Chinese journal of otorhinolaryngology head and neck surgery最新文献

{"title":"[Transoral robotic surgery of tonsillar squamous cell carcinoma: analysis of 157 cases from five medical centers].","authors":"L Tao, F Y Liang, X Lu, A K Yang, L Zhou, Q Zhang, X Zhang, C P Wu, H J Yang, L J Chu, C He, C Z Xu, J T Chen, P Han, Y Wang, X M Huang, M Song","doi":"10.3760/cma.j.cn115330-20240806-00463","DOIUrl":"10.3760/cma.j.cn115330-20240806-00463","url":null,"abstract":"<p><p><b>Objective:</b> To explore the clinical application value of transoral robotic surgery (TORS) in the treatment of tonsil squamous cell carcinoma (TSCC). <b>Methods:</b> A retrospective analysis was conducted. The clinical data of 157 TSCC patients were collected who received TORS at five medical centers, namely, the Sun Yat-sen University Cancer Center, Sun Yat-sen Memorial Hospital, Eye Ear Nose and Throat Hospital of Fudan University, the First Affiliated Hospital of China Medical University, and Tongji Hospital of Tongji Medical College, from January 1 2017 to July 31 2022. There were 130 males and 27 females, aged 24-85 years. All patients were followed-up at least for 2 years (2-year group), among them, 99 patients had a follow-up of 3 years (3-year group). The overall survival (OS), progression-free survival (PFS), clinical stage, human papillomavirus (HPV) infection status were analyzed. SPSS 25.0 and SAS 9.4 were used for statistical analysis. <b>Results:</b> The OS and PFS of the 2-year group were 91.7% and 87.9%, respectively. The OS and PFS of the 3-year group were 85.9% and 82.8%, respectively. The prognosis of patients with locally early-stage was better than that of locally advanced patients, with the OS of 94.4% for T1-2 <i>vs</i>. 78.0% for T3 (<i>P</i>=0.005) and the PFS of 91.2% for T1-2 <i>vs</i>. 75.0% for T3 (<i>P</i>=0.011) in the 2-year group; the OS of 91.1% for T1-2 <i>vs</i>. 65.0% for T3 (<i>P</i>=0.004) and the PFS of 88.6% for T1-2 <i>vs</i>. 60.0% for T3 (<i>P</i>=0.002) in the 3-year group; and also, the OS of 90.0% for stage Ⅰ-Ⅱ <i>vs</i>. 79.5% for stage Ⅲ-Ⅳ (<i>P</i>=0.204) and the PFS of 86.7% for stage Ⅰ-Ⅱ <i>vs</i>. 76.9% for stage Ⅲ-Ⅳ (<i>P</i>=0.188) in the 3-year group. The prognosis of HPV-positive TSCC patients was better than that of HPV-negative patients in the 3-year group, with the OS of 90.9% for HPV-positive <i>vs</i>. 80.5% for HPV-negative (<i>P</i>=0.045) and the PFS of 90.9% for HPV-positive <i>vs</i>. 75.6% for HPV-negative (<i>P</i>=0.047). The average time of postoperative tracheal cannula indwelling was 25.1 days. The indwelling rate and average indwelling time of the postoperative nasogastric tube were 94.3% (148/157) and 8.5 days, respectively. <b>Conclusion:</b> TORS has outstanding survival benefits for TSCC patients. HPV-positive TSCC patients have a better prognosis than HPV-negative patients. TORS treatment of TSCC patients has advantages in postoperative recovery and quality of life.</p>","PeriodicalId":23987,"journal":{"name":"Chinese journal of otorhinolaryngology head and neck surgery","volume":"60 ","pages":"258-265"},"PeriodicalIF":0.0,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143671188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[A new useful tool for minimally invasive and scarless resection of head and neck tumors: transoral robotic surgery].","authors":"R H Sun, J Y Liu, C Li","doi":"10.3760/cma.j.cn115330-20240422-00225","DOIUrl":"10.3760/cma.j.cn115330-20240422-00225","url":null,"abstract":"","PeriodicalId":23987,"journal":{"name":"Chinese journal of otorhinolaryngology head and neck surgery","volume":"60 ","pages":"371-376"},"PeriodicalIF":0.0,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143671170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[The nomogram prediction model for the risk of dropout in sublingual immunotherapy of patients with allergic rhinitis].","authors":"C Peng, Z G Yi, H P Ye, D Liu, M Wu","doi":"10.3760/cma.j.cn115330-20241219-00697","DOIUrl":"10.3760/cma.j.cn115330-20241219-00697","url":null,"abstract":"<p><p><b>Objective:</b> To