Journal of Dermatology Research and Therapy最新文献

{"title":"Approaches to the Potential Use of Stromal Vascular Fraction and Coenzyme Q10 in Dermatological Aesthetics: A Systematic Review","authors":"Bocalon Isabela de Lima, Marques Mayara Fernandes Veri, Filho Idiberto José Zotarelli","doi":"10.23937/2469-5750/1510070","DOIUrl":"https://doi.org/10.23937/2469-5750/1510070","url":null,"abstract":"Introduction: With aging, occurs a decrease in the number of melanocytes active enzymatically around 12.0% to 24.0% every ten years. As a treatment, stem cell therapy with adult stem cells has been the focus of many studies. Among adult stem cells, adipose-derived stem cells (ADSC) ubiquinone, known as coenzyme Q10 (CoQ10), is a lipidsoluble antioxidant. It is shown to reduce lipid peroxidation of low-density lipoprotein regenerates endogenous vitamin E and protects cells against oxidative stress induced by UV radiation. Objective: To explore through the literature review the use of cellular therapy with stromal vascular fraction and coenzyme Q10 to meet the dermatological aesthetics. Methods: Use of Mesh terms: Adipose-derived stem cell. Estromal Vascular Fraction. Aesthetics. Dermatology. In the main databases such as Pubmed, Medline, Bireme, EBSCO, Scielo, etc. The total of 63 papers that were submitted to the eligibility analysis was cross-checked and after that 23 studies were selected, following the rules of systematic review-PRISMA. Results: The production and secretion of growth factors have been identified as an essential function of ADSC, and many skin rejuvenation effects have been demonstrated [1,2]. Thus, ADSC has been shown to stimulate collagen synthesis and dermal migration of fibroblasts during the wound healing process. In addition, the secreted factors of the ADSC protect the dermal fibroblasts against oxidative stress. CoQ10 is also known as ubidecarenone or ubiquinone. This liposome penetrates deep into the epidermis and releases noble actives directly into the sites of action. Powerful antioxidant reduces the organic aging process. Conclusion: The use of stromal vascular fraction is an important option for dermatological aesthetics, according to the observation of the results obtained in this study. This procedure should be improved and has been widely discussed, mainly because it can be performed as an autologous material and associated with the use of coenzyme Q10.","PeriodicalId":237664,"journal":{"name":"Journal of Dermatology Research and Therapy","volume":"18 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127529889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dermatologic Manifestations in Patients on Chronic Hemodialysis","authors":"Bouhamidi Ahmed, A. M. El, Rafik Hicham, Boui Mohammed, Hjira Naoufal","doi":"10.23937/2469-5750/1510069","DOIUrl":"https://doi.org/10.23937/2469-5750/1510069","url":null,"abstract":"Background and aim: Dermatological manifestations are frequent and varied among chronic hemodialysis patients. The aim of this study is to determine the prevalence and characteristics of cutaneous abnormalities observed in hemodialysis patients. Methods: We led a transversal study, conducted at the Nephrology Department of the 5th Military Hospital in Guelmim, from March to May 2017, including 44 hemodialysis patients. Results: The mean duration of hemodialysis was 61.81 months. Causes of end stage renal failure were diabetes (45.45%), high blood pressure (13.63%), lithiasis (4.54%), gout (4.54%), reflux nephropathy (4.54%), glomerulonephritis (4.54%), and indeterminate (22.72%). All our patients had dermatological abnormalities. Pruritus (63.63% of patients), Cutaneous xerosis (40.9%), hair loss (36.36%), and hyperpigmentation (22.72%) were the most common skin manifestations. 68.16% of our patients had nail disorders. Conclusions: The knowledge of these manifestations allows a proper care, so to improve the quality of life of the hemodialysis patient.","PeriodicalId":237664,"journal":{"name":"Journal of Dermatology Research and Therapy","volume":"19 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134365903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Remission of Psoriasis during Treatment with Apatinib in a Patient with Rectal Cancer","authors":"Daoqun Chong, Gai Ge, Dongmei Li, Yang Yang, Rong Wang, Dongmei Shi","doi":"10.23937/2469-5750/1510068","DOIUrl":"https://doi.org/10.23937/2469-5750/1510068","url":null,"abstract":"Psoriasis is a chronic, recurrent inflammatory skin disease characterized by abnormal keratinocyte proliferation and vascular hyperplasia. Apatinib is a tyrosine kinase inhibitor which has been reported to be effective in some tumors thought to be associated with inhibition of the proliferation of endothelial cells by selectively inhibiting vascular endothelial growth factor receptor-2 (VEGFR-2). We present a 54-yearold patient with a 30-year history of psoriasis, who did not respond well to oral treatment with acitretin in combination with topical corticosteroids. The patient was diagnosed with rectal cancer and was treated with oral apatinib 250 mg once daily. To our surprise, all