2015 IEEE International Symposium on Medical Measurements and Applications (MeMeA) Proceedings最新文献_第5页

Targeted quantitation of HMGB1 protein by label-free Mass Spectrometry technique 无标记质谱技术靶向定量HMGB1蛋白

2015 IEEE International Symposium on Medical Measurements and Applications (MeMeA) Proceedings Pub Date : 2015-05-07 DOI: 10.1109/MeMeA.2015.7145260

M. Manfredi, S. Martinotti, M. Patrone, M. Sassi, E. Ranzato, E. Marengo

{"title":"Targeted quantitation of HMGB1 protein by label-free Mass Spectrometry technique","authors":"M. Manfredi, S. Martinotti, M. Patrone, M. Sassi, E. Ranzato, E. Marengo","doi":"10.1109/MeMeA.2015.7145260","DOIUrl":"https://doi.org/10.1109/MeMeA.2015.7145260","url":null,"abstract":"Mass spectrometry (MS)-based methods have become popular in recent years for the quantitation of biomolecules, especially peptides and proteins. High Mobility Group Box-1 protein (HMGB1) is a nuclear DNA-binding protein that resides inside the nucleus and can be released to the extracellular space under specific conditions. HMGB1 has been reported as circulating mechanistic indicators of cell death mode in animal models and in clinical studies. There is accumulating evidence that HMGB1 contributes to the pathogenesis of inflammatory and autoimmune diseases. Moreover, HMGB1 has been found to play an important role in tumor development, growth, and spread. Circulating HMGB1 level could be a useful and specific marker for evaluating different disease status and predicting prognosis in patients. The label-free quantitative comparison without any standard reference or normalization of the target peptide signal is the simplest Liquid Chromatographic-MS (LC-MS) method for the quantitation of a protein. The aim of the research was the development of an analytical method for the quantitation of HMGB1 by a label-free Mass Spectrometry technique. In this paper are presented the preliminary results: the quantitation of HMGB1 was assessed in a cell lysate sample through the use of the standard concentration curve of purified HMGB1 protein.","PeriodicalId":277757,"journal":{"name":"2015 IEEE International Symposium on Medical Measurements and Applications (MeMeA) Proceedings","volume":"24 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121897680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Gait feature analysis of polyneuropathy patients 多发性神经病患者步态特征分析

2015 IEEE International Symposium on Medical Measurements and Applications (MeMeA) Proceedings Pub Date : 2015-05-07 DOI: 10.1109/MeMeA.2015.7145172

Xingchen Wang, O. Kuzmicheva, M. Spranger, A. Gräser

{"title":"Gait feature analysis of polyneuropathy patients","authors":"Xingchen Wang, O. Kuzmicheva, M. Spranger, A. Gräser","doi":"10.1109/MeMeA.2015.7145172","DOIUrl":"https://doi.org/10.1109/MeMeA.2015.7145172","url":null,"abstract":"Polyneuropathy (PNP) and aging both bring changes to the walking pattern of elderly people. However, the identification methods of PNP from gait patterns were not sufficiently investigated from a technical perspective. In this study an automated classification method was developed to discriminate the neuropathic gait from both young healthy and old healthy gait using artificial neural network (ANN). A robust markerless gait detection system was employed and experiments were conducted in normal clinical conditions on 10 young, 10 old and 10 neuropathy patients. Four types of gait features, namely temporal features, kinematic joint trajectories in time domain, the Fourier transform of joint angles in frequency domain, and the symmetry indexes, were extracted. One-way analysis of variance (ANOVA) was employed as a statistical analysis tool and feature selection method. Each type of features and the selected features obtained from ANOVA were served as the input of a two-layer-feed-forward neural network separately. A twofold cross validation method with enhanced generalization was utilized to evaluate the accuracy of classification. The ground truth information for the result validation was provided by the medical experts involved in the study. The outcome of individual feature set showed that the kinematic features in time domain reached the highest classification accuracies of 94.2%, 94.8% and 94.8% for three classes, while the symmetric features yielded the lowest. Combining two sets of features can improve the performance slightly and the best performance was achieved by using the selected significant features with accuracies of 96.2%, 97.0% and 96.9% respectively.","PeriodicalId":277757,"journal":{"name":"2015 IEEE International Symposium on Medical Measurements and Applications (MeMeA) Proceedings","volume":"83 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124419830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

