World Journal of Urology最新文献

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Laparoscopic and robotic management of symptomatic calyceal diverticula: a systematic review on behalf of YAU and EAU endourology. 有症状的肾盏憩室的腹腔镜和机器人治疗:代表YAU和EAU泌尿外科的系统综述。
IF 3.3 2区 医学
World Journal of Urology Pub Date : 2026-10-12 DOI: 10.1007/s00345-026-06846-8
Theodoros Spinos, Rifat Ergul, Angelis Peteinaris, Gernot Ortner, Amelia Pietropaolo, Theodoros Tokas, Evangelos Liatsikos, Panagiotis Kallidonis, Bhaskar Somani, Begoña Ballesta Martinez
{"title":"Laparoscopic and robotic management of symptomatic calyceal diverticula: a systematic review on behalf of YAU and EAU endourology.","authors":"Theodoros Spinos, Rifat Ergul, Angelis Peteinaris, Gernot Ortner, Amelia Pietropaolo, Theodoros Tokas, Evangelos Liatsikos, Panagiotis Kallidonis, Bhaskar Somani, Begoña Ballesta Martinez","doi":"10.1007/s00345-026-06846-8","DOIUrl":"10.1007/s00345-026-06846-8","url":null,"abstract":"<p><strong>Introduction: </strong>Calyceal diverticula (CD) are outpouchings of the pelvicalyceal system into the renal parenchyma. The purpose of this systematic review is to summarize the outcomes associated with laparoscopic and robotic-assisted approaches for the management of symptomatic CD.</p><p><strong>Materials and methods: </strong>Our findings were structured according to the PRISMA statement. We queried three electronic databases, PubMed, Cochrane Library, and Web of Science, to systematically review the literature. Relying on the March 2009 guidelines from the Oxford Centre for Evidence-Based Medicine, two authors independently judged the quality and evidence level of the final articles.</p><p><strong>Results: </strong>Nine studies were included in final qualitative synthesis. The operative time ranged from 80 to 172 (107-197) minutes, while Estimated Blood Loss ranged from 40 (5-100) to 150 (50-300) ml. The Grade I-II complications according to Clavien-Dindo Classification System ranged from 0% to 66.7%, while no Grade III-IV complications were reported in either of the nine studies. The rate of patients reporting flank pain recurrence during the follow-up period ranged from 0% to 28.5%, while recurrence of the diverticulum ranged from 0% to 33.3%. None of the patients with flank pain or diverticulum recurrence needed a reoperation.</p><p><strong>Conclusions: </strong>The findings of this systematic review suggest that laparoscopic and robotic approaches are feasible and have shown favorable outcomes in selected patients with symptomatic CD, particularly in cases with complex anatomy or after failed endourological treatment. However, the available evidence remains limited.</p>","PeriodicalId":23954,"journal":{"name":"World Journal of Urology","volume":"44 1","pages":""},"PeriodicalIF":3.3,"publicationDate":"2026-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149171448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Suprapubic transvesical adenoma resection versus robot-assisted simple prostatectomy for prostates ≥ 80 mL: an exploratory early-outcome comparison. 对于≥80 mL的前列腺,耻骨上经膀胱腺瘤切除与机器人辅助的简单前列腺切除术:一项探索性的早期结果比较
IF 3.3 2区 医学
World Journal of Urology Pub Date : 2026-10-12 DOI: 10.1007/s00345-026-06848-6
B Bucca, A Brassetti, R S Flammia, P Dell'Oglio, F Presicce, M Lo Re, F Chierigo, O Dalpiaz, G Simone, C Gozzi
{"title":"Suprapubic transvesical adenoma resection versus robot-assisted simple prostatectomy for prostates ≥ 80 mL: an exploratory early-outcome comparison.","authors":"B Bucca, A Brassetti, R S Flammia, P Dell'Oglio, F Presicce, M Lo Re, F Chierigo, O Dalpiaz, G Simone, C Gozzi","doi":"10.1007/s00345-026-06848-6","DOIUrl":"10.1007/s00345-026-06848-6","url":null,"abstract":"<p><strong>Purpose: </strong>Robot-assisted simple prostatectomy (RASP) is an established but resource-intensive option for large benign prostatic enlargement. Suprapubic transvesical adenoma resection of the prostate (STAR-P) is a recently described bipolar endoscopic technique that resects the adenoma through a suprapubic access, avoiding transurethral instrumentation. We compared their early outcomes in prostates ≥ 80 mL.