":"10.17352/ojh.000004","DOIUrl":"https://doi.org/10.17352/ojh.000004","url":null,"abstract":"Cholangiocarcinoma is amongst the most common primary tumors of the liver, second only to hepatocellular carcinoma, and it accounts for approximately 15% of primary hepatic malignancies [1].","PeriodicalId":288820,"journal":{"name":"Open Journal of Hepatology","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-11-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122410049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Evaluation of association of demographic profiles and sero prevalence of HBV and HCV among the patients presenting with chronic liver disease and its complications: A Tertiary Care Hospital Based Study","authors":"R. Gomes, Md. Akmat Ali","doi":"10.17352/ojh.000003","DOIUrl":"https://doi.org/10.17352/ojh.000003","url":null,"abstract":"Now-a-days chronic liver disease is one of the major health problems in the world. In developing countries, chronic liver disease due to hepatitis virus (like hepatitis B and hepatitis C virus) is increasing day by day.","PeriodicalId":288820,"journal":{"name":"Open Journal of Hepatology","volume":"6 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130936200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Alcohol, hepatitis C screening and hepatic fibrosis in drug users","authors":"F. DiNino, F. Chaffraix, M. Schaeffer, M. Dofföel","doi":"10.17352/OJH.000002","DOIUrl":"https://doi.org/10.17352/OJH.000002","url":null,"abstract":"Background: In drug users, viral hepatitis C, alcohol abuse, and drug use are three interconnected public health challenges. \u0000Methods: This study assessed the impact of alcohol on hepatitis C screening and hepatic fibrosis in this patient population. In total, 934 substance users were included and divided into three groups: Group A, alcohol use disorder only (n = 511); Group ISDU, intravenous and snorting drug users (n = 142); Group ISDAU, intravenous and snorting drug users with alcohol use disorder (n = 281). A FibroScan was performed first, after which participants were proposed to undergo screening for HCV.","PeriodicalId":288820,"journal":{"name":"Open Journal of Hepatology","volume":"31 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121158436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}