Srpski medicinski casopis Lekarske komore最新文献

{"title":"Bone transplantation in orthopaedic surgery","authors":"Dejan Aleksandric, Lazar Mičeta, Ž. Jovanović, Jovana Grupković, Uroš Dabetić, B. Vukomanović","doi":"10.5937/smclk4-41419","DOIUrl":"https://doi.org/10.5937/smclk4-41419","url":null,"abstract":"Osteons are the basic units of bone tissue. Four types of bone cells are responsible for building the bone matrix, maintaining it and remodeling the bone. Those are osteoprogenitor cells, osteoblasts, osteocytes, and osteoclasts. The main role of the bone is in the construction of the skeleton that provides support and enables the maintenance of a constant body shape and movement, which is achieved by a complex system of levers influenced by muscle forces at the attachment points. A fracture leads to the process of inflammation, healing and, remodeling that can restore the injured bone to its original state. Nowadays, we are more and more often faced with defects of different size and etiology, which increase the need for bone transplantation. This procedure involves a surgical technique that places a new bone or a suitable substitute between or around the fractured fragments or in the area of the defect to promote bone healing. Bone transplantation is possible because bone tissue, unlike most other tissues, has the ability to fully regenerate if it is provided with adequate conditions and the space in which it will grow. The basic biological mechanisms that justify and explain the principle and utilization of bone grafting are osteoconduction, osteoinduction, and osteogenesis, but the idea of osteopromotion is also worth mentioning. Autografts represent the \"gold standard\", but due to an increased need allografts from bone banks are primarily used nowadays, while the development of synthetic replacements is the primary research interest, especially the development of the form which could be applied with the use of minimally invasive techniques.","PeriodicalId":286220,"journal":{"name":"Srpski medicinski casopis Lekarske komore","volume":"26 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128728637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Radiological presentation of COVID-19 pneumonia","authors":"Aleksandra Đurić-Stefanović","doi":"10.5937/smclk2-32749","DOIUrl":"https://doi.org/10.5937/smclk2-32749","url":null,"abstract":"Interstitial pneumonia is the main manifestation of the COVID-19 disease. The aim of this paper is to present the spectrum of typical radiological findings (CT - computed tomography, and radiographic) in COVID-19 pneumonia, the different CT examination techniques, the types and evolution of inflammatory lesions in the lungs, the criteria for assessing the probability of COVID-19 pneumonia in comparison to other types of interstitial pneumonia, and the scoring systems for determining the extent of COVID-19 pneumonia, based on CT findings and radiography. The standard CT examination protocol is a native CT examination of the chest, and, due to high sensitivity of low-dose CT protocols for detecting lung lesions, this imaging technique has become widely used in radiological practice during the COVID-19 pandemic. Bilateral, multiple, round or confluent zones of ground-glass density, predominantly localized subpleurally, peripherally and posteriorly, usually most extensive in the lower lobes, represent a typical CT presentation of COVID-19 pneumonia. Consolidations may develop at a later stage. A chest X-ray shows homogeneously reduced transparency in the lateral pulmonary fields, circular and irregular cloudlike shadows, and confluent patchy shadows, usually most extensive basally and laterally. RSNA and CO-RADS criteria are used to assess the probability of COVID-19 pneumonia, based on the criteria of a typical/atypical CT finding. Four stages of COVID-19 pneumonia have been defined, based on the dynamics of inflammatory lung lesion presentation: early, progressive, the phase of consolidation and the phase of organization. To assess the extent and severity of pneumonia, various scoring systems have been proposed, the most widely accepted one being the CT severity scoring system, based on visual semiquantitative assessment of the percentage of lung parenchyma inflammation lesions involvement of each of the five lobes, on a scale of 1 (<5%) to 5 (>75%), whereby the maximum score can be 25.","PeriodicalId":286220,"journal":{"name":"Srpski medicinski casopis Lekarske komore","volume":"46 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115511510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Changes in primary health care in response to the COVID-19 pandemic in Montenegro","authors":"L. Šćepanović, N. Terzić","doi":"10.5937/smclk3-37722","DOIUrl":"https://doi.org/10.5937/smclk3-37722","url":null,"abstract":"Introduction: Primary health care is considered the basis, not only for meeting healthcare needs, but also for responding to crisis situations, such as