World Journal of Surgery最新文献

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Postoperative pain following laser fistula closure versus ligation of the intersphincteric fistula tract: A prospective double-blinded randomized controlled trial. 激光瘘管闭合术后疼痛与括约肌间瘘管结扎术后疼痛:一项前瞻性双盲随机对照试验。
IF 2.3 3区 医学
World Journal of Surgery Pub Date : 2024-08-01 Epub Date: 2024-06-06 DOI: 10.1002/wjs.12242
Jolynn Qian Lin Low, Retnagowri Rajandram, Mohamed Rezal Abdul Aziz, April Camilla Roslani
{"title":"Postoperative pain following laser fistula closure versus ligation of the intersphincteric fistula tract: A prospective double-blinded randomized controlled trial.","authors":"Jolynn Qian Lin Low, Retnagowri Rajandram, Mohamed Rezal Abdul Aziz, April Camilla Roslani","doi":"10.1002/wjs.12242","DOIUrl":"10.1002/wjs.12242","url":null,"abstract":"<p><strong>Background: </strong>Prior studies focus primarily on surgical outcomes of anal fistula treatment, such as healing rates, rather than patient-reported outcomes, such as postoperative pain, which could influence surgical choice.</p><p><strong>Objective: </strong>To compare pain scores at 6 and 24 h postoperatively between laser closure and ligation of the intersphincteric tract for anal fistula.</p><p><strong>Design: </strong>Prospective, double-blinded randomized controlled trial.</p><p><strong>Settings: </strong>A quaternary hospital in Malaysia.</p><p><strong>Patients: </strong>Patients aged 18-75 years with high transsphincteric fistulas.</p><p><strong>Intervention: </strong>Fistula laser closure versus ligation of the fistula tract (LIFT) treatment.</p><p><strong>Main outcome measures: </strong>Pain scores, continence, quality of life (QOL), operative time, and treatment failure were compared using chi-square, Fisher's exact test, student t-test, or Mann-Whitney with p < 0.05 denoting statistical significance.</p><p><strong>Results: </strong>Fifty-six patients were recruited (laser, n = 28, LIFT, n = 28). Median pain scores for laser versus LIFT at 6 h postoperatively were 1.0 versus 2.0 (Rest, p = 0.213) and 3.0 versus 4.0 (Movement, p = 0.448), respectively. At 24 h, this reduced to 2.5 in both arms at rest (p = 0.842) but increased to 4.8 versus 3.5 on movement (p = 0.383). Median operative time for laser was significantly shorter (32.5 min) than LIFT (p < 0.001). Laser treated patients trended toward quicker return to work (10.5 vs. 14.0, p = 0.181) but treatment failure was similar (54% vs. 50%, p = 0.71). No patients developed postoperative incontinence. Mean SF-36 scores increased from baseline (67.1 ± 17.0; 95% CI 63.6-82.4 vs. 71.3 ± 11.4; 95% CI 64.0-75.0) to 6 months postoperatively (77.7 ± 21.0; 95% CI 57.0-80.3 vs. 74.0 ± 14.3; 95% CI 67.6-81.4) regardless of the type of surgery (P > 0.05).</p><p><strong>Limitations: </strong>Patients with prior fistula surgery (approximately 20%) led to heterogeneity. The total laser energy delivered varied depending on fistula anatomy.</p><p><strong>Conclusion: </strong>Laser fistula closure is an alternative to LIFT, with similar postoperative pain and shorter operative time despite more complex fistula anatomy in the laser arm, with a greater improvement in QOL.</p><p><strong>Trial registration: </strong>ClinicalTrials.gov: NCT06212739.</p>","PeriodicalId":23926,"journal":{"name":"World Journal of Surgery","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141284937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Health-related quality of life is a predictor of readmission following emergency laparotomy. 健康相关生活质量是急诊开腹手术后再次入院的预测因素。
IF 2.3 3区 医学
World Journal of Surgery Pub Date : 2024-08-01 Epub Date: 2024-06-19 DOI: 10.1002/wjs.12260
Lív Í Soylu, Jannick Brander Hansen, Madeline Kvist, Jakob Burcharth, Dunja Kokotovic
