International Journal of Pharmaceutical Sciences and Medicine最新文献_第10页

Formulation and Evaluation of Gastro Retentive Drug Delivery System of Domperidone Mouth Dissolving Tablet by using Super Disintegrating Agents 多潘立酮口腔溶片超级崩解剂胃保留给药系统的研制与评价

International Journal of Pharmaceutical Sciences and Medicine Pub Date : 2023-03-30 DOI: 10.47760/ijpsm.2023.v08i03.004

Patel Rupali, Upadhyay Nikita, Sonartiya Sunita, Jain Sourabh, D. P.K.

引用次数: 0

A Comprehensive Review Article on Transdermal Patch 透皮贴剂研究综述

International Journal of Pharmaceutical Sciences and Medicine Pub Date : 2023-03-30 DOI: 10.47760/ijpsm.2023.v08i03.006

G. Patel, Kantilal B. Narkhede, Anuradha P. Prajapati, Sachin B. Narkhede

{"title":"A Comprehensive Review Article on Transdermal Patch","authors":"G. Patel, Kantilal B. Narkhede, Anuradha P. Prajapati, Sachin B. Narkhede","doi":"10.47760/ijpsm.2023.v08i03.006","DOIUrl":"https://doi.org/10.47760/ijpsm.2023.v08i03.006","url":null,"abstract":"Transdermal drug delivery system (TDDS) established itself as an integral part of novel drug delivery systems. In a broad sense, the term transdermal delivery system includes all topically administered drug formulations intended to deliver the active ingredient into the general circulation. Transdermal drug delivery systems are polymeric formulations which when applied to skin deliver the drug at a predetermined rate across dermis to achieve systemic effects. A transdermal patch is medicated adhesive patch that is placed on the skin to deliver a specific dose of medication through the skin and into the bloodstream. Often, this promotes healing to an injured area of the body. An advantage of a transdermal drug delivery route over other types of medication delivery such as oral, topical, intravenous, intramuscular, etc. is that the patch provides a controlled release of the medication into the patient, usually through either a porous membrane covering a reservoir of medication or through body heat melting thin layers of medication embedded in the adhesive. The main disadvantage to transdermal delivery systems stems from the fact that the skin is a very effective barrier; as a result, only medications whose molecules are small enough to penetrate the skin can be delivered in this method.","PeriodicalId":246486,"journal":{"name":"International Journal of Pharmaceutical Sciences and Medicine","volume":"34 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128893034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Study of Antimicrobial Activity of the Rubiaceae Family: A Review 茜草科植物抗菌活性研究进展

International Journal of Pharmaceutical Sciences and Medicine Pub Date : 2023-03-30 DOI: 10.47760/ijpsm.2023.v08i03.002

Diella Purnama Putri Utami, Anzharni Fajrina, Aried Eriadi

引用次数: 0

MELISSA OFFICINALIS – AN OVERVIEW AND ITS PROPERTIES AS AN ANXIOLYTIC 梅莉莎-概述及其作为抗焦虑药的特性

International Journal of Pharmaceutical Sciences and Medicine Pub Date : 2023-03-30 DOI: 10.47760/ijpsm.2023.v08i03.003

Harshdeep Srivastava, K. K. Maheshwari

引用次数: 0

In–Vitro Drug Interaction between Tulsi and Glimepride Tulsi和Glimepride的体外药物相互作用

International Journal of Pharmaceutical Sciences and Medicine Pub Date : 2023-03-30 DOI: 10.47760/ijpsm.2023.v08i03.011

