Sciences of Phytochemistry最新文献_第3页

Comparison of blood glucose control among type 2 diabetics consuming oral antidiabetic drug versus oral antidiabetic drug with home remedies 2型糖尿病患者口服降糖药与家庭用药的血糖控制比较

Sciences of Phytochemistry Pub Date : 2023-01-12 DOI: 10.58920/sciphy02010001

Kavitha Pai, N. Mathews, M. Garg

{"title":"Comparison of blood glucose control among type 2 diabetics consuming oral antidiabetic drug versus oral antidiabetic drug with home remedies","authors":"Kavitha Pai, N. Mathews, M. Garg","doi":"10.58920/sciphy02010001","DOIUrl":"https://doi.org/10.58920/sciphy02010001","url":null,"abstract":"In this study, we aim to compare the blood glucose control, dietary habits, glycemic load, socio-demographic & lifestyle habits, and anthropometric indices among type 2 diabetics that are consuming oral antidiabetic drug alone versus oral antidiabetic drug with home remedies. A cross-sectional study was undertaken on 300 patients attending OPDs of the Department of Medicine, Kasturba Hospital, Manipal, India, and Goretti Hospital Kallianpura, Udupi, India. The data were subjected to statistical analysis with the SPSS 16 software and dietary analysis was performed with the DietCal software. Out of 300 samples, 127 (42.3%) consumed the antidiabetic drug along with home remedies while 173 (57.7%) participants consumed the antidiabetic drug alone without home remedies. There was no significant difference in glycemic parameters like FBS (0.577NS), PPBS (0.179 NS) HbA1C (0.413NS), and there is no significant difference in the mean glycemic load of the diet between participants of the 2 groups (0.653NS). Dietary habits, socio-demographics, lifestyle habits, and anthropometric indices among the 2 groups do not show a significant difference. Our study revealed the poor control of diet in both groups. Home remedies can give an added benefit if diet and lifestyle modification are followed. Diet and lifestyle modification are very important for glycemic control to prevent long-term complications.","PeriodicalId":287837,"journal":{"name":"Sciences of Phytochemistry","volume":"41 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127164149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A beginner’s guide to molecular docking 分子对接的初学者指南

Sciences of Phytochemistry Pub Date : 2022-12-02 DOI: 10.58920/sciphy01020037

J. H. Zothantluanga, D. Chetia

引用次数: 4

NanoPhytoformulations: what is so interesting about the nanoscale ? 纳米植物配方:纳米尺度有什么有趣的?

Sciences of Phytochemistry Pub Date : 2022-11-29 DOI: 10.58920/sciphy01020034

Sanjoy Das, Taison Jamatia

引用次数: 0

An updated review of Rubus ellipticus (an edible shrub), its bioactive constituents and functional properties 综述了可食灌木红莓及其生物活性成分和功能特性的研究进展

Sciences of Phytochemistry Pub Date : 2022-11-22 DOI: 10.58920/sciphy01020022

A. Karn, M. Quasim, El Bethel Hmar, Sujata Paul, H. Sharma

{"title":"An updated review of Rubus ellipticus (an edible shrub), its bioactive constituents and functional properties","authors":"A. Karn, M. Quasim, El Bethel Hmar, Sujata Paul, H. Sharma","doi":"10.58920/sciphy01020022","DOIUrl":"https://doi.org/10.58920/sciphy01020022","url":null,"abstract":"The vast majority of people continue to view medicinal plants as a low-cost source of medications and treatments. Numerous trees, herbs, plants, and shrubs have been used as remedies for various ailments since the dawn of time. Rubus ellipticus Smith, a weedy wild raspberry that flourishes in damp woods at high elevations, particularly those in the Himalayas and the Nilgiris area, is one of the important ethnomedicinal plants in the genus Rubus. Traditional Tibetan medicine places a great deal of importance on the plant R. ellipticus. Because of the abundance and diversity of phenolics and flavonoids in fruits or berries, which have a high concentration of both, they are generally regarded as inherently healthful foods. The roots and leaves, as well as the fruit, have traditionally been used as therapeutic agents for several illnesses including colic pain, gastrointestinal discomfort, wound healing, diarrhea, antifertility, antibacterial, analgesic, epilepsy, and others. The objective of the current review is to concentrate on the pharmacological characteristics, nutrition profile, phytoconstituents, and folkloric therapeutic applications of R. ellipticus, therefore achieving the review's overall subject.","PeriodicalId":287837,"journal":{"name":"Sciences of Phytochemistry","volume":"32 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115034579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Bambusa vulgaris: A comprehensive review of its traditional uses, phytochemicals and pharmacological activities 竹笋的传统用途、植物化学成分和药理活性综述

