Sciences of Phytochemistry最新文献

Pharmacognostic study and sedative activity of Bryophyllum pinnatum stem methanol extract and fractions 羽扇豆茎甲醇提取物和馏分的药理研究和镇静活性

Sciences of Phytochemistry Pub Date : 2023-11-21 DOI: 10.58920/sciphy02020127

Kosisochukwu Okoye, F. Anowi, InnocentMary Ejiofor, Olanrewaju Ololade

{"title":"Pharmacognostic study and sedative activity of Bryophyllum pinnatum stem methanol extract and fractions","authors":"Kosisochukwu Okoye, F. Anowi, InnocentMary Ejiofor, Olanrewaju Ololade","doi":"10.58920/sciphy02020127","DOIUrl":"https://doi.org/10.58920/sciphy02020127","url":null,"abstract":"Insomnia is known as sleep insufficiency and is considered a capital public health concern. Bryophyllum pinnatum which belongs to the family Grassulaceae is used in folkloric medicine to treat various kind of ailment. The aim of the study was to undertake a pharmacognostic study of the stem and determine the sedative/hypnotic ability of the methanol extract and fraction of the stem. The physicochemical analysis indicated moisture content (12.68%), total ash (3.75%), acid insoluble ash (2.60%), water soluble ash (2.00%), water soluble extractive (6.02%) and alcohol soluble extractive (10.80%). The organoleptic evaluation of the powdered leaves revealed an odorless, green plant with bitter taste. The microscopic analysis of the leaf revealed palisade cell, spongy cell, stoma, collenchyma, xylem tissue, phloem tissue. The transverse section of the stem revealed epidermis, endodermis, xylem and cortex. The acute toxicity result revealed that Picralima nitida had no adverse effect in Wistar mice. The result showed that ethyl acetate fraction had sedative/hypnotic ability, affected the level of liver enzymes (ALT, AST, ALP), improved kidney function, and insignificantly increased body weight of mice. This study demonstrated that B. pinnatum could be an alternative medicine in pharmacological treatment of insomnia.","PeriodicalId":287837,"journal":{"name":"Sciences of Phytochemistry","volume":"57 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139253100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Phytochemical profiling, heavy metals composition, in silico aphrodisiac potential, and ADMET study of Gardenia erubescens 栀子的植物化学特征、重金属组成、硅性春药潜力及ADMET研究

Sciences of Phytochemistry Pub Date : 2023-11-03 DOI: 10.58920/sciphy02020091

Enoch Badgal, Mubarak Dahiru, Neksumi Musa

{"title":"Phytochemical profiling, heavy metals composition, in silico aphrodisiac potential, and ADMET study of Gardenia erubescens","authors":"Enoch Badgal, Mubarak Dahiru, Neksumi Musa","doi":"10.58920/sciphy02020091","DOIUrl":"https://doi.org/10.58920/sciphy02020091","url":null,"abstract":"This study aimed to explore the phytochemical profile, heavy metal composition, in silico aphrodisiac potential, and ADMET study of Gardenia erubescens due to its folkloric acclaimed aphrodisiac use. The phytochemicals were quantified gravimetrically while the identification of bioactive compounds was carried out using a combined Gas spectrophotometer-mass spectrophotometer (GC-MS). Heavy metals were quantified using an atomic absorption spectrophotometer while the aphrodisiac and ADMET studies were in silico. The result showed the presence of alkaloids (22.33% ±1.45), saponins (20.17% ±1.88), glycosides (0.55% ±0.03), and flavonoids (32.67% ±1.45), with the absence of steroids and terpenoids. GC-MS analysis identified 25 compounds with linoleic acid having the highest peak area (28.01%) next to palmitic acid (14.08%). Chromium, Cadmium, and Lead were present in concentrations of 0.145 ±0.03, 0.001 ±0.00, and 0.065 ±0.03 ppm respectively. Ethyl D-glucopyranoside had the least BA (-8) and Ki (1.35 µM) docked with human arginase II while Tyrosinol had the least BA (-6.2) and Ki (28.21 µM) docked with phosphodiesterase 5 though both were higher than Sildenafil citrate. All the top docked compounds were predicted to be neither substrates nor inhibitors of P-glycoproteins and cytochrome P450 enzymes without CNS permeability and hepatotoxicity. Conclusively, the present study supports the folkloric aphrodisiac application of Gardenia erubescens, and the heavy metals level was below the acceptable regulatory level, thus, might be safe for occasional use. Additionally, the identified compounds might be considered a novel source of therapeutics against erectile dysfunction.","PeriodicalId":287837,"journal":{"name":"Sciences of Phytochemistry","volume":"38 7","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135873104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring the potential impact of herbal antioxidants on human cardiovascular diseases 探索草药抗氧化剂对人类心血管疾病的潜在影响

