American Chinese Journal of Medicine and Science最新文献_第2页

Prevalence and Socioeconomic Status Correlation of Depressive Symptoms among Children Living in Urban Beijing 北京城区儿童抑郁症状患病率及社会经济地位相关性研究

American Chinese Journal of Medicine and Science Pub Date : 1900-01-01 DOI: 10.7156/V3I3P153

Xianwen Shang, Dong Wang, Jianping Wang, Xiaoqi Hu, S. Du, Yanping Li

引用次数: 6

Environmental Epidemiology of Sporadic Parkinsons Disease 散发性帕金森病的环境流行病学

American Chinese Journal of Medicine and Science Pub Date : 1900-01-01 DOI: 10.7156/V3I1P073

Honglei Chen, Xuemei Huang

{"title":"Environmental Epidemiology of Sporadic Parkinsons Disease","authors":"Honglei Chen, Xuemei Huang","doi":"10.7156/V3I1P073","DOIUrl":"https://doi.org/10.7156/V3I1P073","url":null,"abstract":"Parkinson’s disease (PD) is the second most prevalent neurodegenerative disease of the elderly. The causes of PD are largely unknown, but probably involve both genetic and environmental factors. Breakthroughs have been made in the past decade to identify genes that are responsible for early-onset familial PD, yet the role of genes in sporadic PD needs to be defined. Twin studies suggest that environmental factors may be crucial in determining the risk of late-onset sporadic PD. To date, strong epidemiological evidence links environmental factors like cigarette smoking and coffee drinking to a lower PD risk, and to a lesser extent, pesticide exposures to a higher PD risk. Several novel findings have emerged from recent prospective studies on PD, such as a positive association with consumption of dairy products, and an inverse relationship with plasma urate concentration. Although gene-environment interactions are thought to be important in PD etiology, they rarely have been investigated. In the search of environmental PD risk factors, future multidisciplinary research is needed that includes input from both genetics and experimental biology. Interaction analysis requires information on both environmental and genetic factors from a large population, and such future studies will benefit from collaborative pooled analysis. [N A J Med Sci. 2010;3(2):73-78.]","PeriodicalId":260439,"journal":{"name":"American Chinese Journal of Medicine and Science","volume":"50 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123076621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Elastotic Changes in the GastrointestinalTract: A Review of Literature 胃肠道弹性变化:文献综述

American Chinese Journal of Medicine and Science Pub Date : 1900-01-01 DOI: 10.7156/V5I2P078

I. Krammer, Hallie Kretsinger, Bruno Mrkl

引用次数: 1

The Epithelioid Variant of Angiomyolipoma in Kidney Expresses a Higher Level of Epidermal Growth Factor Receptor Than Its Conventional Type 肾血管平滑肌脂肪瘤上皮样变体表达比常规型更高水平的表皮生长因子受体

American Chinese Journal of Medicine and Science Pub Date : 1900-01-01 DOI: 10.7156/V3I3P117

Frank Chen, D. Hicks, C. D’Angelis, Haiying Chen, S. Sait, Shaozeng Zhang

{"title":"The Epithelioid Variant of Angiomyolipoma in Kidney Expresses a Higher Level of Epidermal Growth Factor Receptor Than Its Conventional Type","authors":"Frank Chen, D. Hicks, C. D’Angelis, Haiying Chen, S. Sait, Shaozeng Zhang","doi":"10.7156/V3I3P117","DOIUrl":"https://doi.org/10.7156/V3I3P117","url":null,"abstract":"The epidermal growth factor receptor (EGFR) is a transmembrane tyrosine kinase that plays an important role in tumor growth, invasion and metastasis. EGFR Positive immunoreactivity ranged from focal to diffuse in overexpression has been shown in many different tumors and multiple EGFR-targeted therapies are currently being investigated. Renal epithelioid angiomyolipoma (epiAML) is an aggressive and potentially malignant variant of conventional angiomyolipoma (cAML). Currently, the status of EGFR expression in epiAML is unknown. We compared EGFR protein expression, as well as expression levels of several other tumor regulatory proteins including c-Kit, p53, alpha-catenin, beta-catenin and osteopontin in 6 cases of cAML and 10 cases of epiAML by semiquantitative immunohistochemistry (IHC). EGFR gene amplification was analyzed by fluorescent in situ hybridization (FISH). Within epiAML, EGFR immunostaining was significantly higher when compared to cAML (90% vs. 16.7%, p<0.01). epiAML, whereas no diffuse reactivity was found in cAML. EGFR gene amplification was not identified in either cAML or epiAML as illustrated by FISH. Expression levels of c-Kit, osteopontin, p53, alpha-catenin","PeriodicalId":260439,"journal":{"name":"American Chinese Journal of Medicine and Science","volume":"34 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126962228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

