Vascular pharmacology最新文献

{"title":"Chronic thromboembolic disease: Association with exercise-induced pulmonary hypertension and right ventricle deterioration","authors":"Rosalinda Madonna , Mattia Alberti , Filippo Biondi , Riccardo Morganti , Roberto Badagliacca , Carmine Dario Vizza , Raffaele De Caterina","doi":"10.1016/j.vph.2024.107291","DOIUrl":"https://doi.org/10.1016/j.vph.2024.107291","url":null,"abstract":"","PeriodicalId":23949,"journal":{"name":"Vascular pharmacology","volume":null,"pages":null},"PeriodicalIF":4.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141423898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An X-ray computed μ-tomography analysis for the characterization of 3D-heart shape in a model of cardiac plasticity","authors":"Mariacristina Filice , Maria Caterina Crocco , Raffaele Giuseppe Agostino , Riccardo Cristoforo Barberi , Daniela Amelio , Sandra Imbrogno , Vincenzo Formoso , Maria Carmela Cerra","doi":"10.1016/j.vph.2024.107310","DOIUrl":"https://doi.org/10.1016/j.vph.2024.107310","url":null,"abstract":"","PeriodicalId":23949,"journal":{"name":"Vascular pharmacology","volume":null,"pages":null},"PeriodicalIF":4.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141424567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Use of lipid-lowering drugs in restricted health access settings: Results from the Trends in Drug Utilization During COVID-19 Pandemic in Turkey (PANDUTI-TR) study","authors":"Caner Vizdiklar ,&nbsp;Volkan Aydin ,&nbsp;Gokhan Tazegul ,&nbsp;Mert Kaskal ,&nbsp;Ahmet Akici","doi":"10.1016/j.vph.2024.107382","DOIUrl":"10.1016/j.vph.2024.107382","url":null,"abstract":"<div><h3>Background</h3><p>COVID-19 restrictions prompted changes in chronic disease management and lifestyle modifications, potentially altering cardiometabolic indicators and lipid-lowering pharmacotherapy patterns. We aimed to assess lipid-lowering drug (LLD) utilization trends during COVID-19 restrictions.</p></div><div><h3>Methods</h3><p>We obtained nationwide outpatient drug sales and prescribing data for 01.03.2018–31.12.2022 from IQVIA™ Turkey. We evaluated average monthly LLD consumption, their costs, and quarterly prescribing levels in three periods: “before restrictions” (BfR, 01.03.2018–31.03.2020), “during restrictions” (DuR, 01.04.2020–31.03.2022), and “after restrictions” (AfR, 01.04.2022–31.12.2022). Drug utilization was measured via “defined daily dose/1000 inhabitants/day” (DID) metric.</p></div><div><h3>Results</h3><p>LLD utilization increased from 25.4 ± 3.1 DID in BfR to 36.2 ± 6.8 DID in DuR (<em>p</em> &lt; 0.001), and to 42.6 ± 5.3 DID in AfR (<em>p</em> &lt; 0.001 vs. BfR). Statin consumption significantly rose from 22.0 ± 3.0 DID in BfR to 31.6 ± 6.3 DID in DuR (<em>p</em> &lt; 0.001), and further to 37.6 ± 4.7 DID in AfR (<em>p</em> &lt; 0.01 vs. DuR). High-intensity statin consumption elevated by 115.9% in AfR compared to baseline (<em>p</em> &lt; 0.001). Prescribing of LLDs decreased from 12.5 ± 0.6 DID in BfR to 7.2 ± 1.2 DID in DuR (<em>p</em> &lt; 0.001), later reached 13.6 ± 3.8 DID in AfR (<em>p</em> &lt; 0.001 vs. DuR), with prescribing for ongoing users following similar trend. Expenditure on LLDs increased from €8.4 m ± 0.9 m in BfR to €11.4 m ± 2.0 m in DuR (<em>p</em> &lt; 0.001) and to €12.8 m ± 1.9 m in AfR (<em>p</em> &lt; 0.001 vs. BfR).</p></div><div><h3>Conclusions</h3><p>This study revealed a surge in consumption of LLDs in Turkey following the onset of the COVID-19 pandemic. This rise might be related to practices facilitating drug access, in addition to potentially greater adherence, or the necessity for more intense pharmacotherapy due to elevated cardiovascular risk.</p></div>","PeriodicalId":23949,"journal":{"name":"Vascular pharmacology","volume":null,"pages":null},"PeriodicalIF":4.0,"publicationDate":"2024-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141180932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advancements in non-invasive hyperspectral imaging: Mapping blood oxygen levels and vascular health for clinical and research applications","authors":"Yasser H. El-Sharkawy","doi":"10.1016/j.vph.2024.107380","DOIUrl":"10.1016/j.vph.2024.107380","url":null,"abstract":"<div><p>Oxygen content is crucial for the functioning of human body organs, as it plays a vital role in cellular respiration, which generates energy necessary for life-sustaining functions. The absence of adequate oxygen leads to cellular dysfunction and eventual organismal death due to energy deprivation.