World Journal for Pediatric and Congenital Heart Surgery最新文献

{"title":"Does Secondary Antibiotic Prophylaxis Improve Clinical Outcomes in Adult Rheumatic Heart Disease Patients Post-Valve Replacement?","authors":"Abdulrazaq S Al-Jazairi,&nbsp;Ahlam M Althobaiti,&nbsp;Josef Marek,&nbsp;Edward B Devol,&nbsp;Zohair Al Halees,&nbsp;Dania Mohty,&nbsp;Bahaa M Fadel","doi":"10.1177/21501351221139834","DOIUrl":"https://doi.org/10.1177/21501351221139834","url":null,"abstract":"<p><strong>Background: </strong>Secondary prevention of recurrent rheumatic fever in individuals with rheumatic heart disease (RHD) requires continuous antibiotic prophylaxis. However, the impact of antibiotic prophylaxis on the outcome of patients with severe RHD who underwent heart valve replacement is unknown. The objective of the study was to assess the relationship between the use of antibiotics as secondary prophylaxis in RHD patients who underwent valve replacement and clinical outcomes including mortality, reoperation, and valve-related hospitalization.</p><p><strong>Methods: </strong>We retrospectively compared outcomes of adult patients who underwent heart valve replacement for RHD at our institution from 1990 through 2014 and who received secondary antibiotic prophylaxis (prophylaxis group) with those who did not receive prophylaxis (nonprophylaxis group) using propensity score matching analysis.</p><p><strong>Results: </strong>A total of 1094 patients (56% females, median age 40 years, range 31-53 years) were included with a median follow-up of 9.6 years (range 2.9-12.6 years). Antibiotic prophylaxis was prescribed in 201 patients (18%). Propensity score matching analysis demonstrated no significant difference in overall survival (95% [92%-98%] vs 97% [95%-99%], respectively; <i>P</i> = .7), valve-related hospitalization-independent survival (72% [range 65%-78%] vs 81% [range 76%-88%]; <i>P</i> = .25), and redo valve surgery-independent survival [76% [range 70%-83%] vs 75% [range 72%-79%]; <i>P</i> = .41) at 10-year follow-up in the nonantibiotic prophylaxis versus the antibiotic prophylaxis group.</p><p><strong>Conclusion: </strong>Secondary antibiotic prophylaxis among adult RHD patients following valve replacement is not associated with improved clinical outcomes.</p>","PeriodicalId":23974,"journal":{"name":"World Journal for Pediatric and Congenital Heart Surgery","volume":"14 2","pages":"161-167"},"PeriodicalIF":0.9,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9325045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Normothermic Versus Hypothermic Norwood Procedure.","authors":"Eitan Keizman,&nbsp;David Mishaly,&nbsp;Eilon Ram,&nbsp;Soslan Urtaev,&nbsp;Shai Tejman-Yarden,&nbsp;Tal Tirosh Wagner,&nbsp;Alain E Serraf","doi":"10.1177/21501351221140330","DOIUrl":"https://doi.org/10.1177/21501351221140330","url":null,"abstract":"<p><strong>Background: </strong>Either deep hypothermia with circulatory arrest or hypothermic perfusion with antegrade selective cerebral perfusion is used during the Norwood procedure for hypoplastic left heart syndrome. Normothermic perfusion has been described for pediatric patients. The aim of this study was to compare the early outcomes of patients undergoing the Norwood procedure with antegrade selective cerebral perfusion under hypothermia with the procedure under normothermia.</p><p><strong>Methods: </strong>From 2005 to 2020, 117 consecutive patients with hypoplastic left heart syndrome underwent the Norwood procedure: 68 (58.2%) under hypothermia and 49 (41.8%) under normothermia. Antegrade selective cerebral perfusion flow was adjusted to maintain right radial arterial pressure above 50 mm Hg, and a flow rate of 40 to 50 mL kg^-1 min^-1. Baseline characteristics, operative data, and postoperative outcomes including lactate recovery time were compared.</p><p><strong>Results: </strong>The baseline characteristics and cardiovascular diagnosis were similar in both groups. The normothermic group had a significantly shorter bypass time (in minutes) of 90.31 (±31.60) versus 123.63 (±25.33), a cross-clamp time of 45.24 (±16.35) versus 81.93 (±16.34), and an antegrade selective cerebral perfusion time of 25.61 (±13.84) versus 47.30 (±14.35) (<i>P</i> < .001). There were no statistically significant differences in the immediate postoperative course, or in terms of in-hospital mortality, which totaled 9 (18.4%) in the normothermic group, and 10 (14.9%) in the hypothermic group (<i>P</i> = .81).</p><p><strong>Conclusion: </strong>The normothermic Norwood procedure with selective cerebral perfusion is feasible and safe in terms of in-hospital mortality and short-term outcomes. It is comparable to the standard hypothermic Norwood with selective cerebral perfusion.