Revista Hospital Clínico Universidad de Chile最新文献_第8页

Caracterización epidemiológica de pacientes con Covid-19 en el Hospital Clínico Universidad de Chile 智利大学临床医院Covid-19患者的流行病学特征

Revista Hospital Clínico Universidad de Chile Pub Date : 2020-02-27 DOI: 10.5354/2735-7996.2020.69901

M. Simian M, M. Cifuentes D.

引用次数: 1

Clasificación molecular del cáncer colorrectal, su impacto pronóstico y terapéutico: un paso crucial hacia la medicina personalizada 大肠癌的分子分类及其预后和治疗影响:迈向个性化医疗的关键一步

Revista Hospital Clínico Universidad de Chile Pub Date : 2020-02-27 DOI: 10.5354/2735-7996.2020.69859

J. González M., G. Valenzuela T., Mónica Ahumada O., O. Barajas B., K. Marcelain C

{"title":"Clasificación molecular del cáncer colorrectal, su impacto pronóstico y terapéutico: un paso crucial hacia la medicina personalizada","authors":"J. González M., G. Valenzuela T., Mónica Ahumada O., O. Barajas B., K. Marcelain C","doi":"10.5354/2735-7996.2020.69859","DOIUrl":"https://doi.org/10.5354/2735-7996.2020.69859","url":null,"abstract":"Colorectal cancer (CRC) has a high incidence and mortality and is the second leading cause of cancer death worldwide. A total of 25% of patients debut in metastatic stages, and 50% of patients with resectable disease subsequently have disseminated disease, thus their systemic therapy constitutes an important challenge. Although there are advances in their treatment, patients have a variable and unpredictable response due to their molecular heterogeneity, making it necessary to identify the specific mutations that leads oncogenesis in each patient. The CRC classification into 4 molecular subtypes or consensus molecular subtypes (CMS) has had wide clinical acceptance. CMS1 (immune), affects young patients, is rapidly progressive and refractory to conventional therapies, and could benefit from aggressive therapy and immunotherapy. CMS2 (canonical) is characterized by mutation in specific pathways linked to cellular metabolism. The CMS3 (metabolic), where its specific mutation is KRAS. Finally, CMS4 (mesenchymal) is associated with metastasis, worse prognosis and mutation in pathways of fibrogenesis and epithelial-mesenchymal transition. Specific treatments have been proposed for each of these types with the purpose of reaching a personalized medicine. The identification and better understanding of molecular subtypes will lead us to improve the prognostic and therapeutic prediction in this disease.","PeriodicalId":287456,"journal":{"name":"Revista Hospital Clínico Universidad de Chile","volume":"24 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116631270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Uso de cerclaje en Obstetricia (actualización) 环带在产科中的应用(更新)

Revista Hospital Clínico Universidad de Chile Pub Date : 2020-02-27 DOI: 10.5354/2735-7996.2020.69861

Álvaro Sepúlveda-Martínez, R. Guíñez G., María Carolina Silva G., Hermógenes Tobar A., Mauro Parra-Cordero

引用次数: 0

Caracterización clínica y epidemiológica de pacientes con Covid-19 atendidos en Servicio de Emergencia del Hospital Clínico Universidad de Chile entre marzo y mayo 2020 2020年3月至5月在智利大学临床医院急诊科就诊的Covid-19患者的临床和流行病学特征

Revista Hospital Clínico Universidad de Chile Pub Date : 2020-02-27 DOI: 10.5354/2735-7996.2020.69899

Nicole Soto R, César Muñoz P Mariela Cortés M, Mariela Muñoz P., Javiera Postigo V., Ana Suquilanda J., Nelson Mellado T., A. Rojas C.