A Review of Angiomyolipoma and Its Morphological Variants 血管平滑肌脂肪瘤及其形态变异研究进展

American Chinese Journal of Medicine and Science Pub Date : 1900-01-01 DOI: 10.7156/V4I1P084

Simpal Gill, E. Weber-Shrikant, Frank Chen

引用次数: 4

Rationale for the Use of Natural Anti-Inflammatory Agents in Cancer Chemotherapy 在癌症化疗中使用天然抗炎剂的理由

American Chinese Journal of Medicine and Science Pub Date : 1900-01-01 DOI: 10.7156/V3I3P160

Jing Liu, J. Wan, Chengwei He

引用次数: 9

Water-Clear Cell Adenoma of Parathyroid Gland: A Case Report and Literature Review 甲状旁腺水透明细胞腺瘤1例报告并文献复习

American Chinese Journal of Medicine and Science Pub Date : 1900-01-01 DOI: 10.7156/V3I4P194

Yu Liang, W. Mojica, Frank Chen

{"title":"Water-Clear Cell Adenoma of Parathyroid Gland: A Case Report and Literature Review","authors":"Yu Liang, W. Mojica, Frank Chen","doi":"10.7156/V3I4P194","DOIUrl":"https://doi.org/10.7156/V3I4P194","url":null,"abstract":"Parathyroid adenoma of water-clear cell type is an extremely rare neoplasm, and only very few cases have been reported to date. Here we report a case of waterclear cell adenoma of the parathyroid in a 59-year old female patient who presented with hypercalcemia and high parathyroid hormone (PTH) level. Sestamibi scan showed a possible parathyroid adenoma involving the right superior parathyroid gland. The surgically excised specimen weighed 13.3 grams and contained a cystic hemorrhagic mass measuring 1 x 1 x 0.8 cm. Histologically, the tumor mass was surrounded by a thin fibrous capsule with a compressed thin rim of normal parathyroid tissue. High power examination revealed the tumor to be composed of cells with vacuolated cytoplasm, and with minimal nuclear pleomorphism. Immunohistochemical analysis demonstrated positive staining for PTH and chromogranin. Histological examination of the right inferior parathyroid gland showed unremarkable parathyroid tissue. Postoperatively, the patient’s serum calcium level returned to normal. These findings support the diagnosis of waterclear cell adenoma of the parathyroid gland. In this report, we also reviewed related literature and compared our case with similar cases reported before.","PeriodicalId":260439,"journal":{"name":"American Chinese Journal of Medicine and Science","volume":"108 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124150903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 11

Expression of CD38, but not ZAP-70, is Associated with Diffuse Infiltration Pattern and Extent of Bone Marrow Infiltration in Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CLL/SLL) CD38的表达与慢性淋巴细胞白血病/小淋巴细胞淋巴瘤(CLL/SLL)弥漫性浸润模式和骨髓浸润程度相关，而非ZAP-70的表达

American Chinese Journal of Medicine and Science Pub Date : 1900-01-01 DOI: 10.7156/V4I1P057

