Medical Science Journal for Advance Research最新文献

{"title":"Evaluation Of Knee Meniscal Tear Frequency In Symptomatic Patients Setting MRI As Gold Standard","authors":"Sana Javed","doi":"10.46966/msjar.v3i4.78","DOIUrl":"https://doi.org/10.46966/msjar.v3i4.78","url":null,"abstract":"Background: Physical activities like sports gymnastics games, cycling, brisk walking, and running has always been a fun and important activities for people’s health and especially when it became their occupation. Due to increased unhealthy eating disorders in people, they have developed an unhealthy weight which is causing them to be weakened and causing pain especially at joints. For the diagnosis conventional radiography was never helpful because it is not for soft tissues whereas MRI is been using in muscoskeletal as modality of choice. \u0000Methods: total 600 patients were included in this prospective study with acute knee pain held at Lahore. 1.5 T MRI is used to rule out meniscal tears. Duration was of one year. Scans were reported by 2 expert radiologists and spss version 25.0 is used for frequency analysis. Asymptomatic patients were excluded from this study. \u0000Results: Knee meniscal tear frequency was ruled out in symptomatic patients including acute knee pain. Frequency was determined from 600 patients by determining male and female in them. Positive meniscal tear findings were discriminated by negative meniscal tear findings. Men has high ratio of meniscal tears because of many factors as compared to women. \u0000Conclusion: Jumping, supports, running and high intensity physical activities can be the cause of meniscal tear. Early evaluation of tear is necessary for the treatment of symptoms such as acute knee pain etc. Magnetic resonance imaging is non- invasive useful muscoskeletal imaging modality which can detect the tear even at very small grade such as grade 1. \u0000 ","PeriodicalId":245917,"journal":{"name":"Medical Science Journal for Advance Research","volume":"44 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117205165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Overview On Jaundic In Children: Relationship Between Jaundic And Blood Group, Anemia, Causes And Treatment Methods","authors":"Marwa Ahmed Meri","doi":"10.46966/msjar.v3i4.87","DOIUrl":"https://doi.org/10.46966/msjar.v3i4.87","url":null,"abstract":"Background: Jaundice is a condition that makes the skin, body tissues and fluids yellowish in color. You often see the color on the skin or the white parts of the eyes. The yellow color is caused by the accumulation of bilirubin in the blood. Bilirubin is a pigment that leaks into the blood when red blood cells break down. This study aimed to identify jaundice and its relationship to the occurrence of jaundice in newborns with blood groups and its relationship to anemia, to study jaundice, to reveal its causes and what are the methods of diagnosis and treatment methods in all respects, and to clarify the extent of its spread. To the effect of jaundice on the health of the newborn and to know whether the effect of jaundice persists for advanced periods of the patient’s life, the study reached a number of conclusions, the most important of which are: Anemia, yellowing of the skin and eyes, and an enlarged spleen are the symptoms of jaundice, a hereditary condition brought on by a genetic defect in the membrane of red blood cells. The red cells in hemolytic jaundice are less elastic, rounder, and more fragile than normal red cells. Red blood cells frequently become caught in constrictive blood vessels, such as the spleen, which causes them to degrade and result in anemia. An enlarged spleen results from red cell blockage of the spleen. This occurs when red blood cells release their hemoglobin. The heme fraction then produces bilirubin, and too much bilirubin causes gallstones to develop even in young children. Iron-rich red blood cells are also destroyed by excess iron.","PeriodicalId":245917,"journal":{"name":"Medical Science Journal for Advance Research","volume":"29 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123569517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment Of Soluble Fas Ligand In Patients With Chronic Myeloid Leukemia","authors":"Sahar Radhi Yasir","doi":"10.46966/msjar.v3i4.79","DOIUrl":"https://doi.org/10.46966/msjar.v3i4.79","url":null,"abstract":"Background: Soluble FasL (sFasL) generating from Membrane-bound FasL (mFasL) cleaved by matrix metalloproteinases (MMPs). sFasL inhibits the apoptotic and inflammatory activity of mFasL because of sFasL competes with the mFasL and binds to Fas. To evaluate serum soluble Fas ligand (sFasL) level in patients with chronic myeloid leukemia. \u0000Materials and Method: Serum levels of sFasL were measured by ELISA method after venous blood was collected from 56 CML patients (newly diagnosed and optimally treated) and 28 healthy subjects as control group. \u0000Results: There were no significant increases in serum sFasL patient compared to healthy control with P=0.07. When the mean sFasL concentration was obviously highest in newly diagnosed (216.9pg/ml) followed by healthy control (152.5pg/ml) and lowest in optimally treated (147.7 pg/ml). \u0000Conclusion: Production of sFasL in tumor patients may be a key mechanism to inhibit Fas-mediated apoptosis. \u0000 ","PeriodicalId":245917,"journal":{"name":"Medical Science Journal for Advance Research","volume":"119 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132996403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Role Of Gamma-Interferon And Interleukin12 In The Pathogenesis Of Rheumatoid Arthritis Patients In Iraq","authors":"Yousif Sahib Fakher","doi":"10.46966/msjar.v3i4.89","DOIUrl":"https://doi.org/10.46966/msjar.v3i4.89","url":null,"abstract":"Background: Objectives:  To evaluate the significant importance of   IFN-y and  IL-12 level   in Rheumatoid Arthritis patients. Material and Methods: A serum sample was collected from two groups. The first group was patients with Rheumatoid Arthritis (RA), the Second group was healthy volunteers. serum of this sample used to detect IFN-y and IL12 level was quantified by using ELISA.  