World Journal of Urology最新文献

{"title":"The effect of testicular self-examination education on health beliefs in adult men: a systematic review and meta-analysis.","authors":"Mehmet Korkmaz, Tugba Yildirim, Elif Altun, Sevda Uzun, Aycan Kayalar","doi":"10.1007/s00345-025-05877-x","DOIUrl":"10.1007/s00345-025-05877-x","url":null,"abstract":"<p><strong>Purpose: </strong>Testicular cancer is primarily detected by the patient or their sexual partner and is most commonly diagnosed in men between the ages of 15 and 35. This study aims to assess the impact of self-examination education on health beliefs among adult men.</p><p><strong>Materials and methods: </strong>This study, which is a systematic review and meta-analysis, obtained studies by searching PubMed, Web of Scıence, EBSCOhost, Google Scholar, ProQuest and YOK Thesis Centre databases without a year limitation. After the reviews, 12 studies were included in the study. Data were synthesised by meta-analysis and narrative methods.</p><p><strong>Results: </strong>The findings of this systematic review and meta-analysis demonstrate that self-examination education significantly influences health beliefs in adult men (SMD: 1.790; 95% CI: 0.954 to 2.624; Z = 4.198, p = 0.00; I² = 99.109%).</p><p><strong>Conclusion: </strong>This study highlights that self-examination education may play an influential role in the shaping of adult men's health beliefs, potentially contributing to the early detection and prevention of testicular cancer.</p>","PeriodicalId":23954,"journal":{"name":"World Journal of Urology","volume":"43 1","pages":"518"},"PeriodicalIF":2.9,"publicationDate":"2025-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144971756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating the likelihood of pediatric sacral nerve stimulator explantations due to cure or complications: a survival analysis of 13-year institutional cohort.","authors":"Jin Kyu Kim, Konrad M Szymanski, Rosalia Misseri, Shelly J King, Nikhil V Batra, Martin Kaefer, Mark P Cain, Richard C Rink, Joshua Roth, Pankaj Dangle, Kirstan Meldrum, Benjamin M Whittam","doi":"10.1007/s00345-025-05916-7","DOIUrl":"https://doi.org/10.1007/s00345-025-05916-7","url":null,"abstract":"<p><strong>Introduction: </strong>Sacral neuromodulation (SNM) is a treatment option for children with refractory bladder and bowel dysfunction. Prior investigations have shown children may achieve cure of their symptoms following SNM implants and subsequently have their devices explanted. Herein, we present a 13-year experience of pediatric SNM placements and evaluate the likelihood of SNM explantation for any cause, for symptom resolution or complications.</p><p><strong>Methods: </strong>An institutional retrospective review of children who underwent a 2nd stage SNM placement between November 2012 and January 2025 was performed. Reasons for SNM explantation was categorized as a cure or complication. Competing-risk time-to-event analysis was used.</p><p><strong>Results: </strong>There were 129 SNM placements at a median of 10 years old (IQR 8.1-12.7); 88 were females (68.2%) and 41 required SNM revision (31.8%). Median follow-up was 3.5 (IQR 2.0-5.3) years. Subsequently, 46 underwent SNM explantation (35.7%). On survival analysis, median time to explantation (50%) was 6.0 (IQR 4.6-7.3) years. Among explanted, 34 were due to symptom resolution (73.9%) and 13 due to complications (4 infections; 4 pain at site; 3 for MRI requirements; 1 clinically ineffective). On competing risks analysis, 72.5% of the explantations at 6 years were for cure and 27.5% for complications. The 6-year explantation risk was 36.3% for cure and 13.8% for complications. Among 17 children who provided data after device explanation following cure (response rate: 51.5%), 16 (94%) had sustained symptom resolution at a median of 3.8 years (IQR 1.3-5.3) after explantation.</p><p><strong>Conclusion: </strong>Approximately quarter of children with SNM placement achieved cure with increasing probability with follow-up time. More than 70% of explantations are due to cure and less than 10% were due to infections. There is high likelihood of sustained symptom resolution following explantation for cure. SNM remains a safe and viable option for children with refractory BBD with potential for cure.