Sriwijaya Journal of Medicine最新文献_第2页

Potential of Anti-Secretory and Cytoprotective Effect from Azadiradione as GERD Prevention 阿扎地拉二酮作为预防胃食管反流病的抗分泌和细胞保护作用的潜力

Sriwijaya Journal of Medicine Pub Date : 2024-02-15 DOI: 10.32539/sjm.v5i2.144

Corinna Faustina, Villicia Angellika, Alya Rahmadani, Rosalie Dorothea, Ricky Fajar Adiputra, Z. Maritska

引用次数: 0

Potential of Anti-Secretory and Cytoprotective Effect from Azadiradione as GERD Prevention 阿扎地拉二酮作为预防胃食管反流病的抗分泌和细胞保护作用的潜力

Sriwijaya Journal of Medicine Pub Date : 2024-02-15 DOI: 10.32539/sjm.v5i2.144

Corinna Faustina, Villicia Angellika, Alya Rahmadani, Rosalie Dorothea, Ricky Fajar Adiputra, Z. Maritska

引用次数: 0

Correlation Between Neutrophil to Lymphocyte Ratio (NLR) and Patient with Heart Failure: Haematology Variables in Patient with Heart Failure 中性粒细胞与淋巴细胞比值(NLR)与心力衰竭患者的相关性:心力衰竭患者的血液学变量

Sriwijaya Journal of Medicine Pub Date : 2022-01-24 DOI: 10.32539/sjm.v5i1.124

Fransiskus Xaverius Rinaldi, Stefanus Lembar, D. Ridjab, Leonardo Leonardo, Jessica Lauryn, E. Erlina, Gregiorio Gavriel Singgih

{"title":"Correlation Between Neutrophil to Lymphocyte Ratio (NLR) and Patient with Heart Failure: Haematology Variables in Patient with Heart Failure","authors":"Fransiskus Xaverius Rinaldi, Stefanus Lembar, D. Ridjab, Leonardo Leonardo, Jessica Lauryn, E. Erlina, Gregiorio Gavriel Singgih","doi":"10.32539/sjm.v5i1.124","DOIUrl":"https://doi.org/10.32539/sjm.v5i1.124","url":null,"abstract":"Heart failure is a condition of the heart that cannot pump blood adequately resulting in systemic tissue hypoperfusion. This situation will cause systemic inflammatory reactions. Neutrophil to Lymphocyte Ratio (NLR) is an inexpensive and easy parameter that can see inflammatory reactions. This research uses descriptive and analytical studies with cross-sectional studies. The number of samples was 67 heart failure patients who were treated at Atma Jaya Hospital. The statistical test used is unpaired T-test to see if there was a correlation between the NLR value in heart failure, after that NLR cut-off point will be analyzed using a receiver operating curve (ROC). Pearson correlation test was conducted to see the correlation of NLR with laboratory results, including haemoglobin, hematocrit, leukocytes, and platelet. The results showed a significant difference of NLR between controls and heart failure patients (p = 1.0402-10). The cut-off point is 2.16 with an area under the curve of 86.4%, sensitivity 79.1%, and specificity 91%. Analysis of NLR data on heart failure with hemoglobin (p = 0.108), hematocrit (p = 0.091), and platelets (p = 0.832) showed no significant correlation, whereas showed a significant correlation with leukocytes (p = 0.017). This study shows a significant difference of NLR between control and heart failure therefore it can be used to predict the prognosis for heart failure. This study also found no significant correlation between NLR with the amount of haemoglobin, hematocrit, and platelets, while there was a correlation with leukocytes.","PeriodicalId":252478,"journal":{"name":"Sriwijaya Journal of Medicine","volume":"129 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129461290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

The Relationship between Area of Necrosis with Degree of Lymphocytes Infiltration in Breast Rattus norvegicus Induced by DMBA DMBA诱导褐家鼠乳腺坏死面积与淋巴细胞浸润程度的关系

Sriwijaya Journal of Medicine Pub Date : 2022-01-24 DOI: 10.32539/sjm.v5i1.126

Ainiyah Fairus, Aufar Zimamuz Zaman Al Hajiri, Hidayatul Ulya, Syihabuddin Farid, Lysa Veterini, M. Nasir

