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Biochemical criteria for pulmonary surfactant damage in tuberculosis patients with previous work in dusty conditions 肺结核患者肺表面活性物质损伤的生化标准
Ural Medical Journal Pub Date : 2023-06-30 DOI: 10.52420/2071-5943-2023-22-3-46-56
I. M. Pshenichnikova
{"title":"Biochemical criteria for pulmonary surfactant damage in tuberculosis patients with previous work in dusty conditions","authors":"I. M. Pshenichnikova","doi":"10.52420/2071-5943-2023-22-3-46-56","DOIUrl":"https://doi.org/10.52420/2071-5943-2023-22-3-46-56","url":null,"abstract":"Introduction. Among the mechanisms of pathogenesis of tuberculosis is damage to the pulmonary surfactant. In patients with tuberculosis who previously worked in an industrial dusty environment, the pulmonary surfactant system is affected by two damaging factors simultaneously.The aim of the work was to determine the role of biochemical criteria of pulmonary surfactant damage as early molecular markers of the sub-radiological stage of pneumoconiosis in pulmonary tuberculosis patients.Materials and methods. The object of the study was 91 patients with pulmonary tuberculosis, of whom 59 patients had contact with industrial quartz-containing dust in the course of their work (the main group) and 32 patients − with an unburdened professional route (the control group). The content of total protein (TP), total phospholipids (TPL), phospholipid spectrum by thin-layer chromatography as criteria of pulmonary surfactant damage were studied biochemically in bronchoalveolar flushes (BAF).Results. It was found that in bronchoalveolar flushes of patients with tuberculosis of dust-hazardous professions, in group 1, the content of total protein increases, while the level of total phospholipids does not statistically significantly change in comparison with patients with an unburdened professional route. Among the phospholipids of BAF, phosphatidylcholine (PC), phosphatidiylethanolamine (PEA) and cardiolipin (CL) are the most common. In the BAF of the 1st group of patients, a frequent combination of fractions of PC and CL was found, in the 2nd group − PC, PEA and CL. Combinations containing sphingomyelin (SPM), PC and CL were found only in groups 1 and 2. It was also found that the level of total protein in BAF varies depending on the activity of the process, so in patients of group 1 with the presence of areas of destruction of lung tissue, the content of total protein significantly exceeded that in patients with specific inflammation subsiding.Discussion. Patients with pulmonary tuberculosis with dust exposure develop sub-radiological manifestations of pneumoconiosis in the form of impaired metabolism and biochemical composition of pulmonary surfactant, which is caused both by the dust factor and the influence of specific inflammation.Conclusion The role of biochemical criteria of pulmonary surfactant damage as early molecular markers of the sub-radiological stage of pneumoconiosis in pulmonary tuberculosis patients was determined.","PeriodicalId":247511,"journal":{"name":"Ural Medical Journal","volume":"64 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126463017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pediatric chest pain and synopsis is a current problem of pediatrics 小儿胸痛是当前儿科的一个问题
Ural Medical Journal Pub Date : 2023-06-30 DOI: 10.52420/2071-5943-2023-22-3-137-144
A. Sozonov, S. A. Tsarkova, Y. Trunova
{"title":"Pediatric chest pain and synopsis is a current problem of pediatrics","authors":"A. Sozonov, S. A. Tsarkova, Y. Trunova","doi":"10.52420/2071-5943-2023-22-3-137-144","DOIUrl":"https://doi.org/10.52420/2071-5943-2023-22-3-137-144","url":null,"abstract":"Introduction. Cardialgia is a common reason for seeking medical care in the practice of the pediatrician and pediatric cardiologist. The combination of cardialgia and syncope in children can pose a health risk, leading to possible injuries, and is a factor of fear and anxiety in these families. Insufficient information on the pathophysiological basis of the development of cardialgia and syncope in children and the absebce of clear criteria for their prognosis and prevention were the reasons for a detailed study of the literature related to this issue.The aim of the work was to systematize the current literary data on the causes of cardialgia