</p><p>In this study, we designed a rapid, non-invasive, and non-contact custom hyperspectral imaging system to assess blood perfusion in arteries, capillaries, and veins across various human organs, including the arm, eye, and leg. The system recorded cube images consisting of multispectral image ranges, capturing spectral information in both the visible and infrared spectra. Segmentation of the visible spectrum (400 to 700 nm) and the infrared spectrum (700 to 1000 nm) facilitated the mapping of blood oxygen levels in the investigated samples.</p><p>The estimated oxygen levels were calculated using the custom hyperspectral imaging system and associated algorithm, with validation and calibration performed against the gold standard pulse oximeter. Our results demonstrate that the custom hyperspectral imaging system accurately mapped blood perfusion and oxygen levels in organs, showing strong agreement with pulse oximeter measurements.</p><p>This study underscores the utility of custom hyperspectral imaging in non-invasively assessing blood oxygenation and perfusion in human organs, offering a promising avenue for clinical diagnostics and monitoring of vascular health.</p></div>","PeriodicalId":23949,"journal":{"name":"Vascular pharmacology","volume":null,"pages":null},"PeriodicalIF":4.0,"publicationDate":"2024-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141161906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"SEMA3G regulates BMP9 inhibition of VEGF-mediated migration and network formation in pulmonary endothelial cells","authors":"Sarah L. Mirza ,&nbsp;Paul D. Upton ,&nbsp;Joshua Hodgson ,&nbsp;Stefan Gräf ,&nbsp;Nicholas W. Morrell ,&nbsp;Benjamin J. Dunmore","doi":"10.1016/j.vph.2024.107381","DOIUrl":"10.1016/j.vph.2024.107381","url":null,"abstract":"<div><h3>Aims</h3><p>Bone morphogenetic protein-9 (BMP9) is critical for bone morphogenetic protein receptor type-2 (BMPR2) signalling in pulmonary vascular endothelial cells. Furthermore, human genetics studies support the central role of disrupted BMPR2 mediated BMP9 signalling in vascular endothelial cells in the initiation of pulmonary arterial hypertension (PAH). In addition, loss-of-function mutations in BMP9 have been identified in PAH patients. BMP9 is considered to play an important role in vascular homeostasis and quiescence.</p></div><div><h3>Methods and results</h3><p>We identified a novel BMP9 target as the class-3 semaphorin, <em>SEMA3G</em>. Although originally identified as playing a role in neuronal development, class-3 semaphorins may have important roles in endothelial function. Here we show that BMP9 transcriptional regulation of <em>SEMA3G</em> occurs via ALK1 and the canonical Smad pathway, requiring both Smad1 and Smad5. Knockdown studies demonstrated redundancy between type-2 receptors in that BMPR2 and ACTR2A were compensatory. Increased <em>SEMA3G</em> expression by BMP9 was found to be regulated by the transcription factor, SOX17. Moreover, we observed that SEMA3G regulates VEGF signalling by inhibiting VEGFR2 phosphorylation and that VEGF, in contrast to BMP9, negatively regulated <em>SEMA3G</em> transcription. Functional endothelial cell assays of VEGF-mediated migration and network formation revealed that BMP9 inhibition of VEGF was abrogated by SEMA3G knockdown. Conversely, treatment with recombinant SEMA3G partially mimicked the inhibitory action of BMP9 in these assays.</p></div><div><h3>Conclusions</h3><p>This study provides further evidence for the anti-angiogenic role of BMP9 in microvascular endothelial cells and these functions are mediated at least in part via SOX17 and SEMA3G induction.</p></div>","PeriodicalId":23949,"journal":{"name":"Vascular pharmacology","volume":null,"pages":null},"PeriodicalIF":4.0,"publicationDate":"2024-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1537189124001071/pdfft?md5=1169213b4e836cf661b287d1632d6480&pid=1-s2.0-S1537189124001071-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141135284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The diverging roles of insulin-like growth factor binding proteins in pulmonary arterial hypertension","authors":"Beate Christiane Schlueter ,&nbsp;Karin Quanz ,&nbsp;Julia Baldauf ,&nbsp;Aleksandar Petrovic ,&nbsp;Clemens Ruppert ,&nbsp;Andreas Guenther ,&nbsp;Henning Gall ,&nbsp;Khodr Tello ,&nbsp;Friedrich Grimminger ,&nbsp;Hossein-Ardeschir Ghofrani ,&nbsp;Norbert Weissmann ,&nbsp;Werner Seeger ,&nbsp;Ralph Theo Schermuly ,&nbsp;Astrid Weiss","doi":"10.1016/j.vph.2024.107379","DOIUrl":"10.1016/j.vph.2024.107379","url":null,"abstract":"<div><p>Pulmonary hypertension (PH) is a progressive, severe and to date not curable disease of the pulmonary vasculature. Alterations of the insulin-like growth factor 1 (IGF-1) system are known to play a role in