the crisis caused by the outbreak of the COVID-19 pandemic. Aim: The aim of this study is to describe changes in primary health care caused by the outbreak of COVID-19 in Montenegro, with a focus on the organization and provision of health services. Methods: This is a descriptive observational study with the following main outcome measures: number and manner of visits and services, including e-services, prescribed antibiotics and prescriptions according to the diagnosis, per 1,000 inhabitants, in the year 2020, as compared to the same indicators in 2019. Data were generated from the health statistics information system of the Institute of Public Health of Montenegro. Demographic data from official statistics were used. Results: The global pandemic has changed the functioning of primary health care, and ad hoc solutions have been found, in terms of infrastructure, the health workforce, and new e-health services. As compared to 2019, in 2020, the total number of visits per 1,000 inhabitants decreased by 12%, while home visits increased by 15%, in the third quarter. Online scheduling (e-order) was the most commonly used e-service (accessed 983,212 times in 2020). The prescribed antibiotics did not exceed the monthly rates from 2019 (per 1,000 inhabitants). The number of prescriptions issued (per 1,000 inhabitants), in 2020, increased by 8% for the diagnoses for which doctors prescribed the most prescriptions (per 1,000 inhabitants). Conclusion: The COVID-19 pandemic has changed the functioning of primary health care, with a transition from office visits to - home visits, telephone consultations, and e-services, without physical contact. However, there is room for improvement in meeting health needs in the area of prevention and treatment of other diseases.","PeriodicalId":286220,"journal":{"name":"Srpski medicinski casopis Lekarske komore","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126193815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing different determinants influencing the death outcome resulting from acute coronary syndrome in patients treated in the coronary unit of the general hospital in Valjevo, and their differences","authors":"A. Filipović, J. Janković","doi":"10.5937/smclk3-40807","DOIUrl":"https://doi.org/10.5937/smclk3-40807","url":null,"abstract":"Introduction: Cardiovascular diseases are the leading cause of morbidity and mortality in most countries of the world and are responsible for the death of 17.9 million people per year and for 11.8% of total DALYs. In Serbia, acute coronary syndrome (ACS) is the main cause of death among ischemic heart diseases, with a share of 49.9%. Aim: The aim of the study is to examine the association of various determinants (demographic, anthropometric, biological markers, risk factors, presence of comorbidities, and the pharmacotherapeutic approach) with the death outcome resulting from ACS patients treated at the Coronary Unit, as well as their differences. Materials and methods: This cross-sectional study included 384 adults with ACS, who were patients of the Cardiology Department with the Coronary Unit of the General Hospital in Valjevo, in 2020. The so-called Coronary Sheet was used as a research instrument. It was created, based on national needs, by the Institute of Public Health of Serbia \"Dr. Milan Jovanović Batut\", the Institute of Epidemiology, and the Cardiology Society of Serbia. This sheet is in the form of a questionnaire filled out by doctors working at the Coronary Unit, which is then submitted to the Institute of Public Health Valjevo. All respondents gave informed consent for anonymous participation in the research. The obtained data were analyzed using the methods of descriptive and analytical statistics, as well as the methods of univariate and multivariate linear regression. Results: The total sample consisted of 288 (75%) men and 96 (25%) women. The average age of patients who died of ACS was 72.9 ± 9.8 years, while the average age of patients who did not die of ACS was 65.0 ± 12.0 years. The difference was statistically significant (p < 0.001). Statistically significantly more patients who had lower values of both systolic and diastolic blood pressure, when admitted to hospital, died than those who had somewhat higher values of systolic and diastolic pressure at admission (p < 0.001). The mortality rate was lower for patients with ACS who were prescribed acetylsalicylic acid (p < 0.001), beta blockers (p = 0.003), ACE inhibitors (p < 0.001), and statins (p < 0.001) during hospitalization, while all patients whose therapy included inotropes as one of the drugs died (p < 0.001). Conclusion: Our research indicates the existence of a link between the examined determinants and the death outcome in patients suffering from ACS. It is necessary to improve the quality of data, maintain relevant and timely medical documentation and records, and continuously improve prevention programs, with the aim of reducing risk