</p>","PeriodicalId":23954,"journal":{"name":"World Journal of Urology","volume":"43 1","pages":"519"},"PeriodicalIF":2.9,"publicationDate":"2025-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12394247/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144971648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on: \"Is perineal urethrostomy a last resort or a viable alternative? Comparative analysis with buccal mucosal graft urethroplasty\".","authors":"Sedat Cakmak, Abdullah Esmeray","doi":"10.1007/s00345-025-05881-1","DOIUrl":"https://doi.org/10.1007/s00345-025-05881-1","url":null,"abstract":"","PeriodicalId":23954,"journal":{"name":"World Journal of Urology","volume":"43 1","pages":"517"},"PeriodicalIF":2.9,"publicationDate":"2025-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144971671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ureteral stricture pathogenesis includes operative features as well as stone characteristics in patients undergoing ureteroscopic surgery.","authors":"Senol Tonyali, Kazim Can Oba","doi":"10.1007/s00345-025-05889-7","DOIUrl":"https://doi.org/10.1007/s00345-025-05889-7","url":null,"abstract":"","PeriodicalId":23954,"journal":{"name":"World Journal of Urology","volume":"43 1","pages":"515"},"PeriodicalIF":2.9,"publicationDate":"2025-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144971539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In vivo and in vitro evaluation of the Swiss LithoClast^® Trilogy Max Handpiece.","authors":"Angelis Peteinaris, Vasileios Tatanis, Solon Faitatziadis, Theodoros Spinos, Aggelos Samaras, Paraskevi Katsakiori, Christodoulos Chatzigrigoriadis, Theofanis Vrettos, Evangelos Liatsikos, Panagiotis Kallidonis","doi":"10.1007/s00345-025-05902-z","DOIUrl":"https://doi.org/10.1007/s00345-025-05902-z","url":null,"abstract":"<p><strong>Introduction: </strong>The aim of the current study is the comparison between the Swiss LithoClast^® Trilogy Max Handpiece and the Swiss Lithoclast^® Trilogy Handpiece in the boundaries of a standardized in vitro and in vivo experimental set-up.</p><p><strong>Materials and methods: </strong>For the in vitro setup, a PVC tube placed within a plastic box filled with saline solution was used. Five soft and five hard artificial stones were created and the lithotripters were evaluated until complete stone clearance. For the in vivo part of the study, four female pigs were used. After the achievement of percutaneous access, five soft and five hard artificial stones were placed in the pelvicalyceal system. Lithotripsy was conducted. A dynamometer was used to evaluate the force needed during the procedure, while the stone clearance time was recorded.</p><p><strong>Results: </strong>Twenty in vitro and 20 in vivo trials were completed. The Swiss LithoClast^® Trilogy Handpiece weights 1200gr and the Swiss LithoClast^® Trilogy Max Handpiece weights 900gr. In the in vitro setting, the mean SCT(stone clearance time) of the Swiss LithoClast^® Trilogy Handpiece was 17.8±2.3 s and 7.4±1.1 s for hard and soft stones, respectively. The mean SCT of the Swiss LithoClast^® Trilogy Max Handpiece was 16.8±2.9 s for hard and 7±1.2 s for soft stones. In the in vivo setting, the mean SCT of the Swiss LithoClast^® Trilogy Handpiece was 36.2±4.4 s for the hard and 16.2±1.4 s for the soft stones. As for the Swiss LithoClast^® Trilogy Max Handpiece, the mean SCT for the hard and soft stones was 32.4±5.8 s and 14.8±1.1 s, respectively. The mean applied efforts by the surgeon were 36.8±2.5 N for the Swiss LithoClast^® Trilogy Handpiece and 25.9±3.7 N (p < 0.01) for the Swiss LithoClast^® Trilogy Max Handpiece.</p><p><strong>Conclusion: </strong>LithoClast^® Trilogy and LithoClast^® Trilogy Max are equally efficient in terms of lithotripsy. The reduced weight of the Max handpiece demands less effort from the surgeon regarding manipulation and navigation inside the pelvicalyceal system.</p>","PeriodicalId":23954,"journal":{"name":"World Journal of Urology","volume":"43 1","pages":"516"},"PeriodicalIF":2.9,"publicationDate":"2025-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144971660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vibegron in overactive bladder: a comprehensive review of efficacy, safety and patient-reported outcomes.","authors":"Benoit Peyronnet, Benjamin M Brucker, Cosimo De Nunzio, Christian Gratzke, John Heesakkers, Martin C Michel, Maurizio Serati, David Staskin, Christopher Chapple","doi":"10.1007/s00345-025-05799-8","DOIUrl":"10.1007/s00345-025-05799-8","url":null,"abstract":"<p><strong>Introduction: </strong>Overactive bladder (OAB) is a prevalent and potentially debilitating syndrome that significantly impairs quality of life. Mirabegron and vibegron are β₃-adrenoceptor (β₃AR) agonists that provide a different mechanism of action to antimuscarinic medications. Vibegron has high β₃AR selectivity and enhances detrusor relaxation without compromising voiding function. This review summarises the clinical and real-world evidence supporting the efficacy, safety and patient-reported benefits of vibegron in OAB.</p><p><strong>Methods: </strong>A comprehensive search of the PubMed database was conducted in December 2024 using the keyword \"vibegron\". This search yielded 123 entries, which were subsequently screened by title for relevance to the objectives of this narrative review. All relevant articles identified through this process were included.