develop and externally validate a nomogram prediction model for assessing the risk of treatment dropout in allergic rhinitis (AR) patients undergoing sublingual immunotherapy (SLIT). <b>Methods:</b> Between February 2016 and December 2019, data from 358 and 259 AR patients undergoing SLIT were collected from Guizhou Provincial People's Hospital and Huangshi Central Hospital, respectively. The data included general patient information, dust mite sIgE levels, allergen types, and 22 other clinical variables. Data from Guizhou Provincial People's Hospital were used as the training set, while data from Huangshi Central Hospital were served as the external validation set. A multivariable Cox regression model was used to identify independent factors associated with SLIT dropout and to develop a nomogram prediction model. <b>Results:</b> Multivariate Cox regression analysis identified several significant factors influencing SLIT dropout, including dust mite sIgE levels (Grade Ⅱ-Ⅳ; <i>HR</i>=1.48, 95%<i>CI</i>: 1.16-1.88), presence of other allergic diseases (<i>HR</i>=0.47, 95%<i>CI</i>: 0.37-0.61), Rhinoconjunctivitis Quality of Life Questionnaire (RQLQ) score (<i>HR</i>=0.98, 95%<i>CI</i>: 0.97-1.00), WeChat management (<i>HR</i>=0.77, 95%<i>CI</i>: 0.60-0.98), treatment efficacy (<i>HR</i>=0.72, 95%<i>CI</i>: 0.56-0.92), age (5-17 years, <i>HR</i>=0.50, 95%<i>CI</i>: 0.36-0.71;≥60 years, <i>HR</i>=1.42, 95%<i>CI</i>: 1.08-1.87), household income (<5 000 CNY, <i>HR</i>=1.44, 95%<i>CI</i>: 1.09-1.90;>20 000 CNY, <i>HR</i>=0.66, 95%<i>CI</i>: 0.44-0.99), allergen types (single dust mite, <i>HR</i>=0.70, 95%<i>CI</i>: 0.49-0.93; and combined pollen or mold, <i>HR</i>=1.45, 95%<i>CI</i>: 1.02-2.04), and time to efficacy <3 months (<i>HR</i>=0.73, 95%<i>CI</i>: 0.56-0.94), all <i>P</i><0.05. At the third-year follow-up, the area under curve (AUC) for the nomogram model was 0.913 (95%<i>CI</i>: 0.881-0.943) in the training group and 0.886 (95%<i>CI</i>: 0.838-0.933) in the validation group. Calibration and decision curve analyses demonstrated the model's consistency with actual dropout rates and clinical benefit in both groups. Additionally, a Brier score of 0.29 further confirmed the model's predictive accuracy. <b>Conclusion:</b> We successfully develop a nomogram-based prediction model for SLIT dropout in AR patients, which could assist healthcare professionals in effectively identifying high-risk patients and facilitate the development of more personalized and timely treatment plans aimed at enhancing patient compliance.</p>","PeriodicalId":23987,"journal":{"name":"Chinese journal of otorhinolaryngology head and neck surgery","volume":"60 3","pages":"330-337"},"PeriodicalIF":0.0,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143773711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Kabuki syndrome caused by pathogenic variants in the <i>KMT2D</i> gene: report of two cases].","authors":"M F Cai, X Q Yang, M L Zhang, H E Xu, J H Zhang, B Chen","doi":"10.3760/cma.j.cn115330-20240522-00300","DOIUrl":"10.3760/cma.j.cn115330-20240522-00300","url":null,"abstract":"","PeriodicalId":23987,"journal":{"name":"Chinese journal of otorhinolaryngology head and neck surgery","volume":"60 3","pages":"354-357"},"PeriodicalIF":0.0,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143773707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Complication of transoral robotic surgery: single institution study].","authors":"H T Xiao, Y B Zhang, X Y Yuan, B Zhang","doi":"10.3760/cma.j.cn115330-20240423-00227","DOIUrl":"10.3760/cma.j.cn115330-20240423-00227","url":null,"abstract":"<p><p><b>Objective:</b> To investigate the complications of transoral robotic surgery (TORS) and to identify the risk factors for the complications. <b>Methods:</b> This was a retrospective study of 134 cases of head and neck tumors underwent TORS at the Department of Surgery of Beijing United Family Hospital from September 2017 to June 2024. There were 9 cases of benign tumors and 125 cases of malignant tumors, including 119 