factors for the occurrence of ACS.","PeriodicalId":286220,"journal":{"name":"Srpski medicinski casopis Lekarske komore","volume":"37 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126324795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Disseminated intravascular coagulopathy in non-promyelocytic acute myeloid leukemia: Incidence, clinical and laboratory features and prognostic significance","authors":"M. Cvetković, M. Mitrović","doi":"10.5937/smclk2-32467","DOIUrl":"https://doi.org/10.5937/smclk2-32467","url":null,"abstract":"Introduction: Acute promyelocytic leukemia (APL) has the highest risk for overt disseminated intravascular coagulopathy (DIC), with reported incidence of DIC of up to 90%, as compared to 10-40% in other AML types. The influence of DIC on early death in non-APL AML patients has not been evaluated so far. Aim: The aim of our study was to analyze the incidence of DIC, its clinical and laboratory characteristics, and the impact on the survival and early death of patients with non-APL AML. Materials and methods: A total of 176 patients with non-APL AML, diagnosed and treated at the Clinic for Hematology of the Clinical Center of Serbia, between 2015 and 2020, were evaluated retrospectively. The diagnosis of DIC was made on the basis of ISTH (International Society on Thrombosis and Haemostasias) criteria. Results: The mean age of our patients was 53.8 ± 14.6 years, with 99/176 patients being men (56.2%). DIC was present in 74/176 patients (42.05%), who had a significant prevalence of the hemorrhagic syndrome (p = 0.01). The risk factors for overt DIC were the following: older age (p <0.01), comorbidities (p = 0.01), leukocytosis (p <0.001) and a high level of LDH (p <0.001). The FAB (French, American and British) type of non-APL AML, the cytogenetic risk group, and CD56 (cluster of differentiation) had no influence on overt DIC (p > 0.05). No difference was found in early mortality, outcome, and the survival of non-APL AML patients, with and without DIC (p > 0.05). Conclusion: Older age at diagnosis, comorbidities, leukocytosis, and high LDH concentrations are found to be adverse risk factors for overt DIC in non-APL AML patients. If treated promptly, with immediate, adequate and intensive use of blood derivates and components, DIC has no negative impact on early mortality, outcome, and survival.","PeriodicalId":286220,"journal":{"name":"Srpski medicinski casopis Lekarske komore","volume":"9 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133971662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical epidemiology of domestic and industrial hand and wrist circular saw injuries","authors":"Anđela Pantelić, Katarina Gambiroža, S. Matić, G. Tulić","doi":"10.5937/smclk3-39775","DOIUrl":"https://doi.org/10.5937/smclk3-39775","url":null,"abstract":"Introduction: Hand injuries are extremely common. It is estimated that almost a quarter of all injuries treated in the emergency department are hand injuries, due to the fact that the hand is highly exposed to trauma, as the result of its function and its protective movement. These injuries are usually seen in the young working age population, and they involve simultaneous damage to several different tissues. Aim: The purpose of this study is to evaluate the frequency and characteristics of hand injuries sustained by the circular saw, as well as to assess existing risk factors, in order to improve the prevention of these injuries. Materials and methods: This is a retrospective study involving 365 patients, treated during a five-year period. The patients suffered hand injury with a circular saw, either at home or at work. All patients were surgically treated at a single medical center. The patients were mostly men, with an average age of 48.6 ± 14.71 years. The data, which was collected from the medical records, included localization and type of injury, dominance of the injured hand, the type of surgical procedures performed, and the length of hospital stay. Results: The non-dominant hand was injured more often (62%), and this was usually the left hand (60%). The majority (83.2%) of patients were injured at home, while significantly less patients were injured in the workplace (16.7%). Most often, the patients sustained injuries to several different tissues, while there were only 12.5% of isolated injuries. The most commonly injured structures were extensor tendons of the wrist and fingers (245), followed by phalanges (226). Most of the patients sustained injury to one finger (35.1%), especially the thumb (68.4%), while two fingers were injured in 35.1% and three fingers in 20% of cases. The hand was injured in 7.27% of the cases, and the forearm was injured in 5.45% of the cases. Of the 995 surgical procedures carried out in total, the most commonly performed operation was tenorrhaphy (44.67%), followed by fracture fixation (29.3%). Finger reamputation was performed in 6.67% of cases, neurorrhaphy in 6%, and tendon reinsertion