Proceedings of the 2020 4th International Conference on Computational Biology and Bioinformatics最新文献

Statistical Analysis on COVID-19 Based on SIR Model 基于SIR模型的COVID-19统计分析

Proceedings of the 2020 4th International Conference on Computational Biology and Bioinformatics Pub Date : 2020-12-27 DOI: 10.1145/3449258.3449261

Feng Liang, Ziyuan Li

引用次数: 1

Data on Potential of Indonesian variety of Sea holly (Acanthus ilicifolius Linn) as Herbal Medicine 印尼品种海冬青(Acanthus ilicifolius Linn)作为草药潜力的资料

Proceedings of the 2020 4th International Conference on Computational Biology and Bioinformatics Pub Date : 2020-12-27 DOI: 10.1145/3449258.3449268

Tjokorda Sari Nindhia, Tjokorda Gde Tirta Nindhia, Ni Nyoman Trisnawati

{"title":"Data on Potential of Indonesian variety of Sea holly (Acanthus ilicifolius Linn) as Herbal Medicine","authors":"Tjokorda Sari Nindhia, Tjokorda Gde Tirta Nindhia, Ni Nyoman Trisnawati","doi":"10.1145/3449258.3449268","DOIUrl":"https://doi.org/10.1145/3449258.3449268","url":null,"abstract":"Acanthus ilicifolius Linn is a spiny herb found in tropical regions of Asia. Common names of which are holy leaved acanthus, sea holly and holy mangrove. It is a vine shrub or tall herb, up to 1.5 m high, scarcely (hamper) woody, bushy, with very dense growth. Historically, the plant is employed in traditional systems of medicine, including Indian, Chinese, and Indonesian traditional medicine treating various ailments. The information was collected along the year of 2019 from around 45 informants form Bali Island of Indonesia. The age, sex, type of diseases or sickness as well as method of using the pant medicine was used. Investigation on pharmacology activity will be carried out by literature study. Data obtained along the years of 2019 from 45 informants that was cured with Acanthus ilicifolius Linn as medicinal plant. About 30 types of health problem can be cured. The breast cancer was reported with highest case (4) that can be cured, followed by fistule (3). Cyst, lymphadenopathy, bartholin's cyst, acne, diabetic ulcer, gastritis, and dermatitis alergica are among diseases that have 2 cases in this work. The rest of some diseases with only 1 case found along the years 2019 are reported in this article.","PeriodicalId":278216,"journal":{"name":"Proceedings of the 2020 4th International Conference on Computational Biology and Bioinformatics","volume":"6 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121426115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Locomotor Activity Monitoring System in Rodents 啮齿动物运动活动监测系统

Proceedings of the 2020 4th International Conference on Computational Biology and Bioinformatics Pub Date : 2020-12-27 DOI: 10.1145/3449258.3449271

Demetrio Fabian Garcia Nocetti, Pliar Duran Hernandez, Martin Fuentes Cruz, M. Fuentes Cano, Adalberto Joel Duran Ortega

{"title":"Locomotor Activity Monitoring System in Rodents","authors":"Demetrio Fabian Garcia Nocetti, Pliar Duran Hernandez, Martin Fuentes Cruz, M. Fuentes Cano, Adalberto Joel Duran Ortega","doi":"10.1145/3449258.3449271","DOIUrl":"https://doi.org/10.1145/3449258.3449271","url":null,"abstract":"This paper presents the design and implementation of a locomotor activity monitoring system in rodents. The system was developed on an electronic platform based on open code hardware and software (Arduino Nano), which includes additional electronic circuits such as real time clock (RTC) to record date and time and a flash memory (microSD) for storage of records. In order to facilitate both installation and operation of the system, it was designed in a modular way. Each autonomous monitoring system (Arduino Nano + RTC + microSD) includes a sensor signal conditioning electronic interface with the capacity to operate up to ten breeding cages. In the design of the monitoring system an energy backup is considered through an uninterruptible power supply (UPS). The resulting data sets are grouped into periods of 5 or 10 minutes and stored in a microSD memory, for further analysis and presentation. The records are presented in the form of a locomotor activity profile and also in the form of single and double plotted actogram. The contribution of this system is in an increase in the capacity to acquire experimental data, without interfering with other experiments in the same workspace due to its modularity and a reduction in electrical energy costs.","PeriodicalId":278216,"journal":{"name":"Proceedings of the 2020 4th International Conference on Computational Biology and Bioinformatics","volume":"12 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133518092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