the psoriasis lesions were completely resolved after a 53-days course of treatment. Although apatinib and its variants have been extensively used as an anticancer drug, there is no report of their use in psoriasis. As with other antitumor treatments, we speculate that apatinib is effective for psoriasis owing to an inhibition of endothelial cell growth in psoriasis lesions. This observation suggests that apatinib may be a useful drug to treat psoriasis in the future and deserves further investigation in its own right.","PeriodicalId":237664,"journal":{"name":"Journal of Dermatology Research and Therapy","volume":"17 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131386411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Use of Vibrational Optical Coherence Tomography to Image and Characterize a Squamous Cell Carcinoma","authors":"F. Silver, Ruchit Shah, M. Richard, D. Benedetto","doi":"10.23937/2469-5750/1510067","DOIUrl":"https://doi.org/10.23937/2469-5750/1510067","url":null,"abstract":"Previous literature reports suggest that tissue stiffness is a predictor of cancer and metastatic behavior. We have used optical coherence tomography and vibrational analysis (VOCT) to characterize normal skin, scar and a verrucous carcinoma, a squamous cell carcinoma subtype, non-invasively and nondestructively. The results suggest that epidermal thickening and increased keratin production occur in verrucous carcinoma and lead to increases in surface hills and valleys as well as subsequent increases in epidermal stiffness values. Increased stiffness of the epidermis is a result of increased keratin production while the stiffness of the dermis remains similar to that of normal skin, suggesting that dermal changes are not observed in this lesion. It is concluded that VOCT may ultimately be a useful adjunct to dermoscopy and other clinical tools to identify and characterize lesions as small as 0.2 mm. It is hypothesized that the slow growth potential of verrucous carcinoma may be related to the lack of dermal involvement and that other more invasive skin lesions may be characterized by both epidermal and dermal involvement that would lead to changes in both epidermal and dermal stiffnesses.","PeriodicalId":237664,"journal":{"name":"Journal of Dermatology Research and Therapy","volume":"24 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123576346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Seborrheic Keratoses of the Penis: About a Rare Case","authors":"S. Salma, Bouhelab Jamila, Benzekri Asmae, Hassam Badredine","doi":"10.23937/2469-5750/1510062","DOIUrl":"https://doi.org/10.23937/2469-5750/1510062","url":null,"abstract":"Seborrheic keratoses (SK) are very common benign epidermal tumors. Their pathogenesis has been detected already in 2006 and includes several aetiological factors. The participation of human papilloma virus (HPV) is being discussed. SK of the penis is extremely rare and may be misdiagnosed. Histopathology will help in the diagnosis.","PeriodicalId":237664,"journal":{"name":"Journal of Dermatology Research and Therapy","volume":"51 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121547750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Histomorphometric Evaluation of Intraepithelial Papillary Capillaries in Oral Lichen Planus: A Histopathological Study","authors":"Hasegawa Kazuhiro, Sakamaki Hiroyuki, Higuchi Masahiro, Suemitsu Masaaki, Taguchi Chieko, Ito Ko, Morikawa Miyuki, Utsunomiya Tadahiko, Kondoh Toshirou, Kuyama Kayo","doi":"10.23937/2469-5750/1510058","DOIUrl":"https://doi.org/10.23937/2469-5750/1510058","url":null,"abstract":"Background: Definitive diagnosis of oral lichen planus (OLP) is important for planning treatment. The problems and difficulties of diagnosing OLP based on histopathological features were showing interand intra-observer variability. In terms of pathological diagnosis on OLP, microvascular appearance was not highly valued. Comparative histomorphometric analysis of intraepithelial papillary capillary loops (IPCLs) of OLP was performed to investigate the potential for use as diagnostic criteria. Methods: Immunohistochemical and histopathological evaluations of microvascular morphology were performed in 42 cases diagnosed as OLP clinico-histopathologically. Average areas and capillary loop angles at the sites adjacent to the lesion and most prominent and erosive areas of OLP were measured using image analysis software under microscopic observation. Results: Area of IPCLs in sites adjacent to the lesion was larger than those in prominent areas of OLP (p < 0.001). Capillary loop angles were 26.6 ± 19.3*, 84.5 ± 17.8*, 30.2 ± 2.4* and 34.4 ± 19.3* for normal mucosa, sites adjacent to the lesion, prominent areas of OLP, and erosive areas, respectively. Significant differences were observed between the prominent areas and adjacent sites to the lesion (p < 0.001). Conclusions: Characteristic IPCL patterns were identified in the present study despite reticular/erosive type. This research thus suggested the utility of these patterns in pathological diagnostic criteria. Introduction Lichen planus is a