JOURNAL OF ADVANCED APPLIED SCIENTIFIC RESEARCH最新文献_第4页

In Vitro Studies on Binary Mixture of Skimmed Milk and Urea as Solid Dispersion Carrier for Aceclofenac 脱脂乳与尿素二元混合物作为醋酸氯芬酸固体分散载体的体外研究

JOURNAL OF ADVANCED APPLIED SCIENTIFIC RESEARCH Pub Date : 2022-11-05 DOI: 10.46947/joaasr442022446

Prasenjit Sarkar, Saumyajyoti Das, S. Majee

{"title":"In Vitro Studies on Binary Mixture of Skimmed Milk and Urea as Solid Dispersion Carrier for Aceclofenac","authors":"Prasenjit Sarkar, Saumyajyoti Das, S. Majee","doi":"10.46947/joaasr442022446","DOIUrl":"https://doi.org/10.46947/joaasr442022446","url":null,"abstract":"Among the various strategies employed to enhance solubility, dissolution and bioavailability of poorly soluble drugs in vivo, formulation of solid dispersion using hydrophilic and/or water-soluble carriers with varying physicochemical characteristics seems to be a developable, economically viable and easy option. The present study is aimed to use skimmed milk(SKM)-urea(U) as a novel binary mixture of classical carrier-hydrotrope in solid dispersion of poorly water-soluble aceclofenac (ACF). Compatibility of ACF and binary mixture of SKM-U was confirmed by FTIR spectroscopic analysis. Solid dispersions of ACF-SKM and ACF-SKM-U were prepared in varying ratios of 1:1 to 1: 5 for ACF-SKM and 1:4.5:0.5, 1:4.25:0.75 and 1:4:1 for ACF-SKM-U by solvent evaporation technique using ethanol(95%) as the common solvent and were characterised by their physical appearance, solubility enhancement (compared to pure drug) in double distilled water and phosphate buffer (pH 6.8) at 25 ⁰C and drug dissolution profiles in the above mentioned media. Based on solubility enhancement data(71.53% and 31.03%) and maximum cumulative percentage release data (82.37% in 9 mins and 68.03% in 90 secs ) in double distilled water and phosphate buffer respectively, ACF-SKM (1:5) was found to the best which was used for studying the effect of addition of urea as hydrotrope. ACF: SKM: U (1 : 4.5 : 0.75) exhibited maximum solubility enhancement of 75% .and 36.51% and cumulative percentage release of 83.83 % in 9 mins and 69.24% in 90 secs in double distilled water and buffer respectively. Therefore, the binary mixture of skimmed milk-urea has been proved to be marginally superior over skimmed milk in terms of solubility enhancement and drug release profile of aceclofenac.","PeriodicalId":274343,"journal":{"name":"JOURNAL OF ADVANCED APPLIED SCIENTIFIC RESEARCH","volume":"42 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128221719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

VatajaYonivyapada (gynecological condition): Scope in Ayurveda VatajaYonivyapada(妇科病症):阿育吠陀的范围

JOURNAL OF ADVANCED APPLIED SCIENTIFIC RESEARCH Pub Date : 2022-11-05 DOI: 10.46947/joaasr442022450

Monisha VM, Anuradha Roy

{"title":"VatajaYonivyapada (gynecological condition): Scope in Ayurveda","authors":"Monisha VM, Anuradha Roy","doi":"10.46947/joaasr442022450","DOIUrl":"https://doi.org/10.46947/joaasr442022450","url":null,"abstract":"Introduction: Vatajayonivyapada having signs and symptoms such as pain along with abnormalities in menstrual bleeding matches with many of the gynaecologicaldisorders in women of reproductive age group. It hampers their day-to-day chores and disturbing their interpersonal relationship and most importantly compromises quality of life. Therefore, an instant relief of symptoms is required along with an overall improvement in the general condition of those women.In such conditions, a better alterative non-hormonal Ayurvedic management is planned. Ksheerapaka(medicated milk preparations) of Rasna, Gokshuraand Vasa having vedanahara (analgesic effect) is used in the study. Objective: In this research work our objective was to evaluate the therapeutic efficacy of oral RasnadiKsheerapaka in Vatajayonivyapada. Materials and method: Total 30 patients within 20-40 years of ageirrespective of the marital status having classical symptoms of Vatajayonivyapada have been selected randomly from Prasuti Tantra OPD, S.S. Hospital, BHU, Varanasi. After detailed history, complete examination and investigations patients selected for the study on the basis of selection criteria.Patientswere treatedwith Rasnadiksheerapaka50ml orally once in a day for total duration of 45 days. Study was assessed after completion of follow-up period. Result: Among the 28 cases, 5 patients became cured and 6 remained without any improvement and all the remaining 17 patients have got mild to marked improvement in the signs and symptoms. Conclusion: It is concluded that Rasnadiksheerapakahas got the therapeutic efficacy in the Vatajayonivyapadamanagement. Also helps in improving the overall health status and quality of life in such women.","PeriodicalId":274343,"journal":{"name":"JOURNAL OF ADVANCED APPLIED SCIENTIFIC RESEARCH","volume":"19 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115045848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evidence of practice of Nutraceuticals/ Functional foods in our daily life described in Ayurveda 阿育吠陀所描述的营养/功能性食品在我们日常生活中的实践证据