</p><p><strong>Results: </strong>Pivotal phase III trials have demonstrated significant reductions in urgency, urinary frequency and urgency urinary incontinence with vibegron, with rapid onset of action and a more favourable tolerability profile than antimuscarinics. The benefits of vibegron were consistent across diverse patient populations, including older adults and those with concomitant benign prostatic hyperplasia. Real-world data further suggest that vibegron is associated with improved adherence and persistence compared with other OAB therapies. Additionally, cardiovascular safety studies confirm that vibegron has no clinically significant effects on blood pressure or heart rate. While comparative trials with mirabegron indicate similar efficacy, vibegron's higher β₃AR selectivity and lack of cytochrome P450 interactions offer advantages in specific patient groups. Ongoing research, including real-world phase IV studies, aims to further define the long-term effectiveness and safety of vibegron in clinical practice.</p><p><strong>Conclusion: </strong>Vibegron represents an important advance in the pharmacologic management of OAB, providing a well-tolerated and effective alternative to existing therapies.</p>","PeriodicalId":23954,"journal":{"name":"World Journal of Urology","volume":"43 1","pages":"514"},"PeriodicalIF":2.9,"publicationDate":"2025-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12380879/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144971522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The prognostic value of PTEN expression in localized prostate cancer.","authors":"Ayoub Bellouti, Nicolas Sirtaine, Thierry Roumeguere, Alexandre Peltier, Romain Diamand","doi":"10.1007/s00345-025-05853-5","DOIUrl":"https://doi.org/10.1007/s00345-025-05853-5","url":null,"abstract":"<p><strong>Purpose: </strong>Current risk stratification systems for prostate cancer (PCa) lack precision, particularly for intermediate-risk patients. PTEN loss has emerged as a promising biomarker for predicting aggressive disease. This study aims to evaluate the prognostic value of PTEN status in patients diagnosed via magnetic resonance imaging (MRI)-targeted biopsy and treated with radical prostatectomy (RP).</p><p><strong>Methods: </strong>A retrospective analysis was conducted on a cohort of 213 patients diagnosed via MRI-targeted biopsy with available PTEN testing between 2020 and 2023 at a referral center. Patients who underwent RP with undetectable postoperative PSA levels and a minimum follow-up of three months were included. The primary outcome was the prognostic value of PTEN status. Biochemical recurrence (BCR) after RP was analyzed using Kaplan-Meier analysis and the log-rank test, while Cox regression models identified predictors of BCR.</p><p><strong>Results: </strong>Overall, 36/213 (17%) patients exhibited PTEN loss. These patients had more aggressive disease, characterized by higher clinical stage and ISUP grade group (p ≤ 0.01). Among the 56 patients treated with RP and followed for a median of 25 months, BCR-free survival was significantly lower in those with PTEN loss, especially in the intermediate-risk subgroup (log-rank test, p = 0.03). PTEN loss was identified as an independent predictor of BCR (Hazard Ratio: 8.5, p = 0.03).</p><p><strong>Conclusion: </strong>PTEN loss in patients diagnosed via MRI-targeted biopsy and treated with RP is associated with worse prognosis. PTEN testing shows promise as a biomarker to improve patient counseling and guide PCa treatment decisions. Prospective studies with longer follow-up periods are needed to validate these findings fully.</p>","PeriodicalId":23954,"journal":{"name":"World Journal of Urology","volume":"43 1","pages":"509"},"PeriodicalIF":2.9,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144971781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the editor: \"Evaluation of a fluoroscopy-free, ureteral access sheath-free, and stent-free approach to retrograde intrarenal surgery\".","authors":"Ahmet Burak Yilmaz","doi":"10.1007/s00345-025-05891-z","DOIUrl":"https://doi.org/10.1007/s00345-025-05891-z","url":null,"abstract":"","PeriodicalId":23954,"journal":{"name":"World Journal of Urology","volume":"43 1","pages":"511"},"PeriodicalIF":2.9,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144971702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Feasibility and safety of 6.3 Fr vs. 7.5 Fr digital disposable ureteroscopes in retrograde intrarenal surgery: a prospective randomised trial.","authors":"Wojciech Krajewski, Łukasz Nowak, Wojciech Tomczak, Klaudia Molik, Tomasz Ostrowski, Jan Łaszkiewicz, Joanna Chorbińska, Bartosz Małkiewicz, Tomasz Szydełko","doi":"10.1007/s00345-025-05874-0","DOIUrl":"https://doi.org/10.1007/s00345-025-05874-0","url":null,"abstract":"<p><strong>Introduction: </strong>Flexible ureterorenoscopy has become one of the cornerstones of minimally invasive treatment for nephrolithiasis. One of the most critical variables in scope design is the outer diameter, improving accessibility. Recently introduced 6.3 Fr ultra-slim digital ureteroscopes may offer clinical advantages over bigger scopes, but there is no data on their performance.