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FLUORESCENCE ANALYSIS OF EUPHORBIA HIRTA L. 大戟的荧光分析。
World journal of pharmaceutical research Pub Date : 2017-11-01 DOI: 10.20959/wjpr201711-9563
M. Vaidya
{"title":"FLUORESCENCE ANALYSIS OF EUPHORBIA HIRTA L.","authors":"M. Vaidya","doi":"10.20959/wjpr201711-9563","DOIUrl":"https://doi.org/10.20959/wjpr201711-9563","url":null,"abstract":"Unfortunately, most of the compounds have not properly been evaluated for the exploration of new lead molecule or pharmacophore. Hence, extensive research is required to find out the mechanisms of action as well as bioactivity of the various phytochemicals and efficacy of the medicinal values of plants. The plant Euphorbia hirta is commonly called as Asthma weed. It belongs to the family Euphorbiaceae. The present study is detailed out to complete fluorescence analysis. The study will provide proper information about the presence of bioactive molecules in the crude drug i.e. Euphorbia hirta plant. Thus in the near future Euphorbia hirta extracts could be further exploited as a source of useful phytochemical compounds and may play a very important role in modern system of medicine.","PeriodicalId":23796,"journal":{"name":"World journal of pharmaceutical research","volume":"100 1","pages":"818-822"},"PeriodicalIF":0.0,"publicationDate":"2017-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78650636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
STABILITY INDICATING CHROMATOGRAPHIC METHOD DEVELOPMENT AND VALIDATION FOR THE SIMULTANEOUS ESTIMATION OF METFORMIN HCl & ANAGLIPTIN IN ITS SYNTHETIC MIXTURE BY HPLC 稳定性指示色谱方法的建立及高效液相色谱法同时测定盐酸二甲双胍和阿格列汀合成混合物中含量的验证
World journal of pharmaceutical research Pub Date : 2017-11-01 DOI: 10.20959/WJPR201711-9630
Purva B. Bhatti
{"title":"STABILITY INDICATING CHROMATOGRAPHIC METHOD DEVELOPMENT AND VALIDATION FOR THE SIMULTANEOUS ESTIMATION OF METFORMIN HCl & ANAGLIPTIN IN ITS SYNTHETIC MIXTURE BY HPLC","authors":"Purva B. Bhatti","doi":"10.20959/WJPR201711-9630","DOIUrl":"https://doi.org/10.20959/WJPR201711-9630","url":null,"abstract":"A simple, rapid and accurate stability indicating RP-HPLC method was developed for the simultaneous estimation of Metformin HCl & Anagliptin in its synthetic mixture. The method showed a linear response for concentration of range of 5-15μg/ml using Potassium Phosphate Buffer(PH 7): Acetonitrile solution in the ratio of (35:65) as the mobile phase with detection at 240 nm and flow rate 1ml/min and the retention time for Metformin HCl and Anagliptin was found to be 4.227 and 5.893 respectively. The method was validated for the Specificity, Precision, Robustness, Accuracy, LOD, LOQ, Assay. The drug undergoes degradation under Acidic, Basic, Oxidation, Photolytic and Thermal degradation. All the peaks of degraded product were resolved from active ingredient with significantly different retention time. This method can be employed as a stability indicating one.","PeriodicalId":23796,"journal":{"name":"World journal of pharmaceutical research","volume":"46 1","pages":"956-973"},"PeriodicalIF":0.0,"publicationDate":"2017-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77278864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
JANUBASTI: A SHORT COMMUNICATION Janubasti:简短的交流
World journal of pharmaceutical research Pub Date : 2017-11-01 DOI: 10.20959/WJPR201711-9402
D. Geeta
{"title":"JANUBASTI: A SHORT COMMUNICATION","authors":"D. Geeta","doi":"10.20959/WJPR201711-9402","DOIUrl":"https://doi.org/10.20959/WJPR201711-9402","url":null,"abstract":"","PeriodicalId":23796,"journal":{"name":"World journal of pharmaceutical research","volume":"19 1","pages":"491-492"},"PeriodicalIF":0.0,"publicationDate":"2017-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89741562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
