Global Journal of Respiratory Care最新文献_第2页

Intermediate Alpha-1 Antitrypsin Deficiency Can Play a Role in Pulmonary Exacerbation? 中间α -1抗胰蛋白酶缺乏是否在肺恶化中起作用?

Global Journal of Respiratory Care Pub Date : 2021-06-02 DOI: 10.12974/2312-5470.2021.07.01

A. Annunziata, A. Coppola, P. Coni, G. Fiorentino

{"title":"Intermediate Alpha-1 Antitrypsin Deficiency Can Play a Role in Pulmonary Exacerbation?","authors":"A. Annunziata, A. Coppola, P. Coni, G. Fiorentino","doi":"10.12974/2312-5470.2021.07.01","DOIUrl":"https://doi.org/10.12974/2312-5470.2021.07.01","url":null,"abstract":"Background: Alpha-1 antitrypsin deficiency is generally suspected in young patients with pulmonary emphysema or chronic obstructive pulmonary disease (COPD). Patients often suffer from diagnostic delays or are misdiagnosed, for example, with COPD, asthma, or airway hyperresponsiveness because of the nonspecific nature of respiratory symptoms recognised with Alpha-1 antitrypsin deficiency (AATD). These pathologies develop in homozygous patients (both compromised alleles) with severely deficient protein; however, they are also frequently observed in heterozygous patients (only one compromised allele) for the gene mutation with a more or less deficient protein and functional anatomical damage of varying severity depending on the type of mutation and the exposure to environmental risk factors and/or professional that can trigger the repeated injurious inflammatory process. Case Description: We describe two cases of late diagnosis of alpha-1 antitrypsin deficiency, with many exacerbations and intermediate level of alpha-1 antitrypsin. Due to the peculiar clinical history, and the PLowell rare mutation, although intermediate AATD, the patients were subjected to replacement therapy and they obtained clinical improvement. Discussion: Both the cases carried a heterozygous PLowell mutation representing two interesting and rare examples of clinical cases with double heterozygosity. The presence in the other AAT allele of the S-mutation in the first case and a concomitant presence of another mutation in the cystic fibrosis gene in the second case contributed to the protease-antiprotease imbalance and, despite intermediate AATD, was the probable cause of the numerous exacerbations. Conclusion: Alpha-1 antitrypsin deficiency should always be suspected in patients with respiratory disease and an unclear or complex clinical history. It may be useful to recognize and evaluate treatment even outside the established parameters, in selected cases. ","PeriodicalId":245488,"journal":{"name":"Global Journal of Respiratory Care","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129770592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Effects of Covid-19 in Respiratory Functions and Exercise Capacity: A Pilot Study in Young Adults Covid-19对呼吸功能和运动能力的影响:一项针对年轻人的试点研究

Global Journal of Respiratory Care Pub Date : 2021-06-02 DOI: 10.12974/2312-5470.2021.07.03

