Xenotransplantation最新文献_第4页

Long-term control of diabetes by tofacitinib-based immunosuppressive regimen after allo islet transplantation in diabetic rhesus monkeys that rejected previously transplanted porcine islets. 对之前移植猪胰岛产生排斥反应的糖尿病恒河猴进行异体胰岛移植后，使用基于托法替尼的免疫抑制方案可长期控制糖尿病。

IF 3.9 4区医学

Xenotransplantation Pub Date : 2024-03-01 DOI: 10.1111/xen.12850

Jong-Min Kim, Seong-Jun Kang, So-Hee Hong, Hyunwoo Chung, Jun-Seop Shin, Byoung-Hoon Min, Hyun Je Kim, Jongwon Ha, Chung-Gyu Park

{"title":"Long-term control of diabetes by tofacitinib-based immunosuppressive regimen after allo islet transplantation in diabetic rhesus monkeys that rejected previously transplanted porcine islets.","authors":"Jong-Min Kim, Seong-Jun Kang, So-Hee Hong, Hyunwoo Chung, Jun-Seop Shin, Byoung-Hoon Min, Hyun Je Kim, Jongwon Ha, Chung-Gyu Park","doi":"10.1111/xen.12850","DOIUrl":"10.1111/xen.12850","url":null,"abstract":"Porcine islet xenotransplantation has been highlighted as an alternative to allo islet transplantation. Despite the remarkable progress that has been made in porcine-islet pre-clinical studies in nonhuman primates, immunological tolerance to porcine islets has not been achieved to date. Therefore, allo islet transplantation could be required after the failure of porcine islet xenotransplantation. Here, we report the long-term control of diabetes by allogeneic pancreatic islet transplantation in diabetic rhesus monkeys that rejected previously transplanted porcine islets. Four diabetic male rhesus monkeys received the porcine islets and then allo islets (5700-19 000 IEQ/kg) were re-transplanted for a short or long period after the first xeno islet rejection. The recipient monkeys were treated with an immunosuppressive regimen consisting of ATG, humira, and anakinra for induction, and sirolimus and tofacitinib for maintenance therapy. The graft survival days of allo islets in these monkeys were >440, 395, >273, and 127, respectively, similar to that in allo islet transplanted cynomolgus monkeys that received the same immunosuppressive regimen without xeno sensitization. Taken together, it is likely that prior islet xenotransplantation does not affect the survival of subsequent allo islets under clinically applicable immunosuppressants.","PeriodicalId":23866,"journal":{"name":"Xenotransplantation","volume":null,"pages":null},"PeriodicalIF":3.9,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140159084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Close contacts of xenograft recipients: Ethical considerations due to risk of xenozoonosis. 异种移植物接受者的密切接触者：异种动物传染病风险带来的伦理考虑。

IF 3.9 4区医学

Xenotransplantation Pub Date : 2024-03-01 DOI: 10.1111/xen.12847

Daniel J Hurst, Luz Padilla, Daniel Rodger, Tamar Schiff, David K C Cooper

{"title":"Close contacts of xenograft recipients: Ethical considerations due to risk of xenozoonosis.","authors":"Daniel J Hurst, Luz Padilla, Daniel Rodger, Tamar Schiff, David K C Cooper","doi":"10.1111/xen.12847","DOIUrl":"10.1111/xen.12847","url":null,"abstract":"With decades of pre-clinical studies culminating in the recent clinical application of xenotransplantation, it would appear timely to provide recommendations for operationalizing oversight of xenotransplantation clinical trials. Ethical issues with clinical xenotransplantation have been described for decades, largely centering on animal welfare, the risks posed to the recipient, and public health risks posed by potential spread of xenozoonosis. Much less attention has been given to considerations relating to potentially elevated risks faced by those who may care for or otherwise have close contact with xenograft recipients. This paper examines the ethical and logistical issues raised by the potential exposure to xenozoonotic disease faced by close contacts of xenotransplant recipients-defined herein as including but not limited to caregivers, household contacts, and sexual partners-which warrants special attention given their increased risk of exposure to infection compared to the general public. We discuss implications of assent or consent by these close contacts to potentially undergo, along with the recipient, procedures for infection screening and possible quarantine. We then propose several options and recommendations for operationalizing oversight of xenotransplantation clinical trials that could account for and address close contacts' education on and agency regarding the risk of xenozoonosis.","PeriodicalId":23866,"journal":{"name":"Xenotransplantation","volume":null,"pages":null},"PeriodicalIF":3.9,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140102524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Xenotransplantation at 30 years - A personal reminiscence and some thoughts for the future. 异种器官移植 30 年--个人回忆和对未来的一些思考。

IF 3.9 4区医学

Xenotransplantation Pub Date : 2024-03-01 DOI: 10.1111/xen.12846

David H Sachs

引用次数: 0

Evaluation of knowledge, attitude, and awareness of liver transplant patients toward xenotransplantation 评估肝移植患者对异种移植的知识、态度和认识

