{"title":"Dr. Wu: a beautiful, moving and meditative song -- in memory of Dr. Jing Nuan Wu, a pioneer of acupuncture and a Chinese medicine doctor in the United States.","authors":"Arthur Yin Fan, Ziyi Fan","doi":"10.3736/jcim20120801","DOIUrl":"https://doi.org/10.3736/jcim20120801","url":null,"abstract":"","PeriodicalId":23993,"journal":{"name":"Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine","volume":"10 8","pages":"837-40"},"PeriodicalIF":0.0,"publicationDate":"2012-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30826492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Traditional Chinese medicine constitution types in 127 elderly patients with insomnia: an investigation in communities of Yangpu District, Shanghai].","authors":"Chen Xia, Qun-bang Zhu, Feng Huang, Jing-hui Huang, Hong-da Chen, Ming-jun Chen, Wei Gu, Bai Li, Fan-fu Fang, Liang-neng Wu","doi":"10.3736/jcim20120806","DOIUrl":"https://doi.org/10.3736/jcim20120806","url":null,"abstract":"<p><strong>Objective: </strong>To analyze the distribution of traditional Chinese medicine constitution types in elderly patients with insomnia.</p><p><strong>Methods: </strong>The epidemiological data were collected from communities in the Yangpu District, Shanghai via a cross-sectional field survey. The elderly participants were enrolled by using the Pittsburgh Sleep Quality Index (PSQI) scale and the TCM Constitution Questionnaire.</p><p><strong>Results: </strong>(1)The distribution of imbalanced constitutions between the elderly with insomnia and normal subjects showed statistical difference (P<0.01) and the elderly with insomnia tend to be of imbalanced constitutions. Among these unbalanced constitutions, deficient constitutions were more frequent than others in the elderly with insomnia, and yang-deficiency and qi-deficiency occurred mostly in unbalanced and simple constitutions. (2) Blood-stasis and qi-stagnation constitutions were more frequent in females than in males among the elderly with insomnia. Frequency of deficiency constitutions in the elderly increased as the age increases. (3) The frequency of composite constitutions was higher than that of simple constitutions in elderly patients with insomnia (74.8%), among which qi-deficiency was more likely to be composite with other constitutions.</p><p><strong>Conclusion: </strong>Identification and classification of traditional Chinese medicine constitution types will provide further information for devising projects with systematic intervention for insomnia management.</p>","PeriodicalId":23993,"journal":{"name":"Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine","volume":"10 8","pages":"866-73"},"PeriodicalIF":0.0,"publicationDate":"2012-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30826456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Comparative study on WHO western pacific region and world federation of Chinese medicine societies international standard terminologies on traditional medicine: diseases in internal medicine (part 4).","authors":"Zhao-guo Li","doi":"10.3736/jcim20120817","DOIUrl":"https://doi.org/10.3736/jcim20120817","url":null,"abstract":"","PeriodicalId":23993,"journal":{"name":"Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine","volume":"108 1","pages":"948-52"},"PeriodicalIF":0.0,"publicationDate":"2012-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81551468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hong Wang, Jing-Tian Qu, Xin Zhao, Ying Guo, Hao-Ping Mao
{"title":"[Vasodilator effect of oroxylin A on thoracic aorta isolated from rats].","authors":"Hong Wang, Jing-Tian Qu, Xin Zhao, Ying Guo, Hao-Ping Mao","doi":"10.3736/jcim20120808","DOIUrl":"https://doi.org/10.3736/jcim20120808","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the vasodilator effect and the endothelium-dependent mechanism of oroxylin A in thoracic aorta isolated from rats.</p><p><strong>Methods: </strong>Thoracic aorta was isolated from Wistar rats. After pretreatment with norepinephrine or KCl, the effects of oroxylin A at different concentrations were detected on isolated vascular rings prepared from rats' thoracic aorta. The response of thoracic aortic ring was evaluated in the presence and absence of endothelium, and NG-nitro-L-arginine methyl ester (L-NAME), a specific inhibitor of nitric oxide synthase.