Nusantara Medical Science Journal最新文献

Correlation Between Immunohistochemical Expression of Epstein-Barr Virus Latent Membrane Protein-1 (LMP-1) and Clinical Stages of Sinonasal Carcinoma eb病毒潜伏膜蛋白-1 (LMP-1)免疫组化表达与鼻窦癌临床分期的关系

Nusantara Medical Science Journal Pub Date : 2022-10-21 DOI: 10.20956/nmsj.v7i2.20037

Lisa Retno Dewi, M. Akil, E. Savitri, Abdul Qadar Punagi

{"title":"Correlation Between Immunohistochemical Expression of Epstein-Barr Virus Latent Membrane Protein-1 (LMP-1) and Clinical Stages of Sinonasal Carcinoma","authors":"Lisa Retno Dewi, M. Akil, E. Savitri, Abdul Qadar Punagi","doi":"10.20956/nmsj.v7i2.20037","DOIUrl":"https://doi.org/10.20956/nmsj.v7i2.20037","url":null,"abstract":"Introduction: Sinonasal tumors are rarely found. The protected nature of the sinuses makes early detection of tumors growing in these areas difficult. The Epstein-Barr virus is one of the most common viruses found in humans; which expresses Latent Membrane Protein-1 (LMP-1) that can transform cell lines and alter cell phenotype due to its oncogenic potential. Objective: To investigate the relationship between immunohistochemical expression of Latent Membrane Protein-1 (LMP-1) from Epstein-Barr virus and clinical stages of sinonasal carcinoma. Methods: This cross-sectional study was carried out in DR. Wahidin Sudirohusodo General Hospital and anatomic pathology of Hasanuddin University Hospital, Makassar, South Sulawesi, Indonesia, from October 2016 to March 2017. Histopathological samples from biopsy specimen of all subjects diagnosed with sinonasal carcinoma in Otorhinolaryngology-Head and Neck Surgery outpatient clinic were taken and examined for LMP-1 expression using immunohistochemical staining. The samples were taken from paraffin block from patients. Result: There were 33 males (67.3%) and 16 females (32.7%) with sinonasal carcinoma who participated in this study. The majority of participants aged ≥50 years (25 people, 51.0%) and worked as farmers (27 people, 55.1%). A significant correlation between LMP-1 expression and sinonasal carcinoma clinical stages was found (Spearman’s correlation r = 0.355 and p <0.001). Conclusion: Higher LMP-1 expression correlates with higher sinonasal carcinoma clinical stage in patients aged <50 years.","PeriodicalId":266369,"journal":{"name":"Nusantara Medical Science Journal","volume":"5 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121890543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Relationship of Sociodemographic Factors with Near-miss and Missed Cases in Educational and Affiliated Hospitals in Makassar from 2019 to 2020 2019 - 2020年望加锡市教育及附属医院漏诊与社会人口学因素的关系

Nusantara Medical Science Journal Pub Date : 2022-10-21 DOI: 10.20956/nmsj.v7i2.19879

Indah Ria Rezeki Meirisa, E. Jusuf, N. Mappaware

{"title":"The Relationship of Sociodemographic Factors with Near-miss and Missed Cases in Educational and Affiliated Hospitals in Makassar from 2019 to 2020","authors":"Indah Ria Rezeki Meirisa, E. Jusuf, N. Mappaware","doi":"10.20956/nmsj.v7i2.19879","DOIUrl":"https://doi.org/10.20956/nmsj.v7i2.19879","url":null,"abstract":"Introduction: Maternal mortality remains a critical issue in achieving optimal health status. Evaluation through near-miss cases provides valuable data about morbidity to monitor the quality of obstetric services, which can be used to estimate the incidence of life-threatening obstetric complications. A study reported that the incidence of near-miss in pregnant women had a significant relationship with various non-medical factors, included sociodemographic factors. Therefore, this study aims to examine the relationship of sociodemographic factors with near-miss and missed cases. Methods: This analytic retrospective study conducted in Educational and affiliated hospitals in Makassar. Data were retrieved from the obstetric referral registry from 2019 to 2020. Sociodemographic factors of interest include diagnosis, gestational age, maternal age, referral status, maternal parity, and economics. Results: A total of 156 near-miss and missed cases were obtained from January 1, 2019, to December 31, 2020. There was no significant relationship between maternal age (p=0.675), gestational age (p=0.38), parity (p=0.24), economic status (p=0.73), educational background (p=0.85), and referral status (p=0.16) with maternal near-miss and missed cases. Conclusions: There was no significant relationship between sociodemographic characteristics and maternal near-miss and missed cases in Educational and affiliated hospitals in Makassar from 2019 to 2020. More studies are needed to evaluate other factors associated with near-miss and missed cases.","PeriodicalId":266369,"journal":{"name":"Nusantara Medical Science Journal","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130596234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Case Report : Cervical Cellular Angiofibroma 1例报告:宫颈细胞血管纤维瘤

