World Journal of Urology最新文献

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Management of forgotten ureteral stent: is there a difference between pediatric and adult patients? 输尿管支架遗忘的处理:儿童和成人患者有区别吗?
IF 2.9 2区 医学
World Journal of Urology Pub Date : 2025-09-26 DOI: 10.1007/s00345-025-05963-0
Ediz Vuruskan, Mubariz Aydamirov, Kadir Karkin, Ergun Alma, Adem Altunkol, Bugra Aksay, Cafer Akcor, Guclu Gurlen, Hakan Ercil
{"title":"Management of forgotten ureteral stent: is there a difference between pediatric and adult patients?","authors":"Ediz Vuruskan, Mubariz Aydamirov, Kadir Karkin, Ergun Alma, Adem Altunkol, Bugra Aksay, Cafer Akcor, Guclu Gurlen, Hakan Ercil","doi":"10.1007/s00345-025-05963-0","DOIUrl":"https://doi.org/10.1007/s00345-025-05963-0","url":null,"abstract":"<p><strong>Purpose: </strong>We aimed to determine differences in treatment and management of forgotten ureteral stents between adult and pediatric patients.</p><p><strong>Methods: </strong>The records of patients treated for forgotten ureteral stents were retrospectively evaluated. Reasons for stent placement, duration of stenting, stent fragmentation status, types and numbers of surgeries performed for stent removal, length of hospital stay, complications, and treatments were recorded.</p><p><strong>Results: </strong>There were 43 (37%) patients in the pediatric group and 72 (63%) patients in the adult group. Mean age in the pediatric group was 7.65 ± 4.01 years, while it was 53.18 ± 18.29 years in the adult group. Hydronephrosis and hematuria rates were significantly higher in the adult group (40.3% vs. 20.9, p = 0.033; 33.3% vs. 16.3%, p = 0.046, respectively), whereas fever and sepsis rates were significantly higher in the pediatric patient group (39.5% vs. 12.5%, p = 0.001; 11.6% vs. 1.4%, p = 0.027, respectively). In terms of removal method, endoscopic cystolithotripsy and percutaneous nephrolithotomy (37.2%) were the methods most frequently applied in the pediatric group, and ureteroscopic lithotripsy (34.7%) was used in adults.</p><p><strong>Conclusions: </strong>Forgotten ureteral stents can cause life-threatening complications in both pediatric and adult patients due to encrustation and stone formation. Endourological surgeries can be safely performed for treatment in both groups.</p>","PeriodicalId":23954,"journal":{"name":"World Journal of Urology","volume":"43 1","pages":"579"},"PeriodicalIF":2.9,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145151031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Diagnostic accuracy of biparametric vs. multiparametric MRI for clinically significant prostate cancer. 双参数与多参数MRI对临床显著前列腺癌的诊断准确性。
IF 2.9 2区 医学
World Journal of Urology Pub Date : 2025-09-26 DOI: 10.1007/s00345-025-05951-4
Nicholas A Pickersgill, Alex L Shiang, Joel M Vetter, John Sheng, Kainen L Utt, Huaping Jing, R Cody Weimholt, Sheng-Kwei Song, Joseph E Ippolito, Eric H Kim
{"title":"Diagnostic accuracy of biparametric vs. multiparametric MRI for clinically significant prostate cancer.","authors":"Nicholas A Pickersgill, Alex L Shiang, Joel M Vetter, John Sheng, Kainen L Utt, Huaping Jing, R Cody Weimholt, Sheng-Kwei Song, Joseph E Ippolito, Eric H Kim","doi":"10.1007/s00345-025-05951-4","DOIUrl":"https://doi.org/10.1007/s00345-025-05951-4","url":null,"abstract":"<p><strong>Background: </strong>Multiparametric magnetic resonance imaging (MRI) is the most widely used approach for prostate MRI. While biparametric MRI (BP-MRI) involves shorter acquisition time and decreased cost, its diagnostic accuracy compared to multiparametric MRI (MP-MRI) is not well known. We aim to compare the detection of clinically significant prostate cancer with BP-MRI and MP-MRI prior to biopsy.</p><p><strong>Methods: </strong>We retrospectively analyzed men who underwent BP-MRI or MP-MRI between January 2019 and December 2022, interpreted by a single expert radiologist. All patients underwent systematic and targeted transperineal prostate biopsy. Diagnostic performance was compared using Receiver operating characteristic curves, test performance parameters, and assessed net benefit with decision curve analysis, using biopsy with Grade Group ≥ 2 disease as the reference standard.