Sciences of Phytochemistry Pub Date : 2023-11-02 DOI: 10.58920/sciphy02020070

Wrestwar Marak

{"title":"Exploring the potential impact of herbal antioxidants on human cardiovascular diseases","authors":"Wrestwar Marak","doi":"10.58920/sciphy02020070","DOIUrl":"https://doi.org/10.58920/sciphy02020070","url":null,"abstract":"The body's antioxidant system efficiently neutralizes reactive oxygen species, which are intermediates formed during routine metabolic activity. Oxidative stress resulting from an imbalance in this neutralization process is known to be a key factor in many human ailments, including atherosclerosis and various cardiovascular diseases. Observational epidemiological research conducted over the past several decades has shown that consumption of vegetables and fruits rich in vitamins and antioxidants is associated with a reduced incidence of cardiovascular disease. However, it is crucial to exercise caution when considering the use of herbal antioxidants as a treatment for various ailments, including cardiovascular conditions. This caution arises from concerns related to their safety, potentially life-threatening side effects, toxicity, and potential interactions with other medications. Multiple research studies have highlighted these risks associated with antioxidant usage as a form of medical intervention. This overview briefly summarizes cardiovascular disease, associated risk factors, and the role of reactive oxygen species and oxidative stress in its development. Next, delve into some of the most significant plant-based antioxidants, their therapeutic uses, as well as the potential benefits and drawbacks of using them to treat various diseases, with a particular focus on their relevance to cardiovascular disease.","PeriodicalId":287837,"journal":{"name":"Sciences of Phytochemistry","volume":"13 3","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135934947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A narrative review on clinical trials showing contraindicated drugs with grapefruit juice 临床试验的叙述性回顾显示禁忌症药物与葡萄柚汁

Sciences of Phytochemistry Pub Date : 2023-09-30 DOI: 10.58920/sciphy02020048

Ahmed Amer

{"title":"A narrative review on clinical trials showing contraindicated drugs with grapefruit juice","authors":"Ahmed Amer","doi":"10.58920/sciphy02020048","DOIUrl":"https://doi.org/10.58920/sciphy02020048","url":null,"abstract":"Medication and food are frequently consumed together. However, some foods have interactions with medicines by changing key regulators of systemic medication availability. Their consumption is linked to interactions with a wide range of medications. One of the most significant beverages that can be harmful when combined with certain medicines is grapefruit juice. Furanocoumarins' mechanism-based suppression of intestinal cytochrome P450 3A4, which increases the bioavailability of drugs that are substrates, is the main mechanism by which interactions are mediated. There have also been reports of interactions between grapefruit products and uptake transporters such as P-glycoprotein (P-gp) and organic anion-transporting polypeptides (OATPs). It has been suggested that polyphenolic substances like flavonoids are what cause the interactions between P-gp and OATP. The amounts of furanocoumarins and flavonoids in the grapefruit product, the amount of juice consumed, the medium PH, and the inherent diversity of enzymes and transporter components in humans can all have an impact on the processes and magnitudes of interactions. In this review, we are going to shed light on clinical trials showing grapefruit juice-drug interactions and what should the health provider do for better clinical care.","PeriodicalId":287837,"journal":{"name":"Sciences of Phytochemistry","volume":"28 25 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136344864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nutritional analysis of Colocasia esculenta l. tubers aqueous extract and comparative analysis with existing literature 土芋块茎水提物的营养分析及与文献的比较分析