</p><p><strong>Methods: </strong>In an exploratory, non-randomized, two-centre analysis of prospectively maintained data, we compared baseline, perioperative and one-month outcomes, changes from baseline, and a composite endpoint [Trifecta: maximum urinary flow rate (Qmax) > 15 mL/s, International Prostate Symptom Score (IPSS) < 8, no postoperative complications], with a logistic model adjusting for age and baseline IPSS.</p><p><strong>Results: </strong>Sixty-one patients were included (26 STAR-P, 35 RASP). STAR-P patients were older (69.5 vs. 64.0 years; p = 0.019), with higher baseline IPSS (29.5 vs. 25.0; p = 0.005) and more often a prominent median lobe (84.6% vs. 48.6%; p = 0.006). Catheterization was shorter after STAR-P (3 vs. 7 days; p < 0.001), whereas postoperative Qmax was higher after RASP (24.0 vs. 13.8 mL/s; p = 0.002). STAR-P showed a greater IPSS reduction and a smaller haemoglobin decrease; ΔQmax did not differ (p = 0.100). No major bleeding event occurred after STAR-P versus nine (26%) after RASP. Trifecta did not differ (42% vs. 54%; p = 0.440), but the study had only 15% power for this comparison.</p><p><strong>Conclusion: </strong>STAR-P and RASP showed distinct early profiles rather than superiority of either technique: STAR-P favoured shorter catheterization, lower symptoms and less bleeding, whereas RASP produced stronger early flow improvement. Whether avoiding the urethra reduces urethral morbidity remains an untested hypothesis.</p>","PeriodicalId":23954,"journal":{"name":"World Journal of Urology","volume":"44 1","pages":""},"PeriodicalIF":3.3,"publicationDate":"2026-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149170652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comment on "Surgeon-led vs. nurse-led postoperative follow-up after DiLEP: impact on erectile function recovery and patient-reported outcomes". 对“医生主导与护士主导DiLEP术后随访:对勃起功能恢复的影响和患者报告的结果”的评论。
IF 3.3 2区 医学
World Journal of Urology Pub Date : 2026-10-12 DOI: 10.1007/s00345-026-06648-y
Anwar Khan, Usha Yada, Pramila D'Souza
{"title":"Comment on \"Surgeon-led vs. nurse-led postoperative follow-up after DiLEP: impact on erectile function recovery and patient-reported outcomes\".","authors":"Anwar Khan, Usha Yada, Pramila D'Souza","doi":"10.1007/s00345-026-06648-y","DOIUrl":"10.1007/s00345-026-06648-y","url":null,"abstract":"","PeriodicalId":23954,"journal":{"name":"World Journal of Urology","volume":"44 1","pages":""},"PeriodicalIF":3.3,"publicationDate":"2026-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149164526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Letter to the Editor: "DART-VAG: initial clinical experience with a novel autologous technique for penile girth augmentation". 致编辑的信:“DART-VAG:一种新型自体阴茎增粗技术的初步临床经验”。
IF 3.3 2区 医学
World Journal of Urology Pub Date : 2026-10-12 DOI: 10.1007/s00345-026-06851-x
Joshua Levin, Buğra Çetin
{"title":"Letter to the Editor: \"DART-VAG: initial clinical experience with a novel autologous technique for penile girth augmentation\".","authors":"Joshua Levin, Buğra Çetin","doi":"10.1007/s00345-026-06851-x","DOIUrl":"10.1007/s00345-026-06851-x","url":null,"abstract":"","PeriodicalId":23954,"journal":{"name":"World Journal of Urology","volume":"44 1","pages":""},"PeriodicalIF":3.3,"publicationDate":"2026-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149167706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Long-term follow-up outcomes and independent predictors of surgical failure following posterior urethroplasty for pelvic fracture-associated urethral strictures. 骨盆骨折相关性尿道狭窄后尿道成形术后手术失败的长期随访结果和独立预测因素
IF 3.3 2区 医学
World Journal of Urology Pub Date : 2026-10-11 DOI: 10.1007/s00345-026-06804-4
Jie Wang, Guanglin Huang, Guizhong Li, Jianwei Wang