vascular pathologies and IGF-binding proteins (IGFBPs) are important regulators of the bioavailability and function of IGFs. In this study, we show that circulating plasma levels of IGFBP-1, IGFBP-2 and IGFBP-3 are increased in idiopathic pulmonary arterial hypertension (IPAH) patients compared to healthy individuals. These binding proteins inhibit the IGF-1 induced IGF-1 receptor (IGF1R) phosphorylation and exhibit diverging effects on the IGF-1 induced signaling pathways in human pulmonary arterial cells (i.e. healthy as well as IPAH-hPASMCs, and healthy hPAECs). Furthermore, IGFBPs are differentially expressed in an experimental mouse model of PH. In hypoxic mouse lungs, IGFBP-1 mRNA expression is decreased whereas the mRNA for IGFBP-2 is increased. In contrast to IGFBP-1, IGFBP-2 shows vaso-constrictive properties in the murine pulmonary vasculature. Our analyses show that IGFBP-1 and IGFBP-2 exhibit diverging effects on IGF-1 signaling and display a unique IGF1R-independent kinase activation pattern in human pulmonary arterial smooth muscle cells (hPASMCs), which represent a major contributor of PAH pathobiology. Furthermore, we could show that IGFBP-2, in contrast to IGFBP-1, induces epidermal growth factor receptor (EGFR) signaling, Stat-3 activation and expression of Stat-3 target genes. Based on our results, we conclude that the IGFBP family, especially IGFBP-1, IGFBP-2 and IGFBP-3, are deregulated in PAH, that they affect IGF signaling and thereby regulate the cellular phenotype in PH.</p></div>","PeriodicalId":23949,"journal":{"name":"Vascular pharmacology","volume":null,"pages":null},"PeriodicalIF":4.0,"publicationDate":"2024-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1537189124001058/pdfft?md5=d10667cb1090263c0582af46a88de7fe&pid=1-s2.0-S1537189124001058-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140959889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Molecular mechanisms of flavonoids in myocardial ischemia reperfusion injury: Evidence from in-vitro and in-vivo studies","authors":"Jatin Sharma ,&nbsp;Poorva Bhargava ,&nbsp;Prashant Mishra ,&nbsp;Jagriti Bhatia ,&nbsp;Dharamvir Singh Arya","doi":"10.1016/j.vph.2024.107378","DOIUrl":"10.1016/j.vph.2024.107378","url":null,"abstract":"<div><h3>Objectives</h3><p>Flavonoids are polyphenolic compounds found in a wide range of foods, including fruits, vegetables, tea plants, and other natural products. They have been mainly classified as flavanols, flavonols, flavones, isoflavones, flavanones, and flavanonols. In this comprehensive review, we will discuss preclinical pieces of evidence on the potential of flavonoids for the prevention/treatment of myocardial ischemia-reperfusion (IR) injury.</p></div><div><h3>Key findings</h3><p><em>In-vitro</em> and <em>in-vivo</em> studies have shown that flavonoids play an important role in preventing ischemic heart disease (IHD). They possess strong anti-oxidant, anti-inflammatory, anti-bacterial, anti-thrombotic, anti-apoptotic, and anti-carcinogenic activities. In addition, at a molecular level, flavonoids also modulate various pathways like MAPK, NFκB <em>etc.</em> to confer beneficial effects.</p></div><div><h3>Summary</h3><p>The current review of flavonoids in myocardial ischemia-reperfusion injury furnishes updated information that could drive future research. The <em>in-vitro</em> and <em>in-vivo</em> experiments have demonstrated various favourable pharmacological properties of flavonoids. This review provides valuable information to conduct clinical studies, validating the safety aspects of flavonoids in the clinical domain.</p></div>","PeriodicalId":23949,"journal":{"name":"Vascular pharmacology","volume":null,"pages":null},"PeriodicalIF":4.0,"publicationDate":"2024-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140904770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Plasma lipidome differences in patients with and without significant carotid plaque","authors":"Martin Malý ,&nbsp;Ondřej Kučerka ,&nbsp;Kamila Bechyňská ,&nbsp;Karolína Kočí ,&nbsp;Václav Mandys ,&nbsp;Jana Hajšlová ,&nbsp;Vít Kosek","doi":"10.1016/j.vph.2024.107377","DOIUrl":"10.1016/j.vph.2024.107377","url":null,"abstract":"<div><h3>Background</h3><p>Atherosclerosis is a major cause of ischemic stroke, and early detection of advanced atherosclerosis in the carotid artery is important for reducing morbidity and mortality. What is even more important is not only detection of atherosclerosis but early determination whether the patients are at high risk of an event with adverse effects as the size of the plaque does not necessarily reflect its potential to trigger such events.