The Journal of Basic and Clinical Health Sciences最新文献_第2页

Lu-177 PSMA I&T Therapy for Prostate Cancer; Treatment Response, Treatment Toxicity, and Survival Results Lu-177 PSMA I&T治疗前列腺癌治疗反应、治疗毒性和生存结果

The Journal of Basic and Clinical Health Sciences Pub Date : 1900-01-01 DOI: 10.30621/jbachs.2019.708

E. Acar, Burak Sönmezer, E. Derebek, R. Bekiş, O. Ozdoğan, G. Kaya

{"title":"Lu-177 PSMA I&T Therapy for Prostate Cancer; Treatment Response, Treatment Toxicity, and Survival Results","authors":"E. Acar, Burak Sönmezer, E. Derebek, R. Bekiş, O. Ozdoğan, G. Kaya","doi":"10.30621/jbachs.2019.708","DOIUrl":"https://doi.org/10.30621/jbachs.2019.708","url":null,"abstract":"Purpose: This study aims to evaluate the serum PSA response, Ga-68 PSMA PET/CT response, hematological/nephrological toxicity and survival results of patients with castration-resistant metastatic prostate cancer who are receiving Lu-177 PSMA therapy. Methods: The data of 57 patients with a mean age of 68 years who were treated with Lu-177 PSMA I&T were retrospectively reviewed. Secondary toxicity to treatment was determined using the criteria of the Common Toxicity Criteria for Adverse Events v5.0. The Kaplan Meier method was used for survival and progression-free survival analysis. Results: Forty percent of patients’ serum PSA values’ showed >25% regression after the first cycle of treatment. Serum PSA values were stable/ regressed in 75% of the patients. While 2/57 patients showed grade 3 anemia, none showed grade 3 leukopenia or thrombocytopenia. One of 57 patient showed transient nephrotoxicity. Hematological and nephrological toxicity were not observed after treatment of eight cycles, and the serum PSA values of the patients were decreased by 97%. The mean survival time was 11.6 months in all patients, and 17.2 months in patients with serum PSA response. Progression-free survival was an average of 9.9 months. Conclusion: Providing a stable or regressed disease via single cycle treatment in 75% of patients with progression despite the treatments improving survival is an indicator of the success of the therapy. The low rate of hematological and nephrological toxicity in patients (none of the patients that received eight cycles) suggests that the treatment is reliable. Survival was longer in patients with serum PSA response after treatment.","PeriodicalId":245385,"journal":{"name":"The Journal of Basic and Clinical Health Sciences","volume":"30 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126363903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Initial Next-Generation Sequencing (NGS) Results of Alport Syndrome Alport综合征的初始新一代测序(NGS)结果

The Journal of Basic and Clinical Health Sciences Pub Date : 1900-01-01 DOI: 10.30621/jbachs.2019.719

A. Koç, E. Bora, Tayfun Çinleti, Gizem Yıldız, M. Bayram, Ö. Bozkaya, Ayfer Ülgenalp

引用次数: 1

The Aspects of Psychosocial Risks Prevention in a Developing Country: Turkey 发展中国家的心理社会风险预防:土耳其

The Journal of Basic and Clinical Health Sciences Pub Date : 1900-01-01 DOI: 10.30621/JBACHS.2019.511

Ceyda Şahan, Y. Demi̇ral

引用次数: 1

Evaluation of Analytical Process Performance by Six Sigma Method 用六西格玛方法评价分析过程绩效

The Journal of Basic and Clinical Health Sciences Pub Date : 1900-01-01 DOI: 10.30621/jbachs.2019.732

Dilek İren Emekli, Nergiz Zorbozan, Z. Erbayraktar

{"title":"Evaluation of Analytical Process Performance by Six Sigma Method","authors":"Dilek İren Emekli, Nergiz Zorbozan, Z. Erbayraktar","doi":"10.30621/jbachs.2019.732","DOIUrl":"https://doi.org/10.30621/jbachs.2019.732","url":null,"abstract":"Purpose: Clinical laboratories are responsible for producing reliable, reproducible and accurate test results. Should establish quality in their test analysis and evaluate process performance. Six sigma is a quality management strategy that evaluation of processes. The aim of our study is to evaluate the analytical process performance of routine tests in our laboratory with six sigma method. Methods: Internal quality control (IQC) data of routine tests in our laboratory were obtained retrospectively. Mean, standard deviation and coefficient of variation (CV) values of the IQC data were calculated. Process sigma values were calculated using the formula “Total Allowable Error (TEa)%-Bias% /CV% “. TEa values were determined according to CLIA’88. Sigma value ≤3 low quality, between 3 and 6 good quality and ≥6 was recognized as world class quality. Results: The sigma levels of all the tests we evaluated were >3. Sigma levels of albumin, creatinine, LDL, urea, chloride, total cholesterol, HDL, sodium for IQC 1; albumin, urea, UIBC, chloride, creatinine, potassium, sodium and direct bilirubin for IQC2 were between 3–6. The sigma levels of ALP, ALT, AST, CK, CKMB, iron, UIBC, phosphorus, GGT, glucose, calcium, LDH, magnesium, potassium, total protein, triglyceride, uric acid, amylase, lipase, direct bilirubin, total bilirubin, CRP for IQC 1; ALP, ALT, AST, CK, CK-MB, iron, phosphorus, GGT, glucose, calcium, total cholesterol, HDL, LDL, LDH, magnesium, total protein, triglyceride, uric acid, amylase, lipase, total bilirubin, CRP tests for IQC 2 were ≥6. Conclusion: Six sigma methodology is an effective method for evaluating the analytical process performance of the laboratory. According to the results of our study, our laboratory performance is good or first class.","PeriodicalId":245385,"journal":{"name":"The Journal of Basic and Clinical Health Sciences","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130375873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Effects of Muscle Strength and Muscle Endurance on Upper Extremity Functions of Lateral Epicondylitis Patients 肌肉力量和耐力对外上髁炎患者上肢功能的影响

