H. Jelínková, M. Doroshenko, V. Osiko, M. Němec, J. Šulc, M. Jelínek, D. Vyhlídal, V. Kubecek, M. Čech, N. Kovalenko, A. Gerasimenko
{"title":"Fe:ZnMnSe laser active material properties at room and cryogenic temperature","authors":"H. Jelínková, M. Doroshenko, V. Osiko, M. Němec, J. Šulc, M. Jelínek, D. Vyhlídal, V. Kubecek, M. Čech, N. Kovalenko, A. Gerasimenko","doi":"10.1117/12.2228844","DOIUrl":"https://doi.org/10.1117/12.2228844","url":null,"abstract":"Fe:Zn(1-x)Mn(x)Se solid solution spectroscopic and laser properties were investigated in the temperature range 80- 290 K. Two novel samples with different zinc - manganese (Zn–Mn) ratio described by the Mn content x (0.1 or 0.2) were used and the results were compared to the known Fe:ZnSe crystal. The samples had a broad absorption spectra with the maximum around 3 μm and therefore an Er:YAG laser (2.94 μm, 10 mJ, 120 ns) was used as a pump radiation source. The Fe:ZnMnSe fluorescence spectra are generally broad in the range 3.5 – 5.5 μm. In the case of Fe:ZnMnSe x = 0.1, the fluorescence spectrum at 290 K is ranging from 3.5 to 5.5 μm. Lowering the temperature down to 80 K lead to the spectral narrowing mainly in the mid-IR part, but the fluorescence is still up to 5 μm at 80 K. In the case of Fe:ZnMnSe x = 0.2 the fluorescence is shifted towards mid-IR up to 5.2 μm even at 80 K. The fluorescence lifetime decreases from tens of us at 80 K down to 1 us at 240 K. The laser oscillations were successfully achieved with both novel Fe:ZnMnSe crystals in the temperature range 80- 290 K. In the case of x = 0.1, the central wavelength was ~4.2 μm at 80 K and the temperature increase up to 290 K led to almost linear increase of the wavelength up to ~4.75 μm. The tendency was similar in the case of Fe:ZnMnSe x = 0.2: the output wavelength increased from ~4.3 μm up to ~4.8 μm with the temperature increase from 80 to 290 K. The laser spectral linewidth was about 300 nm. In comparison with the Fe:ZnSe crystal, the laser output wavelength shift toward mid-IR region without any spectrally tunable element in the laser cavity can be clearly observed.","PeriodicalId":285152,"journal":{"name":"SPIE Photonics Europe","volume":"18 3","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"120909692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
R. Grasso, M. Gulino, A. Scordino, F. Musumeci, A. Campisi, R. Bonfanti, C. Carbone, G. Puglisi
{"title":"The delayed luminescence spectroscopy as tool to investigate the cytotoxic effect on human cancer cells of drug-loaded nanostructured lipid carrier","authors":"R. Grasso, M. Gulino, A. Scordino, F. Musumeci, A. Campisi, R. Bonfanti, C. Carbone, G. Puglisi","doi":"10.1117/12.2227514","DOIUrl":"https://doi.org/10.1117/12.2227514","url":null,"abstract":"The first results concerning the possibility to use Delayed Luminescence spectroscopy to evaluate the in vitro induction of cytotoxic effects on human glioblastoma cells of nanostructured lipid carrier and drug-loaded nanostructured lipid carrier are showed in this contribution. We tested the effects of nanostructured lipid carrier, ferulic acid and ferulic acidloaded nanostructured lipid carrier on U-87MG cell line. The study seems to confirm the ability of Delayed Luminescence to be sensible indicator of alterations induced on functionality of the mitochondrial respiratory chain complex I in U-87MG cancer cells when treated with nanostructured lipid carriers.","PeriodicalId":285152,"journal":{"name":"SPIE Photonics Europe","volume":"31 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122525573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Z. Hubka, J. Šulc, H. Jelínková, K. Nejezchleb, V. Škoda
{"title":"Cryogenic Tm:YAP microchip laser","authors":"Z. Hubka, J. Šulc, H. Jelínková, K. Nejezchleb, V. Škoda","doi":"10.1117/12.2228890","DOIUrl":"https://doi.org/10.1117/12.2228890","url":null,"abstract":"The spectral characteristics of laser active media, and thus those of the laser output, are temperature dependent. Specifically, in almost every crystal host, cooling to low temperatures leads to better heat removal, a higher efficiency and output power, and a reduced lasing threshold. Tm-ion doped lasers have an emission wavelength around 2 μm and are important in medicine for soft tissue cutting and hemostasis, as well as in LIDAR or atmosphere