{"title":"Long-term follow-up outcomes and independent predictors of surgical failure following posterior urethroplasty for pelvic fracture-associated urethral strictures.","authors":"Jie Wang, Guanglin Huang, Guizhong Li, Jianwei Wang","doi":"10.1007/s00345-026-06804-4","DOIUrl":"https://doi.org/10.1007/s00345-026-06804-4","url":null,"abstract":"<p><strong>Purpose: </strong>To report long-term follow-up outcomes of posterior urethroplasty for pelvic fracture urethral strictures and identify independent predictors of surgical failure.</p><p><strong>Methods: </strong>We retrospectively enrolled patients who underwent delayed posterior urethroplasty for pelvic fracture urethral injury at our center between December 2018 and December 2024. Perioperative and follow-up data were collected and analyzed. Patients with less than 12 months of postoperative follow-up were excluded.</p><p><strong>Results: </strong>Seventy-six male patients were included. Median (IQR) age was 51.5 (40.5, 57.8) years. Injury mechanisms included crush trauma (n = 40, 52.6%), traffic accidents (n = 22, 29.0%), and falls (n = 14, 18.4%). Complete urethral obliteration was present in 54 patients (71.0%), and post-injury erectile dysfunction in 43 (56.6%). Thirty-two patients (42.1%) had prior urethral interventions. All procedures were successful. Median (IQR) urethral defect length was 2.5 (2.0, 3.5) cm. Direct anastomosis was performed in 48 patients (63.2%), and adjunctive maneuvers in 28 (36.8%). Median (IQR) follow-up was 30.0 (15.0, 59.5) months. Treatment success was achieved in 60 patients (79.0%), and failure in 16 (21.0%). On multivariate analysis, prior intervention (OR 11.558, 95% CI 1.356-98.515, P = 0.025) and longer urethral defect length (OR 4.394, 95% CI 1.262-15.292, P = 0.020) were independent predictors of surgical failure.</p><p><strong>Conclusions: </strong>Posterior urethroplasty is safe and effective for pelvic fracture urethral strictures with favorable long-term functional outcomes. Prior intervention and longer urethral defect length are independent predictors of surgical failure.</p>","PeriodicalId":23954,"journal":{"name":"World Journal of Urology","volume":"44 1","pages":""},"PeriodicalIF":3.3,"publicationDate":"2026-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149167815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Retroperitoneal lymph node dissection for isolated node recurrence of renal cell carcinoma after nephrectomy: a systematic review. 腹膜后淋巴结清扫治疗肾细胞癌切除术后孤立淋巴结复发:一项系统综述。
IF 3.3 2区 医学
World Journal of Urology Pub Date : 2026-10-08 DOI: 10.1007/s00345-026-06853-9
Alberto Costa Silva, Noel Clarke, Aziz Gulamhusein
{"title":"Retroperitoneal lymph node dissection for isolated node recurrence of renal cell carcinoma after nephrectomy: a systematic review.","authors":"Alberto Costa Silva, Noel Clarke, Aziz Gulamhusein","doi":"10.1007/s00345-026-06853-9","DOIUrl":"10.1007/s00345-026-06853-9","url":null,"abstract":"<p><strong>Purpose: </strong>Isolated retroperitoneal lymph node recurrence after nephrectomy for renal cell carcinoma (RCC) occurrs in approximately 1-3% of patients. The optimal management of this condition remains undefined. This systematic review aims to evaluate perioperative and oncologic outcomes following retroperitoneal lymph node dissection (RPLND) for isolated nodal recurrence of RCC after nephrectomy.</p><p><strong>Methods: </strong>A systematic literature search was performed in MEDLINE/PubMed and Embase (January 2000-August 2025) according to PRISMA 2020 guidelines (PROSPERO ID: CRD420251167754). Data extracted included patient demographics, perioperative parameters, and oncologic outcomes. The risk of bias was assessed using the ROBINS-I tool.</p><p><strong>Results: </strong>Seven retrospective studies published between 2008 and 2022 met inclusion criteria, encompassing 144 patients. Median age ranged from 57 to 65 years, with a predominance of clear-cell histology (60-100%). The median interval between nephrectomy and recurrence was 9.6-25 months. Median operative time ranged from 155 to 271 min, with estimated blood loss between 200 and 575 mL and hospital stay of 2-6 days. Overall complication rates were 26-47%, with major (Clavien ≥ III) complications in approximately 10%. Median recurrence-free or progression-free survival ranged from 9 to 19.5 months, and 5-year cancer-specific survival from 61% to 74%. Adverse prognostic factors included a disease-free interval ≤ 12 months, high-grade tumors, pN1 status, and nodal metastasis > 3 cm.</p><p><strong>Conclusions: </strong>RPLND is an option for isolated retroperitoneal nodal recurrence of RCC after nephrectomy. Prospective multicentre studies are warranted to define optimal patient selection, the role of minimally invasive techniques, and integration with contemporary systemic immunotherapy.</p>","PeriodicalId":23954,"journal":{"name":"World Journal of Urology","volume":"44 1","pages":""},"PeriodicalIF":3.3,"publicationDate":"2026-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149138187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pressure-flow behavior during RIRS irrigation: a controlled ex vivo porcine kidney study of flow-dependent apparent outflow resistance. 压力-流动行为在RIRS灌溉:一个控制离体猪肾脏的流量依赖的表观流出阻力研究。
