Spinal Surgery最新文献_第7页

Effect of Free Radical Scavenger Edaravone on Experimental Spinal Cord Injury : Functional Recovery and Axonal Protection 自由基清除剂依达拉奉对实验性脊髓损伤的作用:功能恢复和轴突保护

Spinal Surgery Pub Date : 2005-12-31 DOI: 10.2531/SPINALSURG.19.315

Takuro Magaki, K. Kurisu, S. Yamaguchi, T. Okazaki, M. Takeda

{"title":"Effect of Free Radical Scavenger Edaravone on Experimental Spinal Cord Injury : Functional Recovery and Axonal Protection","authors":"Takuro Magaki, K. Kurisu, S. Yamaguchi, T. Okazaki, M. Takeda","doi":"10.2531/SPINALSURG.19.315","DOIUrl":"https://doi.org/10.2531/SPINALSURG.19.315","url":null,"abstract":"Generation of free radical plays an important role in development of secondary spinal cord injury (SCI). Edaravone is a free radical scavenger, and has been used for protection against ischemia in patients with cerebral infarction. We investigated the effect of edaravone on severe experimental SCI. Treatment with edaravone (3mg/kg of body weight administered intravenously and subcutaneously (s.c.) immediately after injury, plus 3mg/kg s.c. on day 1 and day 2) was compared with saline treatment in rats subjected to severe 50 g · cm weight drop thoracic SCI. Neurological recovery was evaluated periodically over 3 weeks by BBB locomotor rating scale and inclined plane method (IPM). To investigate protective effect of edaravone on axons, we evaluated the preservation of rubrospinal tract by counting red nucleus (RN) cells labeled retrogradely from lumbar spinal cord with fluorescent tracer. Edaravone significantly improved recovery in early phase in both BBB scale and IPM. The number of labeled RN neurons of edaravone-treated group had a tendency to be larger than of control group. These results indicate that edaravone has therapeutic potential for protecting the injured spinal cord.","PeriodicalId":283326,"journal":{"name":"Spinal Surgery","volume":"17 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2005-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124789304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Surgical Experience of Lumbar Spinal Stenosis in Twenty New Elder Citizens 20例新老年人腰椎管狭窄症的手术治疗体会

Spinal Surgery Pub Date : 2005-12-01 DOI: 10.2531/SPINALSURG.19.337

H. Hosoda, Shutaro Ochiai

{"title":"Surgical Experience of Lumbar Spinal Stenosis in Twenty New Elder Citizens","authors":"H. Hosoda, Shutaro Ochiai","doi":"10.2531/SPINALSURG.19.337","DOIUrl":"https://doi.org/10.2531/SPINALSURG.19.337","url":null,"abstract":"In the fall of 2000 Dr. S. Hinohara, Tsukiji, Tokyo, launched a campaign of “New Elder Citizen's movements” where people more than 74 years of age are encouraged to lead a more motivated active life. The New Elder Citizen's movement particularly emphasizes physical and mental independence from younger age generations and positive contributions to the contemporary society. During the past three years the authors treated 20 such consecutive elderly patients with lumbar spinal stenosis (LSS) surgically. In this age group of patients the clinical study was conducted to learn how well they can tolerate the operations under general anesthesia, and the various risks existing before the resumption of their previous daily active social life. Causative components of LSS were only one or combination of the two or three or four out of compressive lesions such as intervertebral disc prolapse, hypertrophic lig. flavum, and hypertrophic facets and laminae. Surgical results were evaluated by The Japanese Orthopedic Association (JOA) scores with calculation of recovery rate(%). In 75% of the patients studied, neurogenic intermittent claudication and radicular pain were in complete resolution post operatively, irrelevant to the duration of symptoms, level and number of compressing lesions. None of the 20 patients required spinal fusion because of the absence of spinal instability. During the same span of three years, three patients were considered not to be good candidates for decompressive surgery because of poor physical status for general anesthesia such as severe ischemic coronary heart disease, dementia with hearing loss and pulmonary emphysema with atrial fibrillation and recent stroke.To expect favorable surgical outcomes with full recovery in the age group of patients such as “new elder citizens” with LSS, shorter preoperative duration of symptoms and evaluation of the strong desire to recover and to resume the patient's previous social life without dementia-in-progress seems to be of absolute necessity.","PeriodicalId":283326,"journal":{"name":"Spinal Surgery","volume":"21 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2005-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132526871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Analysis of the Postoperative Palsy of Upper Extremities of the Cases undergone Spinous Process-Splitting Laminoplasty without Foraminotomy 棘突劈裂椎板成形术不开椎间孔术后上肢瘫痪病例分析

Spinal Surgery Pub Date : 2005-12-01 DOI: 10.2531/SPINALSURG.19.321

Ado Tamiya, J. Hanakita, K. Nakanishi, Y. Kitahama, S. Fukao, Mamoru Yoshida, T. Hirai

引用次数: 2

Cervical Intramedullary Cavernous Angioma: A Report of 3 Surgical Case 颈椎髓内海绵状血管瘤:附3例手术报告