sensing technology. This paper presents the performance-temperature dependency of a 4 at. % doped Tm:YAP microchip. During the experiment the Tm:YAP crystal was placed inside an evacuated liquid nitrogen cryostat on a cooling finger. As its temperature was varied from 80 K to 340 K, changes were observed in the absorption spectrum, ranging from 750 nm to 2000 nm and in the fluorescence spectrum from 1600 nm to 2050 nm. Fluorescence lifetime was seen to rise and fall with decreasing temperature. The laser was pumped by a 792 nm laser diode and at 80 K the maximum output peak power of the laser was 4.6 W with 23 % slope efficiency and 0.6 W threshold, compared to 2.4 W output peak power, 13 % slope efficiency and 3.3 W threshold when at 340 K. The laser emission wavelength changed from 1883 nm to 1993 nm for 80 K and 300 K, respectively.","PeriodicalId":285152,"journal":{"name":"SPIE Photonics Europe","volume":"22 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129953816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
J. Grant-Jacob, S. Beecher, Tina L. Parsonage, P. Hua, J. Mackenzie, D. Shepherd, R. Eason
{"title":"Engineering of thin crystal layers grown by pulsed laser deposition","authors":"J. Grant-Jacob, S. Beecher, Tina L. Parsonage, P. Hua, J. Mackenzie, D. Shepherd, R. Eason","doi":"10.1117/12.2229747","DOIUrl":"https://doi.org/10.1117/12.2229747","url":null,"abstract":"Pulsed laser deposition (PLD) is an epitaxial growth technique capable of growing planar layers of crystals with thicknesses up to several 10's of microns. Crystal layers can be grown sequentially without intermediate sample conditioning allowing complicated structures, such as laser-active double-clad designs, to be routinely fabricated. We have recently demonstrated output powers of more than 16W and slope efficiencies of 70% for diode-bar end-pumped planar waveguide oscillators based on PLD Yb:YAG grown on YAG substrates. Here, we present our initial results on varying the growth conditions to tailor the stoichiometry, refractive index, and spectroscopic properties of PLD grown layers. This fine level of control, made possible by this technique, opens the way to bespoke and unique gain media for novel amplifier and lasers designs.","PeriodicalId":285152,"journal":{"name":"SPIE Photonics Europe","volume":"222 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115658551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S. Gawali, L. Leggio, Miguel Sánchez, S. Rodríguez, E. Dadrasnia, D. Gallego, H. Lamela
{"title":"Combining high power diode lasers using fiber bundles for beam delivery in optoacoustic endoscopy applications","authors":"S. Gawali, L. Leggio, Miguel Sánchez, S. Rodríguez, E. Dadrasnia, D. Gallego, H. Lamela","doi":"10.1117/12.2227697","DOIUrl":"https://doi.org/10.1117/12.2227697","url":null,"abstract":"Optoacoustic (OA) effect refers to the generation of the acoustic waves due to absorption of light energy in a biological tissue. The incident laser pulse is absorbed by the tissue, resulting in the generation of ultrasound that is typically detected by a piezoelectric detector. Compared to other techniques, the advantage of OA imaging (OAI) technique consists in combining the high resolution of ultrasound technique with the high contrast of optical imaging. Generally, Nd:YAG and OPO systems are used for the generation of OA waves but their use in clinical environment is limited for many aspects. On the other hand, high-power diode lasers (HPDLs) emerge as potential alternative. However, the power of HPDLs is still relatively low compared to solid-state lasers. We show a side-by-side combination of several HPDLs in an optical fiber bundle to increase the amount of power for OA applications. Initially, we combine the output optical power of several HPDLs at 905 nm using two 7 to 1 round optical fiber bundles featuring a 675 μm and 1.2 mm bundle aperture. In a second step, we couple the output light of these fiber bundles to a 600 μm core diameter endoscopic fiber, reporting the corresponding coupling efficiencies. The fiber bundles with reasonable small diameter are likely to be used for providing sufficient light energy to potential OA endoscopy (OAE) applications.","PeriodicalId":285152,"journal":{"name":"SPIE Photonics Europe","volume":"15 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121441363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Ezerskaia, Silvania F. Pereira, H. Urbach, B. Varghese
