Medical and Clinical Archives最新文献

{"title":"Metabolic cardiomyopathy: A review and pooled analysis of pathophysiology, diagnosis and clinical management","authors":"Aref Albakri","doi":"10.15761/MCA.1000152","DOIUrl":"https://doi.org/10.15761/MCA.1000152","url":null,"abstract":"","PeriodicalId":271232,"journal":{"name":"Medical and Clinical Archives","volume":"23 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121091901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative studies on lumpy skin disease virus in human","authors":"Samia Ahmed Kamal","doi":"10.15761/mca.1000161","DOIUrl":"https://doi.org/10.15761/mca.1000161","url":null,"abstract":"Background: Lumpy Skin Disease Virus (LSDV), capripoxvirus, family poxviridae, was recently (2018-2019- till present) exhibiting its characteristic zoonosis [animal to human]. Moreover, the person- to- person direct transmission [infectious disease] were recorded. Materials and Methods: Whole blood and tissue samples from skin nodules were collected from infected persons (showing characteristic pox nodules). LSDV was isolated on BHK-21 cell culture, and pathogen free embryonated chicken eggs (CAM). Diagnosis were confirmed by conventional Polymerase Chain Reaction and partial sequencing using the primers target gene ORF103 and Negative staining, direct electron microscopic examination. Results: LSDVh was successfully isolated from blood and skin nodules collected from infected persons. Confirmed diagnosis was achieved by the conventional PCR and sequencing procedures. The isolates were genetically characterized as Lumpy skin disease virus isolate Evros/GR/15 by partial sequence with 99 % identity. Meanwhile, LSDV virions and herpes virus particles were visualized by electron microscopic investigations (NS-DEM). The majority of LSD virions were non- enveloped showing Mulberry forms and some capsular form, and the enveloped forms. Herpes virus virions were also detected in large number, the enveloped and the non- enveloped. The apparent pathogenesis on infected human are comparatively similar to LSD in cattle however the progress of illness and stages of the disease depends on level of health care interventions. Unless the nature of human biology is greatly different from that of cattle. Conclusions : Lumpy skin disease virus is capable of infecting humans with direct transmission without the need for insects vector; that most probably by inhalation and certainly by the direct contacts with infected materials, infected persons [man to man], and as laboratory acquired infection. LSDVh causes skin nodules and may lead to death in cases of generalized infections and if involving the internal organs. However, it is obvious that Herpes virus gives hands and helping poxviruses during their pathogenesis in the infected","PeriodicalId":271232,"journal":{"name":"Medical and Clinical Archives","volume":"4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126144005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Culture methods and environmental cues of human pluripotent stem cells","authors":"Hea-Jo Yoon, Woo Jung Ho","doi":"10.15761/MCA.1000147","DOIUrl":"https://doi.org/10.15761/MCA.1000147","url":null,"abstract":"Standard human pluripotent stem cells (hPSCs) cultures have supportive cells such as inactivated mouse embryonic fibroblast (MEF) feeder cells that aid cell growth, secrete several important growth factors into the medium, which help maintain pluripotency and prevent differentiation [1]. Feeder based cultures are suitable for routine maintenance of hPSCs colonies, and MEFs are the most frequently used feeder cells, particularly because they support the robust growth of all types of embryonic stem cells as colonies [2]. However, since MEFs have complex and undefined heterogeneity, a variety of human cell types such as human fibroblasts, tubal, foreskin, and bone marrowderived stromal cells can be used as feeder cells instead of MEF [2]. Feeder based cultures are suitable for routine hPSCs maintenance, genetic engineering and single cell cloning, but are not used for clinical applications.","PeriodicalId":271232,"journal":{"name":"Medical and Clinical Archives","volume":"27 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115515787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A challenge in maternal immunization for Neisseria meningitidis: Optimizing protection for mother and infant using the predictive translational value of mouse