{"title":"Health-related quality of life is a predictor of readmission following emergency laparotomy.","authors":"Lív Í Soylu, Jannick Brander Hansen, Madeline Kvist, Jakob Burcharth, Dunja Kokotovic","doi":"10.1002/wjs.12260","DOIUrl":"10.1002/wjs.12260","url":null,"abstract":"<p><strong>Background: </strong>Health-related quality of life (HRQoL) is a multidimensional concept used to examine the impact of patient-perceived health status on quality of life. Patients' perception of illness affects outcomes in both medical and elective surgical patients; however, not much is known about how HRQoL effects outcomes in the emergency surgical setting. This study aimed to examine if patient-reported HRQoL was a predictor of unplanned readmission after emergency laparotomy.</p><p><strong>Methods: </strong>This study included 215 patients who underwent emergency laparotomy at the Copenhagen University Hospital, Herlev, between August 1, 2021, and July 31, 2022. Patient-reported HRQoL was assessed with the EuroQol group EQ5D index (EQ5D5L descriptive system and EQ-VAS). The population was followed from 0 to 180 days after discharge, and readmissions and days alive and out of hospital were registered. A Cox proportional hazard model was used to examine HRQoL and the risk of readmission within 30 and 180 days.</p><p><strong>Results: </strong>Within 30 days, 28.4% of patients were readmitted; within 180 days, the number accumulated to 45.1%. Low self-evaluated HRQoL predicted 180-day readmission and was significantly associated with fewer days out of hospital within both 90 and 180 days. Low HRQoL and discharge with rehabilitation were independent risk factors for short- (30-day) and long-term (180-day) emergency readmission.</p><p><strong>Conclusion: </strong>Patient-perceived quality of life is an independent predictor of 180-day readmission, and the number of days out of hospital was correlated to self-reported HRQoL.</p>","PeriodicalId":23926,"journal":{"name":"World Journal of Surgery","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141427710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Laparoscopic dissection of the first and second porta hepatis along Laennec's capsule via "Hepatic Serosal Incision" approach: How I do it. 通过 "肝浆膜切口 "方法沿 Laennec 囊进行腹腔镜第一和第二肝门解剖:我是怎么做的
IF 2.3 3区 医学
World Journal of Surgery Pub Date : 2024-08-01 Epub Date: 2024-06-18 DOI: 10.1002/wjs.12255
Chuanhai Zhang, Jinliang Ma, Yi Zhou
{"title":"Laparoscopic dissection of the first and second porta hepatis along Laennec's capsule via \"Hepatic Serosal Incision\" approach: How I do it.","authors":"Chuanhai Zhang, Jinliang Ma, Yi Zhou","doi":"10.1002/wjs.12255","DOIUrl":"10.1002/wjs.12255","url":null,"abstract":"<p><p>To provide a standardized approach for laparoscopic access to dissection of the first and second porta hepatis. By opening a portion of the hepatic serosa and subsequently exposing the hepatic Laennec's capsule, dissection of the first and second porta hepatis was performed along the Laennec's capsule. Utilizing the \"Hepatic Serosal Incision\" approach along the Laennec's capsule enabled the precise dissection of the left and right hepatic pedicles of the first porta hepatis and the root of the hepatic veins at the second porta hepatis under laparoscopy. This method allows for rapid and accurate access to the space between Laennec's capsule and the hepatic hilar plate system under laparoscopy as well as clear exposure of the root of the hepatic veins and their branches, facilitating more precise laparoscopic anatomical liver resection.</p>","PeriodicalId":23926,"journal":{"name":"World Journal of Surgery","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141421186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Letter to the Editor: "Conflict of interest disclosure by US cardiothoracic surgeons". 致编辑的信:"美国心胸外科医生的利益冲突披露"。
IF 2.3 3区 医学
World Journal of Surgery Pub Date : 2024-08-01 Epub Date: 2024-06-27 DOI: 10.1002/wjs.12270
Hinpetch Daungsupawong, Rujittika Mungmunpuntipantip, Viroj Wiwanitkit
{"title":"Letter to the Editor: \"Conflict of interest disclosure by US cardiothoracic surgeons\".","authors":"Hinpetch Daungsupawong, Rujittika Mungmunpuntipantip, Viroj Wiwanitkit","doi":"10.1002/wjs.12270","DOIUrl":"10.1002/wjs.12270","url":null,"abstract":"","PeriodicalId":23926,"journal":{"name":"World Journal of Surgery","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141471132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Urgency adjusted outcomes of emergency abdominal surgery for inflammatory bowel disease. 炎症性肠病急诊腹部手术的紧急调整结果。
