Medical and Clinical Archives最新文献_第2页

A comparative study of serum vascular endothelial growth factor in patients with tuberculous meningitis with and without stroke 结核性脑膜炎伴和不伴脑卒中患者血清血管内皮生长因子的比较研究

Medical and Clinical Archives Pub Date : 1900-01-01 DOI: 10.15761/mca.1000164

R. Jhamb, Bhupindar Singh, R. Kar, P. Gogoi, S. Madhu

{"title":"A comparative study of serum vascular endothelial growth factor in patients with tuberculous meningitis with and without stroke","authors":"R. Jhamb, Bhupindar Singh, R. Kar, P. Gogoi, S. Madhu","doi":"10.15761/mca.1000164","DOIUrl":"https://doi.org/10.15761/mca.1000164","url":null,"abstract":"Background and objectives: Stroke in tuberculous meningitis (TBM) has been reported in approximately 13-57% of patients with TBM. There are several mechanisms postulated for stroke in tuberculous meningitis including the role of various cytokines, chemokines and vascular endothelial growth factor (VEGF). VEGF is a potent regulator of endothelial permeability.There is a paucity of data regarding comparison of VEGF levels in patients of TBM with and without stroke. The aim of the study was to compare Serum VEGF in patients of tuberculous meningitis with and without Stroke and correlate it with various clinical, biochemical and radiological features. Methods: We compared 40 patients of probable or definite TBM with 40 age and sex matched patients of TBM with stroke.The two groups were compared for duration of illness, BMRC staging, various clinical parameters, CSF parameters (cytology, glucose and protein), MRI Brain scan features and serum VEGF levels. Results: The serum VEGF levels were significantly higher in TBM patients with stroke as compared to patients without stroke. The mean serum VEGF levels were 499.338 ± 230.320 pg/ml in patients of TBM without stroke and 1218.372 ± 570.114 pg/ml in patients of TBM with stroke. On multivariate analysis, out of the significantly different variables between patients of TBM without stroke and with stroke(i.e. duration of illness at presentation, hemiparesis, GCS score, Stage 3 BMRC, CSF protein concentration, CSF sugar, CSF lymphocyte count, presence of hydrocephalus on MRI Brain scan and serum VEGF) only GCS score and serum VEGF levels were significant. Interpretation and conclusion: The stroke in tuberculous meningitis was correlated to higher serum VEGF levels, lower GCS score. We conclude that features such as presentation in stage 3 BMRC, poor GCS at presentation, increased duration of illness at presentation, hydrocephalus on MRI and high serum VEGF levels may predict the occurrence of stroke in TBM. *Correspondence to: Rajat Jhamb MD (Medicine), FACP, FICP, FIACM, Professor, Department Of Medicine, University college of Medical Science & GTB Hospital, Delhi, India 110095, Tel: +91-9625900556; E-mail: rajatjhamb@ yahoo.com","PeriodicalId":271232,"journal":{"name":"Medical and Clinical Archives","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130120041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

autoimmune-cardiomyopathy-a-review-and-pooled-analysis-of-pathophysiology-diagnosis-and-clinical-management autoimmune-cardiomyopathy-a-review-and-pooled-analysis-of-pathophysiology-diagnosis-and-clinical-management

Medical and Clinical Archives Pub Date : 1900-01-01 DOI: 10.15761/mca.1000154

Aref Albakri

引用次数: 0

High output heart failure: A review of clinical status - epidemiology, pathophysiology, diagnosis, prognosis and clinical management 高输出心力衰竭:临床现状综述——流行病学、病理生理学、诊断、预后和临床管理

Medical and Clinical Archives Pub Date : 1900-01-01 DOI: 10.15761/mca.1000155

Aref Albakri

引用次数: 4

Effect of fetal microchimeric cells on the development of postnatal depression 胎儿微嵌合细胞对产后抑郁症发展的影响