chronic inflammatory disease in the skin and mucous membranes of unknown etiology. Oral lichen planus (OLP) was first described by Wilson in 1869 [1], and appears more peculiar (that is, more persistent and resistant to treatment) than cutaneous lichen planus [2]. In addition, OLP was included as an oral potentially malignant disorders (OPMDS), defined as clinical presentation carrying a risk of cancer development in the oral cavity in the new World Health Organization classification of head and neck tumors [3], but the frequency of malignant transformation is controversial [4]. Therefore, definitive diagnosis in OLP is very important to decide treatment planning [5]. The diagnosis of OLP is based on both clinical and histopathological features. OLP clinically shows six classical clinical presentations, as described in the literature [6]: Reticular, erosive, atrophic, plaque-like, papular and bullous. In contrast, results of biopsy should be described, particularly when white striae are ill defined, plaques are present, or regions appear in any other way unusual [7]. Even though clinical and histopathological unified criteria for OLP have been unified [8], the potential for disagreement between clinical and histopathological OrIgInal arTICle","PeriodicalId":237664,"journal":{"name":"Journal of Dermatology Research and Therapy","volume":"33 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131503207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"T/NK Lymphoma Nasal Type with Fatal Outcome","authors":"Z. Youssef, Azhari Jaouad El, Hassam Badreddine, Ismaili Nadia","doi":"10.23937/2469-5750/1510060","DOIUrl":"https://doi.org/10.23937/2469-5750/1510060","url":null,"abstract":"T/NK-cell lymphoma of nasal-type was described in 1933 as a malignant medio-facial granuloma. The diagnosis of this rare condition is clinical and immunohistopathological. We report an original case of cutaneous T/NK lymphoma of the nasal type revealed by cutaneous ulcerations.","PeriodicalId":237664,"journal":{"name":"Journal of Dermatology Research and Therapy","volume":"74 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127367927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Management of Keloid Scars: Surgical Versus Medical Therapy","authors":"Jfri Abdulhadi, A. Ali","doi":"10.23937/2469-5750/1510059","DOIUrl":"https://doi.org/10.23937/2469-5750/1510059","url":null,"abstract":"Background: Keloids are benign fibroproliferative tumors that extend beyond the original wound. There are many different medical and surgical modalities to treat keloids. Objective: This article provides a summary and review of the medical and the surgical options available in the literature for treating keloids. Furthermore, this paper organized the data into monotherapy versus combined therapy. Methods: A literature review was conducted using PubMed and MIDLINE that included English publications trials and reviews from April 2005-June 2018. Results: Monotherapy is unable to completely flattened keloids and a combination therapy is always needed. Monotherapy shows success with the intralesional steroid injection, but there is always a room for combination with surgical excision, or other therapies: 5-fluorouracil (5-FU), bleomycin and interferon, topical imiquimod, compression, cryotherapy, radiation, silicon sheeting and lasers or light-based therapies. Conclusion: The treatment of keloid is tested by a big number of trials using different regimens proving the resistance nature of keloid.","PeriodicalId":237664,"journal":{"name":"Journal of Dermatology Research and Therapy","volume":"25 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123741424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erythema and Acute Pain in the Hands","authors":"Tagaqa Chelsea, D. John, W. Suzanne","doi":"10.23937/2469-5750/1510054","DOIUrl":"https://doi.org/10.23937/2469-5750/1510054","url":null,"abstract":"Citation: Tagawa C, DiGiovanni J, Wolf S (2018) Erythema and Acute Pain in the Hands. J Dermatol Res Ther 4:054. doi.org/10.23937/2469-5750/1510054 Accepted: June 05, 2018: Published: June 07, 2018 Copyright: © 2018 Tagawa C, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.","PeriodicalId":237664,"journal":{"name":"Journal of Dermatology Research and Therapy","volume":"81 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132485992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cutis Laxa of the Face: A Case Report and Review of Literature","authors":"M. Misani, S. Fontaine","doi":"10.23937/2469-5750/1510055","DOIUrl":"https://doi.org/10.23937/2469-5750/1510055","url":null,"abstract":"Citation: Misani M, de Fontaine S (2018) Cutis Laxa of the Face: A Case Report and Review of Literature. J Dermatol Res Ther 4:055. doi.org/10.23937/2469-5750/1510055 Accepted: June 06, 2018: Published: June 08, 2018 Copyright: © 2018 Misani M, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.","PeriodicalId":237664,"journal":{"name":"Journal of Dermatology Research and Therapy","volume":"63 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116541397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}