Detection of Necrotizing Enterocolitis in newborns using abdominal thermal signature analysis 应用腹部热特征分析检测新生儿坏死性小肠结肠炎

2015 IEEE International Symposium on Medical Measurements and Applications (MeMeA) Proceedings Pub Date : 2015-05-07 DOI: 10.1109/MeMeA.2015.7145168

Guy Mathurin Kouamou Ntonfo, M. Frize, E. Bariciak

引用次数: 8

Low-cost wearable measurement system for continuous real-time pedobarography 低成本的可穿戴测量系统，用于连续实时的儿童监护

2015 IEEE International Symposium on Medical Measurements and Applications (MeMeA) Proceedings Pub Date : 2015-05-07 DOI: 10.1109/MeMeA.2015.7145281

S. Corbellini, C. Ramella, C. Fallauto, M. Pirola, S. Stassi, G. Canavese

{"title":"Low-cost wearable measurement system for continuous real-time pedobarography","authors":"S. Corbellini, C. Ramella, C. Fallauto, M. Pirola, S. Stassi, G. Canavese","doi":"10.1109/MeMeA.2015.7145281","DOIUrl":"https://doi.org/10.1109/MeMeA.2015.7145281","url":null,"abstract":"Pedobarography is fundamental for kinetic gait analysis and for diagnosis and investigation of a number of neurological and musculoskeletal diseases, such as peripheral neuropathy or Parkinson. Wearable plantar pressure sensing systems represent a powerful tool in this field. The continuous data they can provide are crucial for rehabilitation, sport applications, and to generate real-time alarms for foot ulceration prevention of neuropathic patients. Requirements of compactness, spatial resolution, range and power-consumption lead to the high cost of commercially available pedobarographic systems, which represents the major issue hindering their widespread use. Efforts of the authors' work are therefore aimed at the realization of a single system able to match all these requirements while overcoming the cost issue. This work presents a high-spatial-resolution, flexible system enabling wide-dynamic-range pressure measurements with different sensing materials, and suitable for both platforms and low-cost sensing insoles embeddable into normal shoes. Experimental tests and comparisons adopting an in-house developed piezoresistive substrate and a commercial sensing material are presented and discussed.","PeriodicalId":277757,"journal":{"name":"2015 IEEE International Symposium on Medical Measurements and Applications (MeMeA) Proceedings","volume":"12 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131600941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 12

Dynamic Posturography: Perturbed equilibrium assessment on healthy adult subjects 动态体位术:健康成人受试者的摄动平衡评估

2015 IEEE International Symposium on Medical Measurements and Applications (MeMeA) Proceedings Pub Date : 2015-05-07 DOI: 10.1109/MeMeA.2015.7145173

