Advanced Chemicobiology Research最新文献_第2页

A Novel, Simple Method for Detection of Caffeine in Urine as a Predictive Marker for Liver Diseases 一种新的、简单的检测尿液中咖啡因作为肝脏疾病预测标志物的方法

Advanced Chemicobiology Research Pub Date : 2022-09-13 DOI: 10.37256/acbr.2120231639

Sarah Ali Qutb, Mariam Ahmed Moustafa, Mirna Fawzy Nazmi, Ahmed Hany Abed Mahmoud, George Safwat Mounir Abdel Masih, Safa Gamal Abdel Fattah Suleiman, Maryellen Amen, Mohamed Omar Ewis Khamis, A. Mohamed

引用次数: 0

A Versatile Bio-packing Based on Natural Extract from Calotropis procera a Sustainable Alternative for Agriculture and Biofouling Applications 一种多功能生物填料，基于牛角豆天然提取物-农业和生物污染应用的可持续替代品

Advanced Chemicobiology Research Pub Date : 2022-09-01 DOI: 10.37256/acbr.2120231622

Ana Júlia M. Souza, Cristiane T. Lima, M. P. Gonçalves, P. N. D. C. Souza, S. S. Santana, S. Carvalho, Andressa França, Poliane Chagas, A. Paiva, Jonathan Frank Baez Vasquez, M. Morris, F. Borsagli

{"title":"A Versatile Bio-packing Based on Natural Extract from Calotropis procera a Sustainable Alternative for Agriculture and Biofouling Applications","authors":"Ana Júlia M. Souza, Cristiane T. Lima, M. P. Gonçalves, P. N. D. C. Souza, S. S. Santana, S. Carvalho, Andressa França, Poliane Chagas, A. Paiva, Jonathan Frank Baez Vasquez, M. Morris, F. Borsagli","doi":"10.37256/acbr.2120231622","DOIUrl":"https://doi.org/10.37256/acbr.2120231622","url":null,"abstract":"Background and objective: Despite the situation in the north of Minas Gerais being semiarid, this region presents a plant with low water demand, Calotropis procera. This plant has a great potential as an antifungicide supply, although other important characteristics. In this context, this research proposes an extraction of natural material from C. procera to produce a bio-packing for agriculture and anticorrosive applications as a sustainable alternative. This biopacking is eco-friendly, low-cost, widely available, and quickly produced. The antifungicide and anticorrosive activity were evaluated as the control of fruit ripening based on in vivo tests. Materials and methods: This research is based on the production of bio-packing based on natural extracts from C. procera seeds for agricultural and anticorrosive applications. The material was characterized by Fourier transform infrared (FTIR), nuclear magnetic resonance (NMR) and surface contact angle. In addition, in vitro and in vivo biological experiments were performed to analyze the antifungal activity and control of fruit ripening. Moreover, the anticorrosive property was also analysed. Results: The results indicated the presence of proteins in the composition of the product based on natural extract, which may contribute to the antifungal and anticorrosive characteristics. Furthermore, the natural extract demonstrated anticorrosive protection in simulated seawater. The in vivo analysis of bananas showed that the extract concentration of 50 μL mL-1 presented the best results, controlling the fruit ripening and protecting against diseases. Conclusion: Thus, for the first time, these products extracted from C. procera seeds presented a great future for applications as a versatile action for agriculture and anticorrosive applications.","PeriodicalId":256283,"journal":{"name":"Advanced Chemicobiology Research","volume":"50 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127421022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Diversity of Endophytic Mycobiota through Metagenomic Approach and Bioprospecting the Phytoconstituent 基于宏基因组的内生菌群多样性及植物成分的生物勘探

Advanced Chemicobiology Research Pub Date : 2022-07-29 DOI: 10.37256/acbr.2120231614