Spinal Surgery Pub Date : 2005-12-01 DOI: 10.2531/SPINALSURG.19.345

Y. S. Park, H. Nakase, T. Sakaki, T. Morimoto

引用次数: 0

Circumferential Fusion using Combined Unilateral TLIF and Contralateral Pedicle Screw Fixation for Spondylolytic Spondylolisthesis at L4/5 and L5/S1: A Case Report 单侧TLIF联合对侧椎弓根螺钉周向融合治疗L4/5和L5/S1峡部滑脱1例

Spinal Surgery Pub Date : 2005-09-30 DOI: 10.2531/SPINALSURG.19.247

A. Adam, J. Mizuno, H. Nakagawa, Y. Kubo, Kahdar Wiriadisastra

{"title":"Circumferential Fusion using Combined Unilateral TLIF and Contralateral Pedicle Screw Fixation for Spondylolytic Spondylolisthesis at L4/5 and L5/S1: A Case Report","authors":"A. Adam, J. Mizuno, H. Nakagawa, Y. Kubo, Kahdar Wiriadisastra","doi":"10.2531/SPINALSURG.19.247","DOIUrl":"https://doi.org/10.2531/SPINALSURG.19.247","url":null,"abstract":"Objective: A case of spondylolytic spondylolisthesis at L4/5 and L5/S1 was treated by performing 360 degree fusion using combined unilateral transforaminal lumbar interbody fusion (TLIF) and contralateral pedicle screw fixation (PSF).Case report: A 78-year-old man presented with 8-year history of low back pain and left leg pain. Neurological examination showed positive straight leg raising test on the right and hypesthesia in the left L4 region. Computerized tomography and magnetic resonance imaging demonstrated spondylolysis at L4 and L5 with slip at L4/5. The patient was treated with a single cage by performing TLIF from the left L4-5 foramen obliquely to the ventral cortex (45 degree to vertical plane), and then PSF at L4, L5 and S1 under an intraoperative fluoroscopy.Result: Postoperatively, the patient showed a marked recovery. His left leg pain and low back pain subsided, and he was back to work shortly after the operation.Conclusion: Spondylolytic spondylolisthesis is one of the targets of spinal instrumentation. Although a broad combination of implants can be selected for this pathological condition, combined TLIF after discectomy and contralateral PSF was useful in a case like this.","PeriodicalId":283326,"journal":{"name":"Spinal Surgery","volume":"6 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2005-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132015927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Case of Cervical Spondylosis presenting Meralgia Paresthetica-Like Symptoms 颈椎病伴触痛样症状1例

Spinal Surgery Pub Date : 2005-09-30 DOI: 10.2531/SPINALSURG.19.253

K. Sugita, Kazuhiro Nakamura, N. Kato, Y. Nakai, S. Okamoto, M. Sonobe

引用次数: 0

Complications and Outcome in Dynamic Plated Single Level Anterior Corpectomy and Fusion Including Two Level Complete Diskectomies 动态镀单节段前椎体切除术和融合包括两节段完整椎间盘切除术的并发症和结果

Spinal Surgery Pub Date : 2005-09-30 DOI: 10.2531/SPINALSURG.19.201

N. Epstein

{"title":"Complications and Outcome in Dynamic Plated Single Level Anterior Corpectomy and Fusion Including Two Level Complete Diskectomies","authors":"N. Epstein","doi":"10.2531/SPINALSURG.19.201","DOIUrl":"https://doi.org/10.2531/SPINALSURG.19.201","url":null,"abstract":"Background and Context: The efficacy of iliac crest strut autograft and dynamic plating (ABC: Aesculap, Tuttlingen, Germany) for one level anterior cervical corpectomy/fusion with two level diskectomy (1 level ACF ) needs to be established.Purpose: To document fusion (2D-CT and dynamic X-rays) and outcomes (SF-36) following 1 level ACF.Study Design/Setting: Graft and plate-related complications and outcomes were prospectively evaluated in 86 consecutive patients undergoing 1 level ACF.Patient Sample: Preoperative MR/CT studies documented contiguous two-level disc disease, spondylosis, stenosis and/or ossification of the posterior longitudinal ligament (OPLL).Outcome Measures: Fusion was documented on 2D-CT/dynamic X-rays. Outcomes (Odom's Criteria, Nurick Grades and SF-36 ) were assessed 3, 6, 12, and 24 months postoperatively.Methods: Patients averaged 48 years of age and exhibited moderate/severe preoperative myelopathy (average Nurick Grade 3.0). All underwent 1 level ACF, and were followed an average of 3.5 years (minimum 2 years).Results: Two pseudarthroses, 2 delayed strut fractures, and 1 plate/graft extrusion (5.8% total) developed postoperatively; all required secondary posterior fusion. Outcomes 2 years postoperatively revealed mild residual radiculopathy (average Nurick Grades 0.24), 82 good/excellent outcomes (Odom's Criteria), and marked improvement on 6 SF-36 Health Scales. The average time to fusion was 4.7 months.Conclusions: Successful 2D-CT/dynamic X-ray documented fusion occurred in 94.2% of patients undergoing 1 level ACF performed with iliac crest autograft and dynamic ABC plates. Results were comparable to those cited for fixed-plates in other series.","PeriodicalId":283326,"journal":{"name":"Spinal Surgery","volume":"22 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2005-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123625061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cervical Neurinoma associated with Hydrocephalus: Case Report 颈神经瘤合并脑积水1例报告