IF 2.3 3区 医学
World Journal of Surgery Pub Date : 2024-08-01 Epub Date: 2024-06-30 DOI: 10.1002/wjs.12257
J A Bunce, J N Lund, G M Tierney
{"title":"Urgency adjusted outcomes of emergency abdominal surgery for inflammatory bowel disease.","authors":"J A Bunce, J N Lund, G M Tierney","doi":"10.1002/wjs.12257","DOIUrl":"10.1002/wjs.12257","url":null,"abstract":"<p><strong>Introduction: </strong>Patients undergoing emergency abdominal surgery for inflammatory bowel disease (IBD) are a complex cohort who are relatively poorly represented in published literature. This is partly due to the lack of consensus of the definition of the term emergency in IBD surgery. There is ongoing and recent work defining clinical urgency for unplanned surgical procedures and categorizing the high-risk surgical patient. This paper aims to report the difference in patient metrics and risks as recorded by the National Emergency Laparotomy Audit (NELA).</p><p><strong>Methods: </strong>Complete patient data, including histology, were available in the NELA database between 2013 and 2016. Urgency categories recorded by NELA are <2 h, 2-6 h, 6-18 h, and >18 h. Patient characteristics, physiology, biochemistry, and outcomes are reported according to these urgency categories with regression analysis used to compare differences between them.</p><p><strong>Results: </strong>Mortality in Crohn's disease (CD) ranged from 1.4% in the >18 h urgency to 14.6% in the most urgent. In ulcerative colitis (UC), this range was from 3.1% to 14.8%. In both CD and UC, there were significant trends in hemodynamic instability, serum white cell count, serum electrolytes and creatinine, and outcome measures length of stay and unplanned return to theater.</p><p><strong>Conclusions: </strong>Patients having emergency surgery for IBD are not a single cohort when considering physiology, blood biochemistry, or most importantly, outcomes. Risk counseling and management should reflect this. Hemodynamic changes are subtle and may be missed in this cohort.</p>","PeriodicalId":23926,"journal":{"name":"World Journal of Surgery","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141471175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pancreaticogastrostomy versus pancreaticojejunostomy after pancreatic head resection: An updated meta-analysis. 胰头切除术后的胰胃造口术与胰空肠造口术:最新荟萃分析。
IF 2.3 3区 医学
World Journal of Surgery Pub Date : 2024-08-01 Epub Date: 2024-06-12 DOI: 10.1002/wjs.12250
Maurizio Zizzo, Andrea Morini, Magda Zanelli, David Tumiati, Massimiliano Fabozzi
{"title":"Pancreaticogastrostomy versus pancreaticojejunostomy after pancreatic head resection: An updated meta-analysis.","authors":"Maurizio Zizzo, Andrea Morini, Magda Zanelli, David Tumiati, Massimiliano Fabozzi","doi":"10.1002/wjs.12250","DOIUrl":"10.1002/wjs.12250","url":null,"abstract":"","PeriodicalId":23926,"journal":{"name":"World Journal of Surgery","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141311913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Retraction: Validation of the aldosteronoma resolution score as a predictive resolution score of hypertension after unilateral adrenalectomy for primary aldosteronism in a North-African population. 撤回:醛固酮瘤消退评分作为原发性醛固酮增多症单侧肾上腺切除术后高血压预测消退评分在北非人群中的验证。
IF 2.3 3区 医学
World Journal of Surgery Pub Date : 2024-08-01 Epub Date: 2024-06-27 DOI: 10.1002/wjs.12266
{"title":"Retraction: Validation of the aldosteronoma resolution score as a predictive resolution score of hypertension after unilateral adrenalectomy for primary aldosteronism in a North-African population.","authors":"","doi":"10.1002/wjs.12266","DOIUrl":"10.1002/wjs.12266","url":null,"abstract":"","PeriodicalId":23926,"journal":{"name":"World Journal of Surgery","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141471135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Implementation of a perioperative registry in Ethiopia to enhance surgical quality improvement. 在埃塞俄比亚实施围手术期登记,以提高手术质量。
IF 2.3 3区 医学
World Journal of Surgery Pub Date : 2024-08-01 Epub Date: 2024-06-06 DOI: 10.1002/wjs.12240
