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Vascular pharmacology最新文献

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The life cycle of a capillary: Mechanisms of angiogenesis and rarefaction in microvascular physiology and pathologies 毛细血管的生命周期：微血管生理和病理中的血管生成和稀释机制。
IF 4 3区 医学
Vascular pharmacology Pub Date : 2024-06-08 DOI: 10.1016/j.vph.2024.107393
Declan Manning, Ernesto J. Rivera, L. Fernando Santana
{"title":"The life cycle of a capillary: Mechanisms of angiogenesis and rarefaction in microvascular physiology and pathologies","authors":"Declan Manning,&nbsp;Ernesto J. Rivera,&nbsp;L. Fernando Santana","doi":"10.1016/j.vph.2024.107393","DOIUrl":"10.1016/j.vph.2024.107393","url":null,"abstract":"<div><p>Capillaries are the smallest blood vessels (&lt;10 μm in diameter) in the body and their walls are lined by endothelial cells. These microvessels play a crucial role in nutrient and gas exchange between blood and tissues. Capillary endothelial cells also produce vasoactive molecules and initiate the electrical signals that underlie functional hyperemia and neurovascular coupling. Accordingly, capillary function and density are critical for all cell types to match blood flow to cellular activity. This begins with the process of angiogenesis, when new capillary blood vessels emerge from pre-existing vessels, and ends with rarefaction, the loss of these microvascular structures. This review explores the mechanisms behind these processes, emphasizing their roles in various microvascular diseases and their impact on surrounding cells in health and disease. We discuss recent work on the mechanisms controlling endothelial cell proliferation, migration, and tube formation that underlie angiogenesis under physiological and pathological conditions. The mechanisms underlying functional and anatomical rarefaction and the role of pericytes in this process are also discussed. Based on this work, a model is proposed in which the balance of angiogenic and rarefaction signaling pathways in a particular tissue match microvascular density to the metabolic demands of the surrounding cells. This negative feedback loop becomes disrupted during microvascular rarefaction: angiogenic mechanisms are blunted, reactive oxygen species accumulate, capillary function declines and eventually, capillaries disappear. This, we propose, forms the foundation of the reciprocal relationship between vascular density, blood flow, and metabolic needs and functionality of nearby cells.</p></div>","PeriodicalId":23949,"journal":{"name":"Vascular pharmacology","volume":"156 ","pages":"Article 107393"},"PeriodicalIF":4.0,"publicationDate":"2024-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141301753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Protective effects of Salvia Haenkei extract on a model of Doxorubicin-induced cardiotoxicity 丹参提取物对多柔比星诱导的心脏毒性模型的保护作用
IF 4 3区 医学
Vascular pharmacology Pub Date : 2024-06-01 DOI: 10.1016/j.vph.2024.107327
Edoardo Lazzarini , Vanessa Biemmi , Carolina Balbi , Azucena Rendon , Claudia Altomare , Andrea Giori , Manuel Colucci , Andrea Alimonti , Lucio Barile
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引用次数: 0
Novel NLRP3 inflammasome inhibitors INF150 and INF195 attenuate isoproterenol-induced hypertrophy in H9c2 rat cardiac myoblast 新型 NLRP3 炎症小体抑制剂 INF150 和 INF195 可减轻异丙肾上腺素诱导的 H9c2 大鼠心肌细胞肥大
IF 4 3区 医学
Vascular pharmacology Pub Date : 2024-06-01 DOI: 10.1016/j.vph.2024.107321
Magalì Giordano , Chiara Rubeo , Tommaso Angelone , Giovanna Gambarotta , Stefano Comità , Francesco Fedele , Massimo Bertinaria , Pasquale Pagliaro , Claudia Penna