IF 3.9 4区医学

Xenotransplantation Pub Date : 2024-02-26 DOI: 10.1111/xen.12844

Bahar Aslan Dogan, Gurkan Ozden, Sevim Dolu, Mesut Mese, Sami Akbulut

引用次数: 0

A study of knowledge and acceptance of kidney xenotransplantation among Chinese kidney transplant recipients and candidates 关于中国肾移植受者和候选者对肾脏异种移植的了解和接受程度的研究

IF 3.9 4区医学

Xenotransplantation Pub Date : 2024-02-26 DOI: 10.1111/xen.12843

Yuhao Tu, Xiangli Zhao, Gang Chen, Lan Zhu

引用次数: 0

Pressing ethical issues relating to clinical pig organ transplantation studies 与临床猪器官移植研究有关的紧迫伦理问题

IF 3.9 4区医学

Xenotransplantation Pub Date : 2024-02-26 DOI: 10.1111/xen.12848

Daniel J. Hurst, David K. C. Cooper

引用次数: 0

Hemodynamics in pig-to-baboon heterotopic thoracic cardiac xenotransplantation: Recovery from perioperative cardiac xenograft dysfunction and impairment by cardiac overgrowth 猪-狒狒异位胸腔心脏异种移植的血液动力学：从围术期心脏异种移植的功能障碍和心脏过度生长的损害中恢复过来

IF 3.9 4区医学

Xenotransplantation Pub Date : 2024-01-25 DOI: 10.1111/xen.12841

Martin Bender, Alessandro Panelli, Bruno Reichart, Julia Radan, Maren Mokelke, Elisabeth Neumann, Ines Buttgereit, Sebastian Michel, Andreas Bauer, Ann Kathrin Fresch, Tanja Mayr, Fabian Werner, Stefanie Egerer, Andrea Bähr, Barbara Kessler, Nikolai Klymiuk, David Ayares, Eckhard Wolf, Christian Hagl, Paolo Brenner, Matthias Längin, Jan-Michael Abicht

引用次数: 0

Porcine embryonic stem cells: An alternative solution for the shortage of human islets to treat type 1 diabetes? 猪胚胎干细胞：治疗 1 型糖尿病的人类胰岛不足的替代解决方案？

IF 3.9 4区医学

Xenotransplantation Pub Date : 2024-01-25 DOI: 10.1111/xen.12840

Mark B. Nottle, Ivan Vassiliev, Wayne J. Hawthorne, Peter J. Cowan

引用次数: 0

Alteration of γδ T cell subsets in non-human primates transplanted with GGTA1 gene-deficient porcine blood vessels. 移植了 GGTA1 基因缺陷猪血管的非人灵长类动物体内 γδ T 细胞亚群的变化。

IF 3.9 4区医学

Xenotransplantation Pub Date : 2024-01-01 Epub Date: 2023-12-19 DOI: 10.1111/xen.12838

Sujin Lee, Yun Shin Chung, Kyo Won Lee, Miran Choi, Chung Hee Sonn, Won Jun Oh, Hun Gi Hong, Joohyun Shim, Kimyung Choi, Sung Joo Kim, Jae Berm Park, Tae Jin Kim

{"title":"Alteration of γδ T cell subsets in non-human primates transplanted with GGTA1 gene-deficient porcine blood vessels.","authors":"Sujin Lee, Yun Shin Chung, Kyo Won Lee, Miran Choi, Chung Hee Sonn, Won Jun Oh, Hun Gi Hong, Joohyun Shim, Kimyung Choi, Sung Joo Kim, Jae Berm Park, Tae Jin Kim","doi":"10.1111/xen.12838","DOIUrl":"10.1111/xen.12838","url":null,"abstract":"Background: αGal-deficient xenografts are protected from hyperacute rejection during xenotransplantation but are still rejected more rapidly than allografts. Despite studies showing the roles of non-Gal antibodies and αβ T cells in xenograft rejection, the involvement of γδ T cells in xenograft rejection has been limitedly investigated.Methods: Six male cynomolgus monkeys were transplanted with porcine vessel xenografts from wild-type (n = 3) or GGTA1 knockout (n = 3) pigs. We measured the proportions and T cell receptor (TCR) repertoires of blood γδ T cells before and after xenotransplant. Grafted porcine vessel-infiltrating immune cells were visualized at the end of experiments.Results: Blood γδ T cells expanded and infiltrated into the graft vessel adventitia following xenotransplantation of α-Gal-deficient pig blood vessels. Pre- and post-transplant analysis of γδ TCR repertoire revealed a transition in δ chain usage post-transplantation, with the expansion of several clonotypes of δ1, δ3, or δ7 chains. Furthermore, the distinctions between pre- and post-transplant δ chain usages were more prominent than those observed for γ chain usages.Conclusion: γδ TCR repertoire was significantly altered by xenotransplantation, suggesting the role of γδ T cells in sustained xenoreactive immune responses.","PeriodicalId":23866,"journal":{"name":"Xenotransplantation","volume":null,"pages":null},"PeriodicalIF":3.9,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138804413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Xenotransplantation literature update March 2023-November 2023. 2023 年 3 月至 2023 年 11 月异种移植文献更新。

IF 3.9 4区医学

Xenotransplantation Pub Date : 2024-01-01 DOI: 10.1111/xen.12837

Shani Kamberi, Raphael P H Meier

引用次数: 0