JOURNAL OF ADVANCED APPLIED SCIENTIFIC RESEARCH Pub Date : 2022-11-05 DOI: 10.46947/joaasr442022454

Samiksha Rai, Vandana Verma

{"title":"Evidence of practice of Nutraceuticals/ Functional foods in our daily life described in Ayurveda","authors":"Samiksha Rai, Vandana Verma","doi":"10.46947/joaasr442022454","DOIUrl":"https://doi.org/10.46947/joaasr442022454","url":null,"abstract":"Ayurveda Scholars has considered food (Ahara) as an important pillar for development, sustenance of a healthy life and longevity. Considering the importance of food in health and disease.Charak has mentioned that the health or state of disease depends on rationale use of food. Food has been also considered as an etiological factor of several disorder as well as management and prevention of diseases. Ayurveda has given the comprehensive classification of food that are described in respect of their rasa(taste), vīrya(potency), vipāka (taste after digestion) and prabhāva (special actions) under the chapter Annapana Vidhi Adhyaya of Charak Samhita e.g. corn with spike/awn, corn with pods/legumes, pulses, meat, leaf, fruits, greens, leafy vegetables, wine, water, milk, products of sugar cane juice. In the mid of 1980s the term ‘functional food’ was coined in Japan to refer the food substances which have additional special health benefits. Spices and condiments which are commonly used in every kitchen on regular basis during different cooking preparations such as turmeric, ginger, garlic, onion, coriander, cinnamon, cumin, clove, fennel, barley, Indian gooseberry, tulsi, aloe vera etc. has been described in Ayurveda thousands year back with their special health benefits. In India there are number of traditional products used as functional food but needs more scientific validation, it could be a research opportunity in nutrition to explore the relation between certain diseases and these food components.Functional foods provide great potential for prevention of several chronic diseases, when consumed in balanced proportion in food preparations with a healthy lifestyle.","PeriodicalId":274343,"journal":{"name":"JOURNAL OF ADVANCED APPLIED SCIENTIFIC RESEARCH","volume":"7 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114252515","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

New Drug Development strategies with special reference to the endocarp of multifaceted agriculture crop – Cocos nucifera Linn 多面体作物椰子内果皮的新药开发策略

JOURNAL OF ADVANCED APPLIED SCIENTIFIC RESEARCH Pub Date : 2022-11-05 DOI: 10.46947/joaasr442022447

S. V, Dwivedi K. N, Santoshkumar Singh

{"title":"New Drug Development strategies with special reference to the endocarp of multifaceted agriculture crop – Cocos nucifera Linn","authors":"S. V, Dwivedi K. N, Santoshkumar Singh","doi":"10.46947/joaasr442022447","DOIUrl":"https://doi.org/10.46947/joaasr442022447","url":null,"abstract":"Coconut shell botanically represents the hard endocarp from the fruit of Cocos nucifera Linn. It is the usually discarded part of the plant with folklore claim in metabolic disorders.Being an inexpensive and easily availablenatural product with ethno medicinal significance, it seems highly relevant to scientifically validate the pharmaceutical implications of the drug. Till date, the new drug development strategies based on quality and efficacy parameters for the crude drug sample of Coconut shell has not been developed. The present study was intended to develop and scientifically validate the quality, purity, safety, potency and efficacy parameters of Coconut shell and thereby exploring the new drug development strategies for the drug. Materials andmethods: The study focused on the screening ofCoconut shell based on macroscopic, microscopic, organoleptic, histo-chemicaland HPTLC studies. Results:Characteristic presence of thin walled fibres, fibrosclereids,lignins and tannins were observed in themicroscopic analysis of Coconut shell. HPTLC studies also exemplifiedthe detailed bioactive chemical profile of Coconut shell.Conclusion: The study outcome suggestsCoconut shell as a novel reliable source of bioactive phytoconstituents with broad prospective in new drug development process.","PeriodicalId":274343,"journal":{"name":"JOURNAL OF ADVANCED APPLIED SCIENTIFIC RESEARCH","volume":"16 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115429186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Plant Extracts as Alternative Therapeutic Agents for Anaemia: A Review 植物提取物作为贫血替代治疗剂的研究进展