End-to-end Deep Reinforcement Learning for Targeted Drug Generation 端到端深度强化学习用于靶向药物生成

Proceedings of the 2020 4th International Conference on Computational Biology and Bioinformatics Pub Date : 2020-12-27 DOI: 10.1145/3449258.3449260

Tiago Oliveira Pereira, Maryam Abbasi, B. Ribeiro, Joel P. Arrais

{"title":"End-to-end Deep Reinforcement Learning for Targeted Drug Generation","authors":"Tiago Oliveira Pereira, Maryam Abbasi, B. Ribeiro, Joel P. Arrais","doi":"10.1145/3449258.3449260","DOIUrl":"https://doi.org/10.1145/3449258.3449260","url":null,"abstract":"The long period of time and the enormous financial costs required to bring a new drug to the market are a clear impediment to the development of new drugs. Deep Learning techniques at early stages of drug discovery can help to select candidate drugs with biological properties of interest, reduce the enormous research space of drug-like compounds and minimize these issues. This study aims to perform generation of targeted molecules by training the recurrent neural network to learn the building rules of production of valid molecules in the form of SMILES strings and optimize it to produce molecules with bespoke properties through Reinforcement Learning. The fitness of the newly generated molecules is obtained by a second neural network model. To demonstrate the effectiveness of the method, we trained the proposed model to design molecules with high inhibitory power for the k-opioid receptor (KOR). The optimized model was able to generate molecules with a stronger affinity for KOR, maintaining the percentage of valid molecules and, with satisfactory internal and external diversities based on Tanimoto similarity over 95%.","PeriodicalId":278216,"journal":{"name":"Proceedings of the 2020 4th International Conference on Computational Biology and Bioinformatics","volume":"33 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117092214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Research on and Comparison of the Stimulating Peripheral Activity to Relieve Conditions and Acupuncture 刺激外周活动缓解病症与针灸的研究与比较

Proceedings of the 2020 4th International Conference on Computational Biology and Bioinformatics Pub Date : 2020-12-27 DOI: 10.1145/3449258.3449265

Taoran Jia

{"title":"Research on and Comparison of the Stimulating Peripheral Activity to Relieve Conditions and Acupuncture","authors":"Taoran Jia","doi":"10.1145/3449258.3449265","DOIUrl":"https://doi.org/10.1145/3449258.3449265","url":null,"abstract":"Acupuncture and SPARC program have similar neuroscientific principles and therapeutic mechanisms. This paper introduces two therapies and their scientific principles and applications. The Stimulating Peripheral Activity to Relieve Conditions (SPARC) program is a National Institutes of Health (NIH) Common Fund committed to exploring the interrelation between nerves and organs and treating diseases caused by neurological dysregulation through developing new neurostimulation devices and treatment protocols. Traditional Chinese acupuncture refers to a disease treatment method that silver needles are applied to stimulate specified sites on the body surface of patients via different manipulations, so as to regulate the neuro-endocrine-immune (NEI) system. Therefore, the SPARC program resembles acupuncture in terms of the therapeutic mechanism and stimulation site, but they are slightly different regarding the theoretical and ideological foundation, therapeutic range and manipulation method. The treatment thoughts of dominant diseases should be mutually referenced by the development of traditional Chinese and Western medicine, so as to provide new enlightenments for their own development. In this paper, the two therapies were compared in this paper, and the way to promote their advancement was explored.","PeriodicalId":278216,"journal":{"name":"Proceedings of the 2020 4th International Conference on Computational Biology and Bioinformatics","volume":"8 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117159521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Racial Disparities During the COVID-19 Pandemic COVID-19大流行期间的种族差异

Proceedings of the 2020 4th International Conference on Computational Biology and Bioinformatics Pub Date : 2020-12-27 DOI: 10.1145/3449258.3449263

Xiuqi Han

引用次数: 0

An Analysis on the Feasibility of a Low-cost Fall Detection System: Feasibility study on threshold-based fall detection system that is realized using ADXL 345 tri-axial accelerometer which is considered as a low-cost sensor 低成本跌倒检测系统可行性分析:以低成本传感器ADXL 345三轴加速度计实现基于阈值的跌倒检测系统的可行性研究

Proceedings of the 2020 4th International Conference on Computational Biology and Bioinformatics Pub Date : 2020-12-27 DOI: 10.1145/3449258.3449270

