The Korean Journal of Cytopathology最新文献_第2页

Imprint Cytology of Hibernoma -A Case Report - 冬眠瘤的印迹细胞学1例报告

The Korean Journal of Cytopathology Pub Date : 2008-09-01 DOI: 10.3338/KJC.2008.19.2.200

J. Choi, D. Shin

引用次数: 1

Cytologic Findings of Malakoplakia of the Uterine Cervix and the Vagina -A Case Report- 宫颈阴道斑疹的细胞学表现- 1例报告

The Korean Journal of Cytopathology Pub Date : 2008-09-01 DOI: 10.3338/KJC.2008.19.2.164

Y. Chun, S. Hong, H. Kim, Ji-Young Kim, B. Kim, H. Kim

引用次数: 0

Pulmonary Adenocarcinoma with a Micropapillary Pattern Detected by Bronchial Washing - A Brief Case Report - 支气管冲洗检查肺腺癌伴微乳头状征象1例报告

The Korean Journal of Cytopathology Pub Date : 2008-09-01 DOI: 10.3338/KJC.2008.19.2.206

J. Park, S. Ha, H. Cho, D. Chung, N. Kim, Sanghui Park

引用次数: 0

Methylation Abnormality in Body Fluid Cytology: A Supplemental Molecular Marker for the Diagnosis of Malignant Mesothelioma 体液细胞学甲基化异常:恶性间皮瘤诊断的补充分子标志物

The Korean Journal of Cytopathology Pub Date : 2008-09-01 DOI: 10.3338/KJC.2008.19.2.126

J. Song, J. Jung, J. Kang, I. Hwang, S. Jang

{"title":"Methylation Abnormality in Body Fluid Cytology: A Supplemental Molecular Marker for the Diagnosis of Malignant Mesothelioma","authors":"J. Song, J. Jung, J. Kang, I. Hwang, S. Jang","doi":"10.3338/KJC.2008.19.2.126","DOIUrl":"https://doi.org/10.3338/KJC.2008.19.2.126","url":null,"abstract":"Malignant mesothelioma (MM) is a highly lethal neoplasm arising in pleura and the peritoneum and a rapid and accurate diagnosis is crucial for treatment of the disease. However, the sensitivity of cytological analysis using pleural or ascitic fluid is relatively low, yielding an accurate diagnosis in only of cases. We tested the diagnostic value of epigenetic alterations in body fluid cytology as a supplement to conventional methods. Paraffin-embedded tissue blocks from 21 MM patients and associated body fluid cytology slides considered no evidence of malignancy were used to test for epigenetic alteration. Using methylation-specific PCR, we detected methylation of RASSF1A and p16 in 47.6% (10/21) of both surgically resected tumor samples, respectively. Body fluid samples of MM also showed abnormal methylation of RASSF1A and p16INK4a genes in 38.1% (8/21) and 33.3% (7/21) of cases. The concordance in the rates of RASSF1A and p16INK4a gene-methylation abnormalities determined from cytology samples and tissue samples were 61.9% (13/21) and 66.7% (14/21), respectively. Combining both genes increases the sensitivity of the test to 57.1 % (12 of 21) of cases. Our results suggest that testing for methylation abnormalities in selected individual genes or gene combinations has diagnostic value as an alternative or adjunct method to conventional cytological diagnosis.","PeriodicalId":261069,"journal":{"name":"The Korean Journal of Cytopathology","volume":"88 28 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2008-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130779403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Imprint Cytology of Hepatic Angiomyolipoma -A Case Report- 肝血管平滑肌脂肪瘤印迹细胞学1例报告

The Korean Journal of Cytopathology Pub Date : 2008-09-01 DOI: 10.3338/KJC.2008.19.2.188

A. Kim, Hong-Jin Kim, J. Choi

引用次数: 2

Diagnostic Accuracy of Cervicovaginal Cytology in the Detection of Squamous Epithelial Lesions of the Uterine Cervix; Cytologic/Histologic Correlation of 481 Cases 宫颈阴道细胞学检测宫颈鳞状上皮病变的诊断准确性481例细胞学/组织学相关性分析

The Korean Journal of Cytopathology Pub Date : 2008-09-01 DOI: 10.3338/KJC.2008.19.2.111

