Zeitschrift fur Rheumatologie最新文献_第9页

[Head-to-head studies on connective tissue diseases and vasculitides]. [结缔组织疾病和血管病的正面研究]。

IF 0.9 4区医学

Zeitschrift fur Rheumatologie Pub Date : 2024-10-01 Epub Date: 2024-07-17 DOI: 10.1007/s00393-024-01537-4

Bernhard Hellmich, Johanna Mucke, Martin Aringer

{"title":"[Head-to-head studies on connective tissue diseases and vasculitides].","authors":"Bernhard Hellmich, Johanna Mucke, Martin Aringer","doi":"10.1007/s00393-024-01537-4","DOIUrl":"10.1007/s00393-024-01537-4","url":null,"abstract":"Head-to-head (H2H) studies enable the direct comparison of several alternative therapeutic approaches and thus provide the evidence-based foundation for the relative position of one treatment as compared to others for a specific indication. These trials constitute an important addition to placebo-controlled clinical trials. Among the controlled clinical trials not performed by the pharmaceutical industry, there are a relevant number of H2H trials for connective tissue diseases (CTDs) and vasculitides, particularly for systemic lupus erythematosus (SLE), systemic sclerosis (SSc), and anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV). This article encompasses a review of the H2H trials for CTDs and vasculitides and discusses their relevance for current treatment algorithms. For SLE the H2H trials were predominantly performed for the treatment of lupus nephritis, demonstrating the impact of low-dose cyclophosphamide and mycophenolate as well as azathioprine for maintenance therapy. In recent H2H trials rituximab could be established as induction and maintenance therapy for AAV, which has now been incorporated into current treatment guidelines. Further comparative trials will be necessary in order to select the most effective and safest treatment for every patient, in the sense of personalized medicine.","PeriodicalId":23834,"journal":{"name":"Zeitschrift fur Rheumatologie","volume":" ","pages":"620-628"},"PeriodicalIF":0.9,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141627823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Is lymphoma screening necessary in Sjögren`s disease, and if so, how?] [是否有必要对斯约格伦病患者进行淋巴瘤筛查，如果有必要，如何筛查？］

IF 0.9 4区医学

Zeitschrift fur Rheumatologie Pub Date : 2024-10-01 Epub Date: 2024-09-12 DOI: 10.1007/s00393-024-01562-3

Torsten Witte

引用次数: 0

[Head-to-head studies on radiographic progression in axial spondyloarthritis]. [轴性脊柱关节炎放射学进展的头对头研究]。

IF 0.9 4区医学

Zeitschrift fur Rheumatologie Pub Date : 2024-10-01 Epub Date: 2024-05-21 DOI: 10.1007/s00393-024-01518-7

Uta Kiltz, Hildrun Haibel

{"title":"[Head-to-head studies on radiographic progression in axial spondyloarthritis].","authors":"Uta Kiltz, Hildrun Haibel","doi":"10.1007/s00393-024-01518-7","DOIUrl":"10.1007/s00393-024-01518-7","url":null,"abstract":"In this review article four clinical comparative studies in axial spondylarthritis (axSpA) are presented and discussed. SURPASS as the only head-to-head study investigated the effect of adalimumab biosimilar disease-modifying antirheumatic drug (bsDMARD) or secukinumab on radiographic progression over a time period of 2 years. Overall, the radiographic progression of the spine was low and no significant difference between adalimumab bsDMARD or secukinumab was noted. The three other studies were not constructed as direct head-to-head studies but compared the efficacy of non-steroidal antirheumatic drugs (NSARD) with and without simultaneous treatment with biological DMARDs (bDMARD). The CONSUL study showed no statistically significant difference in the delay of radiographic progression of the spine over 2 years in radiographic axSpA (r-axSpA) patients, who underwent either combined treatment with golimumab and celecoxib or treatment with golimumab alone over 2 years. The ESTHER study showed that patients with early axSpA active inflammatory lesions, which were detected by whole-body magnetic resonance imaging (MRI), showed a significantly greater improvement under treatment with etanercept than those treated with sulfasalazine. The INFAST study showed that patients with early active axSpA who received a combined treatment of infliximab and naproxen, achieved a clinical remission twice as frequently as those who only received naproxen. Therefore, for the endpoint of radiological progression no difference could be shown in the inhibition of radiological progression between the mechanisms of action investigated. The comparative data for the endpoint of clinical efficacy showed that patients with bDMARDs showed a clearly better response to treatment than patients with NSAR or conventional synthetic DMARDs (csDMARD).","PeriodicalId":23834,"journal":{"name":"Zeitschrift fur Rheumatologie","volume":" ","pages":"629-633"},"PeriodicalIF":0.9,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141072045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[The subanalysis of Rheuma-VOR demonstrates a considerable need for rheumatological care]. [Rheuma-VOR 的子分析表明，对风湿病护理的需求相当大]。

IF 0.9 4区医学

Zeitschrift fur Rheumatologie Pub Date : 2024-10-01 Epub Date: 2024-03-08 DOI: 10.1007/s00393-024-01490-2

Stefanie Hirsch, K Hoeper, D Meyer-Olson, A Schwarting, K Gente, M Dreher, J Hoeper, T Witte, T Thiele