</p></div><div><h3>Aim</h3><p>We studied whether plasma lipidomics profile can be used as a diagnostic tool for stratification of stable or unstable plaques without the need of removing the carotid plaque.</p></div><div><h3>Methods</h3><p>This study used liquid chromatography high-resolution tandem mass spectrometry lipidomics to characterize lipid profiles in patients' plasma and found that patients with significant and complicated (vulnerable) atherosclerotic plaque had distinct lipid profiles compared to those with insignificant plaques.</p></div><div><h3>Results</h3><p>The lipid classes that were most predictive of vulnerable plaque were lysophosphoethanolamines, fatty acyl esters of hydroxy fatty acids, free fatty acids, plasmalogens, and triacylglycerols. Most of these compounds were found decreased in plasma of patients with unstable plaques which enabled sufficient performance of a statistical model used for patient stratification.</p></div><div><h3>Conclusions</h3><p>Plasma lipidomes measured by liquid chromatography-mass spectrometry show differences in patients with stable and unstable carotid plaques, therefore these compounds could potentially be used as biomarkers for unstable plaque in future clinical diagnosis.</p></div>","PeriodicalId":23949,"journal":{"name":"Vascular pharmacology","volume":null,"pages":null},"PeriodicalIF":4.0,"publicationDate":"2024-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140868258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The diverging roles of insulin-like growth factor binding proteins in pulmonary arterial hypertension","authors":"Beate Christiane Schlueter, K. Quanz, Julia Baldauf, Aleksandar Petrovic, C. Ruppert, Andreas Guenther, H. Gall, Khodr Tello, F. Grimminger, H. Ghofrani, Norbert Weissmann, Werner Seeger, Ralph T Schermuly, Astrid Weiss","doi":"10.1016/j.vph.2024.107379","DOIUrl":"https://doi.org/10.1016/j.vph.2024.107379","url":null,"abstract":"","PeriodicalId":23949,"journal":{"name":"Vascular pharmacology","volume":null,"pages":null},"PeriodicalIF":4.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141044268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Empagliflozin on Vascular and Skeletal Mineralization in Hyperlipidemic Mice","authors":"Sophia Kalanski ,&nbsp;Stuti Pradhan ,&nbsp;Andy Hon ,&nbsp;Yuxuan Xia ,&nbsp;Nora Safvati ,&nbsp;Juan Carlos Rivera ,&nbsp;Mimi Lu ,&nbsp;Linda L. Demer ,&nbsp;Yin Tintut","doi":"10.1016/j.vph.2024.107376","DOIUrl":"10.1016/j.vph.2024.107376","url":null,"abstract":"<div><p>Cardiovascular disease and osteoporosis, major causes of morbidity and mortality, are associated with hyperlipidemia. Recent studies show that empagliflozin (EMPA), an inhibitor of sodium-glucose cotransporter-2 (SGLT2), improves cardiovascular health. In preclinical animal studies, EMPA mitigates vascular calcification in the males but its effects in the females are not known. Thus, we used female mice to test the effects of EMPA on calcification in the artery wall, cardiac function, and skeletal bone. By serial in vivo microCT imaging, we followed the progression of aortic calcification and bone mineral density in young and older female <em>Apoe</em>^{<em>−/−</em>} mice fed a high-fat diet with or without EMPA. The two different age groups were used to compare early vs. advanced stages of aortic calcification. Results show that EMPA treatment increased urine glucose levels. Aortic calcium content increased in both the controls and the EMPA-treated mice, and EMPA did not affect progression of aortic calcium content in both young and older mice. However, 3-D segmentation analysis of aortic calcium deposits on microCT images revealed that EMPA-treated mice had significantly less surface area and volume of calcified deposits as well as fewer numbers of deposits than the control mice. To test for direct effects on vascular cell calcification, we treated murine aortic smooth muscle cells with EMPA, and results showed a slight inhibition of alkaline phosphatase activity and inflammatory matrix calcification. As for skeletal bone, EMPA-treated mice had significantly lower BMD than the controls in both the lumbar vertebrae and femoral bones in both young and older mice. The findings suggest that, in hyperlipidemic female mice, unlike males, SGLT2 inhibition with empagliflozin does not mitigate progression of aortic calcification and may even lower skeletal bone density.</p></div>","PeriodicalId":23949,"journal":{"name":"Vascular pharmacology","volume":null,"pages":null},"PeriodicalIF":4.0,"publicationDate":"2024-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140860494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}