S. Jin, Sang Mo Park, Mee Sun Kim, Y. Jeen, Dong Won Kim, Dong Wha Lee

{"title":"Diagnostic Accuracy of Cervicovaginal Cytology in the Detection of Squamous Epithelial Lesions of the Uterine Cervix; Cytologic/Histologic Correlation of 481 Cases","authors":"S. Jin, Sang Mo Park, Mee Sun Kim, Y. Jeen, Dong Won Kim, Dong Wha Lee","doi":"10.3338/KJC.2008.19.2.111","DOIUrl":"https://doi.org/10.3338/KJC.2008.19.2.111","url":null,"abstract":"Background : Cervicovaginal cytology is a screening test of uterine cervical cancer. The sensitivity of cervicovaginal cytology is less than 50%, but studies of cytologic/histologic correlation are limited. We analyzed the diagnostic accuracy of cervicovaginal cytology in the detection of the squamous epithelial lesions of the uterine cervix and investigate the cause of diagnostic discordance. Materials and Methods : We collected a total of 481 sets of cervicovaginal cytology and biopsies over 5 years. The cytologic diagnoses were categorized based on The Bethesda System and the histologic diagnoses were classified as negative, flat condyloma, cervical intraepithelial neoplasia (CIN) I, CIN II, CIN III, or squamous cell carcinoma. Cytohistologic discrepancies were reviewed. Results: The concordance rate between the cytological and the histological diagnosis was 79.0%. The sensitivity and specificity of cervicovaginal cytology were 80.6% and 92.6%, respectively. Its positive predictive value and negative predictive value were 93.7% and 77.7%, respectively. The false negative rate was 19.4%. Among 54 false negative cytology cases, they were confirmed by histology as 50 flat condylomas, 2 CIN I, 1 CIN III, and 1 squamous cell carcinoma. The causes of false negative cytology were sampling errors in 75.6% and interpretation errors in 24.4%. The false positive rate was 7.4%. Among 15 false positive cytology cases, they were confirmed by histology as 12 atypical squamous cells of undetermined significance (ASCUS) and 3 low grade squamous intraepithelial lesions (LSIL). The cause of error was interpretation error in all cases. The overall diagnostic accuracy of cervicovaginal cytology was 85.7%. Conclusions : Cervicovaginal cytology shows high overall diagnostic accuracy and is a useful primary screen of uterine cervical cancer.","PeriodicalId":261069,"journal":{"name":"The Korean Journal of Cytopathology","volume":"46 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2008-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115085279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Detecting Malignant Urothelial Cells by Morphometric Analysis of ThinPrep(R) Liquid-based Urine Cytology Specimens. 用ThinPrep(R)液基尿液细胞学标本的形态计量学分析检测恶性尿路上皮细胞。

The Korean Journal of Cytopathology Pub Date : 2008-09-01 DOI: 10.3338/KJC.2008.19.2.136

B. Shin, Youngsuk Lee, Hoiseon Jeong, S. H. Lee, Hyunchul Kim, A. Kim, I. Kim, H. Kim

{"title":"Detecting Malignant Urothelial Cells by Morphometric Analysis of ThinPrep(R) Liquid-based Urine Cytology Specimens.","authors":"B. Shin, Youngsuk Lee, Hoiseon Jeong, S. H. Lee, Hyunchul Kim, A. Kim, I. Kim, H. Kim","doi":"10.3338/KJC.2008.19.2.136","DOIUrl":"https://doi.org/10.3338/KJC.2008.19.2.136","url":null,"abstract":"Urothelial carcinoma accounts for 90% of all the cases of bladder cancer. Although many cases can be easily managed by local excision, urothelial carcinoma rather frequently recurs, tends to progress to muscle invasion, and requires regular follow-ups. Urine cytology is a main approach for the follow-up of bladder tumors. It is noninvasive, but it has low sensitivity of around 50% with using the conventional cytospin preparation. Liquid-based cytology (LBC) has been developed as a replacement for the conventional technique. We compared the cytomorphometric parameters of and cytospin preparation urine cytology to see whether there are definite differences between the two methods and which technique allows malignant cells to be more effectively discriminated from benign cells. The nuclear-to-cytoplasmic ratio value, as measured by digital image analysis, was efficient for differentiating malignant and benign urothelial cells, and this was irrespective of the preparation method and the tumor grade. Neither the nor the conventional preparation cytology was definitely superior for distinguishing malignant cells from benign cells by cytomorphometric analysis of the adequately preserved cells. However, the preparation showed significant advantages when considering the better preservation and cellularity with a clear background.","PeriodicalId":261069,"journal":{"name":"The Korean Journal of Cytopathology","volume":"29 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2008-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122634834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Cytologic Findings of Cerebrospinal Fluid 脑脊液的细胞学检查

