IIUM Journal of Orofacial and Health Sciences最新文献

Anti-MRSA activity of Stereospermum fimbriatum’s stem bark extracted using subcritical and supercritical carbon dioxide 亚临界和超临界二氧化碳提取的直精茎皮抗mrsa活性研究

IIUM Journal of Orofacial and Health Sciences Pub Date : 2023-07-31 DOI: 10.31436/ijohs.v4i2.221

Anis Fadhlina, Hassan Ibrahim Sheikh

{"title":"Anti-MRSA activity of Stereospermum fimbriatum’s stem bark extracted using subcritical and supercritical carbon dioxide","authors":"Anis Fadhlina, Hassan Ibrahim Sheikh","doi":"10.31436/ijohs.v4i2.221","DOIUrl":"https://doi.org/10.31436/ijohs.v4i2.221","url":null,"abstract":"Antibiotic resistance is a major challenge in healthcare, and this is further worsened by the presence of the dreadful Methicillin-resistant Staphylococcus aureus (MRSA) infection. This has urged scientists to find new effective antimicrobial drugs. Earth is enriched with natural resources such as plants that have been used traditionally to cure diseases. Stereospermum fimbriatum or “Chicha” had been used traditionally to treat several illnesses such as stomachache, earache, itchy skin, and postpartum illness. Thus, this study was designed to investigate the antibacterial potential of S. fimbriatum’s stem bark against MRSA. Subcritical (Sub-CO2) and supercritical carbon dioxide (Sup-CO2) extractions were used to extract the stem bark, with and without the addition of co-solvent (ethanol). The antimicrobial assay was carried out using disc diffusion (200, 400 and 600 µg/disc), minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) tests. There was no anti-MRSA activity observed on both the Sub-CO2 and Sup-CO2 extracts without 10% ethanol. The most potent anti-MRSA was observed by the Sup-CO2 extract with 10% ethanol with the MIC value of 500 µg/mL. Therefore, the use of ethanol (10 %) in the extraction increased the antibacterial activity of the S. fimbriatum’s extract against MRSA. These research findings could potentially facilitate future investigations into the utilization of green extraction methods to uncover promising antibacterial agents that can effectively target MRSA, a formidable pathogen. Future studies on the other parts of S. fimbriatum, its potential toxicity, and the possible mechanisms of action are needed to investigate its promising therapeutic values on MRSA infections.","PeriodicalId":239255,"journal":{"name":"IIUM Journal of Orofacial and Health Sciences","volume":"8 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135313531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The effect of probiotic Lactobacillus rhamnosus GG on Candida albicans and Candida tropicalis biofilm formation: A preliminary study 益生菌鼠李糖乳杆菌GG对白色念珠菌和热带念珠菌生物膜形成影响的初步研究

IIUM Journal of Orofacial and Health Sciences Pub Date : 2023-07-31 DOI: 10.31436/ijohs.v4i2.204

Aalina Mohd Fuad, Wan Nur Akma Wan Mazlan, Ridhwan Abdul Wahab, Nurrul Shaqinah Nasruddin, Mohd Hafiz Arzmi

{"title":"The effect of probiotic Lactobacillus rhamnosus GG on Candida albicans and Candida tropicalis biofilm formation: A preliminary study","authors":"Aalina Mohd Fuad, Wan Nur Akma Wan Mazlan, Ridhwan Abdul Wahab, Nurrul Shaqinah Nasruddin, Mohd Hafiz Arzmi","doi":"10.31436/ijohs.v4i2.204","DOIUrl":"https://doi.org/10.31436/ijohs.v4i2.204","url":null,"abstract":"Lactobacillus rhamnosus are Gram-positive and lactic acid-producing bacteria. Meanwhile, Candida albicans and Candida tropicalis are opportunistic fungi that cause oral candidiasis. This study aimed to determine the effect of LGG on the biofilm formation of C. tropicalis and C. albicans with the hypothesis that LGG inhibits the biofilm of the yeasts. C. albicans ATCC MYA-4901 and C. tropicalis ATCC 13803 were standardised to 1x106 cells to form a mono-species biofilm. L. rhamnosus GG (LGG) was standardised to 1x107 cells, equivalent to absorbance 0.5 at OD620nm. The microorganisms were cultivated in nutrient broth in a 96-well plate and incubated at 37°C for 24 h and 48 h. Co-culture biofilm was developed by combining Candida spp. with LGG in the same well at a similar concentration as the mono-culture. Crystal violet assay was conducted to assess the biofilm biomass with absorbance measured at OD620nm wavelength. After 24 hours, polymicrobial biofilms of C. albicans with LGG decreased by 37.1 ± 9.2%. At 48 hours, it further decreased to 44.7 ± 5.9%. For C. tropicalis, co-culture biofilms with LGG decreased by 16.3 ± 5.9% and 35.7 ± 7.6% after 24 h and 48 h incubation, respectively. LGG significantly reduced C. albicans biofilm compared to C. tropicalis (P<0.05). In conclusion, LGG has antibiofilm activity against C. albicans and C. tropicalis. However, further study is needed to conclude the effect against other species strains.","PeriodicalId":239255,"journal":{"name":"IIUM Journal of Orofacial and Health Sciences","volume":"22 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135313412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pressurised putty technique: A technical report 压腻子技术:技术报告