Result: The level of serum INF-gamma was significantly lower in patients with rheumatoid arthritis in comparison with control group, 54.01 (14.81) versus 62.55 (28.11), respectively (p = 0.006) . The level of serum IL-12 was significantly lower in patients with rheumatoid arthritis in comparison with control group, 8.47 (2.44) versus 132.82 (56.30), respectively (p < 0.001).  \u0000Conclusion: On the basis of the current study, the level of serum INF-gamma was significantly lower in patients with rheumatoid arthritis it means have no significant effect on disease susceptibility of patients. This study has found that the level of serum IL-12 was significantly lower in patients with rheumatoid arthritis.","PeriodicalId":245917,"journal":{"name":"Medical Science Journal for Advance Research","volume":"32 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129507992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association Of Cellular Communication Network Factor 3 (CCN3) With Rheumatoid Arthritis Disease And It's Severity (Case-Control Study)","authors":"Nawara Saleem Zayed","doi":"10.46966/msjar.v3i4.85","DOIUrl":"https://doi.org/10.46966/msjar.v3i4.85","url":null,"abstract":"Background: An inflammatory condition that affects the joints in the limbs is rheumatoid arthritis. The most common symptom is chronic, recurrent joint inflammation. When patients are advanced, joint deformities and impairments may cause major impediments in the cardiac, skin, as well as other tissues and organs. A protein called cellular CCN3 is implicated in many biological processes such as cell adhesion, migration, as well as proliferation. Additionally, CCN3 has a role in a number of pathological processes, such as fibrosis, angiogenesis, and wound healing. CCN3 can be released from the cytoplasm. CCN3 may also be an inflammatory component in the course of RA. Future therapy approaches that focus on the activities and mechanisms of action of these proteins may result from better knowledge of how CCN proteins alter the pathophysiological processes underlying these types of arthritis and successfully reduce patients' pain (Wei et al., 2020). It was discovered that RA sera and tissues had increased levels of all CCN family members. IL6 production and CCN3 expression are correlated with disease activity (Giusti & Scotlandi, 2021). \u0000Methods: Between November 2021 and April 2022, a study including 70 patients with RA who met four or more 2010 American College of Rheumatology and European League Against Rheumatism (ACR/EULAR) classification criteria for the condition and 70 healthy persons serving as control groups was conducted. All subjects had their disease activity score (DAS28-ESR), clinical activity index (CDAI), and rheumatoid factors (RF) detected by latex agglutination. By using an enzyme-linked immunosorbent assay, the levels of anti-cyclic citrullinated peptide (ACCP) and CCN3 in human serum samples were determined (ELISA).The age group of both the patients and the controls included in this study was 20-70. RA was found to be high in individuals of the age group >40 years, at a percentage of 71.4%. The mean age was 46.2±10.3 years for patients and 1.7±0.5 for controls.Results:  The results clearly showed high serum CCN3 levels in patient groups with RA compared to control (P = 0.0001). CCN3 and ACCP have a significantly positive association  at control (P = 0.0001). According to DAS28-ESR, there were significantly increased concentrations of  CCN3 in severe patients at  P values of  0.0001 in comparison to mild patients. \u0000Conclusions: The biomarker CCN3 is a good prognostic marker for the severity of RA. \u0000 ","PeriodicalId":245917,"journal":{"name":"Medical Science Journal for Advance Research","volume":"49 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133154346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Awareness Of Thalassemia In Male And Female Students","authors":"Rimsha Qayyum","doi":"10.46966/msjar.v3i4.92","DOIUrl":"https://doi.org/10.46966/msjar.v3i4.92","url":null,"abstract":"Objective:-Objective of this look at is to access the awareness stage of Thalassaemia in University college students. Method:  Study design was chosen to be crosssectional prospective. Sample size for this study was taken as 64.                                . A wellstructured:data collecting form or questionnaire was created, analysedand filled out during the interview.The data was summarized using descriptive statistics. Results The total 64 cases of all age groups were enrolled in this study. The are 64 cases of all age group are involved in this study in which there are 21 male (32.8%) and 43 females (67.2%).  