Nusantara Medical Science Journal Pub Date : 2022-10-21 DOI: 10.20956/nmsj.v7i2.19923

M. Hidayatullah, S. Arifuddin, Nur Rakhmah

{"title":"Case Report : Cervical Cellular Angiofibroma","authors":"M. Hidayatullah, S. Arifuddin, Nur Rakhmah","doi":"10.20956/nmsj.v7i2.19923","DOIUrl":"https://doi.org/10.20956/nmsj.v7i2.19923","url":null,"abstract":"Background: Cellular angiofibroma is a rare benign tumor in the distal genitalia introduced by Nucci et al in 1997 that can occur in both women and men with an age range of 46 – 54 years. In women it usually occurs in the vulva and vagina. These tumors are often diagnosed as Bartholin cysts, vulvar cysts, myomas, and unspecified complex tumors. \u0000Objective: Report a case of cellular angiofibroma previously diagnosed with cervical myoma \u0000Case: A 51-year-old female patient para 5 abortion 0 with complaints of lumps that have been felt to come in and out since 4 months but since 1 week it feels enlarged and cannot be inserted again, and diagnosed as cervical tumor. History of menopause since 1 year ago. The general condition of the patient is good with vital signs within normal limits. On physical examination of the abdomen, there was no tumor mass, tenderness or flux. On inspection, there was a reddish mass coming out of the vaginal introitus with some blackish necrotic appearance. On vaginal examination, a mass with a solid consistency was found with the impression of the cervix with a border of the tumor stalk that was not palpable. In this patient, Total Abdominal Hysterectomy and Bilateral Salpingoophorectomy were performed and the tissue was examined for anatomical pathology with cervical angiofibroma results with non-specific chronic inflammation and atypical complex endometrial gland hyperplasia. \u0000Conclusion : Cellular angiofibroma is a rare tumor that usually occur in the vulva and vagina, which is often diagnosed as Bartholin's cyst, vulvar cyst, myoma and unspecified complex tumor. Action in the form of total excision of tumor tissue gives a low recurrence. \u0000Keywords : Cervical angiofibroma, cervical tumor","PeriodicalId":266369,"journal":{"name":"Nusantara Medical Science Journal","volume":"36 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122196410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Association of Cumulative Fluid Balance and Sepsis Patient Mortality During Treatment in the Intensive Care Unit 重症监护病房治疗期间积液平衡与败血症患者死亡率的关系

Nusantara Medical Science Journal Pub Date : 2022-10-21 DOI: 10.20956/nmsj.v7i2.20229