JOURNAL OF ADVANCED APPLIED SCIENTIFIC RESEARCH Pub Date : 2022-11-05 DOI: 10.46947/joaasr442022453

Km Sukh Wati, Mohd. Ehsan, A. K. SINGH, M K Nandi

{"title":"Plant Extracts as Alternative Therapeutic Agents for Anaemia: A Review","authors":"Km Sukh Wati, Mohd. Ehsan, A. K. SINGH, M K Nandi","doi":"10.46947/joaasr442022453","DOIUrl":"https://doi.org/10.46947/joaasr442022453","url":null,"abstract":"Anaemia, one of the most common blood nutrition deficiency affecting at all ages of people. In Ayurveda, according to Acharya Charak, sign and symptoms of anaemia has close resemblance to Pandu Roga as like paleness, weakness, Heart Tonic, Eye Inflammation etc. As WHO claims, Anaemia is a medical situation in which the amount of RBCs or Hb count is lower than the normal individual and it is estimated that over 40 percent of children below age five are anaemic. On the basis of reported data plant extracts have been proved to be effective alternative therapy for the management of anaemic conditions. Physicians mostly prescribe iron-rich diet and vitamin supplements for the treatment of anaemia. Iron supplements are easily available in markets, if consumed prolonged, it can cause severe problems like gastro intestinal problems, hepatic disorders and sometimes even cause cancer. Hence, scientists are looking for an alternative for these iron supplements for the management of anaemia. Plant extracts could play a great role against anaemia. In this study, extracts of 20different plants as like- Solanum nigrum, Terminalia chebula, Beta Vulgaris etc. are discussed, which are experimentally proven to be effective in anaemia. Applications of these medicinal plants in anaemia is also mentioned in classical Ayurveda literature from ancient time. So, these plant extracts are may be an alternative therapy for the management of anaemia and this study could help researchers for research in anaemia and other related disorders.","PeriodicalId":274343,"journal":{"name":"JOURNAL OF ADVANCED APPLIED SCIENTIFIC RESEARCH","volume":"50 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127256001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impacts of Paracetamol on the growth of Cicer arietinum (Gram) 扑热息痛对黄萎病菌生长的影响

JOURNAL OF ADVANCED APPLIED SCIENTIFIC RESEARCH Pub Date : 2022-11-05 DOI: 10.46947/joaasr442022452

Vijai Krishna, Chameli Soren

引用次数: 0

Development and in-vitro evaluation of Etoricoxib loaded Transdermal Film containing MWCNT 依托昔布负载含MWCNT透皮膜的研制和体外评价

JOURNAL OF ADVANCED APPLIED SCIENTIFIC RESEARCH Pub Date : 2022-11-04 DOI: 10.46947/joaasr442022439

Rabinarayan Parhi

{"title":"Development and in-vitro evaluation of Etoricoxib loaded Transdermal Film containing MWCNT","authors":"Rabinarayan Parhi","doi":"10.46947/joaasr442022439","DOIUrl":"https://doi.org/10.46947/joaasr442022439","url":null,"abstract":"Nanocomposites are materials that integrate either a unit of nanoscale material or multi-units of nanoscale material into a matrix of a standard substance. The main purpose of the current study is to fabricate and evaluate nanocomposite transdermal films of Etoricoxib. The transdermal films of etoricoxib were developed with a mixture of polymers viz. Eudragit RL-100 and HPMC K4M, with or without different percentages of multi-walled carbon nanotubes (MWCNT, 1, 3, 5, and 10%, w/w of total polymer) using solvent casting method. Various parameters including FT-IR, DSC, drug content, folding endurance, moisture content, moisture uptake, water vapour permeability (WVP), and in-vitro drug release employing Franz diffusion cell were assessed for the prepared films. The absence of interaction between the drug and polymers was confirmed by FT-IR and DSC studies. The thickness of the resulted films was within the range of 0.33±2.76 µm to 0.43±2.76 µm. The weights of prepared films were between 85.1±1.3 mg to 85.15±0.8 mg. The drug content was measured to be between 4.486 and 5.993 mg. The folding endurance of the developed films ranged from 237.33±7.8 to 342±6.5. The moisture content (%) was between 5.91 ± 1.2% and 8.84 ± 4.0%, whereas the percent moisture uptake of prepared films was observed to be between 8.23 ± 2.1% and 12.38 ±3.6%. The WVP of films was found to be 97.08 ± 0.57 g/m2/day to 194.17 ± 0.81 g/m2/day. In-vitro release studies revealed that formulation F4 prepared with an equal amount (50:50) of Eudragit RL-100 and HPMC K4M, and 5% MWCNT shows the highest drug release after 24 hr of study.The above results imply that the nanocomposite films could be an effective tool for transdermal delivery of etoricoxib and could act as a better prospect in replacing the oral dosage form. ","PeriodicalId":274343,"journal":{"name":"JOURNAL OF ADVANCED APPLIED SCIENTIFIC RESEARCH","volume":"83 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131654496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Annotations and suggestions on elephant proof trenches to reduce human elephant conflicts in Coimbatore forest division South India 南印度哥印拜陀林区防象沟减少人象冲突的注释与建议