</p><p><strong>Results: </strong>Among 310 patients (192 MP-MRI, 118 BP-MRI), suspicious lesions were identified in 63% vs. 47%, respectively. Area under the curve values were 0.81 for MP-MRI and 0.88 for BP-MRI (p = 0.4). At PI-RADS ≥ 4, BP-MRI sensitivity/specificity were 71%/79% vs. 79%/55% for MP-MRI. At PI-RADS ≥ 3, sensitivities were similar but specificities were lower for both. Decision curve analysis showed similar net benefit for both protocols across clinically relevant thresholds. In multivariable analysis adjusting for age and PI-RADS, MRI type was not associated with clinically significant cancer detection (OR 0.88, 95% CI 0.53-1.45).</p><p><strong>Conclusions: </strong>Biparametric and multiparametric MRI protocols demonstrate comparable accuracy in the detection of clinically significant prostate cancer, suggesting that dynamic contrast enhancement offers limited clinical benefit. Biparametric MRI should be considered the standard for pre-biopsy imaging in patients with suspected prostate cancer.</p>","PeriodicalId":23954,"journal":{"name":"World Journal of Urology","volume":"43 1","pages":"577"},"PeriodicalIF":2.9,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145150944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Perioperative antibiotic prophylaxis in elective scrotal surgery: a retrospective cohort analysis of surgical site infections and risk factors. 选择性阴囊手术围手术期抗生素预防:手术部位感染和危险因素的回顾性队列分析。
IF 2.9 2区 医学
World Journal of Urology Pub Date : 2025-09-26 DOI: 10.1007/s00345-025-05966-x
Nico C Grossmann, Lea Barmettler, Mihaela Sava, Maxime Vallée, Fabian P Stangl, Philipp Baumeister, Bhaskar K Somani, Agostino Mattei, Christian D Fankhauser
{"title":"Perioperative antibiotic prophylaxis in elective scrotal surgery: a retrospective cohort analysis of surgical site infections and risk factors.","authors":"Nico C Grossmann, Lea Barmettler, Mihaela Sava, Maxime Vallée, Fabian P Stangl, Philipp Baumeister, Bhaskar K Somani, Agostino Mattei, Christian D Fankhauser","doi":"10.1007/s00345-025-05966-x","DOIUrl":"https://doi.org/10.1007/s00345-025-05966-x","url":null,"abstract":"","PeriodicalId":23954,"journal":{"name":"World Journal of Urology","volume":"43 1","pages":"580"},"PeriodicalIF":2.9,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145179188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Impact of intra-abdominal pressure with AirSeal® system on patient-reported outcomes and experience measurements after robot-assisted radical prostatectomy. AirSeal®腹内压系统对机器人辅助根治性前列腺切除术后患者报告的结果和经验测量的影响
IF 2.9 2区 医学
World Journal of Urology Pub Date : 2025-09-25 DOI: 10.1007/s00345-025-05958-x
Bogdan Adrian Buhas, Olivier Skowron, Martin Sié, Stéphane de Vergie, Eric Potiron, Naoufel Miaadi, Gilles Pasticier, Nam-Son Vuong, Laurent Brureau, Christophe Almeras, Vidal Azancot, Jean-Baptiste Beauval, Olivier Belas, Aude De Fourmestraux, Thomas Bommelaere, Nordine Deffar, Gilles Gourtaud, Julien Guillotreau, Truong An Nguyen, Pourya Pashootan, Grégoire Poinas, Arthur Peyrottes, Jean Rouffilange, Mathieu Roumiguié, Philippe Rouvellat, Antoine Van Hove, Caroline Pettenati, Benjamin Pradère, Alexandre de la Taille, Gaëlle Fiard, Charles Dariane, Guillaume Ploussard
{"title":"Impact of intra-abdominal pressure with AirSeal<sup>®</sup> system on patient-reported outcomes and experience measurements after robot-assisted radical prostatectomy.","authors":"Bogdan Adrian Buhas, Olivier Skowron, Martin Sié, Stéphane de Vergie, Eric Potiron, Naoufel Miaadi, Gilles Pasticier, Nam-Son Vuong, Laurent Brureau, Christophe Almeras, Vidal Azancot, Jean-Baptiste Beauval, Olivier Belas, Aude De Fourmestraux, Thomas Bommelaere, Nordine Deffar, Gilles Gourtaud, Julien Guillotreau, Truong An Nguyen, Pourya Pashootan, Grégoire Poinas, Arthur Peyrottes, Jean Rouffilange, Mathieu Roumiguié, Philippe Rouvellat, Antoine Van Hove, Caroline Pettenati, Benjamin Pradère, Alexandre de la Taille, Gaëlle Fiard, Charles Dariane, Guillaume Ploussard","doi":"10.1007/s00345-025-05958-x","DOIUrl":"10.1007/s00345-025-05958-x","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the impact of the AirSeal<sup>®</sup> insufflation system on postoperative pain, analgesic consumption, and patient satisfaction following robot-assisted radical prostatectomy (RARP), using real-world patient-reported outcomes (PROMs) collected via a digital health platform.