In this survey out of 64 persons 53 persons know about thalassemia. 5 people know about thalassemia gene. 40 persons  know that thalassemia is inherited from parents. 53 persons know that thalassemia is blood related disease. 45 persons know severe anaemia is the clinical presentation of thalassemia. 25 persons know about the permanent treatment of thalassemia. 37 persons know that thalassemia is treated by bone marrowtransplantation.However, the study findings revealed that education status had a substantial impact. \u0000Conclusion:-  Females have more awareness about thalassemia then man.","PeriodicalId":245917,"journal":{"name":"Medical Science Journal for Advance Research","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130954085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Breast Cancer Awareness Survey","authors":"Areej Ilyas","doi":"10.46966/msjar.v3i4.90","DOIUrl":"https://doi.org/10.46966/msjar.v3i4.90","url":null,"abstract":"Background: Breast cancer is the most frequent malignancy among women. Early detection of breast cancer is critical for reducing the disease's morbidity and mortality. Therefore, extreme cautions are required. And if it discovered late, it may have bad prognosis. Objective:  The goal of this study was to establish whether university students were aware of breast cancer, its symptoms, and the risk factors associated with it, as well as the level of knowledge and awareness of BSE and mammography. METHODS:  The current research employed a cross-sectional strategy.A questionnaire was self-administered to all the students. A total of 122 respondents completed the online survey that enrolled in various universities in Punjab. Results:  The age of study participants was ranged between 21_30years.Most of them were aware if breast cancer.(73.8%) (90) of students know about brrast cancer through social media, being the most important source of information.Regardi g different aspect of study 78.7% (96) had the knowlegde of risk factor i.e Breast cancer occur mostly with increasing age.An adequate number if participants 77.9% (95) have the knowlegde of self examination. To educate people about breast cancer, we should host seminars. because raising awareness of cancer is essential for early identification and more proactive health-seeking. Despite the fact that breast cancer is relatively widespread in both developing and wealthy nations, broad public awareness is still low. No matter how old or young a woman is, breast care is a need. \u0000Conclusion:  According to this survey, majority of the participants have basic information about breast cancer and its risk factors. Many participants also know about breast self-examination as it is a simple, quick, non-invasive, and costfree technique for women to check their own breasts for any changes that could be an early indicator of breast cancer in the early stages, when the disease can be treated successfully, boosting the survival rate from breast cancer. any participants also have information about mammography and its advantages in detection of cancer. Hence students are aware of breast cancer.","PeriodicalId":245917,"journal":{"name":"Medical Science Journal for Advance Research","volume":"30 9 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128487931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of IL-β1, PGj2 Among Patient with First Episode Psychosis (Case-control study)","authors":"Sumeiya Mahdi Al Har","doi":"10.46966/msjar.v3i4.77","DOIUrl":"https://doi.org/10.46966/msjar.v3i4.77","url":null,"abstract":"Background: A first episode of psychosis is the primary point in time a person experiences a psychotic period. it is frequently very confusing. frightening and distressing, particularly for the reason that it is an unusual experience. unluckily, there are moreover many negative misconceptions and stereotypes linked with psychosis that can additional to one’s distress. Aim of the study Investigate the association between some inflammatory biomarkers with first episode psychosis (FEP) and to find out the correlation with different socio demographic profile \u0000Methods: A case-control study was involve patients with first episode psychosis and healthy control. peripheral Blood samples collected from 44 cases they were attending AL-Hakeem General hospital, Psychiatric Department, in the period between January, 2019 to may, 2019. the cases included females and  males, and the age was 18-70 years. Control: 44 healthy controls who had no history or clinical evidence of fist episode psychosis or any other disease. \u0000Results:     revealed  that increase in the level of Interlaken β1, and decrease PGJ-2 among FEP patients (1591.8±108.6, and 3.82±0.36) respectively in comparison to control were mean (554.8±54.8,  and 9.94±0.67). \u0000Conclusion: The inflammatory response is an immune system that allow the individual to cope with various menacing advise, but in long-lasting conditions  and pathological, the continuous of this stimulate could develop into harmful. The regulation of the all development involves endogenous counter-balancing mechanisms that control special effects of deleterious pro inflammatory mediators.  