Tomar Mahendra Singh, Y. Swati, S. Karunakar

{"title":"In–Vitro Drug Interaction between Tulsi and Glimepride","authors":"Tomar Mahendra Singh, Y. Swati, S. Karunakar","doi":"10.47760/ijpsm.2023.v08i03.011","DOIUrl":"https://doi.org/10.47760/ijpsm.2023.v08i03.011","url":null,"abstract":"The study was designed to determine the interaction of O. sanctum, an herbal drug used in many herbal formulations for hypoglycemic activity with Glimepiride, a sulfonylurea (SU) derivative, widely used in the treatment of type-2 diabetes, in diabetic rats. Whole study was divided into four phases in which hypoglycaemic activity with single doses of O. sanctum and glimeperide was established in single day study and repeated dose treatment of O. sanctum (7 days) followed by a single dose of glimeperide on 8th day was also established. Further the interaction between the two drugs was studied in both single and repeated treatment, i.e., the effect of single and glimeperide repeated doses treatment on O. sanctum. All the results were analysed by one way ANOVA followed by Dunnett’s‘t’ test. Rats were administered with streptozotocin for inducing diabetes and left for 2 weeks to stabilize blood glucose levels. Various doses of O. sanctum (100, 200 and 400 mg/kg) and glimeperide (½ TD, TD and 2 TD) upon single dose treatment of each in different groups of diabetic rats produced a dose dependent decrease in blood glucose levels. The maximum reduction in serum glucose was observed at 6 th h in all the groups. Single dose of O. sanctum prolonged the effect of glimepiride from 4th to 6th h without any hypoglycemic convulsions.","PeriodicalId":246486,"journal":{"name":"International Journal of Pharmaceutical Sciences and Medicine","volume":"27 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131150920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hepatoprotective Effect of Methanolic Leaf Extract of Prosopis Cineraria on Paracetamol Induced Hepatotoxicity in Swiss Albino Mice 藜麦醇叶提取物对对乙酰氨基酚所致瑞士白化小鼠肝毒性的保护作用

International Journal of Pharmaceutical Sciences and Medicine Pub Date : 2023-03-30 DOI: 10.47760/ijpsm.2023.v08i03.009

Ranu Yadav, P. Dubey, Anant K. Patel

{"title":"Hepatoprotective Effect of Methanolic Leaf Extract of Prosopis Cineraria on Paracetamol Induced Hepatotoxicity in Swiss Albino Mice","authors":"Ranu Yadav, P. Dubey, Anant K. Patel","doi":"10.47760/ijpsm.2023.v08i03.009","DOIUrl":"https://doi.org/10.47760/ijpsm.2023.v08i03.009","url":null,"abstract":"Aim: To evaluate the protective effect of methanolic leaf extract of Prosopis Cineraria on paracetamol-induced hepatotoxicity in mice. Materials and Methods: 30 Swiss albino mice of eithersex mice were used in this study and divided into 5 groups (for each 6). Group 1 Control group fed basal diet and maintained as positive control group. Group 2 received Paracetamol in a dose of (3 g/kg b. wt.). Group 3 received Paracetamolalong with Standard Drug (Silymarin) in a dose of (100 mg/kg). Groups 4 and 5 were treated with Paracetamol along with plant extracts of Prosopis Cineraria at a dose level of 250 g/kg and 500 mg/kg. Results:The activities of serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), triglyceride (TG), bilirubin, and total protein were measured. The values of urea, sodium, potassium and chloride were significantly increased in rats exposed to paracetamol. Moreover, administration of paracetamol resulted in damage to liver structures. Administration of methanolic extract of Prosopis Cineraria before Paracetamol exposure prevented severe alterations of biochemical parameters and disruptions of liver structures. Conclusions: This study obviously demonstrated that pre-treatment with methanolic extract of Prosopis Cinerariasignificantly attenuated the physiological and histopathological alterations induced by paracetamol.","PeriodicalId":246486,"journal":{"name":"International Journal of Pharmaceutical Sciences and Medicine","volume":" 1260","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"120826613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antifungal Potential of Purified Gambier (Uncaria gambir Roxb.) 纯化甘比尔(Uncaria gambir Roxb.)的抗真菌活性

International Journal of Pharmaceutical Sciences and Medicine Pub Date : 2023-02-28 DOI: 10.47760/ijpsm.2023.v08i02.004

Ifora Ifora, Dicha Efelzita, Rezlie Bellatasie, Hendri Satria Kamal Uyun

引用次数: 0

A COMPREHENSIVE REVIEW ON TINOSPORA CORDIFOLIA: A PANACEA TREATMENT STRATEGY 综合综述:一种灵丹妙药的治疗策略

International Journal of Pharmaceutical Sciences and Medicine Pub Date : 2023-02-28 DOI: 10.47760/ijpsm.2023.v08i02.003

S. Sonali, K. K. Maheshwari

引用次数: 0

Antiurolithiatic Activity of Pascopyrum smithii in a Polyherbal Formulation Inhibition of Calcium Oxalate Crystallization on Urolithiasis Induced Rats 多草药配方中的山茱萸抗尿石活性对草酸钙结晶对尿石症大鼠的抑制作用