research","authors":"E. Gaspari","doi":"10.15761/mca.1000143","DOIUrl":"https://doi.org/10.15761/mca.1000143","url":null,"abstract":"This correspondence concerns our publication: de Almeida AF, De Gaspari E. Pathog Dis. 2018 Feb 1;76(1) with results obtained using mouse model that analyzed the passage of IgG antibodies with high avidity through the placenta described for the first time for Neisseria meningitidis B. Below, we explain the importance of results obtained by calling attention to check vaccines for protection in this age group with a high number of cases, including São Paulo, Brazil. Thus, further studies on the use of maternal immunization and vaccines for protection against this disease are needed. I would like to show the importance of translational research as in different diseases, especially in studies of vaccines to N.meningitidis as existing studies to Bordetella pertussis described in literature. *Correspondence to: Elizabeth N De Gaspari PhD, Scientific Reseacher, Immunology Center, Adolfo Lutz Institute, Monoclonal Laboratory (Production and Aplication ) Vaccine and adjuvants, Brazil, E-mail: egaspari@ial.sp.gov.br","PeriodicalId":271232,"journal":{"name":"Medical and Clinical Archives","volume":"33 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122638519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Implantable cardioverter defibrillator for the prevention of sudden cardiac death: Systematic review and pooled analysis","authors":"Aref Albakri","doi":"10.15761/mca.1000146","DOIUrl":"https://doi.org/10.15761/mca.1000146","url":null,"abstract":"Implantable cardioverter defibrillator (ICD) is an innovative biomedical device designed to detect and terminate malignant ventricular arrhythmias (VAs) with convincing evidence of substantial life-saving properties. Its prophylactic use for sudden cardiac death (SCD) in patients resuscitated from cardiac arrest or at risk for malignant VAs has revolutionized the face of clinical care for many cardiac diseases with a shift from antiarrhythmic drugs. Progressive improvements in ICD device has expanded the prophylactic use of ICD to include pre-emptive therapy in a large population of patients with significantly depressed left ventricular systolic function. This expansion increased the incidence of inappropriate shocks potentially affecting treatment efficacy. Moreover, inadequate attention paid to the patient’s psychosocial concerns and cost-effectiveness of therapy has affected treatment outcomes as well as quality of life. The knowledge of these complications and challenges is critical for appropriate selection of patients who will benefit from the therapy as well as improve treatment outcomes. The purpose of this literature review and pooled analysis is to summarize the current knowledge base of clinical indications, treatment outcomes, psychosocial concerns and healthcare costs for ICD patients and to identify gaps in ICD literature that would be appropriate targets for future research. *Correspondence to: Aref Albakri, St-Marien hospital Bonn Venusberg, Department of Internal Medicine, Bonn, Germany, E-mail: arefalbakri@yahoo.com","PeriodicalId":271232,"journal":{"name":"Medical and Clinical Archives","volume":"100 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128819242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of cytogenetic abnormalities in chronic lymphocytic leukemia (CLL)","authors":"Gadhia Pk, Modi Py, V. Sn","doi":"10.15761/mca.1000165","DOIUrl":"https://doi.org/10.15761/mca.1000165","url":null,"abstract":"","PeriodicalId":271232,"journal":{"name":"Medical and Clinical Archives","volume":"2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128135185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Isolated bone erosions likely not clinically significant","authors":"B. Rothschild, L. Jellema","doi":"10.15761/mca.1000162","DOIUrl":"https://doi.org/10.15761/mca.1000162","url":null,"abstract":"Background: Synovial joint erosions are generally considered the result of an inflammatory process, permitting identification of the underlying form of arthritis. However, they are sometimes perceived in isolation, in the absence of any disorder known to produce erosions. In addition to the character of the erosions, a tool helpful in characterizing known forms of inflammatory arthritis is their gender and age distribution as a population phenomenon. Methods: Hands and feet of individuals in the Hamann-Todd human skeletal collection were macroscopically