IIUM Journal of Orofacial and Health Sciences Pub Date : 2023-07-31 DOI: 10.31436/ijohs.v4i2.215

Joshua Ee Xin Ong

引用次数: 0

Molecular docking study of hyaluronic acid against interleukin-6 (7DC8 protein) in COVID-19 patients with periodontitis 透明质酸对COVID-19牙周炎患者白细胞介素-6 (7DC8蛋白)的分子对接研究

IIUM Journal of Orofacial and Health Sciences Pub Date : 2023-07-31 DOI: 10.31436/ijohs.v4i2.219

Ade Ismail, Syafirudin Aulia Azhar

{"title":"Molecular docking study of hyaluronic acid against interleukin-6 (7DC8 protein) in COVID-19 patients with periodontitis","authors":"Ade Ismail, Syafirudin Aulia Azhar","doi":"10.31436/ijohs.v4i2.219","DOIUrl":"https://doi.org/10.31436/ijohs.v4i2.219","url":null,"abstract":"Coronavirus disease 2019 (COVID-19) is a new disease caused by a coronavirus, namely SARS-CoV-2. This virus was entered inside the host by angiotensin-converting enzyme receptors (ACE2). Recent evidence suggests that sulcus fluid in the periodontal pockets of patients with periodontitis may be a source of SARS-CoV-2 and a potential reservoir for increasing oral viral load in patients with confirmed COVID-19. ACE-2 is expressed in stratified squamous epithelium mainly on the dorsal tongue and gingiva. The gingival sulcular epithelium is the entry point for SARS-CoV-2 into the periodontal pocket epithelium through the gingival crevicular fluid (GCF). Hyaluronic acid (HA) is a high molecule of heavy polysaccharide (glycosaminoglycan) which has several functions, such as anti-inflammatory and accelerated wound healing. It could decrease the levels of several cytokines. This study aims to analyze the interaction of HA against the IL-6 coronavirus receptor in periodontitis through a molecular docking study using MOE 2015.10 software with IL-6 receptor (7DC8) as the protein model to predict the binding of HA with 10 poses. The 7DC8 protein was prepared by adding charge and the validation method was performed with RMSD <2Å which indicates this method is valid. The results of this study showed that there are interaction between HA and the IL-6 receptor via amino acid residue interaction at the Leucine 98 (bond energy -0.7 kcal/mol), Serine 52 (bond energy -1.7 kcal/mol), Glycine 53 (bond energy -1.5 kcal/mol), and Glycine 299 (bond energy -1.6 kcal/mol). HA has an interaction with coronavirus at the IL-6 receptor of periodontitis based on molecular docking study and can potentially be used as a therapeutic option in COVID-19 with periodontitis. In conclusion, hyaluronic acid has the potential as an anti-inflammatory drug of choice in COVID-19 patients with periodontitis.","PeriodicalId":239255,"journal":{"name":"IIUM Journal of Orofacial and Health Sciences","volume":"42 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135313416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prevalence and orthodontic management of missing permanent maxillary lateral incisor at a referral centre in Sabah 沙巴转诊中心上颌侧切牙缺失的患病率和正畸治疗

IIUM Journal of Orofacial and Health Sciences Pub Date : 2023-07-31 DOI: 10.31436/ijohs.v4i2.212