{"title":"The Relationship between Area of Necrosis with Degree of Lymphocytes Infiltration in Breast Rattus norvegicus Induced by DMBA","authors":"Ainiyah Fairus, Aufar Zimamuz Zaman Al Hajiri, Hidayatul Ulya, Syihabuddin Farid, Lysa Veterini, M. Nasir","doi":"10.32539/sjm.v5i1.126","DOIUrl":"https://doi.org/10.32539/sjm.v5i1.126","url":null,"abstract":"Breast cancer is one of the leading causes of death in women in the world. According to WHO, the incidence of breast cancer is about 2.1 million. The high mortality rate is often influenced by various reasons, one of which is the prognosis in patients. The level of lymphocyte infiltration in tumor cell tissue has been shown to correlate with a better prognosis in patients, while necrotic tissue found in breast cancer often shows worse prognostic value. To determine the relationship between the area of necrosis with the degree of infiltration of lymphocytes in the breast of Rattus norvegicus induced by DMBA. Method: True experimental study with post-test only controlled group design method using 40 Wistar strains of female (Rattus norvegicus) mice 12-13 weeks old. The technique for taking uses simple random sampling. Examining 2 variables, namely the dependent variable area of necrosis and the independent variable degree of lymphocyte infiltration. The treated group is injected with subcutaneous DMBA 10 mg/Kg BW between the two lower nipples during the middle of the fifth week with a three-week interval of administration to reach 14 times the total administration. Cancer tissue is taken in the fifth week. Data are analyzed by the Spearman test. Results: This study shows no relationship (P> 0.05) between the area of necrosis with the degree of lymphocyte infiltration. Conclusions: There is no relationship the area of necrosis with the degree of lymphocytes infiltration in breast Rattus norvegicus Induced by DMBA.","PeriodicalId":252478,"journal":{"name":"Sriwijaya Journal of Medicine","volume":"111 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124257408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lifestyle Alterations During the COVID-19 Pandemic and Its Impact on Obesity amongst Indonesian University Students COVID-19大流行期间生活方式的改变及其对印度尼西亚大学生肥胖的影响

Sriwijaya Journal of Medicine Pub Date : 2022-01-24 DOI: 10.32539/sjm.v5i1.129

Nur Adriana binti Azhar, Z. Zahra, Dina Anandita Irawan, Sofa Rahmannia

{"title":"Lifestyle Alterations During the COVID-19 Pandemic and Its Impact on Obesity amongst Indonesian University Students","authors":"Nur Adriana binti Azhar, Z. Zahra, Dina Anandita Irawan, Sofa Rahmannia","doi":"10.32539/sjm.v5i1.129","DOIUrl":"https://doi.org/10.32539/sjm.v5i1.129","url":null,"abstract":"Covid-19 pandemic caused large-scale mobility restrictions, including for students. This condition might induce lifestyle changes which could impact metabolic conditions. This study aims to (1) investigate lifestyles pre and mid pandemic; (2) investigate the relative differences of the students' BMI early pandemic until recent; (3) estimate the relationship between lifestyle alterations and increased BMI during the pandemic. The research conduct using an online survey of 110 students spread across Indonesia in the first to ninth semesters. Analysis was performed using the Wilcoxon signed-rank test and Spearman's analysis. The results showed that there were lifestyle alterations; namely, 15% of respondents reduced their walking habits, duration, and the number of steps. 9% reduced exercise frequency, with more than 50% of respondents reducing their exercise duration. Nearly 20% increased sedentary frequency. 11% experience stress and take it out on food. As many as 93% of respondents maintain the habit of consuming sweet drinks. Moreover, 66% experienced increased BMI during the pandemic, with almost 30% changing nutritional status from normal to overweight or obese. The median BMI increased by 0.5 kg/m2 with a significant difference (p=0.001). Finally, of all lifestyle alterations during the pandemic, two lifestyles had a significant effect on the increase in BMI, namely changes in the frequency of exercise (p=0.03) and consumption habits of sugary drinks (p=0.05). In conclusion, lifestyle changes in students during the pandemic occurred and impacted the increase in BMI. Priority of intervention should be made in this population to prevent a further increase in obesity in Indonesia.","PeriodicalId":252478,"journal":{"name":"Sriwijaya Journal of Medicine","volume":"52 5","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132870728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

D-dimer and NLR Levels as Potential Biomarkers to Predict Mortality in Patients with Covid-19 d-二聚体和NLR水平作为预测Covid-19患者死亡率的潜在生物标志物