</p><p><strong>Methods: </strong>This retrospective multicenter study included 312 patients undergoing RARP for localized prostate cancer across 19 French centers (September 2024-June 2025). Forty-seven patients (15.1%) underwent RARP with AirSeal<sup>®</sup> (low or standard pressure) and 265 (84.9%) with conventional insufflation (standard pressure). Pain scores, measured using the Visual Analogue Scale and analgesic use were recorded daily from postoperative day (POD) 1-14 via the CE-certified Betty Coaching smartphone application. Secondary outcomes included length of stay, sick leave duration, patient satisfaction at 6 weeks, and postoperative complications.</p><p><strong>Results: </strong>Baseline characteristics were comparable between groups. Median pain scores were consistently lower with AirSeal<sup>®</sup>, with complete pain resolution by POD8 versus POD14 for conventional insufflation. By POD8, all AirSeal<sup>®</sup> patients were analgesic-free, compared to 83% at POD14 in the control group. All patients were opioid-free within 2 weeks. Hospital stay (median 1 day) and satisfaction (median score 10/10) were similar. Complication rates (10.6% vs. 6.8%, p = 0.352) and readmissions did not differ significantly.</p><p><strong>Conclusion: </strong>Use of the AirSeal<sup>®</sup> system in RARP was associated with faster pain resolution and earlier cessation of analgesics without compromising perioperative safety. Digital PROMs collection via the Betty Coaching platform offers precise recovery monitoring, reinforcing its role in enhanced recovery pathways and supporting the integration of valveless insufflation technology into minimally invasive urologic surgery.</p>","PeriodicalId":23954,"journal":{"name":"World Journal of Urology","volume":"43 1","pages":"574"},"PeriodicalIF":2.9,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145138754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Predicting postoperative fever in culture-negative patients undergoing mini-PCNL using MAP score-augmented machine learning: a retrospective cohort study. 使用MAP评分增强机器学习预测微型pcnl培养阴性患者术后发热:一项回顾性队列研究。
IF 2.9 2区 医学
World Journal of Urology Pub Date : 2025-09-25 DOI: 10.1007/s00345-025-05952-3
Rong Xu, Jia-Jia Wang, Wei-Hong Zhao, Jin Xiong, Zi-Wen Lu, Li-Cai Mo
{"title":"Predicting postoperative fever in culture-negative patients undergoing mini-PCNL using MAP score-augmented machine learning: a retrospective cohort study.","authors":"Rong Xu, Jia-Jia Wang, Wei-Hong Zhao, Jin Xiong, Zi-Wen Lu, Li-Cai Mo","doi":"10.1007/s00345-025-05952-3","DOIUrl":"10.1007/s00345-025-05952-3","url":null,"abstract":"<p><strong>Purpose: </strong>Postoperative fever is a common complication following percutaneous nephrolithotomy (PCNL) that occurs even in patients with sterile urine cultures. Traditional risk-assessment tools are insufficient in this subset of patients. This study aims to develop a risk prediction model for detecting postoperative fever in patients with sterile preoperative urine cultures by integrating the Mayo Adhesive Probability (MAP) score with machine learning (ML) techniques.</p><p><strong>Methods: </strong>This retrospective cohort study included 730 patients with sterile urine cultures who underwent mini-percutaneous nephrolithotomy (mini-PCNL) at Taizhou Hospital from March 2022 to March 2025. The least absolute shrinkage and selection operator (LASSO) regression was employed to identify key variables. Ten ML models were built, and Shapley Additive exPlanations (SHAP) analysis was used to enhance model interpretability, and the optimal model was selected. An online tool was deployed for clinical use.</p><p><strong>Results: </strong>Postoperative fever occurred in 17.4% of the patients. Logistic regression (LR) demonstrated the best predictive performance (AUC = 0.914, accuracy = 92.1%, specificity = 97.3%). Major predictive factors for fever risk included MAP score ≥ 3, diabetes mellitus, female sex, positive urine leukocytes, and low lymphocyte-monocyte ratio (LMR). SHAP analysis confirmed MAP score and urine leukocytes as the most influential variables. Limitations of the study include its single-centre design.