examined to identify individuals with isolated (single or two) appendicular articular or peri-articular cortical disruptions in absence of axial skeletal erosions, fusion, syndesmophytes or calcium pyrophosphate deposition disease-related calcific deposits. Gender and age were additionally recorded for individuals identified with rheumatoid arthritis, spondyloarthropathy and calcium pyrophosphate deposition disease. Results: Isolated articular and periarticular cortical disruption was recognized in 61 (4 women, 57 men) among 1620 individuals, independent of race. Discussion: Epidemiologic analysis revealed a pattern of isolated erosions that could not be attributed to the diseases that today are recognized to commonly cause bone erosion. If not associated with other skeletal manifestations of inflammatory/crystalline arthritis or clinical evidence of synovitis, they likely are not clinically significant. *Correspondence to: Bruce Rothschild, Carnegie Museum, 4400 Forbes Ave, Pittsburgh, PA 15213, USA, Tel: 785-615-1523; E-mail: spondylair@gmail.com","PeriodicalId":271232,"journal":{"name":"Medical and Clinical Archives","volume":"15 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128391198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Parasitic (Helminthic) cardiomyopathy: A review and pooled analysis of pathophysiology, diagnosis and clinical management","authors":"Aref Albakri","doi":"10.15761/mca.1000153","DOIUrl":"https://doi.org/10.15761/mca.1000153","url":null,"abstract":"Neglected tropical diseases form an important component of the burden of cardiac disease in resource-constrained countries. Some diseases resulting from infection by helminthic parasites such as endomyocardial fibrosis, schistosomiasis and hookworm infections are part of the neglected tropical diseases. The neglect has contributed to the under-appreciation and under-research of helminthic cardiac diseases. In contrast, infections by helminthic parasites are prevalent in resource-constrained countries and are among the leading aetiology of cardiac diseases including cardiomyopathy often associated with an ominous prognosis. Infection by a wide variety of helminth parasites, more commonly Trichinella, Taenia solium, Echinococcus, Schistosoma, Toxocara and Ascaris, and less commonly, Heterophyes, Paragonimus, Strongyloides and Dirofilaria Immitis can result in myocardial injury ultimately progressing to cardiomyopathy. However, data on epidemiology, presentation, diagnosis and management of helminthic cardiomyopathy are few and disparate effectively undermining exact understanding. Moreover, expert guidelines specific to the diagnosis and management of helminthic cardiac diseases are also conspicuously lacking. Current clinical practices on management of helminthic cardiomyopathy appear to depend on health centre experience. This paper aims to provide a broadened view of the clinical status of helminthic cardiomyopathy by reviewing published evidence with a particular focus on the causative helminthic parasites, pathophysiology, diagnosis and clinical management. *Correspondence to: Aref Albakri, St-Marien hospital Bonn Venusberg, Department of Internal Medicine, Bonn, Germany, E-mail: arefalbakri@yahoo.com","PeriodicalId":271232,"journal":{"name":"Medical and Clinical Archives","volume":"69 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128020951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Seroprevalence of HIV in polytransfused adult sickle cell disease: Case of the center of mixed medicine and SS anemia of kinshasa","authors":"I Mwanaut, B. Bongenya, Ben Ilunga Bulanda, Divine Chuga, C Tshibumbu, J. Kabasele, M. Okanda, E. Kamangu","doi":"10.15761/mca.1000157","DOIUrl":"https://doi.org/10.15761/mca.1000157","url":null,"abstract":"Context: Sickle cell disease is an inherited disease of hemoglobin, which is manifested primarily by vaso-occlusive or hemolytic crises and often requires a recurrent therapeutic transfusion. Its prevalence in sub-Saharan Africa is very high. Objective: To establish seroprevalence of HIV in polytransfused adult homozygous sickle cell patients at the Center of Mixed Medicine and Anemia SS (CMMASS) in Kinshasa. Methods: A retrospective study was conducted at the CMMASS between January 2006 and June 2017 to determine the number of confirmed cases of HIV infection in homozygous adult polytransfused patients. Have been included, all patients diagnosed by electrophoresis of hemoglobin and who received a