Sciences of Phytochemistry Pub Date : 2022-11-22 DOI: 10.58920/sciphy01020011

Jeba Akhtar, Lima Patowary

引用次数: 1

In-silico design and screening of cephalosporin derivatives for their inhibitory potential against Haemophilus influenza 头孢菌素衍生物对流感嗜血杆菌抑制潜力的硅晶设计和筛选

Sciences of Phytochemistry Pub Date : 2022-10-12 DOI: 10.58920/sciphy01020001

Chikame Sangma, D. Chetia, Malita Borthakur, Lima Patowary, Dubom Tayeng

{"title":"In-silico design and screening of cephalosporin derivatives for their inhibitory potential against Haemophilus influenza","authors":"Chikame Sangma, D. Chetia, Malita Borthakur, Lima Patowary, Dubom Tayeng","doi":"10.58920/sciphy01020001","DOIUrl":"https://doi.org/10.58920/sciphy01020001","url":null,"abstract":"Antibiotics kill bacteria by blocking essential metabolic processes which prevent them from reproducing thereby allowing the immune system to fight bacterial infections. However, the emergence and the quick spread of bacterial resistance against clinically approved antibiotics have become alarming. This necessitates the development of novel treatment options and alternative antimicrobial therapies in the fight against bacterial infections. In this study, we aim to virtually design and carry out in-silico studies to identify a cephalosporin derivative with inhibitory potential against Haemophilus influenza. Data Warrior software, Discovery studio software, PyRx tool, Swiss ADME web tool, and ProTox-II web tool were used to screen the cephalosporin derivatives. Initially, 17 cephalosporin derivatives were preliminarily screened for their toxicity followed by in-silico ADME studies. Among the cephalosporin derivatives, C1, C6, and C12 were found to be the potential drug-like molecules with binding energies of -7.4 kcal/mol, -7.1 kcal/mol, and -7.1 kcal/mol, respectively. In particular, C1 was predicted to have a moderate biological activity with a high bioavailability score. Based on the ADME profile, toxicity, binding energy, drug-likeness, and drug score, we conclude C1 (‘F’ at the 3rd position) as the potential lead molecule to inhibit H. influenza.","PeriodicalId":287837,"journal":{"name":"Sciences of Phytochemistry","volume":"9 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132603771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Neuromodulatory effect of plant metabolites 植物代谢物的神经调节作用

Sciences of Phytochemistry Pub Date : 2022-07-26 DOI: 10.58920/sciphy01010047

Dhunusmita Barman, N. Dey, S. Sen, B. Kakoti, Catherine Vanlalhriatpuii

{"title":"Neuromodulatory effect of plant metabolites","authors":"Dhunusmita Barman, N. Dey, S. Sen, B. Kakoti, Catherine Vanlalhriatpuii","doi":"10.58920/sciphy01010047","DOIUrl":"https://doi.org/10.58920/sciphy01010047","url":null,"abstract":"Neurological disorders (NDDs) are diseases that affect the central and peripheral nervous systems. Gradual malfunction and destruction of the neurons or the nerve cells characterize them. Every year, NDDs affect millions of people worldwide. Over the years, several neuromodulatory techniques have been introduced to improve the quality of life for those affected by NDDs. NDDs are chronic and incurable conditions, however, bioactive substances derived from medicinal plants have emerged as the greatest choice for their prevention and treatment. Literature evidences several benefits of plant metabolites as alternative medicines for the prevention and treatment of NDDs. Numerous investigations have shown plant metabolites to possess beneficial biological effects because of their qualities, which include but are not limited to anti-inflammatory, antioxidant, and neuroprotective actions. Practices of folk medicine and several studies have also guided many phytopharmacological interventions toward the treatment of NDDs. This review aims to highlight secondary metabolites (alkaloids, flavonoids, steroids, terpenoids) of plants with neuroprotective action that could potentially play an important role in the prevention and management of NDDs.","PeriodicalId":287837,"journal":{"name":"Sciences of Phytochemistry","volume":"37 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133027285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Challenges and opportunities in the management of cardiovascular diseases 心血管疾病管理的挑战与机遇

Sciences of Phytochemistry Pub Date : 2022-07-25 DOI: 10.58920/sciphy01010042

H. Sarma, J. Sahariah, Rajlakhsmi Devi, H. Sharma

引用次数: 1

Computational studies of Bridelia retusa phytochemicals for the identification of promising molecules with inhibitory potential against the spike protein and papain-like protease of SARS-CoV-2 对具有抑制SARS-CoV-2刺突蛋白和木瓜蛋白酶潜力分子的计算研究