</p><p><strong>Conclusions: </strong>The proposed tool, combining MAP scores with ML, significantly enhances the accuracy of predicting the risk of postoperative fever following mini-PCNL in patients with sterile urine cultures. The LR model demonstrates strong utility and interpretability, offers personalised risk assessments preoperatively and constitutes a practical and accessible online tool for individualised clinical decision-making.</p>","PeriodicalId":23954,"journal":{"name":"World Journal of Urology","volume":"43 1","pages":"575"},"PeriodicalIF":2.9,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12464075/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145138734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The effect of bladder training with mobile application on quality of life and sexual satisfaction in women with overactive bladder: randomized controlled study. 移动应用膀胱训练对膀胱过动症患者生活质量和性满意度的影响:随机对照研究。
IF 2.9 2区 医学
World Journal of Urology Pub Date : 2025-09-25 DOI: 10.1007/s00345-025-05917-6
Rüveyda Ölmez Yalazı, Nurdan Demirci
{"title":"The effect of bladder training with mobile application on quality of life and sexual satisfaction in women with overactive bladder: randomized controlled study.","authors":"Rüveyda Ölmez Yalazı, Nurdan Demirci","doi":"10.1007/s00345-025-05917-6","DOIUrl":"10.1007/s00345-025-05917-6","url":null,"abstract":"<p><strong>Purpose: </strong>Overactive bladder (OAB) symptoms negatively affect women's quality of life and sexual satisfaction. Although mobile health tools are increasingly used for symptom management, evidence regarding their effectiveness on OAB-related outcomes remains limited. This study aimed to evaluate the impact of a mobile application-based bladder training program on quality of life and sexual satisfaction in women with OAB.</p><p><strong>Methods: </strong>A randomized controlled trial was conducted with 100 women diagnosed with OAB, randomly assigned to either a mobile application group or a control group. The intervention was delivered via a mobile application developed using the ADDIE (Analysis, Design, Development, Implementation, Evaluation) model as a structured design framework. Outcomes were assessed using validated instruments, including the International Consultation on Incontinence Questionnaire-Lower Urinary Tract Symptoms Quality of Life (ICIQ-LUTSqol) and the New Sexual Satisfaction Scale (NSSS), at baseline and at 3-month follow-up.</p><p><strong>Results: </strong>After 3 months, the intervention group showed significantly greater improvements in ICIQ-LUTSqol scores compared to the control group (p < 0.05). Sexual satisfaction also increased in both self-centered and partner-centered subdomains. Usability, willingness to use, and loyalty scales indicated high user acceptance and continued engagement with the app. No adverse events or compliance issues were reported.</p><p><strong>Conclusion: </strong>The mobile application-based bladder training program significantly improved quality of life and sexual satisfaction among women with OAB. High usability and engagement levels support the potential of mHealth interventions as viable, scalable, non-pharmacological management options for OAB.</p><p><strong>Trial registration: </strong>ClinicalTrials.gov Identifier: NCT05413629.</p>","PeriodicalId":23954,"journal":{"name":"World Journal of Urology","volume":"43 1","pages":"573"},"PeriodicalIF":2.9,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145138704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical study of the postural drainage lithotripsy system for the treatment of residual fragments after retrograde intrarenal surgery. 体位引流碎石系统治疗逆行肾内手术后残留碎片的临床研究。
IF 2.9 2区 医学
World Journal of Urology Pub Date : 2025-09-25 DOI: 10.1007/s00345-025-05956-z
Dai Liangliang, Wei Hanping, Qiu Chenjie, Wu Tingchun, Jiao Zhimin, Yuan Xiaoliang, Yang Tao, Shi Honglei