{"title":"Infrared spectroscopic measurement of skin hydration and sebum levels and comparison to corneometer and sebumeter","authors":"A. Ezerskaia, Silvania F. Pereira, H. Urbach, B. Varghese","doi":"10.1117/12.2225434","DOIUrl":"https://doi.org/10.1117/12.2225434","url":null,"abstract":"Skin health characterized by a system of water and lipids in Stratum Corneum provide protection from harmful external elements and prevent trans-epidermal water loss. Skin hydration (moisture) and sebum (skin surface lipids) are considered to be important factors in skin health; a right balance between these components is an indication of skin health and plays a central role in protecting and preserving skin integrity. In this manuscript we present an infrared spectroscopic method for simultaneous and quantitative measurement of skin hydration and sebum levels utilizing differential detection with three wavelengths 1720, 1750, and 1770 nm, corresponding to the lipid vibrational bands that lie “in between” the prominent water absorption bands. The skin sebum and hydration values on the forehead under natural conditions and its variations to external stimuli were measured using our experimental set-up. The experimental results obtained with the optical set-up show good correlation with the results obtained with the commercially available instruments Corneometer and Sebumeter.","PeriodicalId":285152,"journal":{"name":"SPIE Photonics Europe","volume":"85 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122772070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
N. Demoli, H. Skenderović, M. Stipčević, M. Pavičić
{"title":"Photon counting digital holography","authors":"N. Demoli, H. Skenderović, M. Stipčević, M. Pavičić","doi":"10.1117/12.2227063","DOIUrl":"https://doi.org/10.1117/12.2227063","url":null,"abstract":"Digital holography uses electronic sensors for hologram recording and numerical method for hologram reconstruction enabling thus the development of advanced holography applications. However, in some cases, the useful information is concealed in a very wide dynamic range of illumination intensities and successful recording requires an appropriate dynamic range of the sensor. An effective solution to this problem is the use of a photon-counting detector. Such detectors possess counting rates of the order of tens to hundreds of millions counts per second, but conditions of recording holograms have to be investigated in greater detail. Here, we summarize our main findings on this problem. First, conditions for optimum recording of digital holograms for detecting a signal significantly below detector's noise are analyzed in terms of the most important holographic measures. Second, for time-averaged digital holograms, optimum recordings were investigated for exposures shorter than the vibration cycle. In both cases, these conditions are studied by simulations and experiments.","PeriodicalId":285152,"journal":{"name":"SPIE Photonics Europe","volume":"9 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127801234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
C. Taudt, T. Baselt, B. Nelsen, H. Assmann, A. Greiner, E. Koch, P. Hartmann
{"title":"Two-dimensional low-coherence interferometry for the characterization of nanometer wafer topographies","authors":"C. Taudt, T. Baselt, B. Nelsen, H. Assmann, A. Greiner, E. Koch, P. Hartmann","doi":"10.1117/12.2227887","DOIUrl":"https://doi.org/10.1117/12.2227887","url":null,"abstract":"Within this work a scan-free, low-coherence interferometry approach for surface profilometry with nm-precision is presented. The basic setup consist of a Michelson-type interferometer which is powered by a super-continuum light-source (Δλ= 400-1700 nm). The introduction of an element with known dispersion delivers a controlled phase variation which can be detected in the spectral domain and used to reconstruct height differences on a sample. In order to enable scan-free measurements, the interference signal is spectrally decomposed with a grating and imaged onto a two-dimensional detector. One dimension of this detector records spectral, and therefore height information, while the other dimension stores the spatial position of the