</p><p><strong>Results: </strong>Oroxylin A (10 and 100 μmol/L) caused vasodilation on endothelium-intact aortic rings pretreated with norepinephrine (1 μmol/L) and KCl (60 mmol/L) compared with the control (P<0.05, P<0.01). The vasodilation function of 10 and 100 μmol/L oroxylin A on the endothelium-denuded aorta rings was significantly lower than that on the endothelium-intact aorta rings (P<0.05, P<0.01). L-NAME pretreatment significantly attenuated the effect of 100 μmol/L oroxylin A on endothelium-intact aorta rings (P<0.05, P<0.01).</p><p><strong>Conclusion: </strong>Oroxylin A can induce the relaxation of the aorta ring in endothelium-dependent manner. Nitric oxide may be involved in the endothelium-dependent effect of oroxylin A.</p>","PeriodicalId":23993,"journal":{"name":"Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine","volume":"10 8","pages":"880-5"},"PeriodicalIF":0.0,"publicationDate":"2012-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30826458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Zi-Hui Li, Jian Wang, Rong-Lin Cai, You-Wen Wang, Jian-Peng Hu
{"title":"[Establishment and evaluation of a rat model of ulcerative colitis with syndrome of dampness stagnancy due to spleen deficiency].","authors":"Zi-Hui Li, Jian Wang, Rong-Lin Cai, You-Wen Wang, Jian-Peng Hu","doi":"10.3736/jcim20120813","DOIUrl":"https://doi.org/10.3736/jcim20120813","url":null,"abstract":"<p><strong>Objective: </strong>To establish a rat model of ulcerative colitis with syndrome of spleen deficiency and dampness stagnancy.</p><p><strong>Methods: </strong>Sixty rats were divided into normal control group, ulcerative colitis group, ulcerative colitis with syndrome of spleen deficiency and dampness stagnancy group (model group) and strengthening spleen for resolving dampness group. Ulcerative colitis in rats was induced by enema containing trinitrobenzene sulfonic acid (TNBS) and ethanol. The rats in the model group were suffered from standing in water, limiting sleeping time and abnormal diet based on administration of TNBS and ethanol. The rats in the spleen strengthening and dampness resolving group were gastrically administered with Shenlin Baizhu Powder, a compound traditional Chinese herbal medicine. Symptoms, signs and pathological changes in colon tissue of rats were observed after modeling. The levels of interleukin (IL)-6, IL-8 and tumor necrosis factor-α (TNF-α) in serum of rats were measured by enzyme-linked immunosorbent assay.</p><p><strong>Results: </strong>The rats in the model group showed lethargy, poor appetite, loss of energy, diarrhea and bloody stool. Their body weight decreased significantly compared with the normal control group, and similar changes were found in the comparison of food intake, drinking amount, urine amount, stool wet weight and assay of spontaneous activity (P<0.05). When observed under a light microscope, the colon tissues of rats in the model group showed mucosal edema, congestion, inflammatory cell infiltration and ulceration. The degree of colon injury and IL-6, IL-8 and TNF-α levels were significantly increased (P<0.05) as compared to those in the normal control group. The changes mentioned above were improved by Shenlin Baizhu Powder (P<0.05).</p><p><strong>Conclusion: </strong>The rat model of ulcerative colitis with syndrome of spleen deficiency and dampness stagnancy is successfully induced and has the characteristics of ulcerative colitis of humans both in pathological changes and in syndrome.</p>","PeriodicalId":23993,"journal":{"name":"Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine","volume":"10 8","pages":"918-24"},"PeriodicalIF":0.0,"publicationDate":"2012-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30826463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Adequate application of quantitative and qualitative statistic analytic methods in acupuncture clinical trials].","authors":"Ming T Tan, Jian-ping Liu, Lixing Lao","doi":"10.3736/jcim20120803","DOIUrl":"https://doi.org/10.3736/jcim20120803","url":null,"abstract":"<p><p>Recently, proper use of the statistical methods in traditional Chinese medicine (TCM) randomized controlled trials (RCTs) has received increased attention. Statistical inference based on hypothesis testing is the foundation of clinical trials and evidence-based medicine. In this article, the