</p>","PeriodicalId":23974,"journal":{"name":"World Journal for Pediatric and Congenital Heart Surgery","volume":"14 2","pages":"125-132"},"PeriodicalIF":0.9,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9329672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Noninvasive Monitoring to Demonstrate Postoperative Differences in Regional Hemodynamics in Newborn Infants With d-Transposition of the Great Arteries and Hypoplastic Left Heart Syndrome.","authors":"Prateek V Sahni,&nbsp;Ganga Krishnamurthy,&nbsp;Rakesh Sahni","doi":"10.1177/21501351221141425","DOIUrl":"https://doi.org/10.1177/21501351221141425","url":null,"abstract":"<p><strong>Background: </strong>The adequacy of tissue O₂ delivery in infants receiving intensive care is difficult to measure directly. Regional O₂ (rSO₂) and fractional tissue O₂ extraction (FTOE), the ratio of O₂ consumption to O₂ delivery, obtained from newer noninvasive tools, such as near-infrared spectroscopy (INVOS) and microvascular tissue oximetry (T-Stat) can provide important information on the adequacy of tissue oxygenation and aid in managing critically ill infants.</p><p><strong>Methods: </strong>We prospectively evaluated differences in rSO₂ and FTOE in 26 infants with hypoplastic left heart syndrome (HLHS) (n = 12) or d-transposition of the great arteries (d-TGA) (n = 14). Continuous noninvasive monitoring of SpO₂, heart rate, and perfusion index with pulse oximetry, cerebral-rSO₂ and renal-rSO₂ with INVOS, and buccal tissue oxygenation using T-Stat were performed during immediate postoperative period for 24 hours.</p><p><strong>Results: </strong>The SpO₂ and rSO₂ in infants with d-TGA were higher compared with the infants with HLHS at all measured sites (buccal mucosa, cerebral, and renal). Significant regional differences were also observed in FTOE across all infants with the highest at the buccal mucosa tissue level, followed by cerebral and renal measurement sites. As compared with infants with d-TGA, infants with HLHS had higher regional FTOE and heart rate, with a lower arterial O₂ content and perfusion index.</p><p><strong>Conclusions: </strong>Our study demonstrates the utility of noninvasive hemodynamic monitoring to assess regional oxygenation and perfusion, as evidenced by significant differences in infants with HLHS and d-TGA, conditions with different circulation physiologies. Such comprehensive monitoring can potentially aid in evaluating treatment strategies aimed at preventing organ damage from O₂ insufficiency.</p>","PeriodicalId":23974,"journal":{"name":"World Journal for Pediatric and Congenital Heart Surgery","volume":"14 2","pages":"194-200"},"PeriodicalIF":0.9,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9380552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Surgical Experience With Crossed and Anomalous Origin of the Pulmonary Arteries From the Pulmonary Trunk: A Single Center Report of 24 Cases.","authors":"Sameh M Said,&nbsp;Eric Hoggard,&nbsp;Shanti Narasimhan","doi":"10.1177/21501351221139833","DOIUrl":"https://doi.org/10.1177/21501351221139833","url":null,"abstract":"<p><strong>Background: </strong>Anomalies of the pulmonary origin of the pulmonary arteries are uncommon; however, the true incidence is unknown and may be underestimated. We sought to review our experience with this unusual pathology and examine its surgical implications.</p><p><strong>Methods: </strong>We reviewed medical records between 2011 and 2022.</p><p><strong>Results: </strong>A total of 24 patients were identified. Genetic syndromes were present in 12 patients (50%). The patients were divided into two main groups. Those with septal defects (14 patients,58.3%), and those without (10 patients, 41.7%). Aortic arch hypoplasia with/without coarctation was present in nine patients (37.5%). Pulmonary arterial branch hypoplasia and/or obstruction was present in six patients (25%) with resultant preoperative systemic or suprasystemic right ventricular pressure. Four patients (16.7%) underwent pulmonary artery branch and/or right ventricular outflow tract interventions prior to surgery. All patients underwent surgical interventions for their associated cardiac defects. The crossed pulmonary arteries were uncrossed for those four patients (16.7%) who required concomitant pulmonary arterioplasties and pulmonary arterial branch rehabilitation and who had elevated right ventricular pressures preoperatively. No early or late mortalities. One Alagille's syndrome underwent liver transplant prior to discharge. Late transcatheter interventions were needed in four (16.7%) during the follow-up period, while four patients required repeat aortic arch augmentation for recurrent arch obstruction.</p><p><strong>Conclusions: </strong>Anomalous origin of the pulmonary arteries from the pulmonary trunk including crossed pulmonary arteries is an uncommon anomaly that may be underrecognized. It can occur in isolation or in association with other heart defects. Recognition of this malpositional anomaly is important as it has specific surgical and/or transcatheter implications.