{"title":"Novel NLRP3 inflammasome inhibitors INF150 and INF195 attenuate isoproterenol-induced hypertrophy in H9c2 rat cardiac myoblast","authors":"Magalì Giordano ,&nbsp;Chiara Rubeo ,&nbsp;Tommaso Angelone ,&nbsp;Giovanna Gambarotta ,&nbsp;Stefano Comità ,&nbsp;Francesco Fedele ,&nbsp;Massimo Bertinaria ,&nbsp;Pasquale Pagliaro ,&nbsp;Claudia Penna","doi":"10.1016/j.vph.2024.107321","DOIUrl":"https://doi.org/10.1016/j.vph.2024.107321","url":null,"abstract":"","PeriodicalId":23949,"journal":{"name":"Vascular pharmacology","volume":"155 ","pages":"Article 107321"},"PeriodicalIF":4.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141423014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A detailed mathematical model of the human atrial cardiomyocyte: Integration of electrophysiology and cardiomechanics 人类心房心肌细胞的详细数学模型：电生理学与心脏力学的结合
IF 4 3区 医学
Vascular pharmacology Pub Date : 2024-06-01 DOI: 10.1016/j.vph.2024.107330
Fazeelat Mazhar , Chiara Bartolucci , Francesco Regazzoni , Michelangelo Paci , Luca Dedè , Alfio Quarteroni , Cristiana Corsi , Stefano Severi
{"title":"A detailed mathematical model of the human atrial cardiomyocyte: Integration of electrophysiology and cardiomechanics","authors":"Fazeelat Mazhar ,&nbsp;Chiara Bartolucci ,&nbsp;Francesco Regazzoni ,&nbsp;Michelangelo Paci ,&nbsp;Luca Dedè ,&nbsp;Alfio Quarteroni ,&nbsp;Cristiana Corsi ,&nbsp;Stefano Severi","doi":"10.1016/j.vph.2024.107330","DOIUrl":"https://doi.org/10.1016/j.vph.2024.107330","url":null,"abstract":"","PeriodicalId":23949,"journal":{"name":"Vascular pharmacology","volume":"155 ","pages":"Article 107330"},"PeriodicalIF":4.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141423068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Gas-loaded nanocarriers to improve cardioprotection by cardioplegic solution 气体纳米载体改善心脏麻痹溶液对心脏的保护作用
IF 4 3区 医学
Vascular pharmacology Pub Date : 2024-06-01 DOI: 10.1016/j.vph.2024.107346
Chiara Rubeo , Magalì Giordano , Maria Tannous , Adrian Matencio Duràn , Stefano Comità , Vanessa Landolfi , Manuela Aragno , Roberta Cavalli , Claudia Penna , Francesco Trotta , Pasquale Pagliaro
{"title":"Gas-loaded nanocarriers to improve cardioprotection by cardioplegic solution","authors":"Chiara Rubeo ,&nbsp;Magalì Giordano ,&nbsp;Maria Tannous ,&nbsp;Adrian Matencio Duràn ,&nbsp;Stefano Comità ,&nbsp;Vanessa Landolfi ,&nbsp;Manuela Aragno ,&nbsp;Roberta Cavalli ,&nbsp;Claudia Penna ,&nbsp;Francesco Trotta ,&nbsp;Pasquale Pagliaro","doi":"10.1016/j.vph.2024.107346","DOIUrl":"https://doi.org/10.1016/j.vph.2024.107346","url":null,"abstract":"","PeriodicalId":23949,"journal":{"name":"Vascular pharmacology","volume":"155 ","pages":"Article 107346"},"PeriodicalIF":4.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141423524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The transfer of gut microbiota/metabolites from children to mice affects cardiometabolic development and induces sex-dimorphism in recipients 从儿童向小鼠转移肠道微生物群/代谢物会影响受体的心脏代谢发育并诱发性别畸形
IF 4 3区 医学
Vascular pharmacology Pub Date : 2024-06-01 DOI: 10.1016/j.vph.2024.107325
Maria Angela Guzzardi , Federica La Rosa , Francesco Faita , Lamia Ait-Ali , Daniele Panetta , Claudia Kusmic , Federico Granziera , Pierluigi Festa , Mercedes Pardo-Tendero , Patrizia Brigidi , Daniel Monelon , Patricia Iozzo
{"title":"The transfer of gut microbiota/metabolites from children to mice affects cardiometabolic development and induces sex-dimorphism in recipients","authors":"Maria Angela Guzzardi ,&nbsp;Federica La Rosa ,&nbsp;Francesco Faita ,&nbsp;Lamia Ait-Ali ,&nbsp;Daniele Panetta ,&nbsp;Claudia Kusmic ,&nbsp;Federico Granziera ,&nbsp;Pierluigi Festa ,&nbsp;Mercedes Pardo-Tendero ,&nbsp;Patrizia Brigidi ,&nbsp;Daniel Monelon ,&nbsp;Patricia Iozzo","doi":"10.1016/j.vph.2024.107325","DOIUrl":"https://doi.org/10.1016/j.vph.2024.107325","url":null,"abstract":"","PeriodicalId":23949,"journal":{"name":"Vascular pharmacology","volume":"155 ","pages":"Article 107325"},"PeriodicalIF":4.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141423807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Assessing the peripheral effect of ischemic preconditioning using electrically-stimulated contraction of the adductor pollicis 利用电刺激内收肌收缩评估缺血预处理的外周效应
IF 4 3区 医学
Vascular pharmacology Pub Date : 2024-06-01 DOI: 10.1016/j.vph.2024.107294