{"title":"Clinical study of the postural drainage lithotripsy system for the treatment of residual fragments after retrograde intrarenal surgery.","authors":"Dai Liangliang, Wei Hanping, Qiu Chenjie, Wu Tingchun, Jiao Zhimin, Yuan Xiaoliang, Yang Tao, Shi Honglei","doi":"10.1007/s00345-025-05956-z","DOIUrl":"10.1007/s00345-025-05956-z","url":null,"abstract":"<p><strong>Purpose: </strong>The aim of this study was to compare the efficacy of two surgical modalities, Retrograde Intrarenal Ureteral Lithotripsy (RIRS) and PDLS + RIRS (Retrograde Intrarenal Ureteral Lithotripsy Combined with Posterior Drainage Lithotripsy System), in terms of stone removal, and to provide a basis for decision-making in clinical treatment.</p><p><strong>Methods: </strong>This prospective study was carried out from 2022-02-16 to 2025-02-16 and included patients attending our hospital to collect clinical data, with surgery performed by the same attending surgeon. Patients with RFs determined by X-ray or CT 1-3 days after RIRS were selected and randomly divided into a treatment group (PDLS intervention) and a control group (conventional instruction). Patients in the treatment group were treated with preoperative water to hold urine and PDLS for 10 min, adverse effects and stone expulsion were recorded, and stone clearance status was determined by mean imaging follow-up for 20 days. The sample size was calculated using PASS 11 software, and 136 samples were identified for participation in the experiment, and the data were analysed using R 4.3.0 statistical analysis software.</p><p><strong>Results: </strong>There was no statistically significant difference between the two groups in terms of baseline characteristics such as Age, BMI, CT value, Gender, Hypertension, Diabetes, Respiratory disease, History of RIRS surgery, Haematuria, Back pain and Fever (P > 0.05). However, in terms of stone-free rate, the PDLS + RIRS group had a significantly higher stone-free rate (91.67%) than the RIRS group (75.00%), and the difference was statistically significant (χ²=6.94, P = 0.008).</p><p><strong>Conclusion: </strong>Studies have shown that the PDLS + RIRS surgical approach has higher efficiency and advantages in stone removal, which can be used as a reference for clinical treatment.</p><p><strong>Clinical trial registry number: </strong>ChiCTR2300071185; Registration date: 2023-05-06.</p>","PeriodicalId":23954,"journal":{"name":"World Journal of Urology","volume":"43 1","pages":"576"},"PeriodicalIF":2.9,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145150778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
PSMA-PET/CT-based salvage elective nodal radiotherapy for lymph node recurrence following radical prostatectomy. 基于PSMA-PET/ ct的补救性选择性淋巴结放疗治疗根治性前列腺切除术后淋巴结复发。
IF 2.9 2区 医学
World Journal of Urology Pub Date : 2025-09-24 DOI: 10.1007/s00345-025-05950-5
Samuel M Vorbach, Hannah Rittmayer, Thomas Seppi, Bernhard Nilica, Mona Kafka, Ute Ganswindt
{"title":"PSMA-PET/CT-based salvage elective nodal radiotherapy for lymph node recurrence following radical prostatectomy.","authors":"Samuel M Vorbach, Hannah Rittmayer, Thomas Seppi, Bernhard Nilica, Mona Kafka, Ute Ganswindt","doi":"10.1007/s00345-025-05950-5","DOIUrl":"10.1007/s00345-025-05950-5","url":null,"abstract":"<p><strong>Purpose: </strong>For patients with oligometastatic nodal recurrence after radical prostatectomy (RP), salvage radiotherapy is a valuable curative second-line treatment option. However, few clinical data on the impact of PSMA-PET/CT-based salvage elective nodal radiotherapy (sENRT) is available. In order to contribute further clinical data on the outcome of patients treated with sENRT following RP, we analysed the rates of biochemical recurrence-free survival (BRFS) and distant metastasis-free survival (DMFS) as well as potential predictive markers for optimised patient selection.</p><p><strong>Methods: </strong>A retrospective analysis of 76 patients treated with sENRT for nodal recurrence after RP was performed. Primary endpoints were BRFS and DMFS. Cox proportional hazards model was used to analyse potential predictive factors.</p><p><strong>Results: </strong>Median follow-up was 32.6 months. PSMA-PET/CT revealed 1, 2, or ≥ 3 positive lymph nodes in 63.2%, 30.2% and 6.6% of patients, respectively. 96% of the patients had pelvic-only lymph nodes involvement. One-, two- and three-year BRFS were 98.6%, 84.2%, and 71.9%, respectively. Notably, nodal status at the time of RP and biochemical-recurrence prior to sENRT, were associated with reduced BRFS. One-, two-, and three-year DMFS were 98.7%, 94.1%, and 94.1%, respectively, with paraaortic lymph nodes being the only factor indicating reduced DMFS. Concomitant androgen-deprivation therapy was applied in 85.5% of the patients.