authors described the methodological differences between literature published in Chinese and Western journals in the design and analysis of acupuncture RCTs and the application of basic statistical principles. In China, qualitative analysis method has been widely used in acupuncture and TCM clinical trials, while the between-group quantitative analysis methods on clinical symptom scores are commonly used in the West. The evidence for and against these analytical differences were discussed based on the data of RCTs assessing acupuncture for pain relief. The authors concluded that although both methods have their unique advantages, quantitative analysis should be used as the primary analysis while qualitative analysis can be a secondary criterion for analysis. The purpose of this paper is to inspire further discussion of such special issues in clinical research design and thus contribute to the increased scientific rigor of TCM research.</p>","PeriodicalId":23993,"journal":{"name":"Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine","volume":"10 8","pages":"847-52"},"PeriodicalIF":0.0,"publicationDate":"2012-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30826494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sheng Wei, Jin-Liang Hou, Yu-Bin Chao, Xi-Yang Du, Shao-Bo Zong
{"title":"[Analysis on content of serum monoamine neurotransmitters in macaques with anger-in-induced premenstrual syndrome and liver-qi depression syndrome].","authors":"Sheng Wei, Jin-Liang Hou, Yu-Bin Chao, Xi-Yang Du, Shao-Bo Zong","doi":"10.3736/jcim20120814","DOIUrl":"https://doi.org/10.3736/jcim20120814","url":null,"abstract":"OBJECTIVE\u0000To observe the changes in content of monoamine neurotransmitters in the serum of rhesus macaques, and explore the role of serum monoamine neurotransmitters in premenstrual syndrome (PMS) and liver-qi depression induced by anger-in emotion.\u0000\u0000\u0000METHODS\u0000Social level pressure was applied on 24 female macaques to induce the angry emotional reaction, and then nine of the low-status macaques with anger-in emotional reaction were screened out and were divided into anger-in emotion group, PMS and liver-qi depression group (model group) and Jingqianshu Granule group. Macaques in the last two groups were suffered extruding in a pack cage for inducing PMS liver-qi depression. After 5 d of extruding, experimental animals were evaluated according to the emotional evaluation scale, meanwhile, macaque serum of follicular phase and middle-late luteal phase was collected to analyze the content of serum norepinephrine, dopamine, and 5-hydroxytryptamine.\u0000\u0000\u0000RESULTS\u0000Compared with the normal control group, the scores of depression of the model group and the anger-in emotion group evaluated with emotional evaluation scale were significantly increased (P<0.01, P<0.05); while the score of the model group was significantly higher than that of the anger-in emotion group (P<0.05), and it returned to normal after Jingqianshu Granule treatment. As compared to the normal control group, serum monoamine neurotransmitter levels of the model group and the anger-in emotion group were increased (P<0.05, P<0.01), and the serum monoamine neurotransmitter levels of the model group were significantly higher than those of the anger-in emotion group (P<0.05), while there was no significant difference when compared with the normal control group after the treatment.\u0000\u0000\u0000CONCLUSION\u0000Anger-in emotion can induce liver-qi depression syndrome which is related to the changes in monoamine neurotransmitters.","PeriodicalId":23993,"journal":{"name":"Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine","volume":"10 8","pages":"925-31"},"PeriodicalIF":0.0,"publicationDate":"2012-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30827423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Samuel Joshua Pragasam, Vachana Murunikara, Evan Prince Sabina, Mahaboobkhan Rasool