Sriwijaya Journal of Medicine Pub Date : 2022-01-24 DOI: 10.32539/sjm.v5i1.131

Andi Priscillia Al-qodri, Meta Hawika Putri

{"title":"D-dimer and NLR Levels as Potential Biomarkers to Predict Mortality in Patients with Covid-19","authors":"Andi Priscillia Al-qodri, Meta Hawika Putri","doi":"10.32539/sjm.v5i1.131","DOIUrl":"https://doi.org/10.32539/sjm.v5i1.131","url":null,"abstract":"Introduction: Due to the high mortality of the coronavirus disease 2019 (Covid-19) pandemic that continues to strain healthcare systems, early and effective predictors of clinical outcomes are urgently needed to improve management of Covid-19 patients. The aim of this study was to evaluate whether elevated levels of D-dimer and NLR combination could predict mortality in patients with Covid-19. Methods: A total of 60 eligible patients with laboratory confirmed Covid-19 were retrospectively enrolled in Intensive Care Unit of Raden Mattaher Hospital from November 2020 to April 2021. D-dimer value on admission and death events were collected to calculate the optimum cutoff. Results and discussions: The optimum cut off values of D-dimer; NLR to predict in-hospital mortality were ≥2.1 μg/ml; ≥8.09% with both sensitivity 70.4% and specificity 72.7% (P = 0.001). There were 17 patients with D-dimer; NLR value ≥2.1 μg/ml; ≥8.09% on admission, and 15 deaths (88.2%) occurred during hospitalization. Conclusions: D-dimer; NLR values on admission ≥2.1 μg/ml; ≥8.09% could predict in-hospital mortality in patients with Covid-19, which indicated D-dimer and NLR could be an early and helpful markers to improve management of Covid-19 patients.","PeriodicalId":252478,"journal":{"name":"Sriwijaya Journal of Medicine","volume":"61 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121837212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of University Student Eating Pattern Based on “Isi Piringku” [My Plate] Guideline and Their Correlation to Increased Body Weight during Pandemic 基于“我的盘子”指南的大学生饮食模式评价及其与大流行期间体重增加的相关性

Sriwijaya Journal of Medicine Pub Date : 2022-01-24 DOI: 10.32539/sjm.v5i1.132

Dina Anandita Irawan, Z. Zahra, Nur Adriana binti Azhar, Sofa Rahmannia

{"title":"Evaluation of University Student Eating Pattern Based on “Isi Piringku” [My Plate] Guideline and Their Correlation to Increased Body Weight during Pandemic","authors":"Dina Anandita Irawan, Z. Zahra, Nur Adriana binti Azhar, Sofa Rahmannia","doi":"10.32539/sjm.v5i1.132","DOIUrl":"https://doi.org/10.32539/sjm.v5i1.132","url":null,"abstract":"The Ministry of Health has issued dietary guidelines, namely ”Isi Piringku” [My Plate]. However, few studies have evaluated the implementation and its relationship to nutritional status in the university student population, especially during the COVID-19 pandemic. The objectives of this study include (1) evaluating student eating patterns during the pandemic based on the ”Isi Piringku” guidelines; (2) analyze the correlation of diet to changes in body weight during the pandemic. This research was conducted using an online survey of 110 students spread throughout Indonesia in the first to eighth semesters. The analysis was carried out by descriptively comparing the median portion of the type of food to the ”Isi Piringku” recommendations and analyzing the correlation using Spearman's analysis. In 4 types of food (staple food, side dish, vegetables, and fruit), there is a gap between the median proportions eaten by respondents and recommendations including staple foods (29% and 33%), side dish (38% and 17%), vegetables (17% and 33%), and fruit (14% and 17%), respectively. However, staple food intake correlates significantly with weight gain (r=0.24, p=0.012). Conversely, protein intake mainly from vegetable products negatively correlated with weight gain (r=-0.28, p=0.030). In conclusion, there is a large gap in vegetable consumption among Indonesian students. The proportion of staple foods is considered sufficient and needs to be maintained in moderation to avoid the risk of weight gain during the pandemic.","PeriodicalId":252478,"journal":{"name":"Sriwijaya Journal of Medicine","volume":"91 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115573040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Effectiveness of Cinnamon extract (Cinnamomum burmannii) to reducing ureum level in male Rattus norvegicus Unilateral Ureteral Obstruction (UUO) model 肉桂提取物(Cinnamomum burmannii)对雄性褐家鼠单侧输尿管梗阻(UUO)模型降尿水平的影响

Sriwijaya Journal of Medicine Pub Date : 2022-01-24 DOI: 10.32539/sjm.v5i1.112

Evi Lusiana, Theodorus Theodorus, Nita Parisa, F. Fatmawati, M. I. Pratama

引用次数: 0

Molecular Docking Study of Garcinia mangostana (Mangosteen) Compounds as SARS-CoV-2 Potential Inhibitors 山竹果化合物作为SARS-CoV-2潜在抑制剂的分子对接研究