IF 3.3 2区 医学
World Journal of Urology Pub Date : 2026-10-08 DOI: 10.1007/s00345-026-06817-z
Baorong Feng, Yan Yang, Shoule Wang, Xiaoming Li, Ziteng Shen, Haoyuan Liu, Wen Zhong
{"title":"Pressure-flow behavior during RIRS irrigation: a controlled ex vivo porcine kidney study of flow-dependent apparent outflow resistance.","authors":"Baorong Feng, Yan Yang, Shoule Wang, Xiaoming Li, Ziteng Shen, Haoyuan Liu, Wen Zhong","doi":"10.1007/s00345-026-06817-z","DOIUrl":"10.1007/s00345-026-06817-z","url":null,"abstract":"<p><strong>Purpose: </strong>To measure actual irrigation flow and intrarenal pressure (IRP) under different irrigation modes during retrograde intrarenal surgery (RIRS), and to develop a controlled ex vivo empirical pressure-flow model for the tested endoscope-sheath configurations.</p><p><strong>Methods: </strong>A controlled ex vivo porcine kidney-ureter model was used, with all measurements taken using a 200 μm holmium laser fiber in the working channel of a 7.5Fr or 6.3Fr flexible ureteroscope and 10/12Fr or 12/14Fr suction access sheaths. Manual syringe, gravity, and automatic pump irrigation were tested across three porcine kidney-ureter units. Each condition was measured in triplicate (technical repeats); condition-level means were used for model fitting and internal assessment.</p><p><strong>Results: </strong>Actual flow rose with driving pressure and fell with scope deflection. For the ZSR pump, flow increased from 32.0 to 99.8 mL/min (7.5Fr) and from 9.3 to 49.7 mL/min (6.3Fr) across the tested pressures. Pooling pump and syringe data, apparent outflow resistance increased at higher flow, so the non-suction relation was described by [Formula: see text]. Across 20 condition-level means, the complete model gave an RMSE of 1.04 mmHg and R² of 0.994. In a single-operator full-speed syringe test, back-calculated driving pressure was approximately 600 to 770 mmHg.</p><p><strong>Conclusion: </strong>In this controlled ex vivo model, apparent outflow resistance was flow-dependent, and the empirical model described the tested pressure-flow behavior. Forceful syringe flushing should not be routine when controlled pump, water-injection, or adequate gravity irrigation is available. Clinical safety claims require in vivo and clinical validation.</p>","PeriodicalId":23954,"journal":{"name":"World Journal of Urology","volume":"44 1","pages":""},"PeriodicalIF":3.3,"publicationDate":"2026-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149138209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Risk factors and machine learning-based prediction of difficult ureter during retrograde ureteroscopic lithotripsy. 逆行输尿管镜碎石术中输尿管困难的危险因素及机器学习预测。
IF 3.3 2区 医学
World Journal of Urology Pub Date : 2026-10-06 DOI: 10.1007/s00345-026-06793-4
Safa Akyol, Doğan Sabri Tok, Ercan Öğreden, Erhan Demirelli, Ertürk Altun, Eren Baş, Erol Eğrioğlu, Ural Oğuz
{"title":"Risk factors and machine learning-based prediction of difficult ureter during retrograde ureteroscopic lithotripsy.","authors":"Safa Akyol, Doğan Sabri Tok, Ercan Öğreden, Erhan Demirelli, Ertürk Altun, Eren Baş, Erol Eğrioğlu, Ural Oğuz","doi":"10.1007/s00345-026-06793-4","DOIUrl":"10.1007/s00345-026-06793-4","url":null,"abstract":"<p><strong>Objective: </strong>Difficult ureter (DU) is a challenging condition that prevents successful access to the upper urinary tract during retrograde ureteroscopic lithotripsy (URS). The present study aimed to identify clinical risk factors for DU and to evaluate the predictive performance of machine learning-based models in patients undergoing URS for ureteral stones.