Jin Han Lee

{"title":"Prevalence and orthodontic management of missing permanent maxillary lateral incisor at a referral centre in Sabah","authors":"Jin Han Lee","doi":"10.31436/ijohs.v4i2.212","DOIUrl":"https://doi.org/10.31436/ijohs.v4i2.212","url":null,"abstract":"This was a cross-sectional study of the prevalence and orthodontic management of developmental missing permanent maxillary lateral incisor of patients referred for orthodontic treatment from year 2010 to 2020. The dental records of written case notes, radiographs, and study models that fulfilled the inclusion criteria were selected using systematic sampling and were assessed retrospectively. Sample were taken from every five dental records. Dental records that did not fulfil the inclusion criteria were substituted. Data taken were the demographic data, side of the missing maxillary lateral incisor, and the orthodontic management. All variables were analysed descriptively. The differences between orthodontic open space and orthodontic close space with respect of unilateral and bilateral missing permanent maxillary lateral incisor were tested using Fisher’s exact test. From the total of 291 samples, there were 11 (3.78%) patients presented with missing permanent maxillary lateral incisor. The mean age of the patients was 17.46 ± 1.52 years. All 11 patients were females. There were six (54.55%) patients presented with bilateral missing permanent maxillary lateral incisor, while five (45.45%) were unilateral. From the unilateral group, there were three (27.27%) patients presented with right side missing permanent maxillary lateral incisor. Six (54.55%) patients were treated with orthodontic open space, while five (45.45%) patients were treated with orthodontic close space. In conclusion, the prevalence of missing permanent maxillary lateral incisor was 3.78%. All patients were females. More patients presented with bilateral missing permanent maxillary lateral incisor. The treatments provided were orthodontic open space and orthodontic close space.","PeriodicalId":239255,"journal":{"name":"IIUM Journal of Orofacial and Health Sciences","volume":"56 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135313418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Digital and clinical approach to quantifying periodontal tissue changes after crown lengthening surgery: A case series pilot study 数字和临床方法量化牙冠延长手术后牙周组织变化:一项病例系列初步研究

IIUM Journal of Orofacial and Health Sciences Pub Date : 2023-07-31 DOI: 10.31436/ijohs.v4i2.196

Rayner Goh, Samantha Caitlin Smith, Momen Atieh, Andrew Tawse-Smith

{"title":"Digital and clinical approach to quantifying periodontal tissue changes after crown lengthening surgery: A case series pilot study","authors":"Rayner Goh, Samantha Caitlin Smith, Momen Atieh, Andrew Tawse-Smith","doi":"10.31436/ijohs.v4i2.196","DOIUrl":"https://doi.org/10.31436/ijohs.v4i2.196","url":null,"abstract":"Crown lengthening surgery is a common periodontal procedure carried out to increase the amount of tooth exposure for aesthetic or restorative purposes. It is crucial for clinicians to understand the effect of crown lengthening surgery on the periodontal tissues to prevent relapse or over treatment. Even though various clinical parameters have been used by researchers in the past to quantify the amount of suprastructure exposed, the use of digital technology has not been widely adopted. The aim of this case series was to evaluate the changes in periodontal tissue after crown lengthening surgery with both clinical and digital approaches. This case series included five patients who underwent surgery at the Postgraduate Periodontics Clinic at the University of Otago over the period of six months. Clinical parameters such as probing depth, gingival recession, keratinised tissue height, plaque accumulation, gingival inflammation, crown height, gingival phenotype, and bone height were measured with a customised probing stent at baseline and 1-, 3-, and 6-month post-surgery. Digital impressions were also taken along with the clinical parameters to measure the volumetric changes. Most significant changes were observed in crown exposure, gingival recession and bone levels, followed by probing depth reduction for treated sites. Minimal changes were seen for the width of keratinised tissues, plaque levels and gingival scores. Volumetric changes were only significantly reduced after 6 months of healing. This case series found that crown lengthening resulted in an increase in tooth exposure and a reduction in tissue volume. Volumetric changes measured through sequential digital impressions were also comparable to clinical findings.","PeriodicalId":239255,"journal":{"name":"IIUM Journal of Orofacial and Health Sciences","volume":"18 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135313533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Application of 2017 new classification of periodontal diseases and conditions: A commentary 2017年牙周病新分类应用述评

IIUM Journal of Orofacial and Health Sciences Pub Date : 2023-07-31 DOI: 10.31436/ijohs.v4i2.246

Mohd Nor Hafizi Mohd Ali

引用次数: 0

Full mouth rehabilitation of young adults with oligodontia: Two case reports emphasizing implantology, prosthodontics, and restorative intervention 青少年少齿症全口康复:两例报告，强调种植、修复和修复干预

