Zeitschrift fur Rheumatologie最新文献_第3页

[Swelling of the salivary glands and sicca symptoms in Kimura's disease, a rare rheumatological differential diagnosis with an indicatively high IgE serum level-A current overview after literature search]. [木村氏病的唾液腺肿胀和眼科症状--一种罕见的风湿病鉴别诊断，血清 IgE 水平较高--文献检索后的综述]。

IF 0.9 4区医学

Zeitschrift fur Rheumatologie Pub Date : 2024-10-01 Epub Date: 2023-09-14 DOI: 10.1007/s00393-023-01411-9

Jürgen Braun, Kirsten Karberg

引用次数: 0

[Head-to-head studies on connective tissue diseases and vasculitides]. [结缔组织疾病和血管病的正面研究]。

IF 0.9 4区医学

Zeitschrift fur Rheumatologie Pub Date : 2024-10-01 Epub Date: 2024-07-17 DOI: 10.1007/s00393-024-01537-4

Bernhard Hellmich, Johanna Mucke, Martin Aringer

{"title":"[Head-to-head studies on connective tissue diseases and vasculitides].","authors":"Bernhard Hellmich, Johanna Mucke, Martin Aringer","doi":"10.1007/s00393-024-01537-4","DOIUrl":"10.1007/s00393-024-01537-4","url":null,"abstract":"Head-to-head (H2H) studies enable the direct comparison of several alternative therapeutic approaches and thus provide the evidence-based foundation for the relative position of one treatment as compared to others for a specific indication. These trials constitute an important addition to placebo-controlled clinical trials. Among the controlled clinical trials not performed by the pharmaceutical industry, there are a relevant number of H2H trials for connective tissue diseases (CTDs) and vasculitides, particularly for systemic lupus erythematosus (SLE), systemic sclerosis (SSc), and anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV). This article encompasses a review of the H2H trials for CTDs and vasculitides and discusses their relevance for current treatment algorithms. For SLE the H2H trials were predominantly performed for the treatment of lupus nephritis, demonstrating the impact of low-dose cyclophosphamide and mycophenolate as well as azathioprine for maintenance therapy. In recent H2H trials rituximab could be established as induction and maintenance therapy for AAV, which has now been incorporated into current treatment guidelines. Further comparative trials will be necessary in order to select the most effective and safest treatment for every patient, in the sense of personalized medicine.","PeriodicalId":23834,"journal":{"name":"Zeitschrift fur Rheumatologie","volume":" ","pages":"620-628"},"PeriodicalIF":0.9,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141627823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Is lymphoma screening necessary in Sjögren`s disease, and if so, how?] [是否有必要对斯约格伦病患者进行淋巴瘤筛查，如果有必要，如何筛查？］

IF 0.9 4区医学

Zeitschrift fur Rheumatologie Pub Date : 2024-10-01 Epub Date: 2024-09-12 DOI: 10.1007/s00393-024-01562-3

Torsten Witte

引用次数: 0

[Head-to-head studies on radiographic progression in axial spondyloarthritis]. [轴性脊柱关节炎放射学进展的头对头研究]。

IF 0.9 4区医学

Zeitschrift fur Rheumatologie Pub Date : 2024-10-01 Epub Date: 2024-05-21 DOI: 10.1007/s00393-024-01518-7

Uta Kiltz, Hildrun Haibel

{"title":"[Head-to-head studies on radiographic progression in axial spondyloarthritis].","authors":"Uta Kiltz, Hildrun Haibel","doi":"10.1007/s00393-024-01518-7","DOIUrl":"10.1007/s00393-024-01518-7","url":null,"abstract":"In this review article four clinical comparative studies in axial spondylarthritis (axSpA) are presented and discussed. SURPASS as the only head-to-head study investigated the effect of adalimumab biosimilar disease-modifying antirheumatic drug (bsDMARD) or secukinumab on radiographic progression over a time period of 2 years. Overall, the radiographic progression of the spine was low and no significant difference between adalimumab bsDMARD or secukinumab was noted. The three other studies were not constructed as direct head-to-head studies but compared the efficacy of non-steroidal antirheumatic drugs (NSARD) with and without simultaneous treatment with biological DMARDs (bDMARD). The CONSUL study showed no statistically significant difference in the delay of radiographic progression of the spine over 2 years in radiographic axSpA (r-axSpA) patients, who underwent either combined treatment with golimumab and celecoxib or treatment with golimumab alone over 2 years. The ESTHER study showed that patients with early axSpA active inflammatory lesions, which were detected by whole-body magnetic resonance imaging (MRI), showed a significantly greater improvement under treatment with etanercept than those treated with sulfasalazine. The INFAST study showed that patients with early active axSpA who received a combined treatment of infliximab and naproxen, achieved a clinical remission twice as frequently as those who only received naproxen. Therefore, for the endpoint of radiological progression no difference could be shown in the inhibition of radiological progression between the mechanisms of action investigated. The comparative data for the endpoint of clinical efficacy showed that patients with bDMARDs showed a clearly better response to treatment than patients with NSAR or conventional synthetic DMARDs (csDMARD).","PeriodicalId":23834,"journal":{"name":"Zeitschrift fur Rheumatologie","volume":" ","pages":"629-633"},"PeriodicalIF":0.9,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141072045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[The subanalysis of Rheuma-VOR demonstrates a considerable need for rheumatological care]. [Rheuma-VOR 的子分析表明，对风湿病护理的需求相当大]。

IF 0.9 4区医学

Zeitschrift fur Rheumatologie Pub Date : 2024-10-01 Epub Date: 2024-03-08 DOI: 10.1007/s00393-024-01490-2