</p>","PeriodicalId":23974,"journal":{"name":"World Journal for Pediatric and Congenital Heart Surgery","volume":"14 2","pages":"185-193"},"PeriodicalIF":0.9,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9380554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Performance of CardioCel in Cardiac Surgery: A Systematic Review.","authors":"Aditya A Patukale,&nbsp;Jessica Suna,&nbsp;Abhishek Anand,&nbsp;Kim S Betts,&nbsp;Tom R Karl,&nbsp;Prem Venugopal,&nbsp;Supreet P Marathe,&nbsp;Nelson Alphonso","doi":"10.1177/21501351221149416","DOIUrl":"https://doi.org/10.1177/21501351221149416","url":null,"abstract":"<p><p>A systematic review was performed for evaluation of the performance of CardioCel^® in cardiac surgery. The review included all studies published from January 2013 to December 2020. We conclude that CardioCel is a strong, flexible tissue substitute with good handling characteristics and a low incidence of thrombosis, aneurysm formation, infection, or structural degeneration. It can be used for a variety of intracardiac and extracardiac repairs of congenital heart defects in all age groups with good durability at mid-term follow-up. However, the use of CardioCel in certain positions requires caution. Information on the long-term performance of CardioCel is lacking.</p>","PeriodicalId":23974,"journal":{"name":"World Journal for Pediatric and Congenital Heart Surgery","volume":"14 2","pages":"211-219"},"PeriodicalIF":0.9,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9318244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Norwood Aneurysm: Report of a Rare Phenomenon.","authors":"Othman A Aljohani,&nbsp;Ahmad Hasan,&nbsp;Francesca Byrne,&nbsp;John Lamberti,&nbsp;Raghav Murthy","doi":"10.1177/21501351221137288","DOIUrl":"https://doi.org/10.1177/21501351221137288","url":null,"abstract":"<p><p>An 18-year-old male with complex single-ventricle physiology status post-3-stage palliation developed a large Norwood aneurysm (77 × 67 mm). The patient underwent a successful surgical reconstruction. Care providers must be aware of this rare complication and provide appropriate surveillance.</p>","PeriodicalId":23974,"journal":{"name":"World Journal for Pediatric and Congenital Heart Surgery","volume":"14 2","pages":"243-246"},"PeriodicalIF":0.9,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9329669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Invited Commentary: Norwood Procedure Using Regional Cerebral Perfusion at Normothermia: Are We There Yet?","authors":"Christian Pizarro","doi":"10.1177/21501351231155811","DOIUrl":"https://doi.org/10.1177/21501351231155811","url":null,"abstract":"Over the last few decades, significant advances in the field of congenital heart surgery have allowed the successful management of most forms of congenital heart disease even in the smallest patients. The two most significant challenges are the protection of the brain and the myocardium. Interventions on the aortic arch require a perturbation of the cerebral blood flow that, therefore, requires a specific protective strategy. Since the initial report by Bigelow, it was recognized that deep hypothermic circulatory arrest (DHCA) permitted a precise repair and was associated with improved surgical outcomes. This was largely due to the advantage of a “quiet and bloodless operative field” as well as organ protection from ischemia due to a significant reduction of oxygen consumption. Nevertheless, extended periods of DHCA have been associated with neurologic injury leading to adverse neurodevelopmental (ND) outcomes. The search for an optimal strategy led to the Boston Circulatory Arrest Study, which based on a subanalysis of a small subgroup of patients created the perception that low-flow hypothermic bypass was a superior strategy, when in fact the message was that each strategy had its own ND imprint. Based on this notion, when it comes to the reconstruction of the aortic arch, regional cerebral perfusion (RCP) has been widely embraced as a “superior” strategy, because it minimizes the exposure to DHCA. Nevertheless, several studies, including a large prospective randomized trial, have failed to provide such evidence.4–6 Moreover, despite the intuitive notion that antegrade or RCP is protective, Gunn and colleagues reported a 33% incidence of perioperative seizures in a cohort of patients undergoing arch reconstruction while utilizing RCP between 18 °C and 25 °C. Seizures were commonly leftsided and usually present during the period of antegrade cerebral perfusion. In addition, the reduction in left-hemispheric cerebral oxygenation reported by near-infrared spectroscopy during RCP brings into question the safety and effectiveness of this approach in its current