corresponding height values. In experiments on a height standard, it could be shown that the setup is capable of recording multiple height steps of 101 nm over a range of 500 m with an accuracy of about 11.5 nm. Further experiments on conductive paths of a micro-electro-mechanical systems (MEMS) pressure sensor demonstrated that the approach is also suitable to precisely characterize nanometer-sized structures on production-relevant components. The main advantage of the proposed measurement approach is the possibility to collect precise height information over a line on a surface without the need for scanning. This feature makes it interesting for a production-accompanying metrology.","PeriodicalId":285152,"journal":{"name":"SPIE Photonics Europe","volume":"4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125857743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
J. Cárdenas, T. Cadenbach, Z.B. Zhang, C. Costa-Vera, S.-L. Zhang, J. L. Paz
{"title":"Structure and mesoscopic characterization of laser ablated carbon nanoparticles in water by Raman scattering","authors":"J. Cárdenas, T. Cadenbach, Z.B. Zhang, C. Costa-Vera, S.-L. Zhang, J. L. Paz","doi":"10.1117/12.2231116","DOIUrl":"https://doi.org/10.1117/12.2231116","url":null,"abstract":"Optical coherence tomography (OCT) is one of the most advanced optical measurement techniques for complex structure visualization. The advantages of OCT have been used for surface and subsurface defect detection in composite materials, polymers, ceramics, non-metallic protective coatings, and many more. Our research activity has been focused on timefrequency spectroscopic analysis in OCT. It is based on time resolved spectral analysis of the backscattered optical signal delivered by the OCT. The time-frequency method gives spectral characteristic of optical radiation backscattered or backreflected from the particular points inside the tested device. This provides more information about the sample, which are useful for further analysis. Nowadays, the applications of spectroscopic analysis for composite layers characterization or tissue recognition have been reported. During our studies we have found new applications of spectroscopic analysis. We have used this method for thickness estimation of thin films, which are under the resolution of OCT. Also, we have combined the spectroscopic analysis with polarization sensitive OCT (PS-OCT). This approach enables to obtain a multiorder retardation value directly and may become a breakthrough in PS-OCT measurements of highly birefringent media. In this work, we present the time-frequency spectroscopic algorithms and their applications for OCT. Also, the theoretical simulations and measurement validation of this method are shown.","PeriodicalId":285152,"journal":{"name":"SPIE Photonics Europe","volume":"66 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133799599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Silvia Dalla Marta, Stefano Fornasaro, A. Jaworska, G. Toffoli, A. Bonifacio, V. Sergo
{"title":"On the possibility of low cost, adherent therapeutic drug monitoring in oncology","authors":"Silvia Dalla Marta, Stefano Fornasaro, A. Jaworska, G. Toffoli, A. Bonifacio, V. Sergo","doi":"10.1117/12.2225232","DOIUrl":"https://doi.org/10.1117/12.2225232","url":null,"abstract":"A frequent quantification of drugs concentrations in plasma of patients subject to chemotherapy is seldom performed, mostly because the standard methods (Gas or Liquid Chromatography coupled with Mass Spectroscopy) are expensive and time consuming. In this paper we report the approach pursued in one of the research units of the EU project RAMAN4CLINICS to tackle the problem of a low cost, time adherent quantification of drugs used for oncological patients using a Surface Enhanced Raman Scattering (SERS) spectroscopy. More specifically, the issues concerning the repeatability of the nanostructured substrates will be presented and some promising results to increase the selectivity of the measures toward specific drugs will be discussed, with examples concerning one cytotoxic agent, Irinotecan and one kinase inhibitor, Sunitinib.","PeriodicalId":285152,"journal":{"name":"SPIE Photonics Europe","volume":"34 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131656073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}