B. Akıncı, B. Kaya, E. Kısa, A. Koçyiğit, Z. Hoşbay, A. Ozdincler

{"title":"The Effects of Covid-19 in Respiratory Functions and Exercise Capacity: A Pilot Study in Young Adults","authors":"B. Akıncı, B. Kaya, E. Kısa, A. Koçyiğit, Z. Hoşbay, A. Ozdincler","doi":"10.12974/2312-5470.2021.07.03","DOIUrl":"https://doi.org/10.12974/2312-5470.2021.07.03","url":null,"abstract":"Background: The impact of coronavirus (COVID-19) on the pulmonary system and exercise capacity of young adults is important in terms of early detection of the existing or future chronic disease risk and secondary prevention. Objective: To compare the respiratory functions and exercise capacity of young adults who recovered from COVID-19 with healthy peers. Methods: Fifteen individuals (7 male, 8 female) aged 18-25 years, diagnosed with COVID-19 and at least 8 weeks passed after diagnosis (mean time: 239.13±135.77 days; min-max: 67-494 days) were included in the study. Age-sex matched 14 individuals (6 males, 8 females) without any diagnosis of COVID-19 and not been under quarantine because of COVID-19 were invited to the study as a control group. Respiratory functions (FEV1, FVC, FEV1/FVC, PEF) and mouth pressures (maximal inspiratory pressure-MIP, maximal expiratory pressure-MEP) were. Submaximal exercise capacity was evaluated with the “6-minutes walking test”. The lower extremity muscle functions were determined with the “1-minute sit to stand test\". Results: All subjects were treated at home and fatigue (46%), persistent (40%) cough were the most reported ongoing symptoms in subjects who had COVID-19. Ground-glass appearance consistent with viral pneumonia was detected in radiological imaging of 3 (20%) subjects. The 6-minutes walking distance (p=0.037) and the number of sit-stands for 1 minute (p=0.007) were significantly lower in patients who had COVID-19 than age-gender matched healthy controls. Conclusion: The results of our study show that exercise capacity and muscle strength may be affected in young adults with mild COVID-19 compared to their peers.","PeriodicalId":245488,"journal":{"name":"Global Journal of Respiratory Care","volume":"4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121225178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Changes in Respiratory Function and Physical Capacity among Smokers after Switching to IQOS: One Year Follow-Up 吸烟者改用IQOS后呼吸功能和体能的变化:一年随访

Global Journal of Respiratory Care Pub Date : 2020-10-19 DOI: 10.12974/2312-5470.2020.06.03

A. Sharman, T. Nurmagambetov

{"title":"Changes in Respiratory Function and Physical Capacity among Smokers after Switching to IQOS: One Year Follow-Up","authors":"A. Sharman, T. Nurmagambetov","doi":"10.12974/2312-5470.2020.06.03","DOIUrl":"https://doi.org/10.12974/2312-5470.2020.06.03","url":null,"abstract":"Background: Combustible cigarettes (CC) smoking is a common risk factor for chronic obstructive pulmonary disease (COPD), which is the fourth leading cause of death in Kazakhstan. Switching to “heat-not-burn” tobacco products (IQOS) has been shown to have less deleterious health effect compared to CC for those who cannot quit smoking. The goal of the study was to explore respiratory and physical effects of switching from CC to IQOS in a population of long-time smokers in Kazakhstan. Methods: Two cohorts of men and women aged between 40 and 59 residing in Almaty (a large two-million city of Kazakhstan) were recruited into two cohort of 801 CC smokers and 400 IQOS users and matched by gender, age, education, and smoking history. Analyses also included 627 CC smokers and 308 IQOS users who maintained their tobacco product use during the first year of observation. Spirometry measurements and the 6-minute walk test (6MWT) were performed as a part of the baseline and one-year comprehensive assessments. In addition to spirometry, clinical assessments included components of metabolic syndrome and anthropometry. For comparative analysis between two cohorts Student’s t-test and Chi-squared tests were used. Results: We observed significantly better outcomes for IQOS users in most of CAT scores, spirometry outcomes, and in some metabolic syndrome components. Although changes in the results between the baseline and the one-year assessments show comparable results, smokers of CC often show significantly faster decline in the health status compared to IQOS. Specifically, the changes in CAT score and in spirometry FEV1 over FVC ratios were worsening at higher pace for CC smokers compared to IQOS users. Conclusions: After one year of observation IQOS users demonstrated better outcomes for most of CAT scores and in the ratio of FEV1 over FVC in comparison to CC smokers.","PeriodicalId":245488,"journal":{"name":"Global Journal of Respiratory Care","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129324246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Negative Expiratory Pressure (NEP) Technique and Anthropometric Derived Indices as Surrogate Markers for Predicting Obstructive Sleep Apnea Syndrome (OSAS) 呼气负压(NEP)技术和人体测量衍生指数作为预测阻塞性睡眠呼吸暂停综合征(OSAS)的替代指标