in 4% of cases. There was a total of 46 replantations (4.67%), and 27 revascularizations (2.67%). The average length of hospital stay was 9.04 ± 3.91 days. Conclusion: Working with a circular saw is a high-risk activity. The injuries sustained are severe. They can result in significant functional deficit and have major socioeconomic consequences. Lack of prior training and improper handling are clear risk factors. Clinical and epidemiological analysis is therefore of extreme importance, as it can be the key to the prevention of these injuries.","PeriodicalId":286220,"journal":{"name":"Srpski medicinski casopis Lekarske komore","volume":"81 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130940577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An interesting case of Coronary-cameral fistula with angina pectoris","authors":"Dejan Lazovic, M. Kocica, Ivana Đurošev, Milica Kočica-Karadžić, Dragan Cvetkovic","doi":"10.5937/smclk3-37639","DOIUrl":"https://doi.org/10.5937/smclk3-37639","url":null,"abstract":"Introduction: Coronary-cameral fistula (CCF) is an anomalous connection between a coronary artery and a cardiac chamber. Most CCFs are discovered incidentally during angiographic evaluation of coronary vascular disorders. We report a case of CCF with angina pectoris. Case report: A 67-year-old woman presented with chest pain and dyspnea upon exertion. Coronary angiography showed atherosclerotic lesions in the two major coronary arteries, but also communication between three arteries and the cavity of the right ventricle (RV) through many small, diffuse fistulas. Angiography also showed a fistula between the proximal left anterior descending artery (LAD) (first septal branch) and the right ventricle, as well as between the proximal right coronary artery (RCA) (acute marginal branch) and the right ventricle. The patient qualified to undergo coronary artery bypass graft surgery (CABG) and surgical closing of the fistulas, which is why we performed, on a beating heart, double vessel revascularization by autovein graft between the ascending aorta and the RCA and between the ascending aorta and the LAD, as well as closing of the fistulas with hemoclips and polypropylene suture, with a teflon pledget. Conclusion: Hemodynamically insignificant fistulas, which are clinically silent and not associated with other abnormal findings, most commonly do not require further treatment. Large, hemodynamically significant fistulas should be closed by ligation. However, smaller fistulas tend to get larger with age and it is recommended that early elective closure is performed in patients experiencing symptoms or in asymptomatic patients with a continuous murmur or a systolic murmur with an early diastolic component.","PeriodicalId":286220,"journal":{"name":"Srpski medicinski casopis Lekarske komore","volume":"11 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121759705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anticoagulants and corticosteroids in COVID-19: What do we know so far?","authors":"Marija Milenković, Marija Dukić, I. Rović, Đuro Šijan, A. Hadžibegović, V. Popadić, S. Klašnja, Milica Brajkovic, M. Zdravković","doi":"10.5937/smclk3-35014","DOIUrl":"https://doi.org/10.5937/smclk3-35014","url":null,"abstract":"It has been a year and a half since the fight against the COVID-19 pandemic started. In today's protocols for the treatment of COVID-19 and the prevention of its complications, corticosteroid therapy and anticoagulant therapy have a crucial part. The goal of this article is to show, based on available data, both the benefits and the disadvantages of corticosteroid and anticoagulant therapy in treating the infection caused by the Sars-CoV-2 virus. At the very onset of the pandemic, an increased frequency of thrombotic events negatively impacting the course and outcome of the disease, was registered. It has been observed that increased values of D-dimer in patients with COVID-19 do not correlate with the presence of venous thrombosis and are not reliable in the detection of deep vein thrombosis and pulmonary thromboembolism. According to the National Protocol for Treating COVID-19 (Version 12), anticoagulant therapy is recommended in hospitalized patients. Due to the risk of different side effects, such as bleeding and heparin-induced thrombocytopenia, a careful use of anticoagulant therapy is necessary, as well as close monitoring of its effects. With respect to corticosteroids, their efficacy in patients with moderate and severe clinical presentation of COVID-19, who are in need of oxygen support, was analyzed. Corticosteroids have proven efficient in decreasing mortality, decreasing the need for mechanical ventilation, decreasing the length of stay in intensive care units, as well as in shortening the length of hospital stay. Assessing the individual benefits and risks before introducing these drugs into the therapy of a patient with confirmed COVID-19 is of vital importance for