Colloids and Surfaces A: Physicochemical and Engineering Aspects最新文献

{"title":"Selective hydroxylation of benzene via enhanced generation and utilization of hydroxyl radicals with CuZnSbO photocatalyst","authors":"Mengistu Tulu Gonfa ,&nbsp;Sheng Shen ,&nbsp;Lang Chen ,&nbsp;Shuang-Feng Yin","doi":"10.1016/j.colsurfa.2024.135746","DOIUrl":"10.1016/j.colsurfa.2024.135746","url":null,"abstract":"<div><div>Photocatalytic selective benzene hydroxylation via activation of C(sp2)–H under visible light remains a challenging reaction. Copper-incorporated mixed metal oxide photocatalysts have shown promise in addressing this difficulty by enabling visible light harvesting, controlled reactive oxygen species (ROS) generation, effective ROS utilization, and reactant adsorption. However, copper incorporated metal oxide catalysts were suffered from poor catalytic activity and selectivity due to leaching of Cu species. To solve this problem, herein, a novel stable mixed metal oxide (CuZnSbO) was prepared for the first time by applying a facile method. Copper introduction brought about the suitable band gap energy for a wide range of visible light harvesting of the CuZnSbO catalyst. The copper species play a key role in activating H₂O₂ to produce hydroxyl radicals (^•OH) for benzene oxidation by controlling charge recombination. The mixed metal oxide of zinc and antimony supports the included copper strongly enabling copper stability. The CuZnSbO not only generates available hydroxyl radicals but also facilitates efficient hydroxyl radical consumption to initiate C(sp2)–H activation, forming benzene radical intermediates en route to phenol. That is ever reported. CuZnSbO delivered 31.51 % benzene conversion and 100 % phenol selectivity. This work demonstrates the promise of engineered mixed metal oxide that boosts Cu species utilization for H₂O₂ and benzene activation. The photocatalyst showed good activity in selective oxidative hydroxylation reactions through harnessing visible light and controlled ROS generation. Importantly, Cu cations govern the photocatalytic ^•OH generation mechanisms as shown by XPS and active site deactivation analysis.</div></div>","PeriodicalId":278,"journal":{"name":"Colloids and Surfaces A: Physicochemical and Engineering Aspects","volume":"706 ","pages":"Article 135746"},"PeriodicalIF":4.9,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142720801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Surface-grafted MoS₂ for ketoconazole sensing in biological and aqua samples","authors":"Krishnapandi Alagumalai ,&nbsp;Balamurugan Muthukutty ,&nbsp;Mani Sivakumar ,&nbsp;Daeho Lee ,&nbsp;Seong-Cheol Kim","doi":"10.1016/j.colsurfa.2024.135808","DOIUrl":"10.1016/j.colsurfa.2024.135808","url":null,"abstract":"<div><div>Fungal infections necessitate crucial antifungal agents, yet despite their effectiveness, these drugs can induce severe reactions, interact with various medications, and have detrimental environmental effects. Consequently, there is a pressing need for accurate, sensitive, and reliable detection methods to mitigate and ideally prevent these potential negative impacts. Due to that, the present work is devoted to a biocompatible β−cyclodextrin (β−CD) functionalized molybdenum disulfide (MoS₂) nanocomposite using a liquid exfoliated hydrothermal method. β−CD/MoS₂ was assessed for its electrochemical detection capabilities of ketoconazole (KTZ) by modifying the glassy carbon electrode (GCE). The synthesized β−CD/MoS₂ undergoes thorough characterization using various analytical and spectroscopic techniques, such as X−ray crystallography (XRD), X-ray photoelectron spectroscopy (XPS), Field emission scanning electron microscopy (FE−SEM), and Transmission electron microscopy (TEM) analysis. Furthermore, the β−CD/MoS₂ sensor is tested under diverse conditions, including scan rate and pH variations, successfully detecting KTZ at concentrations as low as 1.0 nM. It demonstrates an impressive sensitivity of 1.3567 µA µM⁻¹ cm⁻² and a limit of quantification (LOQ) matching at 0.4 nM, surpassing other electrodes in sensing performance. The proposed sensor was successfully applied to determine KTZ in pharmaceutical formulations and biological samples with good recoveries. In addition, the sensor displayed the high selective detection of KTZ in the existence of other co-interferences, good repeatability, reproducibility, and high storage stability. As a result, this method proves to be practical and devoid of any matrix effect on the KTZ sensor.