Gusriadi B, S. Salam, Hisbullah Hisbullah, Syafri K. Arif, M. Rum, A. Palinrungi

{"title":"The Association of Cumulative Fluid Balance and Sepsis Patient Mortality During Treatment in the Intensive Care Unit","authors":"Gusriadi B, S. Salam, Hisbullah Hisbullah, Syafri K. Arif, M. Rum, A. Palinrungi","doi":"10.20956/nmsj.v7i2.20229","DOIUrl":"https://doi.org/10.20956/nmsj.v7i2.20229","url":null,"abstract":"Introduction: Fluid management in sepsis patients is crucial, especially in the first three hours after sepsis diagnosis is established. However, excessive fluid administration will increase patient mortality. This study’s purpose is to determine the correlation among cumulative fluid balance and mortality in patients with sepsis and/or septic shock admitted to the Intensive Care Unit (ICU) of Dr. Wahidin Sudirohusodo Central Hospital, Makassar. Methods: This comes about as an analytical observational study with a retrospective method. The population involved in this study was patients diagnosed with sepsis and septic shock who were treated in the ICU of Dr. Wahidin Sudirohusodo Central Hospital, Makassar from January to December 2021 with a total sample of 56 people. Data were analyzed using Mann-Whitney and Chi-Square statistical tests with a significance level of α=0.05. Data were studied using SPSS 25.0 (SPSS, Inc. Chicago, IL). Results: The mean cumulative fluid balance in septic patients was -1299.51±5228.34 ml. Based on the fluid balance category, 24 people (42.9%) had a positive balance and 32 people (57.1%) had a negative balance. There was a correlation among cumulative fluid balance and mortality in sepsis patients hospitalized in the ICU of Dr. Wahidin Sudirohusodo Central Hospital (p < 0.001), out of 24 patients with a positive balance, the non-survivors percentage was 66.7% and 33.3% of patients survived, while out of 32 patients with a negative balance, the percentage of non-survivors was 18.7% and 81.3% of patients survived. Conclusions: There is a correlation among cumulative fluid balance and mortality of septic patients in the ICU. A positive cumulative fluid balance will cause a higher mortality rate or risk of death compared to a negative cumulative fluid balance.","PeriodicalId":266369,"journal":{"name":"Nusantara Medical Science Journal","volume":"78 3 Pt 1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131204611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Turbidity, pH, Direct Gram as Predictors of Symptomatic Urinary Tract Infections in Pregnant Women 浊度，pH值，直接革兰氏作为孕妇症状性尿路感染的预测因子

Nusantara Medical Science Journal Pub Date : 2022-10-21 DOI: 10.20956/nmsj.v7i2.20028

Dhian Karina Aprilani Hattah, R. Sjahril, Sriwijaya Sriwijaya

{"title":"Turbidity, pH, Direct Gram as Predictors of Symptomatic Urinary Tract Infections in Pregnant Women","authors":"Dhian Karina Aprilani Hattah, R. Sjahril, Sriwijaya Sriwijaya","doi":"10.20956/nmsj.v7i2.20028","DOIUrl":"https://doi.org/10.20956/nmsj.v7i2.20028","url":null,"abstract":"Introduction: Urinary tract infections (UTIs) are common in the community, including among pregnant women. This study investigates turbidity, urine pH, and direct gram as predictors of symptomatic urinary tract infection in pregnant women. Methods: A total of 177 pregnant women with suspected UTIs based on clinical and laboratories at the community health center in Makassar were collected from September to December 2021. The Urine sample was assessed for turbidity, urine pH, direct gram, and urine culture. Results: Urine turbidity was found in 108 (75.5%) patients who had positive cultures and PPV of 94.7%. The mean pH of the urine from UTI patients was 6.42 and without UTIs was 6.45. Urine that grows Gram-positive bacteria showed the most alkaline pH (mean pH=6.71) and was significantly less acidic than urine with UTI negative. In contrast, urine with Gram-negative bacteria had the most acidic pH (mean PH=6.30). The gram direct test shows a significant association with UTIs. Conclusions: Turbid urine can predict urinary tract infections in pregnant women that provide clinical symptoms. In addition, leukocytes esterase test further selected the samples. Urine pH showed no significant correlation with UTI. Less acidic urine pH is particularly associated with Gram-positive bacterial infections. Furthermore, direct gram can predict the event of UTI.","PeriodicalId":266369,"journal":{"name":"Nusantara Medical Science Journal","volume":"32 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121338348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of Stromal Vascular Fraction and Platelet-Rich Plasma Combination on Polymorphonuclear Cells in Wistar Rats Anal Trauma Model 基质血管组分和富血小板血浆组合对Wistar大鼠肛门创伤模型多形核细胞的影响

Nusantara Medical Science Journal Pub Date : 2022-10-21 DOI: 10.20956/nmsj.v7i2.20846

Erwin Hadi Chandra, Sulmiati Sulmiati, Nita Mariana, Fonny Josh, Sachraswaty Rachman, F. Hamid

引用次数: 0

The Relationship between Neutrophil on Lymphocyte Ratio with Clinical Stage of Nasopharyngeal Carcinoma Patients 中性粒细胞与淋巴细胞比值与鼻咽癌临床分期的关系

Nusantara Medical Science Journal Pub Date : 2022-05-14 DOI: 10.20956/nmsj.v7i1.19121