and syncope in children and to determine directions for further study of the problem to improve monitoring by pediatricians and pediatric cardiologists.Materials and methods. We searched for scientific articles using the keywords pediatric chest pain and syncope in the Pubmed, UpToDate 2022, Customer Service, and RSCI databases. Sixty publications were selected for analysis.Results and discussion. Cardialgia is pain in the heart region, which in combination with fainting can be a symptom of a large number of diseases, which determines the different approach of medical specialists involved in the treatment of diseases of the cardiovascular system, and requires a special diagnosis. Cardialgia is characterized by polymorphism of both complaints and subjective sensations, and objective data. All this is caused by a variety of etiopathogenesis of this symptom.Conclusion. Cardialgia is a current problem in pediatric practice. This literature review summarizes the information accumulated over several years on the diagnosis of cardialgia and syncope in children and determines the trajectory of further study of the problem.","PeriodicalId":247511,"journal":{"name":"Ural Medical Journal","volume":"94 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122671988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hyperkinetic disorder and attention deficiency and hyperactivity syndrome in adults 成人多动障碍和注意缺陷及多动综合征
Ural Medical Journal Pub Date : 2023-06-30 DOI: 10.52420/2071-5943-2023-22-3-108-117
A. V. Gorodnicheva, I. A. Ponomarev, A. Sidenkova
{"title":"Hyperkinetic disorder and attention deficiency and hyperactivity syndrome in adults","authors":"A. V. Gorodnicheva, I. A. Ponomarev, A. Sidenkova","doi":"10.52420/2071-5943-2023-22-3-108-117","DOIUrl":"https://doi.org/10.52420/2071-5943-2023-22-3-108-117","url":null,"abstract":"Introduction. Hyperkinetic disorder (HR) and attention-deficit/hyperactivity disorder (ADHD) are traditionally regarded as a pathology of childhood, but the frequency of its detection among the adult population is high. GR and ADHD has a significant impact on professional, educational activities and social and domestic relationships.The purpose of the work was to systematize the current data in the field of research on hyperkinetic disorder and attention deficit hyperactivity disorder in adults.Materials and methods Full-text publications of metaanalyses from 2017 to 2022 were searched in the PubMed electronic search engine for full-text keyword matches. The criterion for not including a publication in this review was a study conducted on a sample of individuals under 18 years of age. A total of 154 unique references were checked, of which 70 articles were included in the review.Results and discussion. ADHD is a polyethiological disorder. ADHD symptoms can be associated with other pathological conditions, which can influence the pathogenetic and clinical picture. A number of authors consider ADHD symptoms in terms of adaptation to the modern information environment. Positive aspects of ADHD are pointed out: the ability to be creative, the ability to find non-standard, original solutions, an increased capacity for empathy. In a number of modern works, persons with ADHD have an increased ability to “hyperfocus” on activities relevant to the individual, although not all researchers adhere to this opinion.Conclusion. The clinical essence of ADHD is its dysontogenetic nature. The range of etiological factors, both external and internal, that can lead to the development of ADHD symptoms is quite wide, and the likelihood of comorbid conditions is extremely high. Not all of the classifications and diagnostic criteria aimed at identifying ADHD symptoms in individuals under 18 years of age can be applied to adult patients, which shifts the epidemiological indicators toward a reduction of the disorder in the adult population.","PeriodicalId":247511,"journal":{"name":"Ural Medical Journal","volume":"56 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115726305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical manifestations of functionally autonomous cortisol secretion in patients with adrenal masse 肾上腺肿块患者功能自主皮质醇分泌的临床表现
Ural Medical Journal Pub Date : 2023-06-30 DOI: 10.52420/2071-5943-2023-22-3-13-21
T. Chzhen, T. Kiseleva