minimum of 2 blood transfusions during the study period. Results: One hundred and eighty (180) patients constituted the study sample. The age was in the range of 18 to 50 years with a median of 29 years. The most represented age group was 18 to 23 years (48.33%). The female gender was the most represented (64.44%) with a sex ratio of 1.77 (women / men). HIV seroprevalence was of 8.33% (N = 15). Conclusion: The seroprevalence of HIV in the population of polytransfused adult sickle cell disease at the Center of Mixed Medicine and Anemia SS of Kinshasa is 8.33% for the interval from 2006 to 2017. *Correspondence to: Erick Kamangu, Research Group \"HIV/AIDS Focus\", KinshasaDemocratic Republic of the Congo, E-mail: erick.kamangu@unikin.ac.cd","PeriodicalId":271232,"journal":{"name":"Medical and Clinical Archives","volume":"6 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117016126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Female undergraduate sports participation and adequate education, perceived implications of reproductive health problems/male dominance: University sports administration experience","authors":"Eugene Ac, Adline Ac, Blessing I Chike-Ijezie, Edith Aa, C. Uo","doi":"10.15761/mca.1000160","DOIUrl":"https://doi.org/10.15761/mca.1000160","url":null,"abstract":"This study sought to examine female undergraduate’s sports participation and adequate education, perceived implications of reproductive health problems/male dominance: University Sports administration experience. Sports has grown from its earlier humble beginnings of being a mere entertainment and recreational pass-time, to becoming a prominent, business both in the social, political and economic circles of all nations of the world. Hence the researcher tried to verify perceived implications of the reproductive health problems of the girl-child and persistent male dominance in University sports vis a vis female undergraduate’s participation in sports and their education. Consequently, the specific objective of this study was to verify if the reproductive health problems of the girl-child, poorly funded and maintained sports facilities of the universities and perceived male dominance over the girls in virtually all sports determine female undergraduate’s participation in university sports and their education generally. To guide this study 3 research questions were formulated, with 3 corresponding hypotheses that were tested at 0.05 level of significance. The descriptive survey research design was considered appropriate, while the instrument for data collection was a self-structured questionnaire designed after the Likert type by the researcher. Total of 380 female undergraduates of three universities in Anambra State of Nigeria. Nnamdi Azikiwe University, Awka, Uli, and University Elele Port Harcourt (Federal, State and Privately owned universities) constituted the population of the study, out of which a total of 263 respondents were sampled. The descriptive statistics of mean, frequency counts and Standard Deviation (SD) were used to describe the data, while inferential statistics of Chi-square (X 2 ) was used to test the 3 null hypotheses at 0.05 level of significance. Based on the data collected and analyzed, revealed that reproductive health problems (X 2 =84.18, df=3, P>0.05), poor funding/maintenance of sports for faculties (X 2 =75.412, df = 3, P>0.05) male undergraduates dominance in all sports (X 2 =128.68 df. 3, P>0.05) were seen to be determinants of female undergraduates participation and education generally in universities. It was therefore recommended that stiffer measures must be taken and applied to preserve the few sports facilities built around the female hostels, to be strictly used by the female undergraduates, at their convenience. Universities need to further improve on their reproductive health service delivery, to adequately cater for the needs of the female undergraduates who presently seem to be on their own, in terms of solutions to their numerous reproductive health problems that tend to interfere with their sports participation and academic pursuits in the university. Highly qualified Nurses should be employed to serve as Matrons attached to all female hostels in the universities to assist the female undergraduates cop","PeriodicalId":271232,"journal":{"name":"Medical and Clinical Archives","volume":"440 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134406145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}