</p><p><strong>Methods: </strong>Medical records of patients who underwent retrograde ureteroscopic lithotripsy between January 2023 and January 2024 were retrospectively reviewed. A total of 221 patients were included and classified into difficult ureter (DU) and non-difficult ureter (NDU) groups. Demographic characteristics, comorbidities, laboratory parameters, and perioperative findings were compared. Conventional statistical analyses were performed using univariate and multivariate regression models. In addition, supervised machine learning algorithms, including decision tree, logistic regression, naive Bayes, support vector machine, k-nearest neighbors, bagged trees, and multilayer perceptron artificial neural network (ANN), were developed to predict DU. Model performance was assessed using 3-fold cross-validation.</p><p><strong>Results: </strong>Difficult ureter was identified in 34 patients (15.4%). Absence of hydronephrosis, lack of medical expulsive therapy, elevated C-reactive protein (CRP > 5 mg/L), and gout were significantly associated with DU. Multivariate logistic regression analysis identified elevated CRP levels and diabetes mellitus as independent predictors. Among the machine learning models, the multilayer perceptron ANN demonstrated the best performance, with an accuracy of 86.9% and an area under the receiver operating characteristic curve of 0.816. Feature importance analysis revealed CRP as the most influential predictor, consistent with conventional statistical findings.</p><p><strong>Conclusion: </strong>Elevated CRP levels, gout, absence of hydronephrosis, and lack of medical expulsive therapy are important risk factors for difficult ureter during ureteroscopic lithotripsy. Machine learning-based models, particularly artificial neural networks, may provide additional predictive value and serve as decision-support tools for preoperative risk stratification in clinical practice.</p>","PeriodicalId":23954,"journal":{"name":"World Journal of Urology","volume":"44 1","pages":""},"PeriodicalIF":3.3,"publicationDate":"2026-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149115613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Patient awareness and perceptions of a kidney stone multidisciplinary team (MDT): a questionnaire survey. 患者对肾结石多学科小组(MDT)的认识和看法:一项问卷调查。
IF 3.3 2区 医学
World Journal of Urology Pub Date : 2026-10-06 DOI: 10.1007/s00345-026-06842-y
John Bose, Amelia Pietropaolo, Sohani N Dassanayake, Bhaskar Kumar Somani
{"title":"Patient awareness and perceptions of a kidney stone multidisciplinary team (MDT): a questionnaire survey.","authors":"John Bose, Amelia Pietropaolo, Sohani N Dassanayake, Bhaskar Kumar Somani","doi":"10.1007/s00345-026-06842-y","DOIUrl":"10.1007/s00345-026-06842-y","url":null,"abstract":"<p><strong>Introduction: </strong>Kidney stone disease (KSD) is a common condition associated with high recurrence rates and significant healthcare costs. Multidisciplinary team (MDT) working has become central to the management of many complex conditions; however, its use in KSD remains inconsistent. This questionnaire survey aimed to evaluate patient awareness, understanding, and perceptions of the kidney stone MDT, while identifying opportunities to improve communication and patient engagement.</p><p><strong>Methods: </strong>A single-centre questionnaire survey was conducted among patients attending the Southampton General Hospital Urology Department (Southampton, UK) between September and December 2025. Patients with and without a history of KSD were invited to complete an anonymous online questionnaire distributed via QR code. The survey included 17 items consisting of multiple-choice, Likert-scale, and open-ended questions assessing awareness of MDT working, perceived benefits, communication preferences, and areas for improvement. Descriptive statistics and chi-squared testing were used for analysis.