</p><p><strong>Objectives: </strong>This study aimed to prospectively compare the feasibility, safety, durability, and procedural outcomes of RIRS performed using 6.3 Fr and 7.5 Fr digital disposable ureteroscopes from the same manufacturer, evaluating intraoperative parameters, image quality, access rates, and early postoperative results.</p><p><strong>Material and methods: </strong>Thirty adult patients with renal stones < 1.5 cm or cumulative volume < 850 mm³ were enrolled in a single-centre, randomised, prospective trial. All procedures were performed by a single experienced urologist using CE-certified digital disposable ureteroscopes. Lithotripsy was conducted with a high-power holmium laser and a 272-micron fiber. Subjective evaluations of manoeuvrability and image quality were recorded using 5-point Likert scales. Operator workload was assessed with NASA Task Load Index. In-vitro deflection range and image quality were measured before and after clinical use. Postoperative outcomes, complications, and intraoperative stone-free rates were recorded.</p><p><strong>Results: </strong>Baseline characteristics were comparable between groups not showing major differences. Ureteral access sheaths were used in 47% of cases. Endoscope insertion into the kidney was successful in all patients. Lithotripsy was complete in 87% of cases using the 6.3 Fr scope and 73% with the 7.5 Fr scope. No statistically significant differences were found in image quality or manoeuvrability scores. Both devices allowed access to the lower pole with and without a working channel instrument. No intraoperative device failures occurred, and postoperative deflection loss was minor and infrequent. One patient required prolonged hospitalisation due to infection while all remaining patients were discharged within 24 h. No ureteral injuries or complications exceeding Clavien-Dindo grade II were observed.</p><p><strong>Conclusions: </strong>The results of this study indicate that the 6.3 Fr ultra-slim ureteroscope is a feasible and safe alternative to the bigger 7.5 Fr model, with no compromise in visualisation, manoeuvrability, or device integrity. Given its comparable performance and potential for reduced ureteral trauma, the ultra-slim scope may serve as a valuable tool in modern endourology.</p>","PeriodicalId":23954,"journal":{"name":"World Journal of Urology","volume":"43 1","pages":"510"},"PeriodicalIF":2.9,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12378885/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144971715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Physical activity matters: prognostic impact of preoperative functioning scores in patients undergoing radical cystectomy.","authors":"Yannic Volz, Lennert Eismann, Thilo Westhofen, Nikolaos Pyrgidis, Paulo L Pfitzinger, Julian Hermans, Benedikt Ebner, Jan-Friedrich Jokisch, Philipp Weinhold, Robert Bischoff, Michael Chaloupka, Patrick Keller, Alexander Buchner, Gerald B Schulz, Christian G Stief, Julian Marcon","doi":"10.1007/s00345-025-05876-y","DOIUrl":"https://doi.org/10.1007/s00345-025-05876-y","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate the prognostic significance of preoperative health-related quality of life (HRQOL) functioning scores, assessed by the EORTC QLQ-C30 questionnaire, in predicting survival outcomes for patients undergoing radical cystectomy (RC) for urothelial carcinoma (UC) of the bladder. While established prognostic factors include tumor stage and lymph node involvement, the role of HRQOL in survival remains underexplored.</p><p><strong>Methods: </strong>We retrospectively analyzed patients who underwent RC for bladder cancer at a tertiary center between April 2013 and August 2024. Preoperative HRQOL domains-physical (PF), role (RF), and emotional functioning (EF)-were assessed using the EORTC QLQ-C30 questionnaire. Patients were stratified based on PF scores (≥ 90 vs. <90), and propensity score matching was applied. Survival outcomes, including overall survival (OS) and recurrence-free survival (RFS), were analyzed using Kaplan-Meier estimates and Cox regression models.</p><p><strong>Results: </strong>Overall, 276 patients were included. Patients with PF scores ≥ 90 had significantly higher 5-year OS (80.4% vs. 55.5%, p = 0.003) and lower recurrence rates. Low PF scores were an independent predictor of worse OS (HR: 2.54, 95% CI 1.42-4.55, p = 0.002). RF scores also influenced OS, while EF scores showed no association with survival.</p><p><strong>Conclusion: </strong>Preoperative PF and RF scores provide valuable prognostic information for patients undergoing RC. Given the modifiable nature of PF, prehabilitation programs could improve outcomes. Integrating HRQOL assessments into routine preoperative evaluations may enhance personalized risk stratification and patient care.</p>","PeriodicalId":23954,"journal":{"name":"World Journal of Urology","volume":"43 1","pages":"512"},"PeriodicalIF":2.9,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144971741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}