Lucia Grassi, S. Rossi, P. Cappa

{"title":"Dynamic Posturography: Perturbed equilibrium assessment on healthy adult subjects","authors":"Lucia Grassi, S. Rossi, P. Cappa","doi":"10.1109/MeMeA.2015.7145173","DOIUrl":"https://doi.org/10.1109/MeMeA.2015.7145173","url":null,"abstract":"Posturography is a fundamental tool to investigate the systems involved in the postural control either in static and in dynamic conditions. In the present paper we decided, by using sinusoidal perturbations of base support around the anteroposterior axis, to analyze the equilibrium parameters widely used in posture control studies - i.e. Compensatory Postural Adjustments (CPAs) and Anticipatory Postural Adjustments (APAs) - in the perspective of defining a range of equilibrium parameters for healthy adult subjects. Fourteen subjects (9 males and 5 females) with no experience of the experimental procedure participated to the experiments. Sine and step movements of the moving base were imposed through a 3-DOF (Degrees Of Freedom) robotic system and both standard and here proposed novel indices were calculated for the evaluation of equilibrium performance. The results suggest that the length of the Center Of Pressure (COP) trajectory is proportional to the frequency of the oscillations of the platform in the sine perturbation trials, while the range of motion of COP is not influenced. Moreover, we found the absence of asymmetries in the healthy subjects when they performed the session with step perturbations.","PeriodicalId":277757,"journal":{"name":"2015 IEEE International Symposium on Medical Measurements and Applications (MeMeA) Proceedings","volume":"19 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123428478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Receiver operating characteristic: A tool for cell confluence estimation 接收器工作特性:一个用于细胞融合估计的工具

2015 IEEE International Symposium on Medical Measurements and Applications (MeMeA) Proceedings Pub Date : 2015-05-07 DOI: 10.1109/MeMeA.2015.7145269

G. D'Errico

引用次数: 2

An Anytime Voice Controlled Ambient Assisted Living System for motion disabled persons 一个随时语音控制的环境辅助生活系统，为行动不便的人

2015 IEEE International Symposium on Medical Measurements and Applications (MeMeA) Proceedings Pub Date : 2015-05-07 DOI: 10.1109/MeMeA.2015.7145192

Gabriella Nagy, A. Várkonyi-Kóczy, J. Tóth

引用次数: 4

Metrological properties evaluation of a chest wall simulator during simulated quiet breathing 模拟安静呼吸时胸壁模拟器的计量特性评价

2015 IEEE International Symposium on Medical Measurements and Applications (MeMeA) Proceedings Pub Date : 2015-05-07 DOI: 10.1109/MeMeA.2015.7145274

C. Massaroni, F. Leo, E. Schena, P. Saccomandi, S. Silvestri

{"title":"Metrological properties evaluation of a chest wall simulator during simulated quiet breathing","authors":"C. Massaroni, F. Leo, E. Schena, P. Saccomandi, S. Silvestri","doi":"10.1109/MeMeA.2015.7145274","DOIUrl":"https://doi.org/10.1109/MeMeA.2015.7145274","url":null,"abstract":"Opto-electronic Plethysmography (OEP) is a motion analysis system used to measure chest wall kinematics and to indirectly evaluate respiratory volumes during breathing. Its working principle is based on the time-per-time computation of marker displacements placed on the thorax. This work aims at evaluating the metrological properties of a custom made chest wall simulator (CWS) developed to reproduce human chest wall kinematic. The CWS metrological properties were estimated by the comparison of two different motion control strategies of the CWS: the first one is based on the script writing into each motion controller, the second one on macro command sent to the CWS. Three sets of experiments were carried out with the aim to: (i) evaluate precision and accuracy in performing target displacements (i.e., ranging from 2 mm to 8 mm), (ii) evaluate the differences between set and simulated breathing period (i.e., from 10 to 30 breathing per minute), and (iii) assess the movement reproducibility. The precision error, expressed as the ratio between measurement uncertainty and the measured displacement, is always lower than 0.32% (27 μm) with script-based motion control and 0.25% (6 μm) with the macro one, for all the target displacements. The difference between the simulated breathing period and the set one is always lower than 0.30 s in both strategies of motion control (percentage error always lower than 15%). Standard deviation between measure, assumed as reproducibility index, showed values always lower than 37 μm. These performances allows considering both the strategies of control adoptable to be employed for CWS motion control during the OEP performance in further works.","PeriodicalId":277757,"journal":{"name":"2015 IEEE International Symposium on Medical Measurements and Applications (MeMeA) Proceedings","volume":"12 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115392941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