Global Journal of Respiratory Care Pub Date : 2019-01-03 DOI: 10.12974/2312-5470.2017.04.1

George Chras

引用次数: 0

Prevalence of Specific IgE to Dust and Storage Mites in Patients from Buildings with Moisture Damage Using Pharmacia- and DPC-Specific IgE Immunoglobulin Assays 用药理学和dpc特异性IgE免疫球蛋白测定湿气损伤建筑物患者对灰尘和储存螨的特异性IgE的流行

Global Journal of Respiratory Care Pub Date : 2019-01-03 DOI: 10.12974/2312-5470.2018.05.2

S. Pennanen

引用次数: 0

Can Increased Endotoxin Levels in House Dust be used as an Indicator of a Mould Problem? 室内灰尘中内毒素水平的增加可以作为霉菌问题的一个指标吗?

Global Journal of Respiratory Care Pub Date : 2019-01-03 DOI: 10.12974/2312-5470.2018.05.1

H. Mussalo-Rauhamaa

引用次数: 0

Bronchopulmonary Complications of Nasogastric tube Placement 鼻胃管置入的支气管肺并发症

Global Journal of Respiratory Care Pub Date : 2014-02-05 DOI: 10.12974/2312-5470.2014.01.01.3

J. Schreiber, T. Hachenberg, S. Föllner, S. Riedel

引用次数: 6

New Oral Anticoagulants for Acute and Long-Term Treatment of Haemodynamically Stable Pulmonary Embolism 新型口服抗凝剂用于血流动力学稳定型肺栓塞的急性和长期治疗

Global Journal of Respiratory Care Pub Date : 2014-02-05 DOI: 10.12974/2312-5470.2014.01.01.1

L. Masotti, G. Lorenzini, G. Landini, Niccolò Bettoni, G. Panigada, R. Cappelli

{"title":"New Oral Anticoagulants for Acute and Long-Term Treatment of Haemodynamically Stable Pulmonary Embolism ","authors":"L. Masotti, G. Lorenzini, G. Landini, Niccolò Bettoni, G. Panigada, R. Cappelli","doi":"10.12974/2312-5470.2014.01.01.1","DOIUrl":"https://doi.org/10.12974/2312-5470.2014.01.01.1","url":null,"abstract":"Historically, standard treatment of haemodynamically stable pulmonary embolism (PE) in the acute phase consists in parenteral anticoagulants overlapped with oral anticoagulants vitamin K antagonists (VKAs) for at least 5-7 days followed by VKAs alone when their therapeutic range is reached and prolonged for at least three-six months (long term phase). However standard treatment has many pharmacological and practical limitations. For overcoming these limitations, new anticoagulant drugs with better pharmacological profile and easier to use, have been manufactured and tested in pre-clinical and clinical trials with the aim to reach at least non inferiority compared to standard treatment.\u0000In the setting of PE, new oral anticoagulants (NOACs), direct inhibitors of thrombin (dabigatran) or activated factor X (apixaban, edoxaban, rivaroxaban) have been tested in the acute and long-term phases of treatment in phase III randomized clinical trials (RCTs). Rivaroxaban (EINSTEIN-PE study) and apixaban (AMPLIFY study) have been tested directly from diagnosis, dabigatran (RE-COVER I and II studies) and edoxaban (HOKUSAI study) starting after 7-10 days of standard treatment. Overall, these trials have demonstrated that NOACs are effective and safe at least as standard treatment, promising a revolutionary approach to PE treatment in acute/sub-acute PE based on single drug approach or rapid switch from parenteral to oral anticoagulation.\u0000In this paper the Authors focus on phase III RCTs on NOACs in the acute and long-term phases of PE treatment, highlighting the first two weeks of treatment. ","PeriodicalId":245488,"journal":{"name":"Global Journal of Respiratory Care","volume":"7 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121329073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