{"title":"Clinical manifestations of functionally autonomous cortisol secretion in patients with adrenal masse","authors":"T. Chzhen, T. Kiseleva","doi":"10.52420/2071-5943-2023-22-3-13-21","DOIUrl":"https://doi.org/10.52420/2071-5943-2023-22-3-13-21","url":null,"abstract":"Introduction. The choice of tactics for patients with adrenal masses (AM) with functionally autonomous cortisol secretion (FASC) remains controversial.The aim of the study was to determine the most significant clinical manifestations of FASC in unoperated AM patients.Materials and methods Thirty unoperated AM patients aged 67.0 [59.25 to 71.0] years with a disease duration of 92.0 [46.75 to 112.0] months were included in the study.Results. We defined thresholds for morning blood cortisol levels to predict clinical manifestations of FASC: for obesity ≥ 300.7 nmol/L, (p = 0.02), DM2 ≥ 508.0 nmol/L, (p < 0.001), dyslipidemia ≥ 450.0 nmol/L, (p = 0.02). Increases in AM size were determined: at 36 months − by 0.146 cm, at 60 months − by 0.169 cm, its positive marked direct correlation with the initial AM size.Discussion. According to the literature, FASC is diagnosed in 30−50 % of patients with AM. Our data are comparable with scientific sources: AH was observed in 86.7% (n = 26) of patients, obesity − 73.3 % (n = 22), T2DM − 36.7 % (n = 11), dyslipidemia − 60 % (n = 17), osteoporosis − 43.3 % (n = 13).Conclusion In unoperated outpatients with AM, obesity, DM2, and dyslipidemia are the most significant clinical manifestations of FASC. In patients over 60 years of age with a benign CT-phenotype of adrenal masses and controlled clinical manifestations of FASC, the treatment tactic is observation.","PeriodicalId":247511,"journal":{"name":"Ural Medical Journal","volume":"16 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132412966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Factors associated with the progression of nonalcoholic fatty liver disease in young adults 与年轻人非酒精性脂肪性肝病进展相关的因素
Ural Medical Journal Pub Date : 2023-06-30 DOI: 10.52420/2071-5943-2023-22-3-6-12
S. V. Yakovleva, I. Pirogova
{"title":"Factors associated with the progression of nonalcoholic fatty liver disease in young adults","authors":"S. V. Yakovleva, I. Pirogova","doi":"10.52420/2071-5943-2023-22-3-6-12","DOIUrl":"https://doi.org/10.52420/2071-5943-2023-22-3-6-12","url":null,"abstract":"Introduction. Non–alcoholic fatty liver disease (NAFLD) is a chronic metabolic disease associated with insulin resistance, with a high potential for progression and increased prevalence among the population of all countries. The search for modifiable factors associated with the development of NAFLD, especially among young people, is an urgent healthcare task. The relationship between vitamin D availability and the high incidence of metabolic disorders in young adults and its contribution to the progression of NAFLD is currently under active discussion.The aim of the work was to reveal the relationship between the components of metabolic syndrome and the level of vitamin D supply in young men with NAFLD.Materials and methods. The study enrolled 123 male patients aged 18−44 years. Two groups were formed: the main group consisted of the patients with NAFLD, the control group − the patients without NAFLD. Anthropometric data were analyzed; blood plasma parameters of lipid metabolism, glucose, insulin, 25(OH)D levels were determined. Insulin resistance index (HOMA-IR) was calculated. Steatosis and hepatic fibrosis were verified by transient elastometry. The nature and strength of the relationship of the variables were assessed using the Spearman rank correlation coefficient.Results. Significant associations were found between 25(OH)D levels, steatosis scores, liver fibrosis, waist circumference, and NOMA-IR.Discussion. Insufficient vitamin D supply is etiopathogenetically associated with the development of metabolic syndrome (MS) and NAFLD.Conclusion. Low serum vitamin D concentrations are associated with both the severity of hepatic steatosis and components of the metabolic syndrome. Timely detection of vitamin D deficiency and supplementation can reduce the severity of metabolic disorders and progression of NAFLD.","PeriodicalId":247511,"journal":{"name":"Ural Medical Journal","volume":"88 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116714390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correlation between body mass index and prostate volume in patients with benign prostatic hyperplasia 良性前列腺增生患者体重指数与前列腺体积的相关性研究
