Pancreatic Plasmacytoma: A Rare Extramedullary Manifestation of Multiple Myeloma

Abstract

Multiple myeloma is a plasma cell dyscrasia in which neoplastic plasma cells pathologically produce monoclonal immunoglobulin and infiltrate bone marrow throughout the skeletal system. The disease is classically characterized by bone pain caused by lytic bone lesions, marked increases in monoclonal antibodies in blood or urine, hypercalcemia, and other systemic signs and symptoms of malignancy including weight loss and night sweats. A rare variant of multiple myeloma presents with extramedullary plasmacytomas, or plasma cell tumors, which arise in organs outside of the bone marrow 1 . The case presented here exhibits this disease variant, with a woman with severe multiple myeloma refractory to multiple treatment modalities who was found to have a pancreatic plasmacytoma. The patient presented here was a 58-year-old female with a history of refractory multiple myeloma status post autologous stem cell transplant with relapse, hepatitis B virus on entecavir, and recurrent pancreatitis who