Sciences of Phytochemistry Pub Date : 2022-07-06 DOI: 10.58920/sciphy01010029

Lima Patowary, Malita Borthakur

{"title":"Computational studies of Bridelia retusa phytochemicals for the identification of promising molecules with inhibitory potential against the spike protein and papain-like protease of SARS-CoV-2","authors":"Lima Patowary, Malita Borthakur","doi":"10.58920/sciphy01010029","DOIUrl":"https://doi.org/10.58920/sciphy01010029","url":null,"abstract":"SARS-CoV-2 is the pathogen responsible for the on-going COVID-19 pandemic. The two proteins namely, spike protein and papain-like protease are mainly responsible for the penetration and transmission of the virus, respectively. The objective of our study was to find the most promising phytoconstituents of Bridelia retusa that can inhibit both the proteins. Molecular docking, protein-ligand interactions, and molecular dynamics (MD) simulation techniques were used in the study. Bepridil and the co-crystal inhibitors of each protein were used as the standards. All the 14 phytoconstituents along with the standard drug and the co-crystal inhibitor of each protein were subjected to molecular docking. Ten compounds showed better binding affinities than the standards against the spike protein and 7 compounds have shown better binding affinities than the standards against papain-like protease protein. From the protein-ligand interactions, a total of 3 out of 10 for the spike protein and 5 out of 7 for the papain-like protease showed better interactions than the standards. An all-atom MD simulations study revealed that (R)4-(1,5-dimethyl-3-oxo-4-hexenyl)-benzoic acid formed the most stable complex with both proteins. The in-silico study provides an evidence for (R)4-(1,5-dimethyl-3-oxo-4-hexenyl)-benzoic acid as a promising inhibitor of the spike and papain-like protease of SARS-CoV-2. Further investigations such as in-vitro/in-vivo studies are recommended to validate the potency of (R)4-(1,5-dimethyl-3-oxo-4-hexenyl)-benzoic acid.","PeriodicalId":287837,"journal":{"name":"Sciences of Phytochemistry","volume":"28 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114655506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

In-silico study for African plants with possible beta-cell regeneration effect through inhibition of DYRK1A 通过抑制DYRK1A对非洲植物β细胞再生可能产生影响的硅晶研究

Sciences of Phytochemistry Pub Date : 2022-07-01 DOI: 10.58920/sciphy01010013

Igbokwe Chikodili, Ibe Chioma, Nnorom Chinwendu, Ejiofor IfedibaluChukwu

{"title":"In-silico study for African plants with possible beta-cell regeneration effect through inhibition of DYRK1A","authors":"Igbokwe Chikodili, Ibe Chioma, Nnorom Chinwendu, Ejiofor IfedibaluChukwu","doi":"10.58920/sciphy01010013","DOIUrl":"https://doi.org/10.58920/sciphy01010013","url":null,"abstract":"The continuous destruction of normal insulin-producing pancreatic beta-cells is a contributing factor in all common forms of diabetes, due to insufficient production of insulin, especially in type 1 diabetes. There are attempts at beta-cells transplantation, but the cost and availability of donors pose a great challenge to the process. Dual-Specificity Tyrosine Phosphorylation-Regulated Kinase A (DYRK1A) plays a crucial role in beta-cells destruction. Our research targets to identify plants that can be utilized as a possible alternative approach to beta-cell replacement through a pharmacologically induced regeneration of new beta-cells in-silico. The 3D structure DYRK1A and 6511 phytochemicals were obtained from the Protein Data Bank and the African Natural Products Database respectively. They were duly prepared for molecular docking simulations (MDS). MDS was implemented, after validation of docking protocols, in AutoDock-Vina®, with virtual screening scripts. Phytocompounds with good binding affinities for DYRK1A were selected as frontrunners. The compounds were screened for toxicity, Lipinski’s rule confirmation with Data Warrior software followed by kinase inhibitory bioactivity prediction with the Molinspiration Chemoinformatics web tool. Twelve phytocompounds were found to be predictably highly active in-silico against DYRK1A with good drug-like property based on Lipinski’s rule, non-mutagenic, non-tumorigenic, no reproductive effect, and non-irritant, with high predicted bioactivity. In-silico active phytocompounds against DYRK1A with their plant sources and physicochemical parameters were identified. Further studies will be carried out in-vitro and in-vivo to validate the results of this study using plants containing the identified phytocompounds.","PeriodicalId":287837,"journal":{"name":"Sciences of Phytochemistry","volume":"5 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131971454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4