</p><p><strong>Results: </strong>A total of 151 responses were collected, including 51 (33.8%) patients with KSD and 100 (66.2%) without KSD. Most respondents believed that MDT working improved both the quality and efficiency of care, and approximately 84% stated that they would want their case discussed within an MDT. Baseline awareness of the MDT system was low, however 92% self-reported improved understanding immediately after participation in the questionnaire. Patients expressed a preference for greater involvement in MDT decision-making, with mean involvement scores of 6.63 and 6.78 among KSD and non-KSD participants, respectively. Email was the most commonly selected communication method within this digitally recruited cohort. No statistically significant differences were detected between groups, but the study was not powered to establish equivalence.</p><p><strong>Conclusion: </strong>Among respondents, attitudes toward the kidney stone MDT were generally positive, although these findings should be interpreted in the context of a self-selected, single-centre sample. Baseline understanding of MDT working was limited, highlighting opportunities to improve patient information and communication. Future work should use validated tools, broader multicentre recruitment and objective clinical and patient-reported outcomes to evaluate MDT-based care.</p>","PeriodicalId":23954,"journal":{"name":"World Journal of Urology","volume":"44 1","pages":""},"PeriodicalIF":3.3,"publicationDate":"2026-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149115802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association of molecular subtypes based on GATA3, KRT5, and P16 expression with clinicopathological features and prognosis in upper tract urothelial carcinoma. 基于GATA3、KRT5和P16表达的分子亚型与上尿路上皮癌的临床病理特征和预后的关系
IF 3.3 2区 医学
World Journal of Urology Pub Date : 2026-10-06 DOI: 10.1007/s00345-026-06854-8
Jiayu Yang, Wentao Yu, Shengwang Zhang, Qian Chen
{"title":"Association of molecular subtypes based on GATA3, KRT5, and P16 expression with clinicopathological features and prognosis in upper tract urothelial carcinoma.","authors":"Jiayu Yang, Wentao Yu, Shengwang Zhang, Qian Chen","doi":"10.1007/s00345-026-06854-8","DOIUrl":"10.1007/s00345-026-06854-8","url":null,"abstract":"<p><strong>Objectives: </strong>This study aimed to classify upper tract urothelial carcinoma (UTUC) using GATA3, KRT5, and P16 immunohistochemistry and to evaluate associations of these molecular subtypes with clinicopathological features and outcomes.</p><p><strong>Patients/materials and methods: </strong>Tissue samples from 102 UTUC patients who underwent radical nephroureterectomy were analyzed. Tumors were classified into genomically unstable (GU), urothelial-like (URO), and basal subtypes based on GATA3, KRT5, and P16 expression. Associations with pathological features, recurrence, and survival were analyzed. Kaplan-Meier and Cox regression analyses were used.</p><p><strong>Results: </strong>The GU, URO, and basal subtypes accounted for 33%, 45%, and 22% of cases, respectively. Subtype was significantly associated with infiltrative pattern (p = 0.009), perineural invasion (p = 0.016), histological variant (p < 0.001), T stage (p = 0.004), N stage (p = 0.017), and vital status (p = 0.005). The basal subtype showed the poorest prognosis, with 3-year overall survival of 41% vs. 85% for the URO subtype (p < 0.001). Multivariable analysis identified diffuse infiltrative pattern (HR 6.84, P = 0.004), lymphovascular invasion (HR 2.12, p = 0.046), and T4 stage (HR 9.80, p = 0.023) as independent risk factors for overall survival, and diffuse infiltrative pattern (HR 6.37, p = 0.006) and T4 stage (HR 12.6, p = 0.012) for recurrence-free survival.</p><p><strong>Conclusions: </strong>IHC-based subtyping using GATA3, KRT5, and P16 is significantly associated with aggressive clinicopathological features in UTUC, with the basal subtype showing poor prognosis in univariate analysis. However, it was not an independent prognostic factor in multivariable analysis. While this exploratory strategy may aid in risk stratification, its clinical utility requires further validation in larger, prospective cohorts.</p>","PeriodicalId":23954,"journal":{"name":"World Journal of Urology","volume":"44 1","pages":""},"PeriodicalIF":3.3,"publicationDate":"2026-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149115798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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