Prachi M. Patel, Chandala Chitguppi, MD, Alan Gandler, MD, Kira Murphy, MD, Tawfiq Khoury, MD, Stephanie Bork, CRNP, Pamela Monostra, PA, Elina Toskala, MD, PhD, Mindy Rabinowitz, MD, Marc Rosen, MD, Gurston Nyquist, MD, Jessica Most, MD
{"title":"Evaluation of Asthma Control in Patients with and without Sinonasal Polyps following Treatment with Biologic Agents","authors":"Prachi M. Patel, Chandala Chitguppi, MD, Alan Gandler, MD, Kira Murphy, MD, Tawfiq Khoury, MD, Stephanie Bork, CRNP, Pamela Monostra, PA, Elina Toskala, MD, PhD, Mindy Rabinowitz, MD, Marc Rosen, MD, Gurston Nyquist, MD, Jessica Most, MD","doi":"10.29046/tmf.022.1.020","DOIUrl":"https://doi.org/10.29046/tmf.022.1.020","url":null,"abstract":"Conclusions: Patients with and without sinonasal polyps who begin biologic therapy are shown to have significant improvements in their ACT score at follow-up. In addition, patients with polyps are shown to have significantly better control of their asthma while on biologics than patients with no polyps. Comorbid CRSwNP may predict response to biologic therapy in those with severe asthma (SA).","PeriodicalId":246494,"journal":{"name":"The Medicine Forum","volume":"55 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128175965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Thyrotoxic Periodic Paralysis – A Case Report of a Rare Cause of Paralysis in a 39-Year-Old Asian Man","authors":"R. B. Jones, J. Uricheck","doi":"10.29046/TMF.020.1.007","DOIUrl":"https://doi.org/10.29046/TMF.020.1.007","url":null,"abstract":"","PeriodicalId":246494,"journal":{"name":"The Medicine Forum","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129317997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"From the Desk of the Residency Program Director","authors":"Emily Stewart, MD","doi":"10.29046/tmf.020.1.001","DOIUrl":"https://doi.org/10.29046/tmf.020.1.001","url":null,"abstract":"","PeriodicalId":246494,"journal":{"name":"The Medicine Forum","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127427228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The Laws of the Dead","authors":"Gillian Naro, MD, MEd, Marie-Laure Flamer, MD","doi":"10.29046/tmf.023.1.016","DOIUrl":"https://doi.org/10.29046/tmf.023.1.016","url":null,"abstract":"","PeriodicalId":246494,"journal":{"name":"The Medicine Forum","volume":"21 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129208484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A Gram-Negative False-Negative: Normal Procalcitonin Level in a Patient with Multiple Klebsiella Pneumoniae Intra-Abdominal Abscesses: A Case Report and Literature Review","authors":"Mario Caldararo","doi":"10.29046/TMF.020.1.018","DOIUrl":"https://doi.org/10.29046/TMF.020.1.018","url":null,"abstract":"sodium 135 mmol/L [135-145 mmol/L], bicarbonate 24 mmol/L [22-32 mmol/L], normal anion gap, blood urea nitrogen 11 mg/dL [7-20 mg/dL], creatinine 1.0 mg/dL [0.6-1.2], normal liver enzymes and coagulation studies. C-reactive protein was 5.50 mg/dL. Erythrocyte sedimentation rate was 80 mm/hr. TSH was 43.15 μIU/ mL with a low T4 of 0.4 ng/dL. Procalcitonin was 0.07 ng/mL (upper limit of normal 0.09 ng/mL).","PeriodicalId":246494,"journal":{"name":"The Medicine Forum","volume":"42 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126218894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Andrea Molin, MD, Michael Cheung, MD, Timothy Kuchera, MD
{"title":"A Confounding Case of Acute Hepatitis A","authors":"Andrea Molin, MD, Michael Cheung, MD, Timothy Kuchera, MD","doi":"10.29046/tmf.023.1.010","DOIUrl":"https://doi.org/10.29046/tmf.023.1.010","url":null,"abstract":"","PeriodicalId":246494,"journal":{"name":"The Medicine Forum","volume":"55 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121455494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Fibrous Web in the Right Atrium: A Complication of Fungal Endocarditis and Previous Lead Infections","authors":"Harry Wang","doi":"10.29046/tmf.020.1.004","DOIUrl":"https://doi.org/10.29046/tmf.020.1.004","url":null,"abstract":"A 57-year-old woman with a past medical history of severe non-ischemic cardiomyopathy undergoing orthotopic heart transplant evaluation on milrinone, prior extraction of multiple pacemaker and implantable cardiover ter def ibr i l lator ( ICD) leads due to Staphylococcus epidermidis endocarditis, and multiple central venous catheter infections presented with several days of worsening dyspnea on exertion, orthopnea and lower