{"title":"Antiperoxidative potential of p-coumaric acid, a common dietary phenol, in adjuvant-induced arthritis in rats.","authors":"Samuel Joshua Pragasam, Vachana Murunikara, Evan Prince Sabina, Mahaboobkhan Rasool","doi":"10.3736/jcim20120815","DOIUrl":"https://doi.org/10.3736/jcim20120815","url":null,"abstract":"<p><strong>Objective: </strong>The present study was designed to investigate the antiperoxidative potential of p-coumaric acid, a common dietary phenol, in adjuvant-induced arthritis in rats.</p><p><strong>Methods: </strong>Arthritis was induced by an intradermal injection of 0.1 mL complete Freund's adjuvant in the foot pad of right hind limb of rats. p-Coumaric acid (100 mg/kg body weight, intraperitoneally) and the reference drug indomethacin (3 mg/kg body weight, intraperitoneally) were administered to arthritic rats for 8 d from the 11th day to the 18th day after adjuvant injection. The antiperoxidative effect of p-coumaric acid was investigated by assessing changes in lipid peroxidation levels and antioxidant status in liver, spleen and plasma of the adjuvant-induced arthritic rats. In addition, radiological changes in hind limbs of the arthritic rats were also analyzed.</p><p><strong>Results: </strong>p-Coumaric acid treatment reversed the altered lipid peroxidation and antioxidant status observed in arthritic rats to near normal levels. Soft swelling, bone erosion, and joint space narrowing noticed in arthritic rats were found to be mitigated in p-coumaric acid-treated arthritic rats.</p><p><strong>Conclusion: </strong>The study clearly exhibits the antiperoxidative potential of p-coumaric acid against adjuvant-induced arthritis in rats.</p>","PeriodicalId":23993,"journal":{"name":"Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine","volume":"10 8","pages":"932-8"},"PeriodicalIF":0.0,"publicationDate":"2012-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30827424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Comparative study on WHO western pacific region and world federation of Chinese medicine societies international standard terminologies on traditional medicine: diseases in internal medicine (part 4).","authors":"Zhao-guo Li","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":23993,"journal":{"name":"Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine","volume":"10 8","pages":"948-52"},"PeriodicalIF":0.0,"publicationDate":"2012-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30827426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[UPLC/Q-TOF-MS-based chemical profiling approach to evaluate the chemical constitution of Radix Aconiti Lateralis Preparata in the process of decoction].","authors":"Si-Si Zhou, Zeng-Chun Ma, Qian-de Liang, Yu-Guang Wang, Hong-Ling Tan, Cheng-Rong Xiao, Bo-Li Zhang, Yue Gao","doi":"10.3736/jcim20120810","DOIUrl":"https://doi.org/10.3736/jcim20120810","url":null,"abstract":"<p><strong>Objective: </strong>An ultra-performance liquid chromatography coupled with time-of-flight mass spectrometry (UPLC/Q-TOF-MS)-based chemical analytic technology was used to evaluate the chemical constitution of Radix Aconiti Lateralis Preparata in the process of decocting, so as to provide a scientific basis for processing Radix Aconiti Lateralis Preparata.</p><p><strong>Methods: </strong>Radix Aconiti Lateralis Preparata samples with different decocting time were detected using UPLC/Q-TOF-MS to create a fingerprint spectrum. The data of tR-m/z pairs, ion intensities and sample codes were processed by partial least squared-discriminant analysis (PLS-DA) to holistically compare the difference among these samples.</p><p><strong>Results: </strong>The contents of diester-diterpenoid alkaloid such as aconitine, mesaconitine and hypaconitine were higher between 2 to 10 min, while the contents of the lower toxic monoester-diterpenoid alkaloids such as benzoylaconine, benzoylmesaconine and benzoylhypaconine increased during the first 60 min, then their contents stabilized.</p><p><strong>Conclusion: </strong>Selecting the correct processing time for Radix Aconiti Lateralis Preparata according to clinical indications is essential for attenuating toxicity and increasing efficiency. Within 30 min is the best time for diester-diterpenoid alkaloids as the main pharmacodynamic material, and within 60 min is the best time for monoester-diterpenoid alkaloids as the pharmacodynamic material of Radix Aconiti Lateralis Preparata.</p>","PeriodicalId":23993,"journal":{"name":"Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine","volume":"10 8","pages":"894-900"},"PeriodicalIF":0.0,"publicationDate":"2012-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30826460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}