I Zehbe, M Schmidt, M Maeurer, C Leo, M Höckel, H Pilch
{"title":"Different T-cell receptor (TCR) zeta chain expression in cervical cancer and its precursor lesions.","authors":"I Zehbe, M Schmidt, M Maeurer, C Leo, M Höckel, H Pilch","doi":"10.1055/s-2006-933423","DOIUrl":"https://doi.org/10.1055/s-2006-933423","url":null,"abstract":"<p><strong>Objective: </strong>Cervical cancer is associated with infection of epithelial cells with the human papillomavirus (HPV) type 16 and HPV18. A functional signalling machinery in T-cells is required in order to successfully fight and eradicate HPV16+ transformed epithelial cells. One of the key signalling molecules associated with the T-cell receptor (TCR) is the homodimeric zeta chain molecule.</p><p><strong>Material and methods: </strong>28 formalin fixed und paraffin embedded samples of cervical tissue with cervical intraepithelial lesions CIN I (n = 3), CIN III (n = 7), invasive cervical carcinoma (CC) (n = 13) and normal cervical tissue (n = 5) has been evaluated for HPV-PCR und zeta chain immunohistochemistry. For immunohistochemistry a monoclonal IgG1 anti TZR zeta chain-antibody (mAb) has been used (clone 6B 10.2, Santa Cruz, Heidelberg, Germany). According to the performed Western-Blot analysis on peripheral blood monocytes (PBMCs) the used mAb has specifically recognized TCR zeta chains.</p><p><strong>Results: </strong>We show reduced protein zeta chain expression associated with invasive cervical cancer, but not with pre-invasive HPV16-positive lesions or HPV16-negative normal cervix tissue.</p><p><strong>Conclusions: </strong>Thus, reduced TCR zeta chain expression is not necessarily linked to a chronic viral infection, nor to the presence of transformed cells, but rather to the stromal invasion of the cancer lesion.</p>","PeriodicalId":23881,"journal":{"name":"Zentralblatt fur Gynakologie","volume":"128 5","pages":"266-70"},"PeriodicalIF":0.0,"publicationDate":"2006-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1055/s-2006-933423","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"26331375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Audiovisuelle Narkoseaufklärung in der Geburtshilfe","authors":"T. Laux, C. Madler","doi":"10.1055/S-2006-950550","DOIUrl":"https://doi.org/10.1055/S-2006-950550","url":null,"abstract":"","PeriodicalId":23881,"journal":{"name":"Zentralblatt fur Gynakologie","volume":"24 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2006-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80147193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Wo sind die Fortschritte in der gynäkologischen Onkologie","authors":"M. Kaufmann","doi":"10.1055/S-2006-950567","DOIUrl":"https://doi.org/10.1055/S-2006-950567","url":null,"abstract":"","PeriodicalId":23881,"journal":{"name":"Zentralblatt fur Gynakologie","volume":"58 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2006-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80236554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Puhl, C. Interthal, C. Lindner, V. Passuello, D. Macchiella, E. Steiner, H. Kölbl
{"title":"Der Einfluss maternalen Alters auf die Assoziation eines isolierten fetalen intrakardialen echogenen Fokus mit einer chromosomalen Aberration","authors":"A. Puhl, C. Interthal, C. Lindner, V. Passuello, D. Macchiella, E. Steiner, H. Kölbl","doi":"10.1055/S-2006-950544","DOIUrl":"https://doi.org/10.1055/S-2006-950544","url":null,"abstract":"","PeriodicalId":23881,"journal":{"name":"Zentralblatt fur Gynakologie","volume":"88 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2006-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85596219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Rody, U. Holtrich, C. Solbach, V. Müller, E. Ruckhäberle, R. Gätje, M. Gehrmann, G. Minckwitz, T. Karn, M. Kaufmann
{"title":"Das Mammastammzellkonzept – ein theoretisches Konstrukt oder klinisch bedeutsam?","authors":"A. Rody, U. Holtrich, C. Solbach, V. Müller, E. Ruckhäberle, R. Gätje, M. Gehrmann, G. Minckwitz, T. Karn, M. Kaufmann","doi":"10.1055/S-2006-950561","DOIUrl":"https://doi.org/10.1055/S-2006-950561","url":null,"abstract":"","PeriodicalId":23881,"journal":{"name":"Zentralblatt fur Gynakologie","volume":"8 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2006-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76366780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Wieviel Zurückhaltung ist geboten beim Einsatz transvaginaler Netze? Überlegungen zur Indikationsstellung innovativer Methoden","authors":"W. Adelhardt","doi":"10.1055/S-2006-950519","DOIUrl":"https://doi.org/10.1055/S-2006-950519","url":null,"abstract":"","PeriodicalId":23881,"journal":{"name":"Zentralblatt fur Gynakologie","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2006-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83606559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Audiovisuelle Narkoseaufklärung in der operativen Gynäkologie","authors":"T. Laux, C. Madler","doi":"10.1055/S-2006-950569","DOIUrl":"https://doi.org/10.1055/S-2006-950569","url":null,"abstract":"","PeriodicalId":23881,"journal":{"name":"Zentralblatt fur Gynakologie","volume":"104 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2006-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85785600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
F. Melchert, L. Bauer, U. Kraus-Tiefenbacher, F. Wenz
{"title":"Intraoperative Strahlentherapie des Mammakarzinoms – Derzeitiger Stellenwert","authors":"F. Melchert, L. Bauer, U. Kraus-Tiefenbacher, F. Wenz","doi":"10.1055/S-2006-950564","DOIUrl":"https://doi.org/10.1055/S-2006-950564","url":null,"abstract":"","PeriodicalId":23881,"journal":{"name":"Zentralblatt fur Gynakologie","volume":"32 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2006-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79936589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}