</div></div>","PeriodicalId":278,"journal":{"name":"Colloids and Surfaces A: Physicochemical and Engineering Aspects","volume":"706 ","pages":"Article 135808"},"PeriodicalIF":4.9,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142720721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficient detection and degradation of hexavalent chromium wastewater in tourist attractions using dual-fluorescent UiO-66-NH2 stabilized polysulfone Pickering emulsions","authors":"Ying Liu ,&nbsp;Rui Zhao ,&nbsp;Dehai Yu","doi":"10.1016/j.colsurfa.2024.135812","DOIUrl":"10.1016/j.colsurfa.2024.135812","url":null,"abstract":"<div><div>This investigation delineates the synthesis of a novel, bifunctional composite material, embedding cadmium telluride (CdTe) and carbon quantum dots (CQDs) within the metal-organic framework UiO-66-NH₂, fabricated through a Pickering emulsion technique to augment the photocatalytic degradation and detection of hexavalent chromium (Cr(VI)). We elucidate that the integration of these quantum dots substantially narrows the bandgap energy of UiO-66-NH₂ to 1.76 eV for CQDs and 2.83 eV for the composite, thereby enhancing the spectrum of visible light absorption and fortifying charge carrier separation. The foundlings reveal a pronounced elevation in photocatalytic performance, with the composite material accomplishing up to 90 % reduction of Cr(VI) within 200 min under visible light exposure. Moreover, the composite demonstrates robust reusability, sustaining efficacious degradation across numerous cycles with minimal attenuation in activity. The composite material can detect and degrade Cr(VI) in the environment, providing an efficient means of heavy metal pollution remediation for tourist attractions. It is economical and sustainable, aligning with the green and low-carbon tourism development concept.</div></div>","PeriodicalId":278,"journal":{"name":"Colloids and Surfaces A: Physicochemical and Engineering Aspects","volume":"706 ","pages":"Article 135812"},"PeriodicalIF":4.9,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142720962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A novel environmentally friendly thermochemical process for Ti64 alloy surface modification for biomedical implants","authors":"Fadia Ahmed Abdullah Naji,&nbsp;Qasim Murtaza","doi":"10.1016/j.colsurfa.2024.135806","DOIUrl":"10.1016/j.colsurfa.2024.135806","url":null,"abstract":"<div><div>This study develops an environmentally friendly novel thermochemical surface modification process of Ti64 alloy by utilizing citric acid and hydrogen peroxide to improve the mechanical properties, biocompatibility, and bioactivity for biomedical applications. The novel process was developed thermochemically, followed by simulated mineralization in Hanks Balanced Salt Solution (HBSS). The study investigates the effects of thermochemicals on surface characteristics by evaluating the influence of eco-friendly chemicals on modifying surfaces and finding the optimal pH value. The findings demonstrated that the modification effectively enhanced the Ti64 alloy mechanical properties with a significant increase in average microhardness by approximately 71 % and a reduction in wear rate by approximately 64.29 %, compared to untreated Ti64 alloy. The surface modification with pH (5,7, and 9) revealed absorptive properties as evidenced by a contact angle below 90°, indicating a hydrophilic surface, enhancing cells' attachment to biomaterials. After soaking Ti64 alloy in HBSS, a