Myithili Thangavel, Israel Mani, Akash Surendrababu, Mohan Pandi

{"title":"Diversity of Endophytic Mycobiota through Metagenomic Approach and Bioprospecting the Phytoconstituent","authors":"Myithili Thangavel, Israel Mani, Akash Surendrababu, Mohan Pandi","doi":"10.37256/acbr.2120231614","DOIUrl":"https://doi.org/10.37256/acbr.2120231614","url":null,"abstract":"Endophytic fungi are important organisms that live and thrive in the intercellular or intracellular regions of host tissues of plants without causing immediate or adverse effects on the host plant. Endophytes constitute a large diversity of microbial adaptations that have been developed to survive adverse environments. Plant endophytic fungi play an important role to enhance the uptake and transfer of nutrients from the soil to plants simultaneously influencing the physical and chemical properties of soil. The discovery of fungal endophytes in their natural habitat is quite difficult due to few of its non-sporulating and non-culture-dependent endophytes by the traditional methods. The molecular characterization of isolated fungal endophytes can be carried out by isolation of genomic deoxyribonucleic acid (DNA), polymerase chain reaction (PCR) amplification of internal transcribed spacer (ITS) regions, DNA sequencing and analysis. One of the culture-independent approaches known as ‟metagenomics” is capable of reading the variety of ambient microbes that do not include cultivation from the environmental sample. Several researches on fungal endophytes in plants are in progress and have been under exploitation. Several secondary metabolites with diverse biological activities have been discovered in these fungi, suggesting that they have the ability to create a vast selection of secondary metabolites. In the hunt for new medications such as bioactive properties or innovative drug-like compounds, their variety and specialized habituation make them an attractive subject of research. The review highlights the biology of fungal endophytes, their discovery, isolation and identification by molecular methods.","PeriodicalId":256283,"journal":{"name":"Advanced Chemicobiology Research","volume":"10 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129041771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Physiological Roles, not Structure will Categorize Placement of Molecules in Humours (Akhlat) in Unani Medicine: The Case of Human Haemoglobin 生理作用，而不是结构将在Unani医学中对分子在体液(Akhlat)中的位置进行分类:以人类血红蛋白为例

Advanced Chemicobiology Research Pub Date : 2022-06-22 DOI: 10.37256/acbr.1220221465

A. Rizvi, F. Sherani

引用次数: 1

Nickel Toxicity with Reference to Female Reproductive Physiology, Pregnancy and Teratogenesis: A Brief Review 镍毒性与女性生殖生理、妊娠和致畸的关系综述

Advanced Chemicobiology Research Pub Date : 2022-06-09 DOI: 10.37256/acbr.1220221464

Saima Parveen, Asim Rizvi, Imrana Naseem

引用次数: 1

The Informative Nature of the Disappeared SARS-CoV-2 Genomic Sequences: A Mini-review with Perspectives 消失的SARS-CoV-2基因组序列的信息性:一个带有观点的迷你回顾

Advanced Chemicobiology Research Pub Date : 2022-05-09 DOI: 10.37256/acbr.1220221403

A. Rabie

{"title":"The Informative Nature of the Disappeared SARS-CoV-2 Genomic Sequences: A Mini-review with Perspectives","authors":"A. Rabie","doi":"10.37256/acbr.1220221403","DOIUrl":"https://doi.org/10.37256/acbr.1220221403","url":null,"abstract":"The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and its mortal coronavirus disease 2019 (COVID-19) are still mysterious in nature. The emergence of the more virulent newer SARS-CoV-2 variants, e.g., Delta and Omicron variants, made the matters worse. CoViTris2020 compound can be considered the most potent investigational anti-COVID-19 agent among others to date. Meanwhile, all countries took very serious steps in vaccination and have started to vaccinate their citizens beginning with the elders. The current data refer that, in the near future, the available vaccines may gradually lose their effectiveness against the newer SARS-CoV-2 strains which have increased transmissibility and infectivity due to the enhanced human angiotensin-converting enzyme 2 (hACE2) affinities and antibodies resistances, respectively. All the problems facing the continuous and successful use of the current vaccines, antiviral agents, and convalescent plasma in their missions against the COVID-19 infection force us to deeply investigate all the updated available data about all the components of the pandemic in a comprehensive way hour by hour to reveal all the secrets and clues behind the SARS-CoV-2. Herein, a brief article about the up-to-date clues, hypotheses, facts, unsolved issues, and informative genetic data of SARS-CoV-2/COVID-19 is introduced.","PeriodicalId":256283,"journal":{"name":"Advanced Chemicobiology Research","volume":"270 ","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"113981930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