Stefanie Hirsch, K Hoeper, D Meyer-Olson, A Schwarting, K Gente, M Dreher, J Hoeper, T Witte, T Thiele

{"title":"[The subanalysis of Rheuma-VOR demonstrates a considerable need for rheumatological care].","authors":"Stefanie Hirsch, K Hoeper, D Meyer-Olson, A Schwarting, K Gente, M Dreher, J Hoeper, T Witte, T Thiele","doi":"10.1007/s00393-024-01490-2","DOIUrl":"10.1007/s00393-024-01490-2","url":null,"abstract":"Background: Early diagnosis and treatment of inflammatory rheumatic diseases can prevent consequential damage such as permanently limited mobility and joint or organ damage. Simultaneously, there is an increasing deficit in medical care owing to the lack of rheumatological capacity. Rural regions are particularly affected.Objectives: The available unconfirmed diagnoses of the study Rheuma-VOR were analysed regarding another definitive inflammatory rheumatic disease.Materials and methods: The returned questionnaires of the rheumatologists participating in Rheuma-VOR were screened for definitive inflammatory rheumatic diseases other than the required diagnosis of rheumatoid arthritis, psoriatic arthritis or spondyloarthritis.Results: Of 910 unconfirmed diagnoses, in 245 patients another definitive diagnosis could be confirmed. A total of 29.8% of the diagnoses corresponded to degenerative joint changes or chronic pain syndrome, whereas 26.1% involved different forms of inflammatory arthritis. The majority of diagnoses (40.5%) were collagenosis or vasculitis, DISCUSSION: The available data show that a rheumatological presentation was indicated for the majority of patients. Owing to the increasing deficits in medical care a prior selection of the patients is crucial to make optimal use of restricted rheumatological capacities.","PeriodicalId":23834,"journal":{"name":"Zeitschrift fur Rheumatologie","volume":" ","pages":"679-685"},"PeriodicalIF":0.9,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11485139/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140060609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Update on Behçet syndrome]. [贝赫切特综合征的最新进展]。

IF 0.9 4区医学

Zeitschrift fur Rheumatologie Pub Date : 2024-10-01 DOI: 10.1007/s00393-024-01576-x

Ina Kötter, Nikolas Ruffer, Martin Krusche

{"title":"[Update on Behçet syndrome].","authors":"Ina Kötter, Nikolas Ruffer, Martin Krusche","doi":"10.1007/s00393-024-01576-x","DOIUrl":"https://doi.org/10.1007/s00393-024-01576-x","url":null,"abstract":"Background: Behçet syndrome (BS) is a vasculitis of variable vessels with multiple organ manifestations.Objective: This article gives an overview of innovations in the last 2 years.Material and methods: A literature search was carried out using the keyword \"Behcet\" in 2022-2024 in PubMed. The selection of suitable articles was based on the relevance.Results and conclusion: With respect to the pathophysiology it is now clear that BS occupies an intermediate position between autoinflammatory and autoimmune clinical pictures. It is now classified as MHC-I-opathy, i.e., a disease that has a strong association with HLA class I antigens, which also play a prominent role in the pathogenesis. The diagnostic international criteria for Behcet's disease (ICBD) from 2014 with a score of 4 points or more that makes the diagnosis of BS probable have become established; however, in countries with a low prevalence of BS, the differential diagnosis of BS from other diseases is difficult and a higher point limit in the diagnostic score seems to make sense in order to avoid incorrect diagnoses. Clusters or phenotypes of the disease have now been described in various countries in which different symptom complexes frequently occur together; however, the clusters differ between the different countries of origin and depending on the age of the patients. Sonography of the common femoral vein with specific wall thickening in BS patients has been established as an additional tool for the differential diagnosis. Typical characteristics of oral aphthae in BS were also described and the frequency of positivity in the pathergy test could be significantly increased using pneumococcal antigens as the reagent. The treatment recommendations of the EULAR from 2018 still apply; in treatment-refractory cases, tocilizumab, secukinumab, Janus kinase inhibitors (JAKi) and ustekinumab have now also been successfully used. The new EULAR treatment recommendations are expected in 2025.","PeriodicalId":23834,"journal":{"name":"Zeitschrift fur Rheumatologie","volume":" ","pages":""},"PeriodicalIF":0.9,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142362145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mitteilungen der DRL. DRL 的通信。

IF 0.9 4区医学

Zeitschrift fur Rheumatologie Pub Date : 2024-10-01 DOI: 10.1007/s00393-024-01580-1

引用次数: 0

[Lupus nephritis and associated thrombotic microangiopathy]. [狼疮肾炎和相关的血栓性微血管病]。

IF 0.9 4区医学

Zeitschrift fur Rheumatologie Pub Date : 2024-10-01 Epub Date: 2024-03-05 DOI: 10.1007/s00393-024-01489-9

Antonia Schuster, Bernhard Banas, Tobias Bergler

引用次数: 0

Mitteilungen der DGRh - Veranstaltungen der Rheumaakademie. DGRh 的公告 - 风湿病研究院的活动。

IF 0.9 4区医学

Zeitschrift fur Rheumatologie Pub Date : 2024-10-01 DOI: 10.1007/s00393-024-01579-8

引用次数: 0

[Erythema nodosum]. [结节性红斑]。

IF 0.9 4区医学

Zeitschrift fur Rheumatologie Pub Date : 2024-10-01 Epub Date: 2024-06-17 DOI: 10.1007/s00393-024-01529-4

Viktoria Weber, Konstantin Weimann, Isabel Kolm, Barbara Meier-Schiesser

引用次数: 0