IIUM Journal of Orofacial and Health Sciences Pub Date : 2023-07-31 DOI: 10.31436/ijohs.v4i2.167

Seng Boon Chu, Huay Shuan Ooi

{"title":"Full mouth rehabilitation of young adults with oligodontia: Two case reports emphasizing implantology, prosthodontics, and restorative intervention","authors":"Seng Boon Chu, Huay Shuan Ooi","doi":"10.31436/ijohs.v4i2.167","DOIUrl":"https://doi.org/10.31436/ijohs.v4i2.167","url":null,"abstract":"Oligodontia, a severe form of hypodontia characterized by the absence of multiple permanent teeth, presents considerable challenges in dental treatment. Successful management of this condition requires early detection and a comprehensive, multidisciplinary approach. While the complete restoration of missing teeth is typically postponed until all permanent teeth have erupted or after orthodontic therapy, it is crucial to consider additional factors such as the patient's oral hygiene status, socioeconomic circumstances, and long-term maintenance therapy for achieving optimal treatment outcomes. This case reports showcase the effective treatment of oligodontia in two young male patients: a 17-year-old Chinese individual and a 19-year-old Caucasian individual. These cases serve to emphasize the significance of early diagnosis, multidisciplinary collaboration, and personalized treatment planning in addressing the challenges posed by oligodontia. Although orthodontic intervention was not pursued in the presented cases, it is important to recognize its integral role in the overall treatment of oligodontia. The restoration of missing dentition has a profound positive impact on aesthetics, function, and the overall quality of life. The presented cases underscore the importance of early intervention and sustained motivation throughout the treatment process. By emphasizing the value of early detection, comprehensive teamwork, and individualized treatment approaches, clinicians can strive to achieve optimal outcomes for patients with oligodontia.","PeriodicalId":239255,"journal":{"name":"IIUM Journal of Orofacial and Health Sciences","volume":"46 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135313532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Demographic of orthognatic cases seen in Kulliyyah of Dentistry IIUM 库利亚牙科医院正颌病例的人口学分析

IIUM Journal of Orofacial and Health Sciences Pub Date : 2023-07-31 DOI: 10.31436/ijohs.v4i2.199

Noraini Abu Bakar, Nur Arafiqah Amat, Siti Hajjar Nasir

{"title":"Demographic of orthognatic cases seen in Kulliyyah of Dentistry IIUM","authors":"Noraini Abu Bakar, Nur Arafiqah Amat, Siti Hajjar Nasir","doi":"10.31436/ijohs.v4i2.199","DOIUrl":"https://doi.org/10.31436/ijohs.v4i2.199","url":null,"abstract":"Orthognathic treatment is a combination of orthodontics and surgery, aimed to restore functional occlusion and the facial aesthetics. KOD orthognathic team has been established since 2018. There was no published demographic profile of the orthognathic patients referred. This study aimed to enumerate the demographic data and correlations for the orthognathic cases seen in KOD, IIUM from 2018 until December 2020. A total of 28 patients were referred for consultation. One patient was excluded as no referral letter was attached. Data were obtained from patients’ case notes, photos and study models. Data collected were then categorized into patients’ demographic profiles, clinical features, patients’ psychological status and treatment. The demographic pattern and correlations were analysed using SPSS version 25.0. Out of 27 patients, most patients were females (66.7%), Malay (55.6%) and within the age group of 21 to 30 years old (44.4%) and originated from Pahang (88%). Majority of patients presented with Class III skeletal base discrepancy (66.7%), facial asymmetry (76.0%), increased vertical dimension (51.9%), shifted chin point (83.3%), Class III incisal relationship (70.4%), reversed overjet (70.4%), reduced overbite (56.0%) and crossbite (77.7%). Significant relationships were found between skeletal base discrepancy with incisal relationship, overjet, crossbite, canine relationships and right molar relationship. 57.1% agreed to orthognathic surgery, 32.1% opted for orthodontic treatment alone whilst 10.7% refused any treatment. It is hoped that this baseline demographic data may aid in the management and resource planning for this team in the future.","PeriodicalId":239255,"journal":{"name":"IIUM Journal of Orofacial and Health Sciences","volume":"7 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135313414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dentinogenic ghost cell tumour: A case report 牙本质源性鬼影细胞瘤1例

IIUM Journal of Orofacial and Health Sciences Pub Date : 2023-07-31 DOI: 10.31436/ijohs.v4i2.193

Adelaide Ji Fung Kwong, Ramizah Rozaimee

引用次数: 0