The Familial Occurrence of Obstructive Sleep Apnoea Syndrome (OSAS) 阻塞性睡眠呼吸暂停综合征(OSAS)的家族性发生

Global Journal of Respiratory Care Pub Date : 2014-02-05 DOI: 10.12974/2312-5470.2014.01.01.4

P. Bielicki, T. Przybyłowski, R. Chazan

{"title":"The Familial Occurrence of Obstructive Sleep Apnoea Syndrome (OSAS) ","authors":"P. Bielicki, T. Przybyłowski, R. Chazan","doi":"10.12974/2312-5470.2014.01.01.4","DOIUrl":"https://doi.org/10.12974/2312-5470.2014.01.01.4","url":null,"abstract":"The aim of the study was to compare the incidence of obstructive sleep apnoea/hypopnoea syndrome (OSAS) in relatives of subjects with OSAS and in relatives without OSAS but with clinical symptoms of this disease. The study group consisted of 186 relatives of patients with OSAS and 117 relatives of patients with symptoms of OSAS in whom the disease was not confirmed by polysomnography. They were all mailed a questionnaire with questions concerning anthropometric data, the presence of symptoms typical for OSAS and the presence of concomitant diseases. Analysis of the obtained data revealed an increased frequency of snoring, sleep apnea and nycturia in the relatives of patients with OSAS when compared to relatives of patients without OSAS, but the difference was not statistically significant. The incidence of daytime OSAS symptoms was significantly higher in the group of relatives of patients with OSAS. No differences in the incidence of arterial hypertension, ischemic heart disease and diabetes mellitus were found.\u0000In order to confirm the presence of OSAS in family members with typical symptoms, we performed polysomnography. Were diagnosed OSAS in 20 (29.4 %) relatives of patients with OSAS and only in 8 (18.2) relatives of patients without OSAS.\u0000These results confirm the increased incidence of OSAS in patients with a family history of this disease. ","PeriodicalId":245488,"journal":{"name":"Global Journal of Respiratory Care","volume":"5 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122967585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tolerability of Broncho-Alveolar Lavage in Ventilated Patients with Acute Lung Injury 急性肺损伤通气患者支气管肺泡灌洗的耐受性

Global Journal of Respiratory Care Pub Date : 2014-02-05 DOI: 10.12974/2312-5470.2014.01.01.2

A. Medford, A. Millar

{"title":"Tolerability of Broncho-Alveolar Lavage in Ventilated Patients with Acute Lung Injury ","authors":"A. Medford, A. Millar","doi":"10.12974/2312-5470.2014.01.01.2","DOIUrl":"https://doi.org/10.12974/2312-5470.2014.01.01.2","url":null,"abstract":"Broncho-alveolar lavage (BAL) is an important diagnostic tool in many areas of thoracic medicine. On the intensive care unit (ICU), BAL is often required for a variety of indications, including assessment of possible ventilator-associated pneumonia (VAP). Recent data suggest BAL may be superior to less invasive techniques in the assessment of VAP. Older studies have highlighted potential concerns over the safety of BAL in ICU patients but this has not been confirmed in more recent studies in patients with acute respiratory distress syndrome (ARDS). This prospective cohort study aimed to clarify the tolerability of BAL in 162 ventilated ICU patients with ARDS and possible VAP.\u0000BAL was tolerated very well with only 2 patients (1.2%) demonstrating a mild desaturation (fall of 6% in oxygen saturation) due to 1 episode of bronchospasm and secretion retention respectively which were resolved quickly. No major complications or deaths occurred and BAL samples were obtained for microbial analysis in all patients. We conclude BAL is well tolerated in carefully selected and prepared ventilated ICU patients with ARDS in whom VAP is being considered. Further large scale controlled studies comparing BAL to less invasive techniques are indicated in this cohort. ","PeriodicalId":245488,"journal":{"name":"Global Journal of Respiratory Care","volume":"24 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127148529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2