ALPHA AMYLASE AND ALPHA GLUCOSIDASE INHIBITORY ACTIVITY OF AMALAKI RASAYANA-AN AYURVEDIC FORMULATION 阿育吠陀配方的α淀粉酶和α葡萄糖苷酶抑制活性
World journal of pharmaceutical research Pub Date : 2017-11-01 DOI: 10.20959/WJPR201711-9641
P. Bedarkar
{"title":"ALPHA AMYLASE AND ALPHA GLUCOSIDASE INHIBITORY ACTIVITY OF AMALAKI RASAYANA-AN AYURVEDIC FORMULATION","authors":"P. Bedarkar","doi":"10.20959/WJPR201711-9641","DOIUrl":"https://doi.org/10.20959/WJPR201711-9641","url":null,"abstract":"IntroductionPowder of fruit pulp of Indian gooseberry (Amalaki) levigated multiple times with its juice i.e. Amalaki swarasa bhavita Amalaki churna (ASBAC) is commonly regarded as Amalaki Rasayana (AR) is recommended in Ayurvedic classics and practiced in the management (treatment, prevention of complications) of Madhumeha (Diabetes). Alpha amylase and alpha glucosidase activities of Amalaki Rasayana has not been evaluated till the date. Hence, its in-vitro study was conducted. Aims and objectives-To evaluate amylase and glucosidase activities of Amalaki Rasayana. Materials and methodsAmalaki Rasayana was prepared with 16 times levigation (Bhavana) of fine powder of fruit pulp of Indian gooseberry (Amalaki, Emblica officinalis Gaertn.) with its fresh fruit pulp juice equal in quantity for each levigation leading to 36.33% of powder and 63.66% of total solid content derived from 581.39% of fresh fruit pulp juice. Methanolic extract of Amalaki Rasayana was tested for Porcine pancreatic amylase inhibition and intestinal glucosidase activities at 4 concentrations (40, 80, 120 and 160 μg/ml) through starch as base and chromogenic DNSA (3, 5-dinitrosalicylic acid) as colouring agent, in 2 different solutions by recording absorbance with UV VIS Spectrophotometer. Results-Amalaki Rasayana exhibited comparatively better amylase inhibition and -glucosidase inhibition by acetic acid buffer and inhibition was dose dependent at all concentration. ConclusionAmalaki Rasayana exhibited inhibition of Pancreatic Alpha amylase and intestinal alpha glucosidase in dose dependent manner in the concentration of 40, 80, 120 and 160 μg/ml thus have potential to reduce post prandial hyperglycemia. World Journal of Pharmaceutical Research SJIF Impact Factor 7.523 Volume 6, Issue 11, 994-1002. Research Article ISSN 2277– 7105 Article Received on 02 August 2017, Revised on 23 August 2017, Accepted on 13 Sept. 2017 DOI: 10.20959/wjpr201711-9641","PeriodicalId":23796,"journal":{"name":"World journal of pharmaceutical research","volume":"109 1","pages":"994-1002"},"PeriodicalIF":0.0,"publicationDate":"2017-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80585333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
IMMUNOMODULATORY AND ANTI-INFLAMMATORY ACTIVITIES OF ALGERIAN ULVA LACTUCA 阿尔及利亚榆树的免疫调节和抗炎活性
World journal of pharmaceutical research Pub Date : 2017-11-01 DOI: 10.20959/wjpr201711-9478
S. Ameddah
{"title":"IMMUNOMODULATORY AND ANTI-INFLAMMATORY ACTIVITIES OF ALGERIAN ULVA LACTUCA","authors":"S. Ameddah","doi":"10.20959/wjpr201711-9478","DOIUrl":"https://doi.org/10.20959/wjpr201711-9478","url":null,"abstract":"Background: Secondary metabolites such as polysaccharides and lectins from seaweeds were characterized by a broad spectrum of immunomodulatory and anti-inflammatory effect. There are few studies in the literature about the bioactivities of Algerian Ulva lactuca marine algae extracts; that remain largely unexploited, thus this study aimed to examine whether polysaccharide or lectine fraction from Algerian U. lactuca are believed to promote anti-inflammatory and immunomodulatory properties. Methods: the polysaccharide or lectine fraction extracted from Algerian U. lactuca were evaluated in vivo by testing the carrageenan induced acute inflammatory in Wistar rats and the in vivo immunomodulatory effect. The U. lactuca