The Journal of Basic and Clinical Health Sciences Pub Date : 1900-01-01 DOI: 10.30621/JBACHS.2019.503

Golgem Mehmetoglu, Gülbin Ergin, Serkan Bakırhan

引用次数: 2

Correlation Between CT-Simulator and Dynamic Magnetic Resonance Images in Determining The Location of Gross Tumor Volume in Radiotherapy Treatment Planning for Lung Cancer ct模拟器与动态磁共振成像在肺癌放疗计划中确定肿瘤总体积位置的相关性

The Journal of Basic and Clinical Health Sciences Pub Date : 1900-01-01 DOI: 10.30621/jbachs.2019.517

Sevecen Seyhun Nasir, A. Yurt, N. Karabay, C. Umay, Barbaros Aydin, A. Demi̇ral

引用次数: 0

Antimicrobial Effect of Piceatannol, a Resveratrol Metabolite, on Staphylococcus Aureus 白藜芦醇代谢物皮杉醇对金黄色葡萄球菌的抗菌作用

The Journal of Basic and Clinical Health Sciences Pub Date : 1900-01-01 DOI: 10.30621/jbachs.2019.745

N. Güldaş, T. Uysal, H. Ellidokuz, Y. Başbınar

{"title":"Antimicrobial Effect of Piceatannol, a Resveratrol Metabolite, on Staphylococcus Aureus","authors":"N. Güldaş, T. Uysal, H. Ellidokuz, Y. Başbınar","doi":"10.30621/jbachs.2019.745","DOIUrl":"https://doi.org/10.30621/jbachs.2019.745","url":null,"abstract":"Objectives: Staphylococcus aureus (S. aureus) is one of the major human pathogens in both community acquired and nosocomial infections. Heavy increase of antibiotic resistance between S. aureus strains became an important public health problem in progress of time. In this study, the antimicrobial effects of piceatannol on S. aureus growth was investigated. Patients and Methods: The antimicrobial effect of piceatannol on a standard S. aureus (DSMZ 6148) strain and two clinical S. aureus strains (C1 and C2) was tested in vitro at concentrations between 0 and 750 μg/ mL. Tigecycline and gentamicin were used as positive controls. For each strain, the minimum inhibitory concentration (MIC) and the minimum bactericidal concentration (MBC) values of piceatannol and the control antibiotics were determined separately using the broth microdilution method according to CLSI (Clinical and Laboratory Standards Institute) standards at 24 and 48 h. Results: After 24 and 48 h of treatment with piceatannol, the average MIC for all tested strains was 283 μg/mL and 383 μg/mL, respectively. Bactericidal activity increased as piceatannol concentration increased for one of the three strains. After 24 and 48 h of treatment with piceatannol, the average MBC for all strains was 717 μg/ mL and 583 μg/ mL, respectively. The S. aureus strains were found to be susceptible to tigecycline and gentamicin. Conclusion: Piceatannol has antimicrobial effect against S. aureus; however, more data regarding the effects of this compound on other microorganisms and its bioavailability are needed.","PeriodicalId":245385,"journal":{"name":"The Journal of Basic and Clinical Health Sciences","volume":"11 33","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"120853448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

The Relationship Between Psychological Resilience and Social Support Levels in Hemodialysis Patients 血液透析患者心理弹性与社会支持水平的关系

The Journal of Basic and Clinical Health Sciences Pub Date : 1900-01-01 DOI: 10.30621/JBACHS.2019.469

E. Karadağ, O. Ugur, H. Mert, Merve Erunal

{"title":"The Relationship Between Psychological Resilience and Social Support Levels in Hemodialysis Patients","authors":"E. Karadağ, O. Ugur, H. Mert, Merve Erunal","doi":"10.30621/JBACHS.2019.469","DOIUrl":"https://doi.org/10.30621/JBACHS.2019.469","url":null,"abstract":"Purpose: This study was conducted to determine the relationship between psychological resilience and social support in hemodialysis patients in Turkey. Methods: This descriptive, comparative, cross-sectional, and correlational study was conducted with 100 patients who underwent hemodialysis treatment at a university hospital between September and December 2016. In the study, a questionnaire form including sociodemographic data as well as data regarding the disease, the Resilience Scale for Adults (RSA) and the Multidimensional Scale of Perceived Social Support (MSPSS) were used. For statistical evaluation, the Mann-Whitney U-test, the independent t-test, the Kruskal-Wallis test, and the Pearson’s correlation analysis were used for statistical evaluation. Results: A very strong and significant relationship was found between the multidimensional perceived social support scale and the resilience mean scores (r=0.78, p<0.001). It was determined that the patients perceived the highest support from their families which was followed by friends and private support respectively. Conclusion: HD nurses should routinely diagnose the psychological resilience status and social support status of HD patients. Initiatives to promote psychological resilience and mobilize social support resources should be reflected and applied in their nursing care plans.","PeriodicalId":245385,"journal":{"name":"The Journal of Basic and Clinical Health Sciences","volume":"99 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124097471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 15