uniform coating layer of around 20.5 μm formed, leading to increased bioactivity, as evidenced by a Ca/P ratio of 1.67, comparable to hydroxyapatite in human bone. The hemolysis ratio of 0.027 % at pH 7 indicates little red blood cell (RBC) lysis, indicating increased biocompatibility. The corrosion rate was enhanced with pH (5,7, and 9) approximately (1.975 × 10⁻², 1.078 × 10⁻², and 1.615 × 10⁻²) mm/year, respectively. These findings indicate that the novel process with neutral pH (7) is optimal for surface modification as it is the most effective in enhancing the biocompatibility and bioactivity of the Ti64 alloy, making it suitable for biomedical implants.</div></div>","PeriodicalId":278,"journal":{"name":"Colloids and Surfaces A: Physicochemical and Engineering Aspects","volume":"706 ","pages":"Article 135806"},"PeriodicalIF":4.9,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142720805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"pH-responsive polysaccharide-based polymers synergies with h-BN to confer self-healing and barrier properties to waterborne epoxy resins","authors":"Hongxin Yan ,&nbsp;Guoqing Xiao ,&nbsp;Chunlin Chen ,&nbsp;Mingtan Wang ,&nbsp;Rui Zou ,&nbsp;Yinke Lan ,&nbsp;Jing Gou ,&nbsp;Junjie Cao ,&nbsp;Xiyi Ma","doi":"10.1016/j.colsurfa.2024.135790","DOIUrl":"10.1016/j.colsurfa.2024.135790","url":null,"abstract":"<div><div>Hexagonal boron nitride (h-BN) has excellent lamellar structure and electrical insulation properties, and excels in improving the corrosion resistance of coatings. By utilizing the abundant hydroxyl and amino functional groups on the polydopamine surface, h-BN is endowed with excellent hydrophilicity. Simultaneously, the polysaccharide polymer MD-GT-CS (MGC), formed by cross-linking maltodextrin (MD), gelatin (GT), and chitosan (CS), was combined with the active sites on the surface of BN@PDA, which conferred pH-responsive functionality to the BN@PDA@MGC hybrid material. In addition, cerium ions were introduced into the carboxyl and amino sites on the MGC surface, resulting in the synthesis of BN@PDA@MGC(Ce) (BPMGC), a hybrid material that combines the layered barrier properties, pH responsiveness, and self-repairing functions. The BPMGC/EP composite coating was prepared by doping the hybrid material with EP. The EIS test results showed that the |Z|_0.01 Hz value of the composite coating reached 1.45 × 10⁹ Ω cm² after 40 d, which is an improvement of four orders of magnitude compared to EP (6.85 × 10⁵ Ω cm²). The results of EIS tests at different pH conditions showed that after 40 d of immersion at pH = 3 and 5, the |Z|_0.01 Hz value decreased by two orders of magnitude, but was still two orders of magnitude higher than that of EP at pH = 7. Meanwhile, the strong self-healing ability of BPMGC/EP was determined by EIS analysis of the scratched coating, salt spray test, SEM and EDS analysis of the corroded area. The experimental results show that the incorporation of BPMGC provides a new method to improve the barrier and self-healing properties of epoxy resins.</div></div>","PeriodicalId":278,"journal":{"name":"Colloids and Surfaces A: Physicochemical and Engineering Aspects","volume":"706 ","pages":"Article 135790"},"PeriodicalIF":4.9,"publicationDate":"2024-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142721084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fine-tuning photoluminescence and photocatalysis: Exploring the effects of carbon quantum dots synthesis and purification on g-C3N4","authors":"Nijad Ishak ,&nbsp;Pavel Galář ,&nbsp;Roopesh Mekkat ,&nbsp;Mathieu Grandcolas ,&nbsp;Miroslav Šoóš","doi":"10.1016/j.colsurfa.2024.135789","DOIUrl":"10.1016/j.colsurfa.2024.135789","url":null,"abstract":"<div><div>This study investigates the constituents of microwave-synthesized carbon quantum dots (CQDs) and their effects on the photocatalytic performance of graphitic carbon nitride (g-C₃N₄) semiconductors. The synthesized g-C₃N₄ and CQDs were characterized using X-ray diffraction (XRD), Fourier