{"title":"Caracterización clínica y epidemiológica de pacientes con Covid-19 atendidos en Servicio de Emergencia del Hospital Clínico Universidad de Chile entre marzo y mayo 2020","authors":"Nicole Soto R, César Muñoz P Mariela Cortés M, Mariela Muñoz P., Javiera Postigo V., Ana Suquilanda J., Nelson Mellado T., A. Rojas C.","doi":"10.5354/2735-7996.2020.69899","DOIUrl":"https://doi.org/10.5354/2735-7996.2020.69899","url":null,"abstract":"In December 2019, a novel coronavirus (SARS-CoV-2) emerged in China and has spread globally, creating a pandemic. The objective of this is study is to determinate clinical and epidemiological characteristics of patients with coronavirus en emergency department. The HCUCH Emergency Service treated a total of 6959 patients between March 13th and May 31th, of whom 1.278 were positive and had confirmed with coronavirus. The male sex was the most prevalent (59.7%). The most frequent symptoms in both groups were cough, myalgia and fever. In the group of ambulatory patients, headache stood out in 50% and in hospitalized patients, dyspnea with 67%. The mortality rate in hospitalized patients was 15.6%. Of these, 66.6% were older than 65 years. Regarding diagnosis of hospital discharge, 87.5% correspond to pneumonia. There is a higher prevalence of coronavirus disease in male patients. The most frequent comorbidities in hospitalized patients were HT and DM2. The highest rate of hospitalization and case fatality in people over 65 years of age. This information helps to characterize the profile of patients at risk in which prevention efforts should be focused.","PeriodicalId":287456,"journal":{"name":"Revista Hospital Clínico Universidad de Chile","volume":"16 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122276987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Guía y protocolos clínicos sobre atención de embarazadas y recién nacidos en crisis sanitaria coronavirus (junio 2020) 冠状病毒健康危机中孕妇和新生儿护理指南和临床方案(2020年6月)

Revista Hospital Clínico Universidad de Chile Pub Date : 2020-02-27 DOI: 10.5354/2735-7996.2020.69905

Cristina Aleuanlli A., Silvia Araneda V., Constanza Asfora A., Nelson Burgos S., Claudia Campanella, Sonia Cerda C., Luis González I., Diane Gutiérrez C., Alejandro Jankelevich S., Daniel Luna, Stephanie Moya V., M. Parra C, Á. Sepúlveda M, F. Silva O., Helga Vera, Marcela Vilca B.

引用次数: 0

Protocolo de manejo pacientes Covid-19 hospitalizados en sala (junio del 2020) 住院Covid-19患者管理方案(2020年6月)

Revista Hospital Clínico Universidad de Chile Pub Date : 2020-02-27 DOI: 10.5354/2735-7996.2020.69904

Gonzalo Díaz V.

引用次数: 1

Abstracts presentados en congresos internacionales 2019 在2019年国际会议上发表的摘要

Revista Hospital Clínico Universidad de Chile Pub Date : 2020-02-27 DOI: 10.5354/2735-7996.2020.69941

Revista Hospital Clínico Universidad de Chile

引用次数: 0

¿Y dónde está Dios mientras la gente sufre y muere azotada por la peste viral? 当人们被病毒瘟疫折磨和死亡时，上帝在哪里?

Revista Hospital Clínico Universidad de Chile Pub Date : 2020-02-27 DOI: 10.5354/2735-7996.2020.69907

A. Bentué

引用次数: 0

2as Jornadas de Investigación HCUCH Investigación en torno al Covid-19 第二届HCUCH Covid-19研究会议

Revista Hospital Clínico Universidad de Chile Pub Date : 2020-02-27 DOI: 10.5354/2735-7996.2020.69862

C. Miranda V.

引用次数: 0

Herpes zóster diseminado: caso clínico y revisión bibliográfica 散发性带状疱疹:临床病例及文献综述

Revista Hospital Clínico Universidad de Chile Pub Date : 2020-02-27 DOI: 10.5354/2735-7996.2020.69839

Nicolás Moya G., Emilia Neves J.

{"title":"Herpes zóster diseminado: caso clínico y revisión bibliográfica","authors":"Nicolás Moya G., Emilia Neves J.","doi":"10.5354/2735-7996.2020.69839","DOIUrl":"https://doi.org/10.5354/2735-7996.2020.69839","url":null,"abstract":"Herpes zoster classical clinical presentation is the acute onset of multiple vesicles over an erythematous base, disposed over one or two dermatomes with up to 20 vesicles located outside the main dermatome. Disseminated herpes zoster is an atypical and rare form of presentation of herpes zoster, which manifests with lesions beyond the described territory. It occurs mainly in patients with some type of cellular immunosuppression. The diagnosis is made with the medical history and physical examination, however, it should be confirmed with laboratory tests. Treatment must be initiated early to avoid serious complications, such as bacterial infection of the lesions, post-herpetic neuralgia, or even central nervous system involvement. The drug of choice is intravenous acyclovir that must be maintained until the cessation of the appearance of new lesions, and then switch to its oral presentation for another 5-7 days. Disseminated herpes zoster mortality rounds 5-15%. There are varicella-zoster virus vaccines, that have been shown to reduce the incidence of herpes zoster relapses, however its utility to disseminated herpes zoster is uncertain and further studies are required. We present the case of a male patient with a history of rheumatoid arthritis who consults with multiple vesicles distributed throughout his body.","PeriodicalId":287456,"journal":{"name":"Revista Hospital Clínico Universidad de Chile","volume":"48 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126270874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0