Samuel Caryabudi, Atar Fuady Babgei, A. Arifin

引用次数: 0

Platelet Application on Wound Healing 血小板在伤口愈合中的应用

Proceedings of the 2020 4th International Conference on Computational Biology and Bioinformatics Pub Date : 2020-12-27 DOI: 10.1145/3449258.3449267

Mingye W. Xie

引用次数: 0

A Framework for Route Based Pathway Analysis of Gene Expression Data 基于路径的基因表达数据通路分析框架

Proceedings of the 2020 4th International Conference on Computational Biology and Bioinformatics Pub Date : 2020-12-27 DOI: 10.1145/3449258.3449262

Pujan Joshi, Honglin Wang, B. Basso, S. Hong, C. Giardina, Dong-Guk Shin

{"title":"A Framework for Route Based Pathway Analysis of Gene Expression Data","authors":"Pujan Joshi, Honglin Wang, B. Basso, S. Hong, C. Giardina, Dong-Guk Shin","doi":"10.1145/3449258.3449262","DOIUrl":"https://doi.org/10.1145/3449258.3449262","url":null,"abstract":"Pathway analysis is a key step in genomics study to reduce the data complexity and associate prior biological knowledge. Over representation analysis (ORA), Functional class scoring (FCS), and Topology based (TB) analysis are considered as three generations of pathway analysis techniques. These methods only detect the differential activity of an entire pathway, thereby ignoring the importance of routes and sections within the pathway. A novel route-based pathway analysis framework, Route based Pathway Analysis in Cohorts (rPAC), is discussed in this paper which uses pathway topology in true sense by identifying and scoring individual routes within pathways. Activity scores and p-values are calculated for all signaling and effector routes from KEGG signaling pathways with transcriptomics data from each sample in the given cohort. Overall route activity in a cohort is assessed in terms of two summary metrics, “Proportion of Significance” (PS) and “Average Route Score” (ARS). A systematic evaluation based on large number of simulated data showed rPAC significantly outperforming the traditional pathway analysis methods. Case studies of three epithelial cancers from The Cancer Genome Atlas (TCGA) repository revealed that some pathway routes (e.g., tight junction, Th17 cell differentiation, adipocytokine signaling etc.) can notably differentiate cancer types, while other pathway routes that are related to lipid metabolism and adipocytes metabolism are co-regulated in different cancers. While most of the findings are corroborated by the current understanding of cancer biology, many previously uncharacterized mechanisms were identified by rPAC analysis, exhibiting the potential to yield new insights into cancer phenotypes.","PeriodicalId":278216,"journal":{"name":"Proceedings of the 2020 4th International Conference on Computational Biology and Bioinformatics","volume":"11 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122275551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Study on Dairy Nutrition and Association with Chronic 乳制品营养与慢性疾病的关系研究

Proceedings of the 2020 4th International Conference on Computational Biology and Bioinformatics Pub Date : 2020-12-27 DOI: 10.1145/3449258.3449269

Ziwei Liang

{"title":"Study on Dairy Nutrition and Association with Chronic","authors":"Ziwei Liang","doi":"10.1145/3449258.3449269","DOIUrl":"https://doi.org/10.1145/3449258.3449269","url":null,"abstract":"At present, many research results support that dairy products are beneficial to human health. However, the actual consumption of dairy products in China is far lower than that recommended in the dietary guidelines for Chinese residents. There are many kinds of dairy products on the market, which can be divided into seven categories. The most important nutritional components of dairy products are protein, fat, lactose, vitamins and minerals. This paper reviews the association between dairy consumption and various chronic diseases. The results show that: Increased dairy products intake has a positive or neutral effect on Cardiovascular diseases; Dairy products, especially yogurt, can reduce the risk of T2DM; Dairy consumption is related to the reduction of obesity rate, which is more obvious in women; The association between dairy consumption and cancer is more complex, yogurt and low fat dairy products may have positive effect, while high fat dairy products may have negative effect or no correlation. In addition, dairy products are also related to intestinal health, osteoporosis, sarcopenia and chronic kidney disease. Due to the importance of dairy products for various chronic diseases, this article encourages Chinese residents to increase dairy consumption and strengthen dietary balance. At the same time, we call for further research on the mechanism of dairy products on chronic diseases.","PeriodicalId":278216,"journal":{"name":"Proceedings of the 2020 4th International Conference on Computational Biology and Bioinformatics","volume":"126 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128459449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0