</p><p><strong>Conclusion: </strong>We present one of the largest studies on PSMA-PET-based sENRT for nodal recurrence after RP with promising results, highlighting the important role of sENRT. Regarding patient selection, initial lymph node status and prior radiation of the prostate were predictive of reduced BRFS, while involvement of paraaortic lymph nodes was identified as marker for reduced DMFS.</p>","PeriodicalId":23954,"journal":{"name":"World Journal of Urology","volume":"43 1","pages":"571"},"PeriodicalIF":2.9,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12460443/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145132077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Transurethral resection of the prostate in the extreme elderly (≥ 85 years): treatment success, morbidity and survival. 高龄患者(≥85岁)经尿道前列腺切除术:治疗成功、发病率和生存率。
IF 2.9 2区 医学
World Journal of Urology Pub Date : 2025-09-24 DOI: 10.1007/s00345-025-05948-z
Stephen Baug, Christian Beisland, Christian Arvei Moen, Per Odland, Jesper Blomquist, Patrick Juliebø-Jones
{"title":"Transurethral resection of the prostate in the extreme elderly (≥ 85 years): treatment success, morbidity and survival.","authors":"Stephen Baug, Christian Beisland, Christian Arvei Moen, Per Odland, Jesper Blomquist, Patrick Juliebø-Jones","doi":"10.1007/s00345-025-05948-z","DOIUrl":"10.1007/s00345-025-05948-z","url":null,"abstract":"<p><strong>Introduction: </strong>There are few studies evaluating the outcomes associated with transurethral resection of the prostate (TURP) in extremely elderly men. Our objective was to assess the safety and efficacy of this procedure in this special population.</p><p><strong>Methods: </strong>As part of an ethically approved study, retrospective review was carried out of all patients ≥ 85 years who underwent TURP between 2014 and 2023 at a tertiary centre. Data was collected on demographics including frailty status, operative data and complications. Treatment success was defined as catheter free status.</p><p><strong>Results: </strong>Over the study period, 194 patients (median age 87 years, IQR 86-89) underwent TURP, with a median follow-up of 6 years (IQR 3.5-8). The majority (68%) were ASA 3. 28% received home nursing assistance or were nursing home residents at the time of surgery. Median CCI score was 2 (IQR 1-3). 66% used anticoagulant medication. 97% received spinal anaesthesia and median operative time was 63 min (IQR 39-88). The intra-operative complication rate was 2.6%. The 30-day complication rate was 30% (Clavien-Dindo (CD) 1-2: 24%, ≥ CD 3: 5.7%). Among those with a catheter preoperatively (62%, n = 120), 84% had achieved spontaneous voiding (n = 101) at three month follow up. Overall, 93% were still alive at 1 year post surgery. The cumulative reoperation rate during study follow up was 7.2% at 1 year, 10.9% at 3 years, and 11.5% at 5 years.</p><p><strong>Conclusion: </strong>Treatment success for TURP in extremely elderly men (≥ 85 years) is high, but the associated morbidity burden warrants the need for an individualised approach when considering men in this special population who are potential candidates for surgery.</p>","PeriodicalId":23954,"journal":{"name":"World Journal of Urology","volume":"43 1","pages":"572"},"PeriodicalIF":2.9,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12460449/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145132064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Critical insights on vibegron in overactive bladder: a comprehensive review of efficacy, safety and patient-reported outcomes. 对vibegron治疗膀胱过度活动的重要见解:疗效、安全性和患者报告的结果的全面回顾。
IF 2.9 2区 医学
World Journal of Urology Pub Date : 2025-09-23 DOI: 10.1007/s00345-025-05953-2
Bilal Ahmad, Hafsa Farooq, Zara Aqil
{"title":"Critical insights on vibegron in overactive bladder: a comprehensive review of efficacy, safety and patient-reported outcomes.","authors":"Bilal Ahmad, Hafsa Farooq, Zara Aqil","doi":"10.1007/s00345-025-05953-2","DOIUrl":"https://doi.org/10.1007/s00345-025-05953-2","url":null,"abstract":"","PeriodicalId":23954,"journal":{"name":"World Journal of Urology","volume":"43 1","pages":"568"},"PeriodicalIF":2.9,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145125844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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