metabolites were also examined for their capacity to inhibit the synthesis of TNF-α, and the release of NO in mouse macrophages RAW 264.7 stimulated with LPS. Results: The results showed that the both U. lactuca polysachrides (ULPF) and lectines (ULLF) phases at 100 mg/kg proved a significant anti-edema effect. The ULPF phase was significantly more effective in decreasing MPO activity and MDA level in rat paw than ULLF phase. Both ULPF and ULLF phases enhanced the in vivo macrophage phagocytic activity, this effect is more pronounced in the ULLF-group than that in ULPF-group. At 60 μg/mL both ULPF or ULLF fraction from U. lactuca were weakly cytotoxic on RAW cells. Both ULPF or ULLF World Journal of Pharmaceutical Research SJIF Impact Factor 7.523 Volume 6, Issue 11, 72-95. Research Article ISSN 2277– 7105 *Corresponding Author","PeriodicalId":23796,"journal":{"name":"World journal of pharmaceutical research","volume":"73 1","pages":"72-95"},"PeriodicalIF":0.0,"publicationDate":"2017-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90891604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
COLON TARGETED MICROBEADS: A NOVEL APPROACH IN NDDS 结肠靶向微珠:治疗NDDS的新方法
World journal of pharmaceutical research Pub Date : 2017-11-01 DOI: 10.20959/WJPR201711-9586
Piyush Mahajan
{"title":"COLON TARGETED MICROBEADS: A NOVEL APPROACH IN NDDS","authors":"Piyush Mahajan","doi":"10.20959/WJPR201711-9586","DOIUrl":"https://doi.org/10.20959/WJPR201711-9586","url":null,"abstract":"In oral colon-specific drug delivery system, colon has a large amount of lymphoma tissue (facilitates direct absorption in to the blood), negligible brush boarder membrane activity, and much less pancreatic enzymatic activity as compared with the small intestine. Colon-specific drug delivery has gained increased importance not just for the delivery of the drugs for treatment of local diseases associated with the colon but also for its potential for the delivery of proteins and therapeutic peptides. Different approaches are designed based on prodrug formulation, pH-sensitivity, time-dependency (lag time), microbial degradation and osmotic pressure etc to formulate the different dosage forms like tablets, capsules, multiparticulates, microspheres, microbeads, liposome for colon targeting. The efficiency of drug delivery system is evaluated using different in vitro and in vivo release studies. This review updated the research on different approaches for formulation and evaluation of colon-specific drug delivery systems (CDDS).","PeriodicalId":23796,"journal":{"name":"World journal of pharmaceutical research","volume":"88 ","pages":"280-292"},"PeriodicalIF":0.0,"publicationDate":"2017-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91456384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
PHARMACOGNOSTICAL AND PHYTOCHEMICAL STANDARDISATION OF AAP PACHANA VATI – ANAYURVEDIC POLYHERBOMINERAL FORMULATION. 中药多酚制剂的生药学和植物化学标准。
World journal of pharmaceutical research Pub Date : 2017-11-01 DOI: 10.20959/wjpr201711-9591
Hetal B. Nakum
{"title":"PHARMACOGNOSTICAL AND PHYTOCHEMICAL STANDARDISATION OF AAP PACHANA VATI – ANAYURVEDIC POLYHERBOMINERAL FORMULATION.","authors":"Hetal B. Nakum","doi":"10.20959/wjpr201711-9591","DOIUrl":"https://doi.org/10.20959/wjpr201711-9591","url":null,"abstract":"","PeriodicalId":23796,"journal":{"name":"World journal of pharmaceutical research","volume":"25 1","pages":"859-865"},"PeriodicalIF":0.0,"publicationDate":"2017-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77642182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
LITERATURE REVIEW OF SCAVOLA TACCADA 裂唇果的文献综述
World journal of pharmaceutical research Pub Date : 2017-11-01 DOI: 10.20959/wjpr201711-9578
N. G. Sutar