transform infrared (FTIR) spectroscopy, transmission electron microscopy (TEM), thermogravimetric analysis (TGA), UV–visible (UV–vis) spectroscopy, and Raman spectroscopy. The influence of CQD synthesis parameters on photoluminescence (PL) behavior was analyzed through time-integrated photoluminescence spectroscopy and time-resolved photoluminescence spectroscopy (TRPL). CQD purification via column chromatography and heat treatment enhanced the photocatalytic efficiency of CQDs/g-C₃N₄ composites, achieving up to 90 % methylene blue (MB) degradation. Extended CQDs pyrolysis resulted in fluorophore degradation and the formation of carbogenic cores, contributing to increased photocatalytic activity. Cytotoxicity testing confirmed the nontoxic nature of CQDs components and the composite. The high efficiency, low toxicity, and durability of the CQDs/g-C₃N₄ photocatalyst present promising applications for renewable energy, environmental remediation, and sustainable chemical processes.</div></div>","PeriodicalId":278,"journal":{"name":"Colloids and Surfaces A: Physicochemical and Engineering Aspects","volume":"706 ","pages":"Article 135789"},"PeriodicalIF":4.9,"publicationDate":"2024-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142721086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synergistic catalysis of immobilized enzyme and peroxymonosulfate activation: CuFe2O4/kaolin-CTS-Laccase for enhanced performance of reactive blue 19 degradation","authors":"Lingyun Jing ,&nbsp;Xinyong Li ,&nbsp;Jixiang Chen ,&nbsp;Rui Quan ,&nbsp;Tong Wang ,&nbsp;Xia Zhao ,&nbsp;Wenhan Yang ,&nbsp;Shasha Liu ,&nbsp;Yeqiang Hu ,&nbsp;Zhili Sun ,&nbsp;Pengbo Hao ,&nbsp;Hui Yang ,&nbsp;Yinqin Zheng ,&nbsp;Hao Zhu","doi":"10.1016/j.colsurfa.2024.135784","DOIUrl":"10.1016/j.colsurfa.2024.135784","url":null,"abstract":"<div><div>This work constructed an immobilized laccase - peroxymonosulfate (PMS) activation synergistic catalytic system for enhancing the efficient removal of reactive blue 19 (RB19). Superparamagnetic CuFe₂O₄/kaolin (CF/K) composites were prepared by one-step solvothermal and calcination methods and then modified with chitosan as immobilized carriers for laccase. The enzyme activity of CuFe₂O₄/kaolin-CTS-Laccase (CF/K-CTS-Lac) could reach 316.3 U/g under optimal immobilization conditions of 3 h and 2.6 mg/mL. CF/K-CTS-Lac exhibited improved pH stability and thermal stability in comparison to free laccase. The CF/K-CTS-Lac/PMS synergistic catalytic system achieved 98.4 % decolourization of RB19 within 90 min, which was 1.7 and 1.9 times higher than that of the CF/K-CTS-Lac system and CF/K-CTS/PMS system, respectively. Enhanced RB19 degradation efficiency attributed to synergistic catalysis by immobilized laccase and PMS activation. Free radical quenching experiments showed that hydroxyl radicals (•OH), sulfate radicals (SO₄^•-), superoxide radicals (•O₂^-) and singlet oxygen (¹O₂) were involved in the synergistic catalytic system, with •O₂^- and ¹O₂ playing a major role. Our investigations are expected to provide new insights into the construction of synergistic catalytic systems for pollutants.</div></div>","PeriodicalId":278,"journal":{"name":"Colloids and Surfaces A: Physicochemical and Engineering Aspects","volume":"706 ","pages":"Article 135784"},"PeriodicalIF":4.9,"publicationDate":"2024-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142720629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhanced gaseous benzene degradation by bimetallic MIL-101(Fe, Cu) activated persulfate system: Efficiency and mechanism","authors":"Tao Tian,&nbsp;Jie Zhang,&nbsp;Sijie Ge,&nbsp;Lijiang Tian","doi":"10.1016/j.colsurfa.2024.135785","DOIUrl":"10.1016/j.colsurfa.2024.135785","url":null,"abstract":"<div><div>Persulfate oxidation is a promising technology for air pollution control but still suffers from degrading refractory volatile organic compounds (VOCs) under mild conditions. Metal-doped metal-organic frameworks (MOFs) offer a novel strategy to enhance persulfate