Ming Yueh Tan, Karen A. Crouse, Sang Loon Tan, Edward R. T. Tiekink
{"title":"Crystal structure of bis{<i>N</i>′-[1,3-diphenylprop-2-en-1-ylidene]-<i>N</i>-phenylcarbamohydrazonothioato}zinc(II), C<sub>44</sub>H<sub>36</sub>N<sub>6</sub>S<sub>2</sub>Zn","authors":"Ming Yueh Tan, Karen A. Crouse, Sang Loon Tan, Edward R. T. Tiekink","doi":"10.1515/ncrs-2023-0369","DOIUrl":"https://doi.org/10.1515/ncrs-2023-0369","url":null,"abstract":"Abstract C 44 H 36 N 6 S 2 Zn, monoclinic, P 2 1 / c (no. 14), a = 14.5676(4) Å, b = 26.1767(8) Å, c = 10.0963(3) Å, β = 99.140(3)°, V = 3801.2(2) Å 3 , Z = 4, R gt ( F ) = 0.0397, wR ref ( F 2 ) = 0.1000, T = 100 K.","PeriodicalId":23792,"journal":{"name":"Zeitschrift Fur Kristallographie-new Crystal Structures","volume":"60 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136292995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Crystal structure of 1,4-dibromo-2,5-bis(2-methoxyethoxy)benzene-1,4-diol, C<sub>12</sub>H<sub>16</sub>Br<sub>2</sub>O<sub>4</sub>","authors":"Zhi-Yong Wang, Wan-Li Lu, Xu Zhou, Xian-Jiong Yang, Qi-Long Zhang, Hong Xu","doi":"10.1515/ncrs-2023-0394","DOIUrl":"https://doi.org/10.1515/ncrs-2023-0394","url":null,"abstract":"Abstract C 12 H 16 Br 2 O 4 , monoclinic, P 2 1 / n (no. 14), a = 12.594(5) Å, b = 4.4613(16) Å, c = 12.878(4) Å, β = 91.209(12) ∘ , V = 723.4(4) Å 3 , Z = 2, R gt ( F ) = 0.0450, wR ref ( F 2 ) = 0.1103, T = 293 (2) K.","PeriodicalId":23792,"journal":{"name":"Zeitschrift Fur Kristallographie-new Crystal Structures","volume":"8 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136296116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Asuman Deveci Ozkan, Gamze Guney Eskiler, Nur Kazan, Ozge Turna
{"title":"Histone deacetylase inhibitor sodium butyrate regulates the activation of toll-like receptor 4/interferon regulatory factor-3 signaling pathways in prostate cancer cells.","authors":"Asuman Deveci Ozkan, Gamze Guney Eskiler, Nur Kazan, Ozge Turna","doi":"10.4103/jcrt.jcrt_2032_21","DOIUrl":"10.4103/jcrt.jcrt_2032_21","url":null,"abstract":"<p><strong>Context: </strong>The covalent acetylation and deacetylation of histone proteins by the histone deacetylase (HDAC) enzymes can be considered a novel therapeutic target in prostate cancer (PCa) cells. Sodium butyrate (NaBu) is a HDAC inhibitor (HDACi) which is a promising potential anticancer drug. Toll-like receptor 4 (TLR4) expression is increased in PCa cells and HDACi alter TLR-inducible gene expressions.</p><p><strong>Aims: </strong>We aimed to evaluate the effects of NaBu on TLR4 mediating signaling pathways in two different PCa cells (DU-145 and LNCaP) for the first time.</p><p><strong>Subjects and methods: </strong>The cytotoxic and apoptotic effects of NaBu were determined by the water-soluble tetrazolium salt (WST-1) and Annexin V-AO/PI assays, respectively. Subcellular localization of TLR4, interferon regulatory factor-3 (IRF3) and Nuclear factor kappa B proteins was evaluated by IF assay.</p><p><strong>Statistical analysis used: </strong>All data were statistically analyzed by GraphPad Prism software (V60.1, CA). Obtained data were expressed in a mean ± standard deviation of the three repeated experiments. The differences between control and NaBu treated cells were compared by one-way-ANOVA. P < 0.05 value was considered statistically significant.</p><p><strong>Results: </strong>Our results showed that NaBu significantly inhibited the viability of PCa cells and increased the percentage of apoptotic cells. However, DU-145 cells were more sensitive to NaBu than LNCaP cells. Furthermore, NaBu can induce the cytoplasmic TLR4 and IRF3 expression in particularly DU-145 cells without affecting nuclear translocation of NF-kB in PCa cells.</p><p><strong>Conclusions: </strong>NaBu induces apoptotic cell death and regulated the TLR4/IRF3 signaling pathways in DU-145 cells but not in LNCaP cells. Therefore, PCa cells differentially responded to NaBu treatment due to probably androgen receptor status.</p>","PeriodicalId":23792,"journal":{"name":"Zeitschrift Fur Kristallographie-new Crystal Structures","volume":"224 1","pages":"1812-1817"},"PeriodicalIF":1.3,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89167728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Si N. Gu, Zhi Y. Ou, Ting T. Wu, Ting Y. Nie, Yang Liu