squamous cell carcinomas, 3 adenocarcinomas, 2 lymphomas, and 1 sarcoma. There were 37 cases of pure TORS and 96 cases of TORS combined with neck dissection. Postoperative complications within 90 days were collected and graded with the Clavien-Dindo system. <i>χ</i>² test was used for statistical analysis. <b>Results:</b> A total of 25 (18.7%) cases experienced surgical complications, including 9 cases with Clavien-Dindo grade≥Ⅲ complications. Postoperative complications included 2 cases of death, 3 cases of massive hemorrhage, 3 cases of pharyngeal fistula, 2 cases of aspiration pneumonia, 2 cases of minor bleeding, 1 case of tooth injury, 1 case of arytenoid dislocation, 2 cases of tongue laceration, and 10 cases of long-term (>3 months) tracheostomy open. Postoperative pharyngeal fistula was significantly correlated with the scope of neck dissection (<i>χ</i>²=9.86, <i>P</i><0.05), and Clavien-Dindo grade≥Ⅲ complications were significantly correlated with the scope of neck dissection (<i>χ</i>²=13.91, <i>P</i><0.05) and tumor N stage (<i>χ</i>²=14.33, <i>P</i><0.05). <b>Conclusion:</b> The high N-stage and neck dissection involving more than three regions are risk factors for the complications of TORS for head and neck tumors.</p>","PeriodicalId":23987,"journal":{"name":"Chinese journal of otorhinolaryngology head and neck surgery","volume":"60 ","pages":"300-304"},"PeriodicalIF":0.0,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143671172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Psychophysical assessments of olfactory function].","authors":"Q J Liu, J H Guo, Y J Zhang, K P Chen, W Zhou","doi":"10.3760/cma.j.cn115330-20240429-00247","DOIUrl":"10.3760/cma.j.cn115330-20240429-00247","url":null,"abstract":"","PeriodicalId":23987,"journal":{"name":"Chinese journal of otorhinolaryngology head and neck surgery","volume":"60 ","pages":"206-211"},"PeriodicalIF":0.0,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143469338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Diagnosis and treatment of olfactory dysfunction: new advances and perspectives].","authors":"J F Liu","doi":"10.3760/cma.j.cn115330-20240426-00240","DOIUrl":"10.3760/cma.j.cn115330-20240426-00240","url":null,"abstract":"","PeriodicalId":23987,"journal":{"name":"Chinese journal of otorhinolaryngology head and neck surgery","volume":"60 ","pages":"95-100"},"PeriodicalIF":0.0,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143469247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[A case of aortic esophageal fistula caused by an esophageal foreign body].","authors":"J Y Yu, Z L Liu, L B Li, X C Song","doi":"10.3760/cma.j.cn115330-20240712-00416","DOIUrl":"10.3760/cma.j.cn115330-20240712-00416","url":null,"abstract":"","PeriodicalId":23987,"journal":{"name":"Chinese journal of otorhinolaryngology head and neck surgery","volume":"60 2","pages":"183-184"},"PeriodicalIF":0.0,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143516819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[The molecular mechanisms of olfactory dysfunction after SARS-CoV-2 infection: new insights from current research].","authors":"J Zhou, C F Qin","doi":"10.3760/cma.j.cn115330-20240430-00253","DOIUrl":"10.3760/cma.j.cn115330-20240430-00253","url":null,"abstract":"","PeriodicalId":23987,"journal":{"name":"Chinese journal of otorhinolaryngology head and neck surgery","volume":"60 ","pages":"107-112"},"PeriodicalIF":0.0,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143469398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Full-course management of olfactory dysfunction in the era of digital diagnosis and treatment].","authors":"H M Yu, L Wang","doi":"10.3760/cma.j.cn115330-20240430-00252","DOIUrl":"10.3760/cma.j.cn115330-20240430-00252","url":null,"abstract":"","PeriodicalId":23987,"journal":{"name":"Chinese journal of otorhinolaryngology head and neck surgery","volume":"60 ","pages":"101-106"},"PeriodicalIF":0.0,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143469305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}