A Systematic Biomedical Perspective on COVID-19 Pandemic: From Detection to Vaccination COVID-19大流行的系统生物医学视角:从检测到疫苗接种

Advanced Chemicobiology Research Pub Date : 2021-12-30 DOI: 10.37256/acbr.1120211146

J. Mir, R. Wani, Hyqa John, Ejaz Ahmad Kambay, B. A. Malik, S. A. Majid, A. H. Shalla

{"title":"A Systematic Biomedical Perspective on COVID-19 Pandemic: From Detection to Vaccination","authors":"J. Mir, R. Wani, Hyqa John, Ejaz Ahmad Kambay, B. A. Malik, S. A. Majid, A. H. Shalla","doi":"10.37256/acbr.1120211146","DOIUrl":"https://doi.org/10.37256/acbr.1120211146","url":null,"abstract":"The year 2020 witnessed a challenging period for worldwide scientists to find a suitable treatment for the deadly novel coronavirus infectious disease-2019 (nCOVID or COVID-19). The entire scientific community has been eager to develop effective vaccines and medicine against COVID-19. Despite the fact of administration of vaccination in several countries across the globe, the drug repurposing of several antiviral compounds yielded satisfactory results in recovering the affected people. As it is a known fact that vaccination alone is not the end of this pandemic, but the final treatment in terms of drugs/medicines specific to this disease is yet underway. It looks worthy to present a literature survey based on the collective information related to the drug candidates that have been repurposed, the respective theoretical evaluation, and some of the effective therapies usable in treating COVID-19. This review also describes diagnosis and vaccination availed so far. Therefore, a sequential literature extract is hereby presented starting from the detection, going through virulence, drug repositioning, virtual screening, and the final destination in the form of vaccine development. A few commercially available vaccines have also been introduced. Based on the survey, it is clear that the entire world must remain alert for any future pandemic keeping in view the successful and unsuccessful efforts practiced in the COVID-19 pandemic.","PeriodicalId":256283,"journal":{"name":"Advanced Chemicobiology Research","volume":"4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134281544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Utility of Sulfonylhydrazines in the Study and Potential Treatment of African Sleeping Sickness 磺胺酰肼在非洲昏睡病研究和潜在治疗中的应用

Advanced Chemicobiology Research Pub Date : 2021-12-06 DOI: 10.37256/acbr.1120211217

P. Penketh, K. Shyam, R. Baumann, C. Patton

{"title":"The Utility of Sulfonylhydrazines in the Study and Potential Treatment of African Sleeping Sickness","authors":"P. Penketh, K. Shyam, R. Baumann, C. Patton","doi":"10.37256/acbr.1120211217","DOIUrl":"https://doi.org/10.37256/acbr.1120211217","url":null,"abstract":"African sleeping sickness is an invariably fatal disease caused by Trypanosoma brucei group trypanosomes and transmitted by the bite of a Tsetse fly. In the human bloodstream, there are two main forms: long slender rapidly proliferating forms and biochemically distinct, non-proliferating short stumpy forms. These short stumpy forms are preadapted for life in the Tsetse fly gut and cannot sustain or initiate infection in the mammalian host. It was observed that exposure of long slender bloodstream trypomastigotes to a wide range of methylating agents could induce the entire population to differentiate into short stumpy forms. The methylators varied in their nucleophile preference from hard oxygen targets to soft thiol targets. Despite this wide variability, the methylators were all almost equivalently active. It was therefore assumed that the salient target was likely nitrogen of intermediate hardness/softness which would be equivalently targeted by both groups of methylators. A number of sulfonylhydrazine methylators including prodrug forms, with improved biological distribution in animals, were synthesized. In addition, some amidine moiety containing methylators were also synthesized to exploit the propensity of long slender trypanomastigotes to accumulate agents containing this chemical group, in an attempt to enhance their efficacy. These agents may be of utility in the study of differentiation in T. brucei group trypanosomes, and the production of large quantities of short stumpy forms for biochemical studies. Additionally, they could have therapeutic potential in the treatment of late-stage African sleeping sickness.","PeriodicalId":256283,"journal":{"name":"Advanced Chemicobiology Research","volume":"100 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133196154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