Ural Medical Journal Pub Date : 2023-06-30 DOI: 10.52420/2071-5943-2023-22-3-22-27
S. Volkov, R. K. Mikheev, O. Grigoryan, V. Tereshchenko, V. S. Stepanchenko, E. Andreeva
{"title":"Correlation between body mass index and prostate volume in patients with benign prostatic hyperplasia","authors":"S. Volkov, R. K. Mikheev, O. Grigoryan, V. Tereshchenko, V. S. Stepanchenko, E. Andreeva","doi":"10.52420/2071-5943-2023-22-3-22-27","DOIUrl":"https://doi.org/10.52420/2071-5943-2023-22-3-22-27","url":null,"abstract":"Introduction. Obstruction due to benign prostatic hyperplasia (BPH) is a common condition in men over 40 years of age. This study determined the association between body mass index (BMI) and preoperative prostate volume (PV).The purpose of the study was to determine whether there is an association between obesity and prostate volume in men with BPH.Materials and methods. The medical records of 96 patients who underwent holmium enucleation of the prostate as a treatment for BPH and who met the inclusion criteria were retrospectively reviewed. The mean age of the patients was (70.6±8.5) years. Correlation analysis was performed to assess the relationship between BMI and prostatic volume.Results. A total of 96 patient charts were analyzed. When assessing the relationship between BMI and prostate volume, a statistically significant direct correlation of moderate strength was found (ρ = 0.456, p < 0.001). Patients with prostate volume > 75 mL were significantly more likely to have urinary retention (p < 0.001; OR = 4.7; 95% CI: 1.9−11.4).Discussion Studies on larger patient samples are needed to verify the results against true population figures.Conclusion A positive correlation between BMI and prostate volume has been established.","PeriodicalId":247511,"journal":{"name":"Ural Medical Journal","volume":"28 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127830925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Historical preconditions for the formation of a quality control system for forensic examinations 法医检验质量控制体系形成的历史前提条件
Ural Medical Journal Pub Date : 2023-06-30 DOI: 10.52420/2071-5943-2023-22-3-145-155
O. B. Dolgova, P. Romodanovsky
{"title":"Historical preconditions for the formation of a quality control system for forensic examinations","authors":"O. B. Dolgova, P. Romodanovsky","doi":"10.52420/2071-5943-2023-22-3-145-155","DOIUrl":"https://doi.org/10.52420/2071-5943-2023-22-3-145-155","url":null,"abstract":"Introduction. The problem of the quality of forensic examinations has existed throughout the history of forensic medicine, which determines the relevance of quality control of examinations.The purpose of the work was to evaluate and analyze, from a historical perspective, the literature and the provisions of regulatory documents on quality control of forensic examinations, the definition of defects and their prevention at all stages of forensic examination.Materials and methods. A literature search on the subject was performed in the PubMed, ResearchGate, and Elibrary databases. The depth of the search is 151 years. Fifty-six sources were included in the review.Results and discussion. For the first time the right of a forensic physician to err was recognized in the 19th century, doctors were prosecuted for mistakes. Expert errors are relevant nowadays, the conclusions of experts are not satisfied by courts, investigation and prosecutor’s office. The significance of quality control of expert examinations at the state level was determined in 1951. The first measures to improve expert examinations were adopted in 1962. In 1978, provisions were formulated for the execution of the expert report, the possibility of a dubious conclusion was pointed out. In 1991, the requirements for the execution of documents were outlined. In 2003 a procedure for organizing repeated commission expert examonations after poor-quality primary ones was presented. Currently, however, the regulatory documents lack criteria for defective examinations and measures to prevent defects. In the Russian Federation in 2019 a plan of measures to improve the production of expert examinations is approved, which determines the relevance