activation and VOCs degradation. Herein, a novel bimetallic MIL-101 (Fe, Cu) is prepared for more effective degradation of gaseous benzene via persulfate activation. Under optimal conditions (Fe/Cu ratio of 1:4, persulfate concentration of 7 mM/L, pH of 5, and reaction temperature of 70 °C), the MIL-101(Fe1, Cu4) activated persulfate system achieves a benzene degradation efficiency of 79.1 %, a value significantly higher than that of MIL-101(Fe) (20.1 %). The enhanced performance can be attributed to the synergistic effect of Fe²⁺/Fe³⁺ and Cu²⁺/Cu⁺ redox interactions facilitating the activation of persulfate and generation of radical species. Density functional theory (DFT) calculations indicate an increase in the adsorption energy of MIL-101(Fe) in the presence of Cu doping from −3.46 eV to −5.92 eV along with a rise in the Fermi energy level from 0.5 eV to 1.33 eV, enhancing the electron density and mobility. A reaction energy diagram is provided to illustrate the reaction pathways and transition states involved in the degradation of benzene. Overall, the incorporation of Cu in MOFs significantly enhances the efficiency of persulfate-based oxidation systems toward VOCs degradation.</div></div>","PeriodicalId":278,"journal":{"name":"Colloids and Surfaces A: Physicochemical and Engineering Aspects","volume":"706 ","pages":"Article 135785"},"PeriodicalIF":4.9,"publicationDate":"2024-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142721087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigation of the micellization of cationic tetradecyltrimethylammonium bromide in aqueous solution of crystal violet dye: Understanding of the impacts of alcohols and temperature","authors":"Md. Mahade Hasan ,&nbsp;Malik Abdul Rub ,&nbsp;K.M. Anis-Ul-Haque ,&nbsp;Md. Jonayed ,&nbsp;Naved Azum ,&nbsp;Khalid A. Alzahrani ,&nbsp;Shahed Rana ,&nbsp;Md. Anamul Hoque","doi":"10.1016/j.colsurfa.2024.135804","DOIUrl":"10.1016/j.colsurfa.2024.135804","url":null,"abstract":"<div><div>Exploring dye-surfactant interactions is crucial for understanding the properties of their mixtures in various applications. It is of utmost importance to explore the effects of experimental factors on the dye-surfactant interactions. This study examines the micellization of the cationic surfactant tetradecyltrimethylammonium bromide (TTAB) in the presence of crystal violet (CV) dye in different alcohol solutions including methanol (MeOH), ethanol (EtOH), 1-propanol (1-PrOH), and 1-butanol (1-BuOH). Through conductometric analysis, the effects of varying alcohol compositions and temperature on the critical micelle concentration (CMC), degree of ionization (<span><math><mi>α</mi></math></span>), counterion binding (<span><math><mi>β</mi></math></span>), and thermodynamic parameters (<span><math><mrow><mo>∆</mo><msubsup><mrow><mi>G</mi></mrow><mrow><mi>m</mi></mrow><mrow><mn>0</mn></mrow></msubsup></mrow></math></span>, <span><math><mrow><mo>∆</mo><msubsup><mrow><mi>H</mi></mrow><mrow><mi>m</mi></mrow><mrow><mn>0</mn></mrow></msubsup></mrow></math></span>, and <span><math><mrow><mo>∆</mo><msubsup><mrow><mi>S</mi></mrow><mrow><mi>m</mi></mrow><mrow><mn>0</mn></mrow></msubsup></mrow></math></span>) were investigated. The findings show that alcohol causes an increase in CMC, with longer-chain alcohols (1-PrOH and 1-BuOH) having a stronger effect on TTAB + CV aggregation. The CMC values of the investigated system in 5 % alcohol solutions were found to follow this order: CMC (aq. 1-BuOH) &gt; CMC (aq. MeOH) &gt; CMC (aq. EtOH) &gt; CMC (aq. 1-PrOH). As temperature rises at a constant alcohol concentration, CMC initially decreases but then increases due to dehydration of the surfactant’s hydrophilic and hydrophobic regions. Thermodynamic analysis reveals that micellization is mainly entropy-driven at lower temperatures, with dominant hydrophobic interactions. As temperature increases, both enthalpy and entropy play significant roles, on the micellization to be occurred through hydrophobic and ion-induced