Sciences of Phytochemistry Pub Date : 2023-09-27 DOI: 10.58920/sciphy02020040

Novi Yantih, Esti Mulatsari, Yati Sumiyati, Intan Sari, Corry Qisthiara, Angelita Prastica, Johana Rezon, Daffa Azka, Dini Ariyanti

{"title":"Nutritional analysis of Colocasia esculenta l. tubers aqueous extract and comparative analysis with existing literature","authors":"Novi Yantih, Esti Mulatsari, Yati Sumiyati, Intan Sari, Corry Qisthiara, Angelita Prastica, Johana Rezon, Daffa Azka, Dini Ariyanti","doi":"10.58920/sciphy02020040","DOIUrl":"https://doi.org/10.58920/sciphy02020040","url":null,"abstract":"Taro (C. esculenta L.) is a plant in the Araceae family that is farmed as a tuber. This plant is one of the non-animal sources of nutrients, minerals, and trace elements and has had numerous biological activities. Taro plants offer antidiabetic, antibacterial, antifungal, antioxidant, and antihepatotoxic properties. To have better nutritional content and wider and longer-lasting applications in culinary products, the taro tuber requires going through a process that increases its use value, one of which is extraction. The research aim of this work was to use several analytical methods to determine the nutrition components in the aqueous extract of C. esculenta L. Some of the nutrients found in the aqueous extract of C. esculenta L. consist of total protein 10.9%, total carbohydrate 75.5%, amylose 8.20%, amylopectin 43.6%, starch 51.8%, omega 6 0.2%, and fat-soluble vitamins A, D, and E at 0.5 IU/100gr, 24.8 g/100gr, and 0.01 mg/100 gr. Water-soluble vitamins B1, B2, B6, and C were present in amounts of 4.55, 1.96, 0.17, and 0.70 mg/kg, respectively. C. esculenta L. aqueous extract also included minerals such as the trace elements sodium (Na), potassium (K), calcium (Ca), magnesium (Mg), iron (Fe), and zinc (Zn) in the amounts of 35.2, 4638, 137, 129, 47.9, and 13.8 (mg/100gram), respectively. The aqueous extract of C. esculenta L. tubers includes a variety of nutrients and offers the potential to be consumed as a functional food.","PeriodicalId":287837,"journal":{"name":"Sciences of Phytochemistry","volume":"100 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135586949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

In-vitro antimicrobial activity of lemon bark extract against Salmonella shigella and Escherichia coli 柠檬皮提取物对志贺菌和大肠杆菌的体外抑菌活性研究

Sciences of Phytochemistry Pub Date : 2023-09-05 DOI: 10.58920/sciphy02020031

Jimmy Daka, Chansa Mulenga

引用次数: 0

Insights on the Efficacy and Safety of Selected Herbal Teas 精选凉茶的功效和安全性

Sciences of Phytochemistry Pub Date : 2023-09-04 DOI: 10.58920/sciphy02020022

Ahmed Amer

引用次数: 0

A mini review on the analytical method and its validation for Psidium guajava 瓜爪哇番石榴的分析方法及验证方法综述

Sciences of Phytochemistry Pub Date : 2023-07-01 DOI: 10.58920/sciphy02010013

Kshitij Shirke, T. Kamble, Kiran Uppar, N. Naware, Sonal Bangar, Shreya Ambatkar, M. Patil, Ashish Jain

引用次数: 0

A review focusing on the benefits of green tea catechins as nutraceuticals 综述了绿茶儿茶素作为保健品的益处