of studying the issues of organization of quality control of expert examinations and prevention of expert errors.Conclusion. Since the establishment of the State Bureau of Forensic Medicine in the Russian Federation, criteria for the quality of forensic examination based on the identification of defects in the work of a forensic doctor have been developed and used. The formation of successive stages of control based on unified criteria for evaluating the expert work will allow to draw an objective conclusion about the quality of forensic examination.","PeriodicalId":247511,"journal":{"name":"Ural Medical Journal","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129477000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Orbital complications of rhinogenic etiology in children: some aspects 儿童鼻源性眼眶并发症的几个方面
Ural Medical Journal Pub Date : 2023-06-30 DOI: 10.52420/2071-5943-2023-22-3-37-45
I. Veshkurtseva, N. Kuznetsova, A. Izvin, M. Ponomareva, A. А. Izmailova, S. S. Yudina
{"title":"Orbital complications of rhinogenic etiology in children: some aspects","authors":"I. Veshkurtseva, N. Kuznetsova, A. Izvin, M. Ponomareva, A. А. Izmailova, S. S. Yudina","doi":"10.52420/2071-5943-2023-22-3-37-45","DOIUrl":"https://doi.org/10.52420/2071-5943-2023-22-3-37-45","url":null,"abstract":"Introduction. Rhinosinusogenic orbital complications (RSOC) rank first among all serious complications of inflammatory diseases of the paranasal sinuses and require timely diagnosis and an interdisciplinary approach in the administration of this category of patients.The aim of the study. was to study the features of the nature of the course, diagnosis and tactics of managing children with RSOC according to the children’s ENT department of the OKB No. 2, Tyumen.Materials and methods. A retrospective analysis of the medical records of children with RSOC was carried out. The leukocyte shift indices (LSI) were calculated. The microbiological landscape in purulent RSOC and the tactics of introducing patients with these complications were studied.Results and Discussion. Among the entire pathology of the paranasal sinuses, RSOS were observed in 12.9% of cases. In 53.6% of cases, RSOC occurred in boys. Reactive edema of the tissue of the eyelids and orbits was in 86.1% of cases, other forms were less common. Of the microflora, the leading positions were occupied by Staphylococcus spp. In 54.2 % of cases, only conservative therapy was used, in every third case − minimally invasive manipulations, in 11 % − surgery. In 84.6 % of cases, empiric therapy was started with protected aminopenicillins, 3rd generation cephalosporins (12.8 %). In the presence of a subperiosteal abscess or phlegmon of the orbit (23.1 %), a transfer was made to reserve preparations. LSI values greater than 3.58 were more typical for purulent-septic complications of the eyelids and orbit, which required early surgical intervention and prevention of intraorbital and intracranial complications.Conclusion Among RSOC in children, reactive edema of eyelids and eye sockets predominates. The microbial landscape in purulent orbital complications was characterized by pronounced polymorphism, which makes it difficult to choose empirical antibiotic therapy. Calculation of the LSI allows for early diagnosis and timely therapy with the choice of the optimal scope of medical intervention and an interdisciplinary approach, which reduces the risk of developing purulent-septic complications of the orbit and eyelids.","PeriodicalId":247511,"journal":{"name":"Ural Medical Journal","volume":"64 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123461676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Predicting the dynamics of norovirus infection using time series models 利用时间序列模型预测诺如病毒感染的动态
Ural Medical Journal Pub Date : 2023-06-30 DOI: 10.52420/2071-5943-2023-22-3-57-63
A. Kosova, V. Chalapa
