Submitted by the University of Missouri--Columbia Graduate School最新文献_第2页

Parametric Investigation on Thrust Development of a Piezoelectric Transformer Plasma Propulsion System 压电变压器等离子体推进系统推力发展参数化研究

Submitted by the University of Missouri--Columbia Graduate School Pub Date : 1900-01-01 DOI: 10.32469/10355/40208

K. M. Olson

引用次数: 1

Generation and characteriazation of porcine induced trophoblast 猪诱导滋养细胞的产生及特性研究

Submitted by the University of Missouri--Columbia Graduate School Pub Date : 1900-01-01 DOI: 10.32469/10355/40224

H. Matsuyama

引用次数: 0

People re-identification over non-overlapping camera views 人们在不重叠的镜头视图上重新识别

Submitted by the University of Missouri--Columbia Graduate School Pub Date : 1900-01-01 DOI: 10.32469/10355/43678

Yang Liu

引用次数: 0

Secretory phospholipase A2-IIA in Alzheimer's disease and inflammatory responses in astrocytes 阿尔茨海默病的分泌磷脂酶A2-IIA和星形胶质细胞的炎症反应

Submitted by the University of Missouri--Columbia Graduate School Pub Date : 1900-01-01 DOI: 10.32469/10355/6738

M. D. Jensen

{"title":"Secretory phospholipase A2-IIA in Alzheimer's disease and inflammatory responses in astrocytes","authors":"M. D. Jensen","doi":"10.32469/10355/6738","DOIUrl":"https://doi.org/10.32469/10355/6738","url":null,"abstract":"Alzheimer’s disease (AD) is a progressive, fatal neurodegenerative disease and is the most common form of dementia. AD pathology includes neurofibrillary tangles, amyloid plaques, chronic inflammation, and oxidative stress. Secretory phospholipase A2-IIA (sPLA2-IIA) is an inflammatory protein known to have a role in the pathogenesis of multiple inflammatory diseases and is implicated in several neurodegenerative diseases. In AD, astrocytes become reactive and have increased expression of inflammatory cytokines such as IL-1! and TNF-#, and undergo increased oxidative stress. NADPH oxidase is one of the major enzymatic sources of reactive oxygen species in the central nervous system; activation of this enzyme may contribute to increased oxidative stress in cells of AD brains, including astrocytes. The expression and localization of sPLA2-IIA in human AD brains has not been studied in detail. In these studies, we show that sPLA2-IIA mRNA is up-regulated in AD brains (compared to nondemented elderly brains) and sPLA2-IIA immunoreactivity is increased in AD astrocytes. To further elucidate involvement of oxidative pathways in induction of sPLA2-IIA mRNA and protein by pro-inflammatory cytokines, we performed in vitro studies with immortalized astrocytes (DITNC). These studies demonstrated the involvement of PI-3 kinase and ERK1/2, but not p38 MAPK, in the cytokine-induced sPLA2-IIA expression","PeriodicalId":285769,"journal":{"name":"Submitted by the University of Missouri--Columbia Graduate School","volume":"10 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129706652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Qualitative analysis of the impact of a mass shooting on a broadcast journalist 大规模枪击事件对广播记者影响的定性分析

Submitted by the University of Missouri--Columbia Graduate School Pub Date : 1900-01-01 DOI: 10.32469/10355/43048

K. L. Leary

引用次数: 0

Nanocomposites : characterization and applications towards electrical energy storage devices 纳米复合材料:表征及其在电能存储器件中的应用

Submitted by the University of Missouri--Columbia Graduate School Pub Date : 1900-01-01 DOI: 10.32469/10355/44467

S. Hamm

引用次数: 0

Ion-selective electrodes for simultaneous real-time analysis for soil macronutrients 同时实时分析土壤宏量养分的离子选择电极

Submitted by the University of Missouri--Columbia Graduate School Pub Date : 1900-01-01 DOI: 10.32469/10355/4471

H. Kim

引用次数: 6

Present-day and late Quaternary crustal deformation along the southern Dead Sea Fault System, Jordan 约旦死海断裂带南部现今和晚第四纪地壳变形

Submitted by the University of Missouri--Columbia Graduate School Pub Date : 1900-01-01 DOI: 10.32469/10355/43142

W. Cochran

引用次数: 1

Kiss today goodbye, and point me toward tomorrow : reviving the time-bound musical, 1968-1975 跟今天吻别，指引我走向明天:复兴这部有时间限制的音乐剧，1968-1975年

Submitted by the University of Missouri--Columbia Graduate School Pub Date : 1900-01-01 DOI: 10.32469/10355/44509

Bryan M. Vandevender

{"title":"Kiss today goodbye, and point me toward tomorrow : reviving the time-bound musical, 1968-1975","authors":"Bryan M. Vandevender","doi":"10.32469/10355/44509","DOIUrl":"https://doi.org/10.32469/10355/44509","url":null,"abstract":"American musicals are among our country’s most valuable social documents as they depict the dominant discourses and reigning values of the cultural moment from which they first emerged through song, dance, and story. Consequently, all works are innately tied to the era that produced them. Some musicals, however, feature ties to the past are stronger and markedly more visible than others. When the vestiges of the past are so numerous that a given musical says more about the prevailing paradigms of art and thought at a specific moment in American history than it does about the universality of the human condition, then the work might be identified as timebound. A musical’s propensity for time-boundedness is perhaps never more evident than when it is revived years after its original production. When the era that occasioned the piece has passed and the attitudes that it first espoused have changed, a musical that was once fresh and timely can appear dated to a contemporary audience. Moreover, if the forms of song and dance first employed by that musical are outmoded, and not altered or updated in some way, then the work may read aesthetically as well as socially obsolete. This study offers a systematic investigation of the ways in which theatre artists have approached the task of reviving significantly time-bound musicals on Broadway. Through an examination of three representative case studies—Hair (1968), Company (1970), and A Chorus Line (1975)—this project identifies the various ways in which the musicals are anchored to their original era, how those bonds have been negotiated in revivals, and to what effect.","PeriodicalId":285769,"journal":{"name":"Submitted by the University of Missouri--Columbia Graduate School","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129452220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Development of an online planning tool for designing terrace layouts 开发一个设计平台布局的在线规划工具

Submitted by the University of Missouri--Columbia Graduate School Pub Date : 1900-01-01 DOI: 10.32469/10355/10523

M. Bay

引用次数: 0