information  showing a misbalance in some pro inflammatory/anti inflammatory  in blood of person with FES.","PeriodicalId":245917,"journal":{"name":"Medical Science Journal for Advance Research","volume":"132 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127588700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anti-Carbamylated Protein Antibody Test Accuracy In Some Iraqi Patients With Rheumatoid Arthritis","authors":"Ghasak A Ali","doi":"10.46966/msjar.v3i4.81","DOIUrl":"https://doi.org/10.46966/msjar.v3i4.81","url":null,"abstract":"Background: Rheumatoid arthritis is a persistent, immune-mediated disorder that causes pain, edema, and inflammation in the joints. A genetic history that is high in risk, when paired with genomic markers and environmental exposures, triggers a series of actions that not only results in synovitis and arthritis, but also affects a great number of organs that are not related to the joints. The identification of novel autoantibodies playing key roles in different stages of disease remains an issue of interest for RA. Therefore, autoantibodies are necessary to assist in making a diagnosis and prediction more quickly in RA. Anti-Carbamylated Protein antibodies are a different class of anti- transformed protein antibody that is often found in the blood of RA patients. Objective: Rheumatoid arthritis has a recently discovered biomarker, which is an antibody called anti-carbamylated protein (CarP). Our aim is to evaluate the usefulness of anti-CarP as a diagnostic tool for RA. Participants and methods: The study conducted on 60 people diagnosed with RA as well as 60 people who served as healthy controls. Both the disease activity score (DAS28) and the health assessment questionnaire (HAQ) were evaluated. Estimates were made based on laboratory examinations such as ESR and rheumatoid factor (RF). Anti-CarP and Anti-CCP antibodies were measured by enzyme-linked immune-sorbent assay. Results:Anti-CarP levels were considerably higher in the patients with RA compared to the group that provided as a control (p > 0.000). Therefore, the sensitivity and specificity for anti-CarP antibodies were 39% and 98% respectively, while the sensitivity and specificity for anti-CCP antibodies were 83% and 95% respectively, and for RF were 68% and 83% respectively. The area under the curve (AUC) for anti-CarP antibodies was 0.67. \u0000Conclusions: \u0000Anti-CarP antibodies had comparatively lower sensitivity and slightly higher specificity than Anti-CCP.These findings suggest that anti-CarP antibodies works as an additional role in the diagnosis of RA.","PeriodicalId":245917,"journal":{"name":"Medical Science Journal for Advance Research","volume":"3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129879302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Review On The Role Of Host Immune Response In Protection And Immunopathogenesis During Entamoeba Histolytica","authors":"Eman Hassani ALSalami","doi":"10.46966/msjar.v3i4.84","DOIUrl":"https://doi.org/10.46966/msjar.v3i4.84","url":null,"abstract":"Background: A protozoane parasite callede Entamoeba histolyticae (Eh) infects Entamoebae histolytica (Eh), a protozoane parasite that causese 100,000 deaths per year frome amebic dysentery and/or livere abscess, has infectede 10% of the entire world'se population. Usuallye, this extracellular parasitee colonizes the colone with high affinity bindinge to MUC2 mucin without causing illness symptoms, but occasionally, Eh invades the colonic mucosae and triggers an agressivee inflammatory responsee. The particulare host-parasite variables requirede for illnesse etiologye are still mostlye unknown. The parasite's cysteine proteasee cleaved thee C-terminus ofe MUC2, that causese the mucus layer to dissolve, followede by adsorption and cytotoxicitye of the mucosal epitheliume, are the disease's hallmark eventse that cause the condition to worsene. Every time a host cell that causes tissue injurye comes into contact with the host, the host generates an excessively inefficient pro-inflammatory responsee. They can cause cell death through phagocytosis, apoptosis, or trogocytosise (the absorption of livinge cells), which may be cruciale for immune evasion, as well as othere detrimental effects that are brought on by their attachment to the host cellse. Immune evasion techniquese are used by Eh to survive and induce diseasee manifestation in the host; these techniquese are the main focuse of this reviewe. eAn estimated 100,000 individualse are predicted to die eache year from E. histolytica infectione, which is thoughte to impact 1% of peoplee. Clinicale manifestations of a mebice infection can range frome mild to severee, causing extraintestinal abscessese and diarrhea. Onlye 20% of those whoe are affectede, like othere infectious diseasese, reportedly exhibite symptoms. The outcomee of an infection is controllede by both the genetic makee-up of the parasitee and the host ase well as environmental factors like the microbiome. Amebic infection goes through a number of critical stages, includinge the degeneratione of the mucosale layer and infiltratione into it, adherencee to the intestinal epitheliume, invasion intoe the tissuese, and diffusione to other organs.","PeriodicalId":245917,"journal":{"name":"Medical Science Journal for Advance Research","volume":"16 1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125757181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}