achieving the desired effects of the therapy.","PeriodicalId":286220,"journal":{"name":"Srpski medicinski casopis Lekarske komore","volume":"157 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122853547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of the timing of hip fracture surgery on final treatment outcomes","authors":"Uroš Dabetić, Jovana Grupković, S. Zagorac, Marko Šimić, G. Tulić","doi":"10.5937/smclk3-34899","DOIUrl":"https://doi.org/10.5937/smclk3-34899","url":null,"abstract":"Introduction: Globally, the incidence of hip fractures has had an increasing trend, due to longer life expectancy. It is estimated that, by 2050, it will have reached 6.26 million cases a year. The aim of our review is the analysis of available literature on the relationship between the timing of hip fracture surgery and its impact on morbidity and mortality. Results: Over 85% of patients who suffer hip fracture are individuals older than 65 years with existing comorbidities. Even with adequate and optimal treatment, age and comorbidities predispose these patients to a worse prognosis and higher morbidity and mortality, as compared to the general population. The official position of AAOS is that patients who are operated on within 48 hours of hospital admission have a better treatment outcome. The reasons for delaying surgical treatment can be divided into medical and nonmedical. A large number of published studies support the claim that patients who are operated on 24 hours within hospital admission have a better outcome in terms of complications and mortality (after 30 days and after one year) than patients who are operated on later. On the other hand, several retrospective studies and meta-analyzes have shown that there is no significant difference in mortality between patients operated on 24 h, 36 h, and 48 h after admission. However, in these studies, surgical treatment within 4 days of admission has been identified as the most significant factor correlating with reduced mortality. Conclusion: Patients with hip fractures should be operated on within 24 hours of admission unless they have an acute medical condition that prevents surgery. If there is a medical condition that can be corrected, this window is prolonged to 48 hours, but the waiting time for surgical treatment should not be longer than 4 days.","PeriodicalId":286220,"journal":{"name":"Srpski medicinski casopis Lekarske komore","volume":"99 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124099724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical characteristics of COVID-19 and the efficacy of vaccination in patients with hematologic malignancies","authors":"O. Markovic, A. Divac, I. Bukurecki, M. Branković, I. Jovanovic, Predrag Đuran, M. Zdravković","doi":"10.5937/smclk3-35474","DOIUrl":"https://doi.org/10.5937/smclk3-35474","url":null,"abstract":"Patients with hematologic malignancies are at increased risk of severe forms of COVID-19 and have higher mortality, compared to patients with COVID-19 in the general population. The reasons for this include immunosuppression caused by the underlying hematologic disease and/or anticancer therapy received by these patients, advanced age, but also low levels of seroconversion after vaccination. These patients are also at a higher risk of getting infected because of frequent visits to health care facilities and high exposure to other patients. Results from published studies highlight the importance of prevention strategies in these patients, based on infection control measures and physical distancing, but also on well-timed vaccination. Risk factors which have proven to be crucial for severe forms of COVID-19 are age, the presence of comorbidities, malignancy type, progressive disease, and the type of oncologic therapy that these patients receive. Therefore, patients with hematologic malignancies represent a priority group for vaccination, which is recommended by all international professional associations. Considering that these patients are at risk of not developing an adequate immune response to the vaccine, the issues of determining the optimal time period for receiving the vaccine, the optimal dose, and the capacity of developing an immune response to the vaccine in specific groups of patients with hematologic malignancies, are questions that remain unresolved. Studies have shown that, despite the weak immune response to the vaccine, the mortality of vaccinated patients with hematologic malignancies is significantly lower than the mortality of unvaccinated patients. This article provides a review of relevant studies which analyze the characteristics, morbidity and mortality of patients with hematologic malignancies and COVID-19 and the role of vaccination in these patients.","PeriodicalId":286220,"journal":{"name":"Srpski medicinski casopis Lekarske komore","volume":"24 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115958268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}