JOURNAL OF ADVANCED APPLIED SCIENTIFIC RESEARCH Pub Date : 2022-09-26 DOI: 10.46947/joaasr432022268

Salahudeen, Asaikutti A, G. C., Rajasekar P, Siva T

{"title":"Annotations and suggestions on elephant proof trenches to reduce human elephant conflicts in Coimbatore forest division South India","authors":"Salahudeen, Asaikutti A, G. C., Rajasekar P, Siva T","doi":"10.46947/joaasr432022268","DOIUrl":"https://doi.org/10.46947/joaasr432022268","url":null,"abstract":"The structural backbone of India is agriculture. Agriculture encounters more conflicts and one among them is the human-elephant conflict. Traditional agricultural system is declining due to modernisation and urbanization and all the forest covers are being converted into human areas. Reduce forest cover and irregular rainfall and drastic climatic changes are much influencing the animals especially the elephants to enter into the human areas for food and water leading to human-elephant conflict. Though the State government and Forest department are necessary steps to trim down the elephant invading issues in Coimbatore forest division, the problem is still persisting. One best solution to calm down the upshot is the Elephant proof trench method. The present study found 510 damaged trenches by Foot survey method, analysed the effectiveness of Elephant Proof Trench (EPT) by Questionnaire method from the village people in the vicinity of forest fringes and collected all previous available conflict data from the forest department. \u0000Major human-elephant conflict incidences happened during March and October, high during the rainy seasons. Possibly elephants prefer to raid crops during these seasons for accessing sodium and minerals found in the crops. The present study reveals that Elephant Proof Trench reduced 73% of the elephant visits and 58% of crop damages. We also found EPT minimised the economic loss (58%), human deaths (75%) and elephant death incidences (82%) in the Coimbatore forest division. The minimum loss noted was also only because of the poorly maintained trenches. Hence, it is clear that, effectiveness of the Elephant Proof Trench will be most reliable, if trenches are maintained in a well regular manner. These results will help in the better conservation planning and management of forest ecosystem in future which will not have the human elephant conflicts again. \u0000Key words: Elephant proof trench, Human elephant conflict, Forest ecosystem, Agriculture","PeriodicalId":274343,"journal":{"name":"JOURNAL OF ADVANCED APPLIED SCIENTIFIC RESEARCH","volume":"22 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124941510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Green facile synthesis of Ag-doped ZnO nanoparticles from Gymnema sylvestre leaf extract and investigation of their Antibacterial activity 以匙羹藤叶提取物为原料制备银掺杂ZnO纳米颗粒及其抗菌活性研究

JOURNAL OF ADVANCED APPLIED SCIENTIFIC RESEARCH Pub Date : 2022-09-26 DOI: 10.46947/joaasr432022238

Karthikeyan M, Dr. P. Vijayakumar, A. Jafar Ahamed, A. Ravikumar, B. Ragavi

引用次数: 1

Green Synthesis of Nano Ag/Cu Hybrid Particles for Repelling Water from Cotton Fabric 纳米Ag/Cu杂化颗粒的绿色合成及其对棉织物的防水性

JOURNAL OF ADVANCED APPLIED SCIENTIFIC RESEARCH Pub Date : 2022-07-06 DOI: 10.46947/joaasr422022161

A. Zolriasatein, Mohsen Hosseinkhan, Shabnam Karimnejad

引用次数: 0