extremity edema, prompting admission for congestive heart failure exacerbation. While she received aggressive intravenous diuretics, she was also found to be febrile to 101.8°F with a white blood cell count of 11,000/μL. Blood cultures were drawn, her peripherally inserted central catheter was removed, and she was started on broad spectrum antibiotics with imipenem and daptomycin. She remained hemodynamically stable, but several days into her hospitalization, her blood cultures grew Candida albicans. Antibiotics were stopped, and she was empirically started on anidulafungin. A transesophageal echocardiogram (TEE) was then performed and showed linear densities in the right atrium which mimicked the course of previously extracted leads (Figure 1), consistent with fibrous sheaths. Also seen was a 5 x 8 mm mobile vegetation on the ICD lead, multiple linear ‘web-like’ vegetations in the right atrium (Figure 2), and more typical-appearing vegetations in the superior vena cava (Figure 3). These findings, in addition to the fungemia, prompted transvenous ICD extraction, which she tolerated well. Her subsequent blood cultures were negative, but given her previous history of lead and line infections, the decision was made to fit the patient with a wearable defibrillator and re-evaluate her for infection in 6 weeks after completion of treatment for fungal endocarditis. After clearance of infection, her candidacy for cardiac transplant would also be re-evaluated.","PeriodicalId":246494,"journal":{"name":"The Medicine Forum","volume":"36 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121690014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Complicated Persistent Peritonitis","authors":"B. Roth, K. Sarkar","doi":"10.29046/tmf.020.1.009","DOIUrl":"https://doi.org/10.29046/tmf.020.1.009","url":null,"abstract":"Spontaneous bacterial peritonitis (SBP) is a common complication of end-stage liver disease. SBP can present with many symptoms such as abdominal pain, fever and altered mental status. The diagnosis of SBP is made when ascitic fluid from a paracentesis has an absolute neutrophil count (ANC) more than 250/uL, there is a positive ascitic fluid culture, and no secondary source of infection can be idenitifed. However, nearly 60% of patients with SBP have negative fluid cultures. These patients can still potentially have SBP and should be treated as such since in-hospital mortality ranges from 20-40%. Conventional treatment for SBP includes a third-generation cephalosporin for five days, followed by lifetime prophylaxis most commonly with a fluoroquinolone. After 48 hours of antibiotic treatment, a repeat paracentesis should be performed. If the ANC does not decrease by at least 25%, it is considered a therapeutic failure and the antibiotic should be changed. With early diagnosis and appropriate antibiotic regimen, SBP is treatable.","PeriodicalId":246494,"journal":{"name":"The Medicine Forum","volume":"42 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122906776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Pancreatic Plasmacytoma: A Rare Extramedullary Manifestation of Multiple Myeloma","authors":"Justin Robbins, MD, Gregory Habig, MD","doi":"10.29046/tmf.022.1.017","DOIUrl":"https://doi.org/10.29046/tmf.022.1.017","url":null,"abstract":"Multiple myeloma is a plasma cell dyscrasia in which neoplastic plasma cells pathologically produce monoclonal immunoglobulin and infiltrate bone marrow throughout the skeletal system. The disease is classically characterized by bone pain caused by lytic bone lesions, marked increases in monoclonal antibodies in blood or urine, hypercalcemia, and other systemic signs and symptoms of malignancy including weight loss and night sweats. A rare variant of multiple myeloma presents with extramedullary plasmacytomas, or plasma cell tumors, which arise in organs outside of the bone marrow 1 . The case presented here exhibits this disease variant, with a woman with severe multiple myeloma refractory to multiple treatment modalities who was found to have a pancreatic plasmacytoma. The patient presented here was a 58-year-old female with a history of refractory multiple myeloma status post autologous stem cell transplant with relapse, hepatitis B virus on entecavir, and recurrent pancreatitis who","PeriodicalId":246494,"journal":{"name":"The Medicine Forum","volume":"38 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123143024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}