Sciences of Phytochemistry Pub Date : 2023-07-01 DOI: 10.58920/sciphy02020001

N. Naware, Shreya Ambatkar, T. Kamble, Sonal Bangar, Kiran Uppar, Kshitij Shirke, M. Patil, Ashish Jain

{"title":"A review focusing on the benefits of green tea catechins as nutraceuticals \u0000","authors":"N. Naware, Shreya Ambatkar, T. Kamble, Sonal Bangar, Kiran Uppar, Kshitij Shirke, M. Patil, Ashish Jain","doi":"10.58920/sciphy02020001","DOIUrl":"https://doi.org/10.58920/sciphy02020001","url":null,"abstract":"Any product generated from food sources that offer additional health advantages over and above the essential nutritional content present in foods is referred to as a nutraceutical under the broad umbrella term. The catechins in Camellia sinensis (Theaceae) namely (-)-epicatechin, (-)-epicatechin-3-gallate, (-)-epigallocatechin, and (-)-epigallocatechin-3-gallate (EGCG), which can be used as nutraceuticals in food or as a component of food items has been discussed. Catechins being polyphenols and antioxidants are found to have a wide range of therapeutic application like weight loss, anticancer, anti-inflammatory, and a few more therapeutic applications, through various mechanisms like stimulating AMP-activated protein kinase, enhanced apoptosis, decreased expression of interleukin (IL)-6 and IL-8. The most recent method for extracting catechins include combining the extraction processing of PEF or IPL with Subcritical water extraction. Food additives have been mixed with green tea extracts to develop a desired formulation like chewing gum and capsule. As green tea catechins are a beneficial phytoconstituents to improve overall health, its prospects include formulation of a gelatin gummy formulation which will improve its palatability by masking the bitter taste. Gelatin gummy formulation can be carried conveniently and will provide easy access to the consumer as compared to green tea. Furthermore, we found a scope to develop an analytical method for EGCG and carry out its validation by HPLC which will be more reliable and cost-efficient in comparison to the existing UHPLC methods for EGCG.","PeriodicalId":287837,"journal":{"name":"Sciences of Phytochemistry","volume":"10 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115162834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

In-vitro and in-silico evaluation of Brugmansia sauveolens' ability to treat asthma 布鲁曼草治疗哮喘能力的体外和计算机评价

Sciences of Phytochemistry Pub Date : 2023-06-01 DOI: 10.58920/sciphy02010159

S. Nandy, S. Thakur

{"title":"In-vitro and in-silico evaluation of Brugmansia sauveolens' ability to treat asthma","authors":"S. Nandy, S. Thakur","doi":"10.58920/sciphy02010159","DOIUrl":"https://doi.org/10.58920/sciphy02010159","url":null,"abstract":"Asthma is a common chronic inflammatory disease of the airways. The airway epithelium produces bioactive cellular mediators that trigger the chronic inflammatory response. These mediators then attract and activate inflammatory cells in the airways of the lungs and release more biochemical mediators. With several benefits, such as a significant reduction in the cost and time of drug discovery as well as the use of laboratory animals, in-silico studies have grown to be an important and simple method for examining various chemical compounds against various targets. One of the common herbs found in the local Himalayan area is Brugmansia sauveolens, known as Datura, which is a source of tropane alkaloids and asthma can be effectively managed with alkaloids. Using a Soxhlet extractor, the collected plant components were first extracted with petroleum ether (to remove fats) followed by methanol. Online technologies like PASS Online, Molinspiration, SEA, SWISS, and SLAP data were used for a variety of in-silico predictions. After that, we tested the ability of Brugmansia extracts to reduce inflammation using an in-vitro approach. Rat RBC membrane lyses were stabilized using the plant extract fractions. The outcomes were also compared with aspirin (a common anti-inflammatory drug). Bioinformatics techniques were used to detect structural activity. After investigating all the data It was shown that B. sauveolens had anti-asthmatic activity.","PeriodicalId":287837,"journal":{"name":"Sciences of Phytochemistry","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129210288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0