A Mononuclear Nickel(II) Complex: Synthesis, X-ray Structure, Spectroscopic Characterization and Anti-tumor Activity 单核镍(II)配合物:合成、x射线结构、光谱表征和抗肿瘤活性

Advanced Chemicobiology Research Pub Date : 2021-02-23 DOI: 10.37256/acbr.112021752

S. Diyali, A. K. Mohanty, S. Sarkar, Md. Firoj Hossain, Biplab Bhowmik, Bhaskar Biswas

引用次数: 0

Common Cellular Events Implicated in the Regulation of Cold Stress Tolerance and Soft Rot Resistance Induced by Metabolites of Pseudomonas Aeruginosa in Phalaenopsis Orchids 铜绿假单胞菌代谢物诱导蝴蝶兰耐冷胁迫和抗软腐病的共同细胞事件

Advanced Chemicobiology Research Pub Date : 2021-01-21 DOI: 10.37256/acbr.112021725

Huey-Wen Chuang, T. Tseng, Hsin-Yi Hsieh, T. Kao, Guanjun Chen

{"title":"Common Cellular Events Implicated in the Regulation of Cold Stress Tolerance and Soft Rot Resistance Induced by Metabolites of Pseudomonas Aeruginosa in Phalaenopsis Orchids","authors":"Huey-Wen Chuang, T. Tseng, Hsin-Yi Hsieh, T. Kao, Guanjun Chen","doi":"10.37256/acbr.112021725","DOIUrl":"https://doi.org/10.37256/acbr.112021725","url":null,"abstract":"Microbial metabolites induce diverse plant physiological responses. In this study, Pseudomonas aeruginosa strain Y1 was shown to produce metabolites exhibiting a high capacity for metal chelation and moderate reducing power activity. In Phalaenopsis orchids, treatments with Y1 metabolites (Y1M) increased the contents of carbohydrates and lignin and the activity of antioxidant enzymes and phenylalanine ammonia lyase (PAL). Y1M treatments increased the tolerance to cold stress (10°C) by reducing malondialdehyde (MDA) accumulation and electrolyte leakage in a 10°C growth environment and enhanced disease resistance against bacterial soft rot caused by Erwinia chrysanthemi. Protein analyses indicated that, in response to Y1M treatment, the protein levels of antioxidant enzymes, such as catalase (CAT) and ascorbate peroxidase (APX); pathogenesis-related (PR) proteins, such as PR-2 and PR-3; and lipoxygenase 1 (LOX1) were increased in Phalaenopsis orchids. Transcriptome analyses indicated that Y1M increased transcription associated with the iron-deficient response mediated by miRNA, the regulation of reactive oxygen species (ROS) homeostasis, and Jasmonic acid (JA) biosynthesis/perception. Gene groups associated with the induced defense response, including cellular events of pattern-triggered immunity (PTI), hypersensitive response (HR), synthesis of the PR protein, and callose formation, were also increased by the Y1M treatments. Transcription factors involved in regulating the cold stress response, such as C-repeat binding factor 1 (CBF1), and cell strengthening, such as MYB26, also had increased expression. In summary, Y1M can activate cellular pathways implicated in regulating stress tolerance shared by cold stress and bacterial invasion.","PeriodicalId":256283,"journal":{"name":"Advanced Chemicobiology Research","volume":"279 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"113989696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1