form to ameliorate the morbidity associated with DHCA exposure. Keizman and colleagues describe their experience with patients with hypoplastic left heart syndrome comparing a strategy of arch reconstruction with antegrade cerebral perfusion at normothermia (&gt;34 °C) versus hypothermia (&lt;34 °C). This work is courageous and potentially promising. However, it lacks the necessary assurances that normothermic RCP is not detrimental to ND outcomes. The retrospective nature of the study and the lack of universal ND evaluation preand postintervention are serious limitations of this study. As demonstrated by the recent survey of preferences and attitudes toward perfusion techniques during neonatal arch reconstruction, there is a paucity of robust and conclusive data to inform this decision. The choice of DHCA, antegrade or RCP, or DHCA with intermittent perfusion remains largely based on personal expe","PeriodicalId":23974,"journal":{"name":"World Journal for Pediatric and Congenital Heart Surgery","volume":"14 2","pages":"133"},"PeriodicalIF":0.9,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9380597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Multidisciplinary Surgical Approach to Mediastinal Masses in Children.","authors":"Vanessa M Miller, Mitchell Disharoon, Luz A Padilla, Elizabeth A Beierle, Robert J Dabal","doi":"10.1177/21501351221133753","DOIUrl":"10.1177/21501351221133753","url":null,"abstract":"<p><p>The aim of this study is to demonstrate the safety and advantages of a multidisciplinary approach to surgical resection of mediastinal masses in children. Eight patients underwent resection of a mediastinal mass by a team involving both a pediatric general surgeon and pediatric cardiothoracic surgeon. One patient required rapid initiation of cardiopulmonary bypass to complete the tumor resection and repair an aortic injury that occurred when removing adherent tumor from the structure. Perioperative outcomes were excellent for all patients. This series shows that a multidisciplinary surgical approach can be potentially life saving.</p>","PeriodicalId":23974,"journal":{"name":"World Journal for Pediatric and Congenital Heart Surgery","volume":"14 2","pages":"180-184"},"PeriodicalIF":0.9,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9680047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Genetic Disorders in the Surgical Management of Congenital Heart Disease.","authors":"Elizabeth H Stephens,&nbsp;Joseph A Dearani,&nbsp;Heidi M Connolly,&nbsp;Stephen J Gleich,&nbsp;David R Deyle,&nbsp;Jonathan N Johnson","doi":"10.1177/21501351221139837","DOIUrl":"https://doi.org/10.1177/21501351221139837","url":null,"abstract":"<p><p>The congenital heart surgeon frequently encounters patients with various genetic disorders requiring surgical intervention. Although the specifics of the genetics for these patients and their families lie in the purview of specialists in genetics, the surgeon is well-served to be familiar with aspects of specific syndromes that impact surgical management and perioperative care. This aids in counseling families in expectations for the hospital course and recovery as well as can impact intraoperative and surgical management. This review article summarizes key characteristics for the congenital heart surgeon to be familiar with for common genetic disorders as they help coordinate care.</p>","PeriodicalId":23974,"journal":{"name":"World Journal for Pediatric and Congenital Heart Surgery","volume":"14 2","pages":"201-210"},"PeriodicalIF":0.9,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9680062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biventricular Repair for Aortic Atresia, Ventricular Septal Defect, and Type C Interrupted Aortic Arch.","authors":"Yi-Chia Wang,&nbsp;Heng-Wen Chou,&nbsp;Yih-Sharng Chen,&nbsp;Shu-Chien Huang","doi":"10.1177/21501351221145162","DOIUrl":"https://doi.org/10.1177/21501351221145162","url":null,"abstract":"<p><p>Interrupted aortic arch is a rare congenital heart defect. Among patients with interrupted aortic arch, an interruption between the innominate artery and left common carotid artery (type C) is the rarest. Herein, we report the case of a neonate with aortic atresia, ventricular septal defect, type C interrupted aortic arch, and aberrant right subclavian artery who underwent Norwood stage I operation and staged biventricular repair. Due to aortic atresia, coronary artery perfusion was retrograde from the right common carotid artery. The surgical technique and special considerations for cardiopulmonary bypass are presented.</p>","PeriodicalId":23974,"journal":{"name":"World Journal for Pediatric and Congenital Heart Surgery","volume":"14 2","pages":"248-250"},"PeriodicalIF":0.9,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9318241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}