Antiperoxidative potential of p-coumaric acid, a common dietary phenol, in adjuvant-induced arthritis in rats.

Samuel Joshua Pragasam, Vachana Murunikara, Evan Prince Sabina, Mahaboobkhan Rasool
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引用次数: 13

Abstract

Objective: The present study was designed to investigate the antiperoxidative potential of p-coumaric acid, a common dietary phenol, in adjuvant-induced arthritis in rats.

Methods: Arthritis was induced by an intradermal injection of 0.1 mL complete Freund's adjuvant in the foot pad of right hind limb of rats. p-Coumaric acid (100 mg/kg body weight, intraperitoneally) and the reference drug indomethacin (3 mg/kg body weight, intraperitoneally) were administered to arthritic rats for 8 d from the 11th day to the 18th day after adjuvant injection. The antiperoxidative effect of p-coumaric acid was investigated by assessing changes in lipid peroxidation levels and antioxidant status in liver, spleen and plasma of the adjuvant-induced arthritic rats. In addition, radiological changes in hind limbs of the arthritic rats were also analyzed.

Results: p-Coumaric acid treatment reversed the altered lipid peroxidation and antioxidant status observed in arthritic rats to near normal levels. Soft swelling, bone erosion, and joint space narrowing noticed in arthritic rats were found to be mitigated in p-coumaric acid-treated arthritic rats.

Conclusion: The study clearly exhibits the antiperoxidative potential of p-coumaric acid against adjuvant-induced arthritis in rats.

对香豆酸,一种常见的膳食酚,在佐剂诱导的大鼠关节炎中的抗过氧化潜能。
目的:研究对香豆酸(一种常见的膳食酚)在大鼠佐剂性关节炎中的抗过氧化作用。方法:大鼠右后肢足垫皮内注射完全弗氏佐剂0.1 mL诱导关节炎。对香豆酸(100 mg/kg体重,腹腔注射)和对照药吲哚美辛(3 mg/kg体重,腹腔注射),于佐剂注射后第11天至第18天给予8 d。通过观察对香豆酸对大鼠肝、脾及血浆脂质过氧化水平及抗氧化状态的影响,探讨对香豆酸的抗氧化作用。此外,我们还分析了患关节炎大鼠后肢的影像学变化。结果:对香豆酸治疗逆转了关节炎大鼠脂质过氧化和抗氧化状态的改变,接近正常水平。在对香豆酸处理的关节炎大鼠中,发现关节炎大鼠的软肿胀,骨侵蚀和关节间隙狭窄得到缓解。结论:本研究清楚地显示了对香豆酸对佐剂性关节炎大鼠的抗过氧化潜能。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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