Sriwijaya Journal of Medicine Pub Date : 2022-01-24 DOI: 10.32539/sjm.v5i1.127

P.M. Afladhanti, M.D. Romadhan, H. A. Hamzah, Qherine Bhelqis

{"title":"Molecular Docking Study of Garcinia mangostana (Mangosteen) Compounds as SARS-CoV-2 Potential Inhibitors","authors":"P.M. Afladhanti, M.D. Romadhan, H. A. Hamzah, Qherine Bhelqis","doi":"10.32539/sjm.v5i1.127","DOIUrl":"https://doi.org/10.32539/sjm.v5i1.127","url":null,"abstract":"COVID-19 pandemic poses a challenge for researchers all over the world to find effective drugs. Previous studies had identified the role of Mpro, TMPRSS2, RdRp, and ACE2 which are useful as promising drug targets to inhibit SARS-CoV-2. This study aimed to identify the potential compounds derived from Garcinia mangostana (mangosteen) as potential SARS-CoV-2 inhibitors using a molecular docking study. A total of 6 compounds of mangosteen such as 8-desoxygartanin, α-mangostin, β-mangostin, Ƴ-mangostin, garcinon e, and gartanine were used in this study. N-acetylcysteine (NAC), nafamostat, remdesivir, and lopinavir were also used as comparative drugs. Compounds and comparative drugs were docked on Mpro, TMPRSS2, RdRP, and ACE2 using AutodocTools 1.5.6 and Autodock Vina. The visualization of molecular interactions was carried out by Discovery Studio v16. All compounds met the criteria as drugs based on Lipinski’s solubility test and were safe to use based on toxicity test with admetSAR. Docking results showed that all compounds had an affinity to all receptor targets. 8-Desoxygartanin showed strong molecular interactions compared to the comparative drugs with binding energies of -8.0, -9.6, - 7.8, and -8.6 kcal/mol for Mpro, TMPRSS2, RdRp, and ACE2, respectively. All compounds have the potential to be developed as potential inhibitors through inhibiting Mpro, TMPRSS2, RdRp, and ACE2. Therefore, in vitro and in vivo investigations are needed to bring these compounds to the clinical setting.","PeriodicalId":252478,"journal":{"name":"Sriwijaya Journal of Medicine","volume":"158 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116232770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sinovac Adverse Event Following Immunization (AEFI): Correlation to Gender and History Aefi in Students 学生免疫不良事件与性别及不良史的关系

Sriwijaya Journal of Medicine Pub Date : 2022-01-24 DOI: 10.32539/sjm.v5i1.121

Mellybeth Indriani Louis, Merlionarsy Tammuan, Novita Wiratasia Parimpun, Gisel Pali Pasulu, Indah Puspasari Kiyai Demak

{"title":"Sinovac Adverse Event Following Immunization (AEFI): Correlation to Gender and History Aefi in Students","authors":"Mellybeth Indriani Louis, Merlionarsy Tammuan, Novita Wiratasia Parimpun, Gisel Pali Pasulu, Indah Puspasari Kiyai Demak","doi":"10.32539/sjm.v5i1.121","DOIUrl":"https://doi.org/10.32539/sjm.v5i1.121","url":null,"abstract":"As one of the nations impacted by the COVID-19 pandemic, Indonesia adopting a vaccination policy for its population. After vaccination, there will be a chance to have an AEFI that influenced by gender and the history of AEFI from the previous vaccination. This research designed using a cross-sectional approach. Sample is taken from 365 students of Tadulako University. The questionnaire was developed using information based on Indonesia Ministry of Health and the World Health Organization. All data collected was analyzed using the Contingency Coefficient test. There was a significant relationship between gender and pain (p = 0.004, r = 0.148), redness (p = 0.041, r = 0.107), swelling at the injection site (p = 0.037, r = 0.109), cellulitis (p = 0.037, r = 0.109), and headache (p = 0.006, r = 0.143). There was a significant relationship between history of AEFI and pain (p = 0.000, r = 0.182), redness (p = 0.000, r = 0.274), swelling at the injection site (p = 0.001, r = 0.178), cellulitis (p = 0.000, r = 0.249), fever (p = 0.000, r = 0.382), myalgia (p = 0.000, r = 0.239), arthralgia (p = 0.000, r = 0.268), asthenia (p = 0.000, r = 0.254), and headache (p = 0.000, r = 0.218). More students did not get AEFI than did. AEFI was more common experienced by females and students who had no previous history of AEFI. Most of all AEFI will improve in less than a day.","PeriodicalId":252478,"journal":{"name":"Sriwijaya Journal of Medicine","volume":"54 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126646799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0