Taylor J Jaraczewski, Belay M Abebe, Thomas Diehl, Tinbite Esayas, Winta Melaku, Yonas Nigussie, Kaleem S Ahmed, Tien Vo, McKenzie Lee, Biruk Woisha, Ermias Tadesse Woldegiorgis, Taylor H Chen, Bereket A Tegene, Anteneh Gadisa Belachew, Christopher Dodgion, Katherine R Iverson, Girma Tefera, Syed Nabeel Zafar
{"title":"Implementation of a perioperative registry in Ethiopia to enhance surgical quality improvement.","authors":"Taylor J Jaraczewski, Belay M Abebe, Thomas Diehl, Tinbite Esayas, Winta Melaku, Yonas Nigussie, Kaleem S Ahmed, Tien Vo, McKenzie Lee, Biruk Woisha, Ermias Tadesse Woldegiorgis, Taylor H Chen, Bereket A Tegene, Anteneh Gadisa Belachew, Christopher Dodgion, Katherine R Iverson, Girma Tefera, Syed Nabeel Zafar","doi":"10.1002/wjs.12240","DOIUrl":"10.1002/wjs.12240","url":null,"abstract":"<p><strong>Background: </strong>Despite a glaring need and proven efficacy, prospective surgical registries are lacking in low- and middle-income countries. The objective of this study was to design and implement a comprehensive prospective perioperative registry in a low-income country.</p><p><strong>Methods: </strong>This study was conducted at Hawassa University Comprehensive Specialized Hospital in Hawassa, Ethiopia. Design of the registry occurred from June 2021 to May 2022 and pilot implementation from May 2022 to May 2023. All patients undergoing elective or emergent general surgery were included. Following one year, operability and fidelity of the registry were analyzed by assessing capture rate, incidence of missing data, and accuracy.</p><p><strong>Results: </strong>A total of 67 variables were included in the registry including demographics, preoperative, operative, post-operative, and 30-day data. Of 440 eligible patients, 226 (51.4%) were successfully captured. Overall incidence of missing data and accuracy was 5.4% and 90.2% respectively. Post pilot modifications enhanced capture rate to 70.5% and further optimized data collection processes.</p><p><strong>Conclusion: </strong>The establishment of a low-cost electronic prospective perioperative registry in a low-income country represents a significant step forward in enhancing surgical care in under-resourced settings. The initial success of this registry highlights the feasibility of such endeavors when strong partnerships and local context are at the center of implementation. Continuous efforts to refine this registry are ongoing, which will ultimately lead to enhanced surgical quality, research output, and expansion to other sites.</p>","PeriodicalId":23926,"journal":{"name":"World Journal of Surgery","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141284935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nonoperative management of acute complicated diverticulitis with pericolic and/or distant extraluminal air: A systematic review. 急性复杂性憩室炎伴有包膜和/或远端腔外积气的非手术治疗:系统性综述。
IF 2.3 3区 医学
World Journal of Surgery Pub Date : 2024-08-01 Epub Date: 2024-06-06 DOI: 10.1002/wjs.12244
Andrea Morini, Maurizio Zizzo, David Tumiati, Federica Mereu, Diego Bernini, Massimiliano Fabozzi
{"title":"Nonoperative management of acute complicated diverticulitis with pericolic and/or distant extraluminal air: A systematic review.","authors":"Andrea Morini, Maurizio Zizzo, David Tumiati, Federica Mereu, Diego Bernini, Massimiliano Fabozzi","doi":"10.1002/wjs.12244","DOIUrl":"10.1002/wjs.12244","url":null,"abstract":"<p><strong>Introduction: </strong>Colonic Diverticular Disease (CDD) is a multifactorial inflammatory disease. Acute diverticulitis (AD), with extraluminal free air (both pericolic and distant), represents about 15% of radiological scenarios and remains a therapeutic challenge for surgeons. Currently, the WSES guidelines suggest trying a conservative strategy both in the presence of pericolic and distant free extraluminal air, even if both have respectively weak recommendation based on low/very low-quality evidence.</p><p><strong>Methods: </strong>We performed a systematic review following the Preferred Reporting Items for Systematic Reviews and Meta-Analyzes guidelines. PubMed/MEDLINE, Scopus, Web of Science, and Embase databases were used to identify articles of interest.