Pulmonology and allergology最新文献

Metastazavusio nesmulkiųjų ląstelių plaučių vėžio gydymas pembrolizumabu ir chemoterapija. Klinikinės praktikos tyrimo duomenys 用pembrolizumab和化疗治疗转移性非小细胞肺癌。临床实践研究数据

Pulmonology and allergology Pub Date : 2024-05-23 DOI: 10.37499/pia.1430

Neringa Vagulienė

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Asthma: a New Approach to the Bronchial Epithelium 哮喘：支气管上皮的新方法

Pulmonology and allergology Pub Date : 2024-05-23 DOI: 10.37499/pia.1425

Andrius Januškevičius, Eglė Vasylė, Kęstutis Malakauskas

{"title":"Asthma: a New Approach to the Bronchial Epithelium","authors":"Andrius Januškevičius, Eglė Vasylė, Kęstutis Malakauskas","doi":"10.37499/pia.1425","DOIUrl":"https://doi.org/10.37499/pia.1425","url":null,"abstract":"The bronchial epithelium serves as a critical defense line against environmental insults, acting not merely as a barrier but as a complex, dynamic system enriched with diverse cell types such as ciliated cells, goblet cells, and basal cells. Recent advancements in single-cell ribonucleic acid (RNA) sequencing have further unveiled the complexity of this layer by identifying additional cell types like ionocytes, neuroendocrine cells, tuft cells, deuterosomal cells, club cells and mucus ciliated cells. These cells collectively maintain respiratory health through various mechanisms including the mucociliary escalator, mucus production, airway repair, and immune modulation. Disruptions in the epithelial barrier can lead to respiratory diseases like asthma, highlighting the importance of understanding these intricate cellular relationships for developing targeted therapies. This epithelial complexity is crucial for pulmonary homeostasis and the pathogenesis of asthma, where abnormal epithelial remodeling and dysfunction are central. The identification of a novel mucous ciliated cell state in asthma, co-expressing genes associated with both ciliated and goblet cells, offers new insights into the disease’s pathogenesis and therapeutic targets. The epithelial barrier’s integrity, maintained by tight junctions and adherents’ junctions, is essential for protecting the underlying tissue from environmental threats. However, in asthma, this barrier is compromised, leading to increased allergen permeability, airway hyperresponsiveness, inflammation, and remodeling. Despite advances, the need for novel concepts in asthma pathogenesis remains, particularly to address the limitations of the current T helper 2-dominant paradigm in explaining the connection between airway inflammation and remodeling. Understanding the molecular mechanisms underlying epithelial barrier dysfunction could pave the way for novel asthma treatments focused on enhancing barrier integrity, ultimately improving patient outcomes.","PeriodicalId":244051,"journal":{"name":"Pulmonology and allergology","volume":"37 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141107877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Fizinio krūvio sukelta bronchokonstrikcija 运动引起的支气管收缩

Pulmonology and allergology Pub Date : 2024-05-23 DOI: 10.37499/pia.1421

Laima Kondratavičienė

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Cistinės fibrozės diagnostika ir specifinės su liga susijusios būklės 诊断囊性纤维化和特定疾病相关情况

Pulmonology and allergology Pub Date : 2024-05-23 DOI: 10.37499/pia.1423

Virginija Kalinauskaitė-Žukauskė

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Itin smulkių dalelių trijų vaistų derinio veiksmingumas, gydant lėtinę obstrukcinę plaučių ligą. „TriOptimize“ tyrimo duomenys 超微粒子三药联合疗法治疗慢性阻塞性肺病的疗效。"来自 TriOptimize 研究的数据

Pulmonology and allergology Pub Date : 2024-05-23 DOI: 10.37499/pia.1428

Virginija Kalinauskaitė-Žukauskė

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Idiopatinės plaučių fibrozės gydymo siekiai. Klinikinis atvejis 特发性肺纤维化的治疗目标。临床病例

Pulmonology and allergology Pub Date : 2024-05-23 DOI: 10.37499/pia.1424

Gediminas Vasiliauskas

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Sunkios eozinofilinės astmos biologinė terapija interleukino-5 monokloniniu antikūnu mepolizumabu, sergant gretutinėmis ligomis 使用白细胞介素-5单克隆抗体mepolizumab对合并严重嗜酸性粒细胞哮喘进行生物治疗

Pulmonology and allergology Pub Date : 2024-05-23 DOI: 10.37499/pia.1431

Ieva Dimienė

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The Role of the Allergist in the Management of Chemotherapy-Induced Hypersensitivity Reactions 过敏症医生在化疗引起的超敏反应管理中的作用

Pulmonology and allergology Pub Date : 2024-05-23 DOI: 10.37499/pia.1426

Edgars Schlomo Atias, Justina Šematonytė

{"title":"The Role of the Allergist in the Management of Chemotherapy-Induced Hypersensitivity Reactions","authors":"Edgars Schlomo Atias, Justina Šematonytė","doi":"10.37499/pia.1426","DOIUrl":"https://doi.org/10.37499/pia.1426","url":null,"abstract":"Chemotherapy-Induced Hypersensitivity Reactions are one of the main problems for oncology physicians and chemotherapy patients. The hypersensitivity reaction can either cause the cessation of the first-line treatment and it may impair the final result and impede or decrease the chances for successful treatment. Chemotherapy drugs are foreign substances that are capable to inducing the various hypersensitivity reactions from mild cutaneous symptoms to severe respiratory distress and cardiovascular collapse. The original Gell and Coomb’s classification categorizes hypersensitivity reactions into four types according to the type of immune response and the effector mechanism responsible for cell and tissue injury. The most common reactions are caused by platinum compounds, taxanes, epipodophyllotoxins, and asparaginase. The use of biologicals is increasing now, and these drugs are frequent causes of hypersensitivity reactions too. Skin testing is a method of diagnosing drug hypersensitivity, but it has not been developed enough in the field of medical oncology where a variety of the antineoplastic agents may be caused hypersensitivity reactions. Drug desensitization is the benefitial therapy in patients with chemotherapyinduced hypersensitivity reactions to chemotherapeutic drugs. This is useful for chemotherapy patients with malignancies and hematological diseases when no comparable alternative is available.","PeriodicalId":244051,"journal":{"name":"Pulmonology and allergology","volume":"14 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141105523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Plaučių pažeidimas, sergant pirminiu humoraliniu imunodeficitu 原发性体液免疫缺陷症的肺损伤

Pulmonology and allergology Pub Date : 2024-05-23 DOI: 10.37499/pia.1422

Egidija Kukarskytė, Marius Šukys, Jurgita Zaveckienė, Valdas Šarauskas, Ieva Bajoriūnienė

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Idiopatinės plaučių fibrozės ir progresuojančios plaučių fibrozės diagnostikos ir gydymo rekomendacijos 2024 m 特发性肺纤维化和进行性肺纤维化诊断和治疗指南 2024

Pulmonology and allergology Pub Date : 2024-05-23 DOI: 10.37499/pia.1419

Kęstutis Malakauskas (redaktorius), Kristina Biekšienė, Jurgita Zaveckienė, Lina Poškienė, Laima Dobrovolskienė, Valdas Šarauskas, Marius Žemaitis, Skaidrius Miliauskas

引用次数: 0