{"title":"LITERATURE REVIEW OF SCAVOLA TACCADA","authors":"N. G. Sutar","doi":"10.20959/wjpr201711-9578","DOIUrl":"https://doi.org/10.20959/wjpr201711-9578","url":null,"abstract":"","PeriodicalId":23796,"journal":{"name":"World journal of pharmaceutical research","volume":"26 1","pages":"251-258"},"PeriodicalIF":0.0,"publicationDate":"2017-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75025740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
ROLE OF PRIYANGVADI TAILA IN THE MANAGEMENT OF DIABETIC WOUND - A CASE REPORT 缬草在糖尿病创面治疗中的作用1例
World journal of pharmaceutical research Pub Date : 2017-11-01 DOI: 10.20959/WJPR201711-9555
H. Kumari
{"title":"ROLE OF PRIYANGVADI TAILA IN THE MANAGEMENT OF DIABETIC WOUND - A CASE REPORT","authors":"H. Kumari","doi":"10.20959/WJPR201711-9555","DOIUrl":"https://doi.org/10.20959/WJPR201711-9555","url":null,"abstract":"Ayurvedic classics had described Madhumeha thousands of years ago. Acharya Sushruta mentioned prognosis of Madhumehaj vrana as “Krichrasadhya” (difficult to treat), which is experienced even in present day practice. Slight injury to glucose laden tissues of diabetic patients may result in ulcer formation and they become at high risk for major complications, including infection and amputation. PriyangvadiTaila contains the drugs possessing Shodhan and Ropana properties, thus considered as a good curative measure for local treatment of Vrana. A case report of Madhumehajanya Vrana successfully treated by local application of Priyangvadi-Taila has been presented here. The therapy proved to be very effective and the wound got completely healed within 20 days without any complications and side effects.","PeriodicalId":23796,"journal":{"name":"World journal of pharmaceutical research","volume":"56 1","pages":"748-752"},"PeriodicalIF":0.0,"publicationDate":"2017-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73692827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
EVALUATION OF WOUND HEALING EFFECT OF AQUEOUS STEM EXTRACT OF ZANTHOXYLUM RHETSA (ROXB.) DC ON WISTAR RAT 花椒茎水提物创面愈合效果评价接通wistar大鼠
World journal of pharmaceutical research Pub Date : 2017-11-01 DOI: 10.20959/wjpr201711-9552
A. Abarnadevika
{"title":"EVALUATION OF WOUND HEALING EFFECT OF AQUEOUS STEM EXTRACT OF ZANTHOXYLUM RHETSA (ROXB.) DC ON WISTAR RAT","authors":"A. Abarnadevika","doi":"10.20959/wjpr201711-9552","DOIUrl":"https://doi.org/10.20959/wjpr201711-9552","url":null,"abstract":"The present investigation has been undertaken to study the wound healing properties of aqueous extract of Zanthoxylum rhetsa (AQZR). The plant Zanthoxylum rhetsa has a long history in herbal medicine in many countries. Experiments were conducted following standard procedures. The extract was evaluated for their invitro antioxidant, antimicrobial and total phenol and flavonoid content. The AQZR ointment were administered topically, for evaluating the wound healing potential in excision wound model for twenty one days. Povidone iodine ointment was the standard for excision wound model. Extracts treated group showed in vitro antioxidant, anti microbial properties as compared with standard and control group. AQZR exhibited similar wound healing activity that of the standard but with lesser magnitude. The result may be attributed to the phytoconstituents such as flavonoids and phenolics present in it which may be due to their individual or cumulative effect that enhanced wound healing and provided scientific evidence to the ethnomedicinal futures of Zanthoxylum rhetsa. These findings could justify the inclusion of this plant in the management of wound healing.","PeriodicalId":23796,"journal":{"name":"World journal of pharmaceutical research","volume":"1 1","pages":"723-739"},"PeriodicalIF":0.0,"publicationDate":"2017-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77450173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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