W. Cui, J. Woodroof, M. Zucker, Lisa Menninger, J. Rachel, S. Mathur

{"title":"Expression of CD38, but not ZAP-70, is Associated with Diffuse Infiltration Pattern and Extent of Bone Marrow Infiltration in Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CLL/SLL)","authors":"W. Cui, J. Woodroof, M. Zucker, Lisa Menninger, J. Rachel, S. Mathur","doi":"10.7156/V4I1P057","DOIUrl":"https://doi.org/10.7156/V4I1P057","url":null,"abstract":"Background: The prognostic significance of the extent and pattern of bone marrow infiltration by Chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) has been supplanted by newer biologic prognostic markers such as immunoglobulin heavy chain variable region (IgVH) mutation status, CD38 and ZAP70 expression, fluorescence in situ hybridization (FISH) cytogenetics, and serum markers. Expression of CD38 and ZAP-70 correlates with IgVH mutation status, and also provides prognostic value as independent markers. Materials and Methods: Seventy-four cases of CLL/SLL were reviewed and the relationship between expression of CD38, ZAP-70, and bone marrow infiltration was examined. CD38 and ZAP-70 were analyzed by a single laboratory using standardized multiparametric flow cytometry with a threshold of 20% and 30% positive cells for each. Hematoxylin and eosin stained bone marrow biopsy and aspirate clot sections were classified as showing diffuse or non-diffuse (nodular/interstitial) pattern of infiltration; the extent of infiltration was assessed by the proportion of lymphocytes on histologic sections and aspirate smears.","PeriodicalId":260439,"journal":{"name":"American Chinese Journal of Medicine and Science","volume":"24 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117295475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Human Papillomavirus Vaccine Where are We Now 人类乳头瘤病毒疫苗进展如何

American Chinese Journal of Medicine and Science Pub Date : 1900-01-01 DOI: 10.7156/V3I4P201

Tamera A. Paczosl, Weiguo Liu, Frank Chen

引用次数: 3

Extranodal Rosai-Dorfman Disease Involving Colon A Case Report with Review of the Literature 结外Rosai-Dorfman病累及结肠1例并文献复习

American Chinese Journal of Medicine and Science Pub Date : 1900-01-01 DOI: 10.7156/V3I3P128

Haiying Chen, Jianlan Sun, L. Aftab, A. Sands

{"title":"Extranodal Rosai-Dorfman Disease Involving Colon A Case Report with Review of the Literature","authors":"Haiying Chen, Jianlan Sun, L. Aftab, A. Sands","doi":"10.7156/V3I3P128","DOIUrl":"https://doi.org/10.7156/V3I3P128","url":null,"abstract":"Rosai-Dorfman disease (RDD), also known as sinus histiocytosis with massive lymphadenopathy, is a rare, idiopathic and non-neoplastic histiocytic disorder. The most common presentation of RDD is painless cervical lymphadenopathy in a young patient. However, in about 25% of cases there is no lymph node involvement, and the disease presents as a mass in skin, soft tissue, nasal cavity, eye, bone, or other extranodal sites (extranodal type). This can pose a diagnostic challenge if RDD is not considered in differential diagnoses. Gastrointestinal (GI) involvement of RDD is extremely rare; only 15 cases had been reported. We report a case of extra-nodal RDD involving the GI tract of a 24-year-old African-American woman who presented with chronic lower abdominal pain, constipation and an 8 cm mass involving her colonic wall. Microscopically, the mass was well demarcated, partially covered with serosa and extended into the muscularis propria and submucosa of the colon. The lesional cells consisted of spindle-shaped and epithelioid histiocytes intermixed with plasma cells and lymphocytes. Rare histiocytes showed emperipolesis. The histiocytes were positive for S100 (strong) and CD68, and negative for ckit and CD1a. The above morphological and immunohistochemical features are diagnostic for RDD, extra-nodal type. The related literature was reviewed and compared with this case.","PeriodicalId":260439,"journal":{"name":"American Chinese Journal of Medicine and Science","volume":"19 11","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"120877566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3