{"title":"Predicting the dynamics of norovirus infection using time series models","authors":"A. Kosova, V. Chalapa","doi":"10.52420/2071-5943-2023-22-3-57-63","DOIUrl":"https://doi.org/10.52420/2071-5943-2023-22-3-57-63","url":null,"abstract":"Introduction. Norovirus infection (NI) is the most prevalent cause of acute gastroenteritis and outbreaks in semi-closed settings. Forecasting of NI may improve situational awareness and control measures.The aim of the study is to evaluate accuracy of time-series models for forecasting of norovirus incidence (on Sverdlovsk region dataset).Materials and methods. Simple ARIMA time-series models was chosen to forecast NI incidence via regression on its own lagged values. Dataset including passive surveillance monthly reports for Sverdlovsk region was used. All models were trained on data for 2015−2018 and tested on data for 2019. Models were benchmarked using Akaike information criterion (AIC) and mean absolute percentage error (MAPE).Results and discussion. NI incidence in Sverdlovsk raised in 2015-2018 with strong winter-spring seasonality. The time-series incidence data was stationary. Nine significant models were found and the most accurate model was SARIMA (1,0,0)(0,0,1). Despite its accuracy on 2019 test sample, forecast on COVID-19 pandemic period was failed. It was supposed that including additional regressors (climate and herd immunity data) and choosing of more robust time-series models may improve forecasting accuracy.Conclusion. ARIMA time-series models (especially SARIMA) suitable to forecast future incidence of NI in Sverdlovsk region. Additional investigations in terms of possible regressors and improved model robustness are needed.","PeriodicalId":247511,"journal":{"name":"Ural Medical Journal","volume":"62 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121453219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Chronic endometritis: A protracted discussion 慢性子宫内膜炎:一场旷日持久的讨论
Ural Medical Journal Pub Date : 2023-04-30 DOI: 10.52420/2071-5943-2023-22-2-142-152
G. Tolibova, T. Tral
{"title":"Chronic endometritis: A protracted discussion","authors":"G. Tolibova, T. Tral","doi":"10.52420/2071-5943-2023-22-2-142-152","DOIUrl":"https://doi.org/10.52420/2071-5943-2023-22-2-142-152","url":null,"abstract":"Introduction Chronic endometritis is one of the most important factors leading to reduced fertility in women. The protracted discussion about the presence of this nosology in clinical practice for more than 100 years does not allow to establish the true frequency of chronic endometritis in women of reproductive age. At the present stage, due to the unfavorable demographic situation both in the Russian Federation and in many countries, the study of chronic endometritis, as one of the main determinants of the lesions of the morphological and functional state of the endometrium, is relevant.The purpose of the study is to determine the current state of the problem of verification of chronic endometritis in women with infertility, reproductive losses and repeated failure of assisted reproductive technologies (ART).Materials and methods The sources of information were publications from the databases PubMed, Google Scholar, elibrary.ru and Russian medical journals in the field of obstetrics and gynecology, as well as pathological anatomy in the period from 2013 to 2022.Results and discussion An analysis of the literature showed that chronic endometritis is the cause of infertility, miscarriage and ineffective ART protocols and leads to decrease of the regenerative potential and endometrial reserve. Despite the evidence of the negative impact of chronic endometritis on the reproductive function, at the present stage, the discussion regarding diagnostic approaches to this nosology continues. The use of the histological method of research, as the main and available method for diagnosing the state of the endometrium, is not always allow to verify chronic endometritis, which dictates the need of using high technological methods to confirm and clarify the severity of the pathological process.Conclusion A unified algorithm for diagnosing chronic endometritis in patients with infertility, miscarriage, ineffective ART cycles and a qualified approach to the morphological diagnosis of the state of the endometrium, standardization of the diagnosis of chronic endometritis, and competent interpretation of immunohistochemical data make it possible to select a pathogenetically substantiated therapy aimed at the rehabilitation of reproductive function.","PeriodicalId":247511,"journal":{"name":"Ural Medical Journal","volume":"29 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125250568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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