Evaluation of Changes in The Hematological Parameters, Lipid Profile and Depressive Symptoms Before and After Smoking Cessation Treatment 评价戒烟前后血液参数、血脂和抑郁症状的变化

The Journal of Basic and Clinical Health Sciences Pub Date : 1900-01-01 DOI: 10.30621/jbachs.2019.723

Fatma Dağıstan, R. Kutlu

{"title":"Evaluation of Changes in The Hematological Parameters, Lipid Profile and Depressive Symptoms Before and After Smoking Cessation Treatment","authors":"Fatma Dağıstan, R. Kutlu","doi":"10.30621/jbachs.2019.723","DOIUrl":"https://doi.org/10.30621/jbachs.2019.723","url":null,"abstract":"Introduction: Tobacco dependence is a cluster of behavioural, cognitive, and physiological phenomena. We aimed to investigate the changes in the hematological parameters, lipid profile and depressive symptoms before and after smoking cessation. Methods: In this intervention study, 150 cases admitted to the clinic to quit smoking and stopped smoking for at least three months were investigated. All participants have received motivational interview and appropriate medical treatment (varenicline, bupropion, nicotine replacement therapy). We designed the study to evaluate the effects of cigarette smoking on some biochemical markers and depressive symptoms. Results: Motivational interviews were conducted on all participants, and 68,7% (n = 103) were treated with varenicline, 19,3% (n=29) with bupropion and 12% (n=18) with nicotine replacement therapy (NRT). There was a statistically significant relationship between the treatment method and the smoking cessation duration (p=0.002). Cessation period was longer in the group using varenicline. After quitting smoking, the Beck Depression Scores (BDS) decreased significantly (p<0.001). In cases with smoking duration between 3-6 months, the levels of carbon monoxide (CO) (p<0.001), white blood count (WBC) (p<0.001), hematocrit (p=0.003), hemoglobin (Hb) (p=0.002) and mean corpuscular volume (MCV) (p<0.001) decreased significantly. Conclusions: In our study, positive changes were observed in hematologic, biochemical parameters and depressive symptoms after quitting smoking. So, it is important that the society should be informed about the dangers of smoking. In particular, primary health care physicians should ask each patient whether they smoke or not, and encourage to quit smoking.","PeriodicalId":245385,"journal":{"name":"The Journal of Basic and Clinical Health Sciences","volume":"66 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127587483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Overview of Paramedic Quotas at Universities and Number of Health Technician Staff in Turkey Between the Years 2008-2018 2008-2018年土耳其大学护理人员配额和卫生技术人员数量概述

The Journal of Basic and Clinical Health Sciences Pub Date : 1900-01-01 DOI: 10.30621/jbachs.2019.779

Ahu Pakdemirli

{"title":"Overview of Paramedic Quotas at Universities and Number of Health Technician Staff in Turkey Between the Years 2008-2018","authors":"Ahu Pakdemirli","doi":"10.30621/jbachs.2019.779","DOIUrl":"https://doi.org/10.30621/jbachs.2019.779","url":null,"abstract":"Objectives:Over the years the number of paramedic programs and student quotas increased at universities. The aim of this study was to investigate the quota status and program numbers of the universities in Turkey and Turkish Republic of Northern Cyprus (KKTC) and ‘Health Technician’ staff announcements between the years 2008-2018. Patients and Methods:The data was taken from Turkish Republic assessment selection and placement center. Emergency and First Aid programs between 20082018 in Turkey and Turkish Republic of Northern Cyprus including formal education and evening education and quota status of state universities and foundation universities and also ‘Health Technician’ staff announcements between the years 2008-2018 were examined. Results:In 2008, the number of programs was 29, while the total quota was 711; in 2018, the number of programs increased to 324 and the total quota increased to 11829. In the 10-year period, the average annual quota increase rate was 77% for public universities and 75% for foundation universities. Conclusion:In this study, the number of students and programs in Turkey and the Turkish Republic of Northern Cyprus universities Health Services Vocational School Paramedic Programs and health technician staff announcement has been investigated. There was no significant difference between the public and the foundation universities in terms of quota change rates (p> 0.05). First and Emergency Aid programs and quotas have increased continuously over the years. No significant difference was found as a result of the evaluation of the number of programs and quotas with the number of public personnel appointments of the graduates of the department.","PeriodicalId":245385,"journal":{"name":"The Journal of Basic and Clinical Health Sciences","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129195636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1