A novel approach to a phantom based method for maximum depth of penetration measurement in diagnostic ultrasound: a preliminary study 一种基于超声诊断中最大穿透深度测量方法的新方法:初步研究

2015 IEEE International Symposium on Medical Measurements and Applications (MeMeA) Proceedings Pub Date : 2015-05-07 DOI: 10.1109/MeMeA.2015.7145230

A. Scorza, G. Lupi, S. Sciuto, F. Bini, F. Marinozzi

{"title":"A novel approach to a phantom based method for maximum depth of penetration measurement in diagnostic ultrasound: a preliminary study","authors":"A. Scorza, G. Lupi, S. Sciuto, F. Bini, F. Marinozzi","doi":"10.1109/MeMeA.2015.7145230","DOIUrl":"https://doi.org/10.1109/MeMeA.2015.7145230","url":null,"abstract":"In the present work a new approach for maximum depth of ultrasound signal visualization has been proposed by means of a tissue mimicking phantoms: the novel method is based on a threshold on the tangent applied to the mean depth profile that is drawn by averaging adjacent columns in the diagnostic image. It has been implemented and preliminary tested on three different diagnostic systems equipped with linear array probes under similar settings: results have been compared with the mean judgment of 5 observer and with output from another method, based on a threshold of the mean depth profile above the noise level, as suggested in literature. Even though a not negligible difference among some results is observed, due likely to the high electronic noise level displayed in the ultrasound image, the tangent method seems to agree with observer judgment and be more sensitive to echo signal than the other one, even at higher noise levels. Nevertheless other test are going to be performed in the next future for a more detailed characterization of the method.","PeriodicalId":277757,"journal":{"name":"2015 IEEE International Symposium on Medical Measurements and Applications (MeMeA) Proceedings","volume":"7 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128933511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 21

Mechanical Ventilator spontaneous breathing detection tested by robot SIMVENT 机械呼吸机自主呼吸检测机器人SIMVENT试验

2015 IEEE International Symposium on Medical Measurements and Applications (MeMeA) Proceedings Pub Date : 2015-05-07 DOI: 10.1109/MeMeA.2015.7145224

F. Simini, A. Monkas, G. Carballo, J. Aguirre, F. Ferreira, S. Gomez

{"title":"Mechanical Ventilator spontaneous breathing detection tested by robot SIMVENT","authors":"F. Simini, A. Monkas, G. Carballo, J. Aguirre, F. Ferreira, S. Gomez","doi":"10.1109/MeMeA.2015.7145224","DOIUrl":"https://doi.org/10.1109/MeMeA.2015.7145224","url":null,"abstract":"Mechanical Ventilators (MV) are only tested at the manufacturer's facilities in their ability to detect spontaneous breathing so as to trigger concomitant support. A robot patient was developed (called SIMVENT) to test MVs after repair or to compare MVs in hospitals. SIMVENT is a complete active patient simulator, as opposed to rubber bag simulation. SIMVENT implements lung equations under given user selected parameters of ventilatory mechanics to simulate different respiratory conditions. By producing spontaneous breathing (SB) pressure drops (1-10 cm H2O) at random times or phase-locked to ventilation cycles, SIMVENT tests the capacity of MVs to sense spontaneous ventilation. SIMVENT also calculates basic mechanical parameters (frequency, airway pressure, esophageal pressure, resistance and compliance). SIMVENT was designed with a step-motor powered piston moving in a 2-litre cylinder, a second cylinder mimicking residual volume, pressure sensors, a variable resistance tube, a microcontroller and a computer interface. A normalized spontaneous breathing detection graph was constructed for two MVs: one behaved well and the other could be harmful if ventilating a patient during weaning, because SBs were not sensed at the set pressure-drop value.","PeriodicalId":277757,"journal":{"name":"2015 IEEE International Symposium on Medical Measurements and Applications (MeMeA) Proceedings","volume":"97 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127509897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0