dipole interactions. The molar heat capacity (<span><math><msubsup><mrow><mo>∆</mo><mi>C</mi></mrow><mrow><mi>m</mi></mrow><mrow><mn>0</mn></mrow></msubsup></math></span>) assessment indicates the identical orientation of the alcohol chain within the TTAB micellar core. The study also highlights the enthalpy-entropy compensation effect, revealing a strong correlation. By exploring these relationships between alcohol chain length and temperature with thermodynamic and physicochemical properties of surfactant systems, this research offers valuable insights for developing surfactant-based applications in academic and industrial fields.</div></div>","PeriodicalId":278,"journal":{"name":"Colloids and Surfaces A: Physicochemical and Engineering Aspects","volume":"707 ","pages":"Article 135804"},"PeriodicalIF":4.9,"publicationDate":"2024-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142720243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fabrication, characterization, and in vitro biological evaluation of glycyrrhetinic acid ligand-functionalized proliposomes encapsulated docetaxel for treatment of hepatocellular carcinoma","authors":"Yuan Lin ,&nbsp;Chuangnan Li ,&nbsp;Kaijie Cen ,&nbsp;Jucai Xu ,&nbsp;Jing Chen","doi":"10.1016/j.colsurfa.2024.135802","DOIUrl":"10.1016/j.colsurfa.2024.135802","url":null,"abstract":"<div><div>Docetaxel (DTX) is a chemotherapeutic drug extracted from the needles of Taxus baccata with a broad anticancer spectrum that has been widely used for the treatment of various cancers. However, its high hydrophobicity and poor solubility results in low bioavailability that restricted clinical application. To circumvent these challenges, the present investigation was performed to develop DTX proliposomes mediated glycyrrhetinic acid ligand (glycyrrhetinic acid - diaminododecane - cholestrol, GADC) for the treatment of hepatocellular carcinoma. The optimal parameters of liposome formulation were egg phosphatidylcholine/cholesterol mass ratio of 9:1, the ratio of DTX to lipid substance within 1/10, the percent of GADC ligand (8 %), hydration time of 30 min and homogenization time of 10 min. To protect DTX liposomes from external environment during their storage, DTX proliposomes mediated GADC (GADC-DTX-PL), three optimum processing variables, lyoprotectants of sucrose and mannitol, the sucrose/mannitol ratio of 1:1, and the lyoprotectant/egg phosphatidylcholine of 8:1, were obtained after investigation. Under the optimum lyophilization conditions, GADC-DTX-PL was prepared and reconstituted proliposomes were determined to evaluate its physicochemical characterizations. These proliposomes showed that GADC-DTX-PL were spherical particles with an average size of 214.88 ± 11.00 nm, PDI value of 0.23 ± 0.00, zeta potential of –20.04 ±4.94 mV, encapsulation efficiency of 80.58 ± 0.91 %, and drug loading of 7.39 %. In addition, encapsulation of DTX in proliposomal formulation resulted in stable and slow drug release. Furthermore, <em>in vitro</em> bioactivity was evaluated, cytotoxicity effect and apoptosis efficiency of GADC-DTX-PL by HepG2 cells was significantly higher than that of DTX proliposomes without GADC. In the cell cycle assay, the results confirmed that the effect of GADC-DTX-PL regarding the initiation of apoptosis is accompanied with adjustment in the cell cycle progress via generating G2/M arrest. This potential of this novel approach for delivery DTX to hepatocellular cells lies in the ability to combine a targeted ligand of GADC and proliposomes simultaneously. Such formulation of GADC-DTX-PL enhances the selectivity of DTX delivery to hepatocellular cells, thereby improving the efficacy of chemotherapy.</div></div>","PeriodicalId":278,"journal":{"name":"Colloids and Surfaces A: Physicochemical and Engineering Aspects","volume":"707 ","pages":"Article 135802"},"PeriodicalIF":4.9,"publicationDate":"2024-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142745026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}