{"title":"Crystal structure of poly[(μ<sub>6</sub>-ammoniotris(methylene))tris(hydrogen phosphonato)cadmium(II)], C<sub>3</sub>H<sub>10</sub>CdNO<sub>9</sub>P<sub>3</sub>","authors":"Si N. Gu, Zhi Y. Ou, Ting T. Wu, Ting Y. Nie, Yang Liu","doi":"10.1515/ncrs-2023-0332","DOIUrl":"https://doi.org/10.1515/ncrs-2023-0332","url":null,"abstract":"Abstract C 3 H 10 CdNO 9 P 3 , monoclinic, P 2 1 / c (no. 14), a = 9.1770(5) Å, b = 8.3742(4) Å, c = 15.4660(6) Å, β = 119.657(2)°, V = 1032.86(9) Å 3 , Z = 4, R gt ( F ) = 0.0202, w R ref ( F 2 ) = 0.0515, T = 296 K.","PeriodicalId":23792,"journal":{"name":"Zeitschrift Fur Kristallographie-new Crystal Structures","volume":"43 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134885054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The crystal structure of 18-crown-6 ― tetraaqua-dichlorido-di-μ<sub>2</sub>-chloridodicopper(II) (2/1), C<sub>12</sub>H<sub>32</sub>O<sub>10</sub>Cu<sub>2</sub>Cl<sub>4</sub>","authors":"Zhaolong Liu, Shifeng Jin","doi":"10.1515/ncrs-2023-0361","DOIUrl":"https://doi.org/10.1515/ncrs-2023-0361","url":null,"abstract":"Abstract C 12 H 32 O 10 Cu 2 Cl 4 , monoclinic, P 2 1 / n (no. 14), a = 9.0202(4) Å, b = 9.5791(4) Å, c = 13.6994(6) Å, β = 92.555(1) ° , V = 1182.53(9) Å 3 , Z = 2, R gt ( F ) = 0.0308, wR ref ( F 2 ) = 0.0800, T = 293(2) K.","PeriodicalId":23792,"journal":{"name":"Zeitschrift Fur Kristallographie-new Crystal Structures","volume":"16 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136011690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The crystal structure of ethyl 4-hydroxy-2-(4-methoxyphenyl)-5-oxo-1-(2-oxo-2<i>H</i>-chromen-6-yl)-2,5-dihydro-1<i>H</i>-pyrrole-3-carboxylate, C<sub>23</sub>H<sub>19</sub>NO<sub>7</sub>","authors":"Bimal Bhushan Chakraborty, Saurav Paul, Siddique Anwar, Sudip Choudhury","doi":"10.1515/ncrs-2023-0350","DOIUrl":"https://doi.org/10.1515/ncrs-2023-0350","url":null,"abstract":"Abstract C 23 H 19 NO 7 , monoclinic, P 2 1 / n (no. 14), a = 17.9964(9) Å, b = 5.9211 Å, c = 18.8608(10) Å, β = 98.201(3)°, V = 1989.23(18) Å 3 , Z = 4, R gt ( F ) = 0.0496, wR ref ( F 2 ) = 0.1561, T = 296 K.","PeriodicalId":23792,"journal":{"name":"Zeitschrift Fur Kristallographie-new Crystal Structures","volume":"44 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136012155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Crystal structure of <i>N</i>-cyclopropyl-3-hydroxy-4-methoxybenzamide, C<sub>11</sub>H<sub>13</sub>NO<sub>3</sub>","authors":"Hongjuan Tong, Xiaona Xu, Zhoujing Zhu, Bin Liu","doi":"10.1515/ncrs-2023-0379","DOIUrl":"https://doi.org/10.1515/ncrs-2023-0379","url":null,"abstract":"Abstract C 11 H 13 NO 3 , monoclinic, P 2 1 / n (no. 14), a = 8.0478(3) Å, b = 9.8093(4) Å, c = 13.1602(5) Å, β = 104.712(2)°, V = 1004.85(7) Å 3 , Z = 1, R gt ( F ) = 0.0395, wR ref ( F 2 ) = 0.1010, T = 170 K.","PeriodicalId":23792,"journal":{"name":"Zeitschrift Fur Kristallographie-new Crystal Structures","volume":"10 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136129011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yu Fang, Cheng Zhang, Meng-Qing Yin, Xiao-Die Yang, Wen-Jing Ma
{"title":"The crystal structure of 5-chloro-6′-methyl-3-(4-(methylsulfonyl)phenyl)-[2,3′-bipyridin]-1′-ium 4-methylbenzenesulfonate","authors":"Yu Fang, Cheng Zhang, Meng-Qing Yin, Xiao-Die Yang, Wen-Jing Ma","doi":"10.1515/ncrs-2023-0285","DOIUrl":"https://doi.org/10.1515/ncrs-2023-0285","url":null,"abstract":"Abstract C 18 H 16 ClN 2 O 2 S·C 7 H 7 O 3 S, monoclinic, C 2/ c (no. 15), a = 36.911(9) Å, b = 9.931(2) Å, c = 14.795(3) Å, β = 112.32(3)°, V = 5017(2) Å 3 , Z = 8, R gt ( F ) = 0.0500, wR ref ( F 2 ) = 0.1447, T = 293 K.","PeriodicalId":23792,"journal":{"name":"Zeitschrift Fur Kristallographie-new Crystal Structures","volume":"37 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136264242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}