The Korean Journal of Cytopathology Pub Date : 2008-09-01 DOI: 10.3338/KJC.2008.19.2.86

S. Jin

引用次数: 0

Quality Control Program and Its Results of Korean Society for Cytopathologists 韩国细胞病理学家协会的质量控制程序及其结果

The Korean Journal of Cytopathology Pub Date : 2008-09-01 DOI: 10.3338/KJC.2008.19.2.65

Hyekyung Lee, Sung Nam Kim, S. Khang, C. Kang, H. Yoon

{"title":"Quality Control Program and Its Results of Korean Society for Cytopathologists","authors":"Hyekyung Lee, Sung Nam Kim, S. Khang, C. Kang, H. Yoon","doi":"10.3338/KJC.2008.19.2.65","DOIUrl":"https://doi.org/10.3338/KJC.2008.19.2.65","url":null,"abstract":"In Korea, the quality control(QC) program forcytopathology was introduced in 1995. The program consists of a checklist for the cytolopathology departments, analysis data on all the participating institutions' QC data, including the annual data on cytologic examinations, the distribution of the gynecological cytologic diagnoses, as based on The Bethesda System 2001, and the data on cytologic-histolgical correlation of the gynecological field, and an evaluation for diagnostic accuracy. The diagnostic accuracy program has been performed 3 times per year with using gynecological, body fluid and fine needle aspiration cytologic slides. We report here on the institutional QC data and the evaluation for diagnostic accuracy since 2004, and also on the new strategy for quality control and assurance in the cytologic field. The diagnostic accuracy results of both the participating institutions and the QC committee were as follows; Category 0 and A: about 94%, Category B: 4-5%, Category C: less than 2%. As a whole, the cytologic daignostic accuracy is relatively satisfactory. In 2008, on site evaluation for pathology and cytology laboratories, as based on the \"Quality Assurance Program for Pathology Services\" is now going on, and a new method using virtual slides or image files for determining the diagnostic accuracy will be performed in November 2008.","PeriodicalId":261069,"journal":{"name":"The Korean Journal of Cytopathology","volume":"47 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2008-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115704160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 10

Cytologic Features of Ascitic Fluid Complicated by Small Cell Variant T-cell Prolymphocytic Leukemia: A Case Report. 腹水并发小细胞变异型t细胞前淋巴细胞白血病1例

The Korean Journal of Cytopathology Pub Date : 2008-09-01 DOI: 10.3338/KJC.2008.19.2.168

J. Han, Jin-Soo Kim, Dong-Hoon Kim, L. Kim, In-Suh Park, Joon-Mee Kim, Y. Chu, Suk‐Jin Choi

{"title":"Cytologic Features of Ascitic Fluid Complicated by Small Cell Variant T-cell Prolymphocytic Leukemia: A Case Report.","authors":"J. Han, Jin-Soo Kim, Dong-Hoon Kim, L. Kim, In-Suh Park, Joon-Mee Kim, Y. Chu, Suk‐Jin Choi","doi":"10.3338/KJC.2008.19.2.168","DOIUrl":"https://doi.org/10.3338/KJC.2008.19.2.168","url":null,"abstract":"T-cell prolymphocytic leukemia (T-PLL) is a rare, mature T-cell lymphoproliferative disorder with a post-thymic mature T-cell phenotype. The disease is characterized by rapidly rising lymphocytosis, lym-phadenopathy, and splenomegaly. The clinical course is usually aggressive and progresses with frequent skin lesions and serous effusions. In 25% of cases, leukemic cells are small and tumor cells may not have a discrete nucleolus under light microscopy. Although the presence of characteristic cytoplasmic protrusions or blebs in tumor cells is a common morphologic finding in the peripheral blood film irrespective of the nuclear features, small cell variants lacking the typical nuclear features can cause diagnostic problems in clinical cytology. Furthermore, the small leukemic cells can share some cytologic findings with lymphocyte-rich serous effusions caused by non-neoplastic reactive lymphocytosis as well as other small lymphocytic lymphoproliferative disorders. Here, we describe the cytological findings of ascitic fluid complicated by small cell variant T-PLL in a 54-year-old man, the cytology of which was initially interpreted as small lymphocytic malignancy such as small lymphocytic lymphoma/chronic lymphocytic leukemia.","PeriodicalId":261069,"journal":{"name":"The Korean Journal of Cytopathology","volume":"4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2008-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127902696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0