</p><p><strong>Results: </strong>A total of 2380 patients with AD and extraluminal free air (both pericolic and distant) who underwent nonoperative management (NOM) were analyzed. Of the 2380 patients, 2095(88%) were successfully treated with NOM, while 285 (12%) patients failed. A total of 1574 (93.1%) patients with pericolic extraluminal free air had a successful NOM with 6.9% (117) failure rates, while 135 (71.1%) patients with distant extraluminal free air had a successful NOM with 28.9% (55) failure rates. Regarding distant recurrence, we recorded a rate of 18.3% (261/1430), while a rate of 11.3% (167/1472) was recorded for patients undergoing elective surgery.</p><p><strong>Conclusion: </strong>NOM for patients with AD and extraluminal free air (both pericolic and distant) seems to be feasible and safe despite a higher failure rate in the distant subgroup, which remains the most challenging clinical scenario to deal with through conservative treatment.</p>","PeriodicalId":23926,"journal":{"name":"World Journal of Surgery","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141284936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Discrete prognostic implication of sarcopenia according to nutritional status in surgically treated patients with hypopharyngeal cancer. 下咽癌手术治疗患者营养状况对肌肉疏松症预后的不同影响。
IF 2.3 3区 医学
World Journal of Surgery Pub Date : 2024-08-01 Epub Date: 2024-06-12 DOI: 10.1002/wjs.12246
Jun Yong Go, Yoon Se Lee, Young Jun Choi, Min Ji Kim, Min Su Kwon, Young Ho Jung, Seung-Ho Choi, Soon Yuhl Nam
{"title":"Discrete prognostic implication of sarcopenia according to nutritional status in surgically treated patients with hypopharyngeal cancer.","authors":"Jun Yong Go, Yoon Se Lee, Young Jun Choi, Min Ji Kim, Min Su Kwon, Young Ho Jung, Seung-Ho Choi, Soon Yuhl Nam","doi":"10.1002/wjs.12246","DOIUrl":"10.1002/wjs.12246","url":null,"abstract":"<p><strong>Background: </strong>Nutritional status and sarcopenia affects the prognosis of head and neck cancers including hypopharyngeal cancer. Hypopharyngeal cancer patients tend to exhibit sarcopenia, which is associated with poor treatment outcomes. This study aims to determine the correlation between nutritional status and sarcopenia, and their prognostic role in surgically treated hypopharyngeal cancer.</p><p><strong>Materials and methods: </strong>Patients who had been diagnosed with squamous cell carcinoma originating from the hypopharynx and underwent surgery between January 2009 and December 2019 were enrolled in this study. The median neutrophil-to-lymphocyte ratio and prognostic nutritional index (PNI) of the cohort were considered the cut-off values. Sarcopenia was evaluated by measuring skeletal muscle index (SMI) at the third lumbar vertebra. Clinical and serological factors predictive of survival outcomes were evaluated.</p><p><strong>Results: </strong>Patients with high PNI showed better 5-year Overall survival (OS) (52.8% vs. 27.2%, p = 0.001) and disease-free survival (DFS) (59.6% vs. 44.6%, p = 0.033) than those with low PNI. Likewise, patients with low SMI showed worse 5-year OS (25.0% vs. 60.9%, p = 0.002) and DFS (42.4% vs. 68.7%, p = 0.034) than patients with high SMI. Among the patients with high PNI, those with sarcopenia displayed significantly worse OS than those with high SMI (78.0% vs. 34.4%, p = 0.049). High PNI with high SMI presented better overall (p = 0.010) and DFS (p = 0.055) than any other group.</p><p><strong>Conclusions: </strong>Both sarcopenia and PNI were associated with the prognosis of hypopharyngeal cancer. Considering that PNI and sarcopenia indicate the nutritional status, nutritional status may be a significant risk factor. Therefore, nutritional support that ameliorates sarcopenia may improve survival outcomes in surgically treated patients with hypopharyngeal cancer.</p>","PeriodicalId":23926,"journal":{"name":"World Journal of Surgery","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141311912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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