International Journal of Pharmaceutical Sciences and Medicine Pub Date : 2023-02-28 DOI: 10.47760/ijpsm.2023.v08i02.002

P. Kumawat, Ragini Bundela, K. Shukla

{"title":"Antiurolithiatic Activity of Pascopyrum smithii in a Polyherbal Formulation Inhibition of Calcium Oxalate Crystallization on Urolithiasis Induced Rats","authors":"P. Kumawat, Ragini Bundela, K. Shukla","doi":"10.47760/ijpsm.2023.v08i02.002","DOIUrl":"https://doi.org/10.47760/ijpsm.2023.v08i02.002","url":null,"abstract":"The research was aimed to “To formulate a polyherbal formulation of Pascopyrum smithii for Antiurolithiatic activity on Calcium Oxalate Induced Urolithiasis in Rats”Urolithiasis is defined as the presence of one or more stones at any point within the urinary tract. It is the third most common urinary tract disease; the others are frequent urinary tract infections and benign prostatic hyperplasia. The global incidence of urolithiasis is quite high and, despite enormous progress in the field of medicine, there is no truly satisfactory medication available for the treatment of kidney stones. Most patients still have to proceed for surgery to get rid of this painful disease. Hyperoxaluria is the main trigger for urolithiasisThe present study is to formulate an ayurvedic capsule for treatment of urolithiasis. And to study the role of Pascopyrum smithii in preventing and treating kidney stones and to further explore the effective metabolites from the crude extract.The formulated capsules are evaluated as per WHO guidelines and also performed pharmacological activity.","PeriodicalId":246486,"journal":{"name":"International Journal of Pharmaceutical Sciences and Medicine","volume":"16 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121175751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cytotoxic Activity Ethanol Extract Rind of Arumanis Mango (Mangifera indica Linn.) and Ethanol Extract Rind of Kweni Mango (Mangifera odorata Griff.) by Brine Shrimp Lethality Test Method 用盐水对虾致死性试验方法研究了野芒芒果(Mangifera indica Linn.)和桂皮芒果(Mangifera odorata Griff.)乙醇提取物的细胞毒活性

International Journal of Pharmaceutical Sciences and Medicine Pub Date : 2023-02-28 DOI: 10.47760/ijpsm.2023.v08i02.001

Hendri Satria Kamal Uyun, D. Bakhtra, Anzharni Fajrina, Ica Bela Octavia, Meilinda Mustika

{"title":"Cytotoxic Activity Ethanol Extract Rind of Arumanis Mango (Mangifera indica Linn.) and Ethanol Extract Rind of Kweni Mango (Mangifera odorata Griff.) by Brine Shrimp Lethality Test Method","authors":"Hendri Satria Kamal Uyun, D. Bakhtra, Anzharni Fajrina, Ica Bela Octavia, Meilinda Mustika","doi":"10.47760/ijpsm.2023.v08i02.001","DOIUrl":"https://doi.org/10.47760/ijpsm.2023.v08i02.001","url":null,"abstract":"Mango is a plant that has many health benefits such as helping the body to ward off free radicals. Research on the cytotoxic test of the ethanol extract rind of arumanis mango (Mangifera indica Linn.) and rind of kweni mango rind (Mangifera odorata Griff.) with the brine shrimp lethality test method was to determine the cytotoxic activity of the rind. Simplicia powder of mango arumanis rind and mango kweni rind was macerated with 70% ethanol. Cytotoxic testing used various concentrations of 1000 μg/mL, 500 μg/mL, 250 μg/mL, 100 μg/mL, 50 μg/mL. From the results of phytochemical screening, the ethanol extract of the arumanis mango rind contains alkaloids, flavonoids, phenols, tannins, terpenoids, and ethanol extract of kweni mango rind (Mangifera odorata Griff.) Containing alkaloids, saponins, flavonoids, phenols, tannins, and terpenoids. The results of the cytotoxic test obtained LC50 values of 41.6869 μg/mL for arumanis mango and 29.4238 μg/mL for kweni mango with a very toxic category of <30 μg/mL and toxic of 30-1000 μg/mL. From the results of the study, it can be concluded that the ethanol extract rind of arumanis mango and the ethanol extract rind of kweni mango have cytotoxic activity.","PeriodicalId":246486,"journal":{"name":"International Journal of Pharmaceutical Sciences and Medicine","volume":"16 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132275666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0