Medical and Clinical Archives Pub Date : 1900-01-01 DOI: 10.15761/MCA.1000149

O. Demirhan, Nalan Öztürk, N. Aydın, Yildizdas Hy, Bülent Demirbek, I. N. Uslu, Y Gozet, Cavide Çakmak

{"title":"Effect of fetal microchimeric cells on the development of postnatal depression","authors":"O. Demirhan, Nalan Öztürk, N. Aydın, Yildizdas Hy, Bülent Demirbek, I. N. Uslu, Y Gozet, Cavide Çakmak","doi":"10.15761/MCA.1000149","DOIUrl":"https://doi.org/10.15761/MCA.1000149","url":null,"abstract":"Aim: Women are at the highest risk of depression during their childbearing years, and the birth of a child may precipitate a depressive episode in women. Fetal microchimerism (FMc), derived from fetal cells that persist after pregnancy, is usually evaluated by tests for male microchimerism (MMc) in women who gave birth to sons. We investigated FMc in women with sons and examined correlation with postnatal depression (PND) history, and this is one of the first studies in this area. Methods: In this study, we performed real-time quantitative PCR to detect and quantify male DNA in whole peripheral blood of 64 women (32 healthy and 32 with PND), targeting the Y-chromosome-specific DYS14 gene sequence as a marker for microchimerism (Mc) of fetal origin. Results: To verify the role of FMcCs in PND, 32 PND patients and 32 controlswere studied. A total of 32 women were studied of which 3 (9.4%) tested positive for MMc, had given birth to at least one son. None of the 32 control healthy women were positive. FMc was found significantly more often in women with PND than in healthy women (9.4% versus 0%, respectively) (p=0.005). About 41% of the risk for depression of PND women was familial, and smoking and drug usage habits was very high (37.5% and 71.9%, respectively) (p=0.005). Conclusion: MMc levels were higher in women with PND than in healthy women. Although the biological mechanisms are not precisely known, MMc presence in peripheral blood of women can be associated with PND. Genetic factors can also be one of the possible causes of PPD. Continued research on PND is needed to broaden the treatment alternatives in affected women. *Correspondence to: Osman Demirhan, Department of Medical Biology and Genetics, Faculty of Medicine, Cukurova University, 01330 Balcali, Adana, Turkey, E-mail: osdemir@cu.edu.tr Received: March 01, 2019; Accepted: March 18, 2019; Published: March 21, 2019 Introduction PND is defined as a nonpsychotic depressive illness of mild-tomoderate severity occurring in a mother during the first postnatal year, with most cases occurring in the first six months after delivery. The prevalence of NPD is generally reported as between 10% and 15% [1,2]. All women are potential candidates for emotional upheaval during the postpartum period and women who are single, primiparous, or anxious or depressed during pregnancy, as well as those who have a history of mental illness or previous postpartum psychiatric disorders, have problems during labour or delivery, or have concurrent personal or social stresses, may be at increased risk. Since the effects of PND are known to go beyond the mother in that it also affects the partner and the child. Too often women disappear into the home postnatally and have limited outside contact for the crucial first months. Severe forms of depression and puerperal psychosis can lead some women to commit suicide to escape their emotions [3]. Low socioeconomic status; partner’s habits, such as alcoholism; lack of educa","PeriodicalId":271232,"journal":{"name":"Medical and Clinical Archives","volume":"18 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125643197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Heart failure in pregnancy: A review of clinical status and meta-analysis of diagnosis and medication safety 妊娠期心力衰竭:临床状况综述及诊断和用药安全性的荟萃分析

Medical and Clinical Archives Pub Date : 1900-01-01 DOI: 10.15761/MCA.1000144

Aref Albakri

引用次数: 2

Factors inducing depression as effective tool in therapy 诱发抑郁的因素作为治疗的有效工具

Medical and Clinical Archives Pub Date : 1900-01-01 DOI: 10.15761/mca.1000163

Khushboo, B. Sharma

{"title":"Factors inducing depression as effective tool in therapy","authors":"Khushboo, B. Sharma","doi":"10.15761/mca.1000163","DOIUrl":"https://doi.org/10.15761/mca.1000163","url":null,"abstract":"Depression being a psychological disorder is known to cause morbidity and mortality of the concerned individual globally. According to an estimate from the World Health Organisation (WHO), about 57 million people equivalent to about 18% of the global population are suffering from depression in India. There are several known factors responsible for inducing depression in humans such as abusing drugs and alcohol, overwork, poor diet, using excess caffeine or sugar, lack of exercise, poor sleep, sexual abuse, genetic disorders, sadness, physical health issue, brain chemistry imbalance, lack of confidence, rejection/loneliness, loss of loved one etc. According to an epidemiological data, 30~40% of occurrences of depressive disorder involve genetic factors. Consequently, environmental factors also play significant role in development of depression. Studies have shown that cognitive therapy is as efficacious as antidepressant medications in treating depression which is believed to reduce the risk of relapse even after its discontinuation. Cognitive therapy and antidepressant medication probably engage some similar neural mechanisms, as well as mechanisms that are distinctive to each. Extensive research is therefore needed to delineate the population suffering from a specific kind of factor inducing depression which may help develop adequate therapy to treat the patients quickly and effectively.","PeriodicalId":271232,"journal":{"name":"Medical and Clinical Archives","volume":"36 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114573763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Clostridium difficile infection: Antibodies versus antibiotics 艰难梭菌感染:抗体与抗生素

Medical and Clinical Archives Pub Date : 1900-01-01 DOI: 10.15761/MCA.1000151

F. Naddafi

{"title":"Clostridium difficile infection: Antibodies versus antibiotics","authors":"F. Naddafi","doi":"10.15761/MCA.1000151","DOIUrl":"https://doi.org/10.15761/MCA.1000151","url":null,"abstract":"Recently, the dramatic changes in the epidemiology of Clostridium difficile infection (CDI) as well as increases in both incidence and severity of disease in many countries have made it a global public health problem. This increasing severity and incidence could be partially because of frequent antibiotic use and the emergence of a hypervirulent strain of Clostridium difficile. Antibiotics such as metronidazole and vancomycin could be considered as frontline treatment for CDI. But recurrent CDI occurs in ∼ 25 percent of cases and causes morbidity, mortality and healthcare costs. Due to antibiotic treatment failure in this population, novel treatment options are required. Recently, anti-toxin antibodies are developed as new therapeutic approach to the treatment of CDI. Bezlotoxumab, the first therapeutic monoclonal antibody, which is approved for the prevention of CDI recurrence. The aim of this manuscript is to provide the latest information about CDI treatment, with a particular focus on antibiotics and therapeutic antibodies that are utilized in CDI treatment. *Correspondence to: Fatemeh Naddafi, Pharmaceutical Sciences Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran, E-mail: fatemeh.naddafi@yahoo.com","PeriodicalId":271232,"journal":{"name":"Medical and Clinical Archives","volume":"131 9 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125791182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0