Ruben Allois , Pasquale Pagliaro , Silvestro Roatta
{"title":"Assessing the peripheral effect of ischemic preconditioning using electrically-stimulated contraction of the adductor pollicis","authors":"Ruben Allois ,&nbsp;Pasquale Pagliaro ,&nbsp;Silvestro Roatta","doi":"10.1016/j.vph.2024.107294","DOIUrl":"https://doi.org/10.1016/j.vph.2024.107294","url":null,"abstract":"","PeriodicalId":23949,"journal":{"name":"Vascular pharmacology","volume":"155 ","pages":"Article 107294"},"PeriodicalIF":4.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141423945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Istaroxime follow-on compounds: A new class of selective SERCA2a activators for chronic heart failure treatment Istaroxime 后续化合物：一类用于治疗慢性心力衰竭的新型选择性 SERCA2a 激活剂
IF 4 3区 医学
Vascular pharmacology Pub Date : 2024-06-01 DOI: 10.1016/j.vph.2024.107295
Martina Arici , Shih-Che Hsu , Mara Ferrandi , Paolo Barassi , Carlotta Ronchi , Eleonora Torre , Andrea Luraghi , Alessia Metallo , Gwo-Jyh Chang , Patrizia Ferrari , Giuseppe Bianchi , Maria Elena Regonesi , Cristina Airoldi , Francesco Peri , Antonio Zaza , Marcella Rocchetti
{"title":"Istaroxime follow-on compounds: A new class of selective SERCA2a activators for chronic heart failure treatment","authors":"Martina Arici ,&nbsp;Shih-Che Hsu ,&nbsp;Mara Ferrandi ,&nbsp;Paolo Barassi ,&nbsp;Carlotta Ronchi ,&nbsp;Eleonora Torre ,&nbsp;Andrea Luraghi ,&nbsp;Alessia Metallo ,&nbsp;Gwo-Jyh Chang ,&nbsp;Patrizia Ferrari ,&nbsp;Giuseppe Bianchi ,&nbsp;Maria Elena Regonesi ,&nbsp;Cristina Airoldi ,&nbsp;Francesco Peri ,&nbsp;Antonio Zaza ,&nbsp;Marcella Rocchetti","doi":"10.1016/j.vph.2024.107295","DOIUrl":"https://doi.org/10.1016/j.vph.2024.107295","url":null,"abstract":"","PeriodicalId":23949,"journal":{"name":"Vascular pharmacology","volume":"155 ","pages":"Article 107295"},"PeriodicalIF":4.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141423946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
NOD-1 activation increases the spontaneous activity and the I(f) current of murine sinoatrial node cells 激活 NOD-1 可增加小鼠中房结细胞的自发活动和 I(f) 电流
IF 4 3区 医学
Vascular pharmacology Pub Date : 2024-06-01 DOI: 10.1016/j.vph.2024.107304
Serena Canzolino , Giorgia Bertoli , Samira Bakhouba , David Molla , Patrizia Benzoni , Andrea Barbuti , Mirko Baruscotti , Maria Fernández-Velasco , Annalisa Bucchi
{"title":"NOD-1 activation increases the spontaneous activity and the I(f) current of murine sinoatrial node cells","authors":"Serena Canzolino ,&nbsp;Giorgia Bertoli ,&nbsp;Samira Bakhouba ,&nbsp;David Molla ,&nbsp;Patrizia Benzoni ,&nbsp;Andrea Barbuti ,&nbsp;Mirko Baruscotti ,&nbsp;Maria Fernández-Velasco ,&nbsp;Annalisa Bucchi","doi":"10.1016/j.vph.2024.107304","DOIUrl":"https://doi.org/10.1016/j.vph.2024.107304","url":null,"abstract":"","PeriodicalId":23949,"journal":{"name":"Vascular pharmacology","volume":"155 ","pages":"Article 107304"},"PeriodicalIF":4.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141424253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Studying exosome fingerprint in COVID 19 patients using MALDI-TOF 利用 MALDI-TOF 研究 COVID 19 患者的外泌体指纹图谱
IF 4 3区 医学
Vascular pharmacology Pub Date : 2024-06-01 DOI: 10.1016/j.vph.2024.107353
Daniele Stefanizzi, Federica Caponnetto, Riccardo Del Sal, Emanuela Sozio, Carlo Tascini, Francesco Curcio, Antonio Paolo Beltrami
{"title":"Studying exosome fingerprint in COVID 19 patients using MALDI-TOF","authors":"Daniele Stefanizzi,&nbsp;Federica Caponnetto,&nbsp;Riccardo Del Sal,&nbsp;Emanuela Sozio,&nbsp;Carlo Tascini,&nbsp;Francesco Curcio,&nbsp;Antonio Paolo Beltrami","doi":"10.1016/j.vph.2024.107353","DOIUrl":"https://doi.org/10.1016/j.vph.2024.107353","url":null,"abstract":"","PeriodicalId":23949,"journal":{"name":"Vascular pharmacology","volume":"155 ","pages":"Article 107353"},"PeriodicalIF":4.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141422647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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