{"title":"[The subanalysis of Rheuma-VOR demonstrates a considerable need for rheumatological care].","authors":"Stefanie Hirsch, K Hoeper, D Meyer-Olson, A Schwarting, K Gente, M Dreher, J Hoeper, T Witte, T Thiele","doi":"10.1007/s00393-024-01490-2","DOIUrl":"10.1007/s00393-024-01490-2","url":null,"abstract":"Background: Early diagnosis and treatment of inflammatory rheumatic diseases can prevent consequential damage such as permanently limited mobility and joint or organ damage. Simultaneously, there is an increasing deficit in medical care owing to the lack of rheumatological capacity. Rural regions are particularly affected.Objectives: The available unconfirmed diagnoses of the study Rheuma-VOR were analysed regarding another definitive inflammatory rheumatic disease.Materials and methods: The returned questionnaires of the rheumatologists participating in Rheuma-VOR were screened for definitive inflammatory rheumatic diseases other than the required diagnosis of rheumatoid arthritis, psoriatic arthritis or spondyloarthritis.Results: Of 910 unconfirmed diagnoses, in 245 patients another definitive diagnosis could be confirmed. A total of 29.8% of the diagnoses corresponded to degenerative joint changes or chronic pain syndrome, whereas 26.1% involved different forms of inflammatory arthritis. The majority of diagnoses (40.5%) were collagenosis or vasculitis, DISCUSSION: The available data show that a rheumatological presentation was indicated for the majority of patients. Owing to the increasing deficits in medical care a prior selection of the patients is crucial to make optimal use of restricted rheumatological capacities.","PeriodicalId":23834,"journal":{"name":"Zeitschrift fur Rheumatologie","volume":" ","pages":"679-685"},"PeriodicalIF":0.9,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11485139/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140060609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mitteilungen der DRL. DRL 的通信。

IF 0.9 4区医学

Zeitschrift fur Rheumatologie Pub Date : 2024-10-01 DOI: 10.1007/s00393-024-01580-1

引用次数: 0

Mitteilungen der DGRh - Veranstaltungen der Rheumaakademie. DGRh 的公告 - 风湿病研究院的活动。

IF 0.9 4区医学

Zeitschrift fur Rheumatologie Pub Date : 2024-10-01 DOI: 10.1007/s00393-024-01579-8

引用次数: 0

[Lupus nephritis and associated thrombotic microangiopathy]. [狼疮肾炎和相关的血栓性微血管病]。

IF 0.9 4区医学

Zeitschrift fur Rheumatologie Pub Date : 2024-10-01 Epub Date: 2024-03-05 DOI: 10.1007/s00393-024-01489-9

Antonia Schuster, Bernhard Banas, Tobias Bergler

引用次数: 0

[Erythema nodosum]. [结节性红斑]。

IF 0.9 4区医学

Zeitschrift fur Rheumatologie Pub Date : 2024-10-01 Epub Date: 2024-06-17 DOI: 10.1007/s00393-024-01529-4

Viktoria Weber, Konstantin Weimann, Isabel Kolm, Barbara Meier-Schiesser

引用次数: 0

[Vasculitic involvement of the skeletal muscle and the peripheral nervous system: clinical and neuropathologic perspective]. [骨骼肌和周围神经系统血管炎受累：临床和神经病理学视角]。

IF 0.9 4区医学

Zeitschrift fur Rheumatologie Pub Date : 2024-09-24 DOI: 10.1007/s00393-024-01567-y

Nikolas Ruffer, Felix Kleefeld, Marie-Therese Holzer, Martin Krusche, Ina Kötter, Udo Schneider, Werner Stenzel

{"title":"[Vasculitic involvement of the skeletal muscle and the peripheral nervous system: clinical and neuropathologic perspective].","authors":"Nikolas Ruffer, Felix Kleefeld, Marie-Therese Holzer, Martin Krusche, Ina Kötter, Udo Schneider, Werner Stenzel","doi":"10.1007/s00393-024-01567-y","DOIUrl":"https://doi.org/10.1007/s00393-024-01567-y","url":null,"abstract":"The peripheral nervous system is a classic target organ in systemic vasculitis. In addition, the skeletal muscle can also be affected. Myalgia, muscle weakness and sensory deficits are typical signs, which can lead to severe functional limitations and impaired of quality of life. Vasculitic involvement of the skeletal muscle (vasculitic myopathy [VM]) and peripheral nerves (vasculitic neuropathy [VN]) occurs predominantly in polyarteritis nodosa and small-vessel vasculitis. VM presents with elevated markers of inflammation and is typically characterized by immobilizing myalgia with normal creatine kinase activity and diffuse or patchy areas of hyperintensity on T2-weighted MRI (\"MRI myositis without myositis\"). In VN, sensor motor deficits predominantly affect the lower extremity in the area supplied by several peripheral nerves (e.g., mononeuritis multiplex) with acute to subacute history. The histopathological examination of nerve and muscle biopsies is the gold standard for the diagnosis of vasculitic manifestations and has a significant impact on the therapeutic approach.","PeriodicalId":23834,"journal":{"name":"Zeitschrift fur Rheumatologie","volume":" ","pages":""},"PeriodicalIF":0.9,"publicationDate":"2024-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142308654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nachruf auf Herrn Professor Dr. sc. med. Wolfgang Keitel. 沃尔夫冈-凯特尔教授的讣告。

IF 0.9 4区医学

Zeitschrift fur Rheumatologie Pub Date : 2024-09-03 DOI: 10.1007/s00393-024-01561-4

Eugen Feist, Karsten Beyer, Carlo Weimann

引用次数: 0