Nur Fadhila Kurnia, Abdul Qadar Punagi

{"title":"The Relationship between Neutrophil on Lymphocyte Ratio with Clinical Stage of Nasopharyngeal Carcinoma Patients","authors":"Nur Fadhila Kurnia, Abdul Qadar Punagi","doi":"10.20956/nmsj.v7i1.19121","DOIUrl":"https://doi.org/10.20956/nmsj.v7i1.19121","url":null,"abstract":"Introduction: The general objective of this study was to determine the relationship between the ratio of neutrophils to lymphocytes and the clinical stage in patients with nasopharyngeal carcinoma. While the specific goal is to know the characteristics of patients with nasopharyngeal carcinoma. Knowing the description of peripheral neutrophil levels in patients with nasopharyngeal carcinoma. Knowing the description of peripheral lymphocyte levels in patients with nasopharyngeal carcinoma. Knowing the picture of NLR at the clinical stage of patients with nasopharyngeal carcinoma. Methods:The target population in this study were all patients with nasopharyngeal carcinoma. The affordable population is all patients with nasopharyngeal carcinoma who are undergoing treatment at. RSUP. Dr Wahidin Sudirohusodo for the period July 2018 to July 2019.. Results: Based on statistical analysis of the data, this study did not find a significant relationship between the neutrophil-lymphocyte ratio and the clinical stage of nasopharyngeal carcinoma (P = 0.252), even after correcting for sex. Statistical tests were used to see whether or not there was a relationship. between these two variables is the Kruskal-Wallis test, which was chosen because it is a non-parametric comparative test for variables with more than two categories.\u0000Conclusions: Based on statistical analysis of the data, this study did not find a significant relationship between the neutrophil-lymphocyte ratio and the clinical stage of nasopharyngeal carcinoma (P = 0.252), even after correcting for sex.","PeriodicalId":266369,"journal":{"name":"Nusantara Medical Science Journal","volume":"51 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126794415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Microbial Pattern and Sensitivity Analysis of Otitis Externa Patients in Makassar, Indonesia 印尼望加锡地区外耳炎患者微生物类型及敏感性分析

Nusantara Medical Science Journal Pub Date : 2022-05-14 DOI: 10.20956/nmsj.v7i1.18910

Joy Tobing, R. Djamin, S. Rahardjo

{"title":"Microbial Pattern and Sensitivity Analysis of Otitis Externa Patients in Makassar, Indonesia","authors":"Joy Tobing, R. Djamin, S. Rahardjo","doi":"10.20956/nmsj.v7i1.18910","DOIUrl":"https://doi.org/10.20956/nmsj.v7i1.18910","url":null,"abstract":"Introduction: Globally, the cases of otitis externa were increased, followed by the incidence of antimicrobial resistance. Several factors, such as untrained medical health personnel and unprescribed antibiotics, are thought to play a major role in this phenomenon. This study aims to determine the bacterial patterns and antimicrobial sensitivity in otitis externa patients in Makassar, South Sulawesi, Indonesia. Methods: This cross-sectional study was conducted from November 2020 to February 2021 at Dr. Wahidin Sudirohusodo and Health Laboratory Center, Makassar, South Sulawesi, Indonesia. There were in total 33 subjects with otitis externa participating in this study. The secretion from the outer ear canal was taken and cultured using Mac Conkey agar for bacteriological examination and Vitek 2 for antimicrobial sensitivity. This study assessed age, sex, and type of otitis externa. All data analyses used SPSS version 26.00 (IBM Corp., Armonk, New York). Bacteria patterns and otitis externa were analyzed using the Fisher test. Results: Fourteen cases (42.4%) were caused by Pseudomonas Aeruginosa. Most Gram-negative bacteria were sensitive to ciprofloxacin, gentamicin, amikacin, and meropenem. Staphylococcus haemolyticus, Staphylococcus capitis, and Staphylococcus epidermidis were the most resistant Gram-positive bacteria. Aerobic bacteria in otitis externa were sensitive to antimicrobials (p<0.023). Conclusion: Gram-negative aerobic bacteria were common causes of otitis externa, with Pseudomonas aeruginosa being the most common isolated bacteria. Ciprofloxacin, gentamicin, amikacin, and meropenem were sensitive antimicrobials for otitis externa.","PeriodicalId":266369,"journal":{"name":"Nusantara Medical Science Journal","volume":"106 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132425549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Survivability Rates Based on Molecular Subtype, Stage and Metastasis of 36 months cohort in Breast Cancer Patients 基于分子亚型、分期和转移的乳腺癌患者36个月队列生存率