Spinal Surgery Pub Date : 2005-09-30 DOI: 10.2531/SPINALSURG.19.241

M. T. Romli, H. Nakagawa, J. Mizuno, Kiyoshi Ito

引用次数: 0

Minimally Invasive Resection of a Spinal Epidural Cavernous Hemangioma 脊髓硬膜外海绵状血管瘤的微创切除

Spinal Surgery Pub Date : 2005-09-30 DOI: 10.2531/SPINALSURG.19.235

David S. Rosen, Trent L. Tredway, P. Santiago, R. Fessler

{"title":"Minimally Invasive Resection of a Spinal Epidural Cavernous Hemangioma","authors":"David S. Rosen, Trent L. Tredway, P. Santiago, R. Fessler","doi":"10.2531/SPINALSURG.19.235","DOIUrl":"https://doi.org/10.2531/SPINALSURG.19.235","url":null,"abstract":"Objective and ImportanceMinimally invasive techniques for spinal surgery are rapidly evolving. We present a rare case of a symptomatic spinal epidural cavernous hemangioma that was treated using minimally invasive surgical techniques. The pathophysiology, radiology, and histology of epidural cavernous hemangiomas are reviewed. The advantages and pitfalls of minimally invasive spinal surgery techniques are discussed.Clinical PresentationA 45 year-old woman presented with a four-year history of right leg weakness and difficulty with ambulation. MRI examination of the lumbar spine revealed an epidural mass.InterventionThe patient elected to undergo a minimally invasive, microendoscopic resection of the lesion. The MetRxTM (Medtronic, Memphis, TN) dilator system was employed to gain access to the L2 lamina. A hemilaminectomy and resection of the lesion was accomplished without complication.ConclusionSpinal epidural masses, in this case a cavernous hemangioma, can be safely and effectively treated with minimally invasive techniques. With decreased soft tissue injury, minimal blood loss, and shortened operative time, minimally invasive techniques should be considered when resecting epidural masses.","PeriodicalId":283326,"journal":{"name":"Spinal Surgery","volume":"54 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2005-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114668429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Efficacy of Beta Tricalcium Phosphate and MacroPore Sheet in Anterior Iliac Crest Reconstruction 磷酸三钙与大孔片在髂前嵴重建中的疗效

Spinal Surgery Pub Date : 2005-06-01 DOI: 10.2531/SPINALSURG.19.103

N. Epstein

{"title":"Efficacy of Beta Tricalcium Phosphate and MacroPore Sheet in Anterior Iliac Crest Reconstruction","authors":"N. Epstein","doi":"10.2531/SPINALSURG.19.103","DOIUrl":"https://doi.org/10.2531/SPINALSURG.19.103","url":null,"abstract":"Beta-tricalcium phosphate (B-TCP: Vitoss, Orthovita, Malverne, PA) is a newly developed non-weight bearing bone void filler. Blocks of B-TCP are osteoconductive. When combined with autogenous bone marrow aspirate, its substantial wicking capabilities, trap osteoblasts and nutrients, making it additionally osteoinductive and osteogenic.Ten patients underwent single level anterior cervical corpectomy and fusion procedures (i.e. C5-C7) with dynamic ABC plates (Aesculap, Tuttlingen, Germany). Iliac crest autografts, averaging 1.2 cm in depth x 1.4 cm in width x 2.8 cm in length, were harvested, and defects were filled with blocks of B-TCP and MacroPore Sheet (San Diego, CA). 2D-CT scans at 3 and 6 months postoperatively documented progressive fusion characterized by increasing ossification and coalescence of B-TCP particles within the defect; Grade I (50%), Grade II (70%), and Grade III (100%). Outcomes were assessed utilizing a Visual Analog Pain Scale (1-10) and the SF-36 Bodily Pain Scale recorded 3 and 6 months postoperatively.Postoperative 2D-CT studies of iliac crest reconstructions revealed Grade II (70%) partial fusion within 3 months, and Grade III (100%) complete fusion 6 months following surgery. One patient who developed a hematoma at the operative site demonstrated moderate myositis ossificans on the 2D-CT examination. On the Visual Analog Pain Scale patients demonstrated an average score of 5.2 at three months and 2.0 six months postoperatively. Bodily Pain Scores on the SF-36 showed average preoperative scores of 20, which improved to 35 at three months and 52 at six months postoperatively (higher numbers reflected better outcomes). Patients were followed a minimum of 6 months and average of 12 months postoperatively.B-TCP proved effective as a bone void filler in iliac crest donor site reconstruction and may supplement autograft and supplant allograft for comparable types of fusions.","PeriodicalId":283326,"journal":{"name":"Spinal Surgery","volume":"80 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2005-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123241052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1