Nusantara Medical Science Journal Pub Date : 2022-04-16 DOI: 10.20956/nmsj.v7i1.20092

Adi Wijayanto, J. Pieter, P. Prihantono, S. Syamsu, Nilam Smaradhania Thaufix, A. Abdi

{"title":"Survivability Rates Based on Molecular Subtype, Stage and Metastasis of 36 months cohort in Breast Cancer Patients","authors":"Adi Wijayanto, J. Pieter, P. Prihantono, S. Syamsu, Nilam Smaradhania Thaufix, A. Abdi","doi":"10.20956/nmsj.v7i1.20092","DOIUrl":"https://doi.org/10.20956/nmsj.v7i1.20092","url":null,"abstract":"Introduction: Breast cancer treatment is carried out at the early stage of the disease, and a comprehensive assessment of the subtype, stage, and incidence of metastases is required. This study aims to determine breast cancer patients' overall survival (OS) and disease-free survival (DFS) based on subtype, stage, and incidence of metastases. Methods: An observational analytic study with a retrospective cohort design was performed on eligible breast cancer patients at Wahidin Sudirohusodo Hospital from 2016 to 2019. Univariate analysis, and the Kaplan-Meier survival log-rank method (Mantel-Cox), were used to determine differences in survivability rates (OS and DFS) based on subtype, stage, and incidence of metastases. Results: A total of 172 breast cancer patients from 32 years to 84 years with a mean age of 53.5 years. The most subtypes were Luminal A (34.9%) patients, and the least was Luminal B (15.7%) patients. A total of 85 (49.4%) patients survived during these three years, while 87 (50.6%) died. Based on the results of statistical tests in this study, there were no significant differences between the subtypes with DFS and OS, but on the contrary, there was a significant difference between the stage and incidence of metastases with OS and DFS (p<0.05). Conclusions: There were no statistically significant differences between the subtypes with OS and DFS. This study showed a significant difference between the stage and incidence of metastases with OS and DFS","PeriodicalId":266369,"journal":{"name":"Nusantara Medical Science Journal","volume":"42 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127339227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

MIC and MBC Levels of Combination Camellia Sinensis and Mentha Piperita Extract Mouthwash Against Streptococcus Mutans 山茶和薄荷提取物联合漱口水抗变形链球菌的MIC和MBC水平

Nusantara Medical Science Journal Pub Date : 2022-04-16 DOI: 10.20956/nmsj.v7i1.19203

Yuani Setiawati, Muflikhah Ramadhani, Jihan Bobsaid, Dennia Oktavia Zahidah Hulwah

{"title":"MIC and MBC Levels of Combination Camellia Sinensis and Mentha Piperita Extract Mouthwash Against Streptococcus Mutans","authors":"Yuani Setiawati, Muflikhah Ramadhani, Jihan Bobsaid, Dennia Oktavia Zahidah Hulwah","doi":"10.20956/nmsj.v7i1.19203","DOIUrl":"https://doi.org/10.20956/nmsj.v7i1.19203","url":null,"abstract":"Introduction: Awareness of Indonesian people in maintaining dental and oral health is low, proved by an increase in the percentage of dental and oral health problems by 2.7%. Caries is a dental and oral health problem that occurs in many children. The main cause of dental caries is Streptococcus mutans. To solve this problem, it is necessary to use herbal mouthwash made from a combination of Camellia sinensis and Mentha piperita extract as an antibacterial against Streptococcus mutans. Methods: Mouthwash is made through several processes namely plant determination, extraction, and mouthwash making. Minimal Inhibitory Concentration (MIC) is determined by diluted methods, Minimal Bactericidal Concentration (MBC) is determined by the agar streaking method, and colony tests are calculated using colony counters. Results: The result of plant determination showed the plants in this study were Camellia sinensis and Mentha piperita. At a concentration of 6.25%, no growth of bacteria in each repetition with the number of colonies 0 CFU / ml. While at a concentration of 3.125% found the average number of colonies 13 CFU / ml. Conclusions: Based on good MIC and MBC results, mouthwash containing Camellia sinensis and Mentha piperita has been shown to kill and inhibit the growth of Streptococcus mutans bacteria","PeriodicalId":266369,"journal":{"name":"Nusantara Medical Science Journal","volume":"274 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124221029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0