Yearbook of Paediatric Endocrinology最新文献_第10页

Should Dehydroepiandrosterone be administered to women? 女性是否应该使用脱氢表雄酮?

Yearbook of Paediatric Endocrinology Pub Date : 2022-09-12 DOI: 10.1530/ey.19.8.14

Wierman Me, Kiseljak-Vassiliades K

{"title":"Should Dehydroepiandrosterone be administered to women?","authors":"Wierman Me, Kiseljak-Vassiliades K","doi":"10.1530/ey.19.8.14","DOIUrl":"https://doi.org/10.1530/ey.19.8.14","url":null,"abstract":"Context: Androgen prohormones such as dehydroepiandrosterone (DHEA) increase in early puberty, peak in the second and third decade, and thereafter decline, independent of menopausal status. Investigators have examined their potential beneficial effects in normal women and those with DHEA-deficient states. Evidence Acquisition: A review of the literature from 1985 to 2021 on the potential benefits and risks of androgen prohormones in women. Evidence Synthesis: Studies have examined the potential benefit of DHEA therapy for anti-aging, sexual dysfunction, infertility, metabolic bone health, cognition, and wellbeing in hormone-deficient states such as primary adrenal insufficiency, hypopituitarism, and anorexia as well as administration to normal women across the lifespan. Conclusions: Data support small benefits in quality of life and mood but not for anxiety or sexual function in women with primary or secondary adrenal insufficiency or anorexia. No consistent beneficial effects of DHEA administration have been observed for menopausal symptoms, sexual function, cognition, or overall wellbeing in normal women. Local administration of DHEA shows benefit in vulvovaginal atrophy. Use of DHEA to improve induction of ovulation response in women with diminished ovarian reserve is not recommended. Risks of high physiologic or pharmacologic use of DHEA include androgenic and estrogenic side effects which are of concern for long-term administration. Clinical Case: A 49-year-old woman with Addison’s disease who is on low dose estrogen with cyclic progesterone therapy for menopausal symptoms returns for follow-up. She is on a stable glucocorticoid replacement strategy of hydrocortisone 10 mg in the morning and 5 mg in the early afternoon and fludrocortisone 0.05 mg each morning. She has read on the internet that additional therapy with DHEA may help her overall quality of life and libido. She asks whether she should add this therapy to her regimen and at what dose.","PeriodicalId":23743,"journal":{"name":"Yearbook of Paediatric Endocrinology","volume":"31 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78195616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Validation study and outcomes of the diabetes quality of life in youth instrument in Haitian youth with type 1 diabetes residing in Haiti 在海地居住的海地青少年1型糖尿病患者糖尿病生活质量仪器的验证研究和结果

Yearbook of Paediatric Endocrinology Pub Date : 2022-09-12 DOI: 10.1530/ey.19.13.11

Victor Y, Lorgeat V, Coriolan B, K. z, Vincent R, V. Je, Altenor K

引用次数: 0

Large birth size, infancy growth pattern, insulin resistance and β-cell function 大出生尺寸，婴儿期生长模式，胰岛素抵抗和β细胞功能

Yearbook of Paediatric Endocrinology Pub Date : 2022-09-12 DOI: 10.1530/ey.19.2.22

Huang R, D. Y, Nuyt Am, L. E., Wei Sq, J. P., Fraser Wd, Luo Zc

引用次数: 0

Broad-spectrum XX and XY gonadal dysgenesis in patients with a homozygous L193S variant in PPP2R3C PPP2R3C纯合子L193S变异患者的广谱XX和XY性腺发育不良

Yearbook of Paediatric Endocrinology Pub Date : 2022-09-12 DOI: 10.1530/ey.19.6.5

C. D., Warr N, Yesil G, H. K. Eker, Bas F, Poyrazoglu S, Darendeliler F, Direk G, Hatipoglu N, E. M, Z. Y. Abalı, B. G. Tosun, Kaygusuz Sb, T. S. Menevşe, Helvacioglu D, Turan S, Bereket A, Reeves R, S. M, M. M., T. L., Greenfield A, G. T

引用次数: 0

Testing for rare genetic causes of obesity: findings and experiences from a pediatric weight management program 检测罕见的肥胖遗传原因:来自儿科体重管理项目的发现和经验

Yearbook of Paediatric Endocrinology Pub Date : 2022-09-12 DOI: 10.1530/ey.19.11.1

Robertson Kj, Ariza Aj, S. K., Quadri M, M. C., Neault S, Davis Ee, Binns Hj

引用次数: 0

Mortality trends over five decades in adult transgender people receiving hormone treatment: a report from the Amsterdam cohort of gender dysphoria 50年来接受激素治疗的成年变性人的死亡率趋势:一份来自阿姆斯特丹性别焦虑队列的报告

Yearbook of Paediatric Endocrinology Pub Date : 2022-09-12 DOI: 10.1530/ey.19.6.16

CJ de Blok, Wiepjes Cm, D. V. Velzen, Staphorsius As, Nota Nm, Gooren Lj, Kreukels Bp, M. Heijer

引用次数: 0

A century past the discovery of insulin: global progress and challenges for type 1 diabetes among children and adolescents in low-income and middle-income countries 胰岛素发现一个世纪后:低收入和中等收入国家儿童和青少年1型糖尿病的全球进展和挑战

Yearbook of Paediatric Endocrinology Pub Date : 2022-09-12 DOI: 10.1530/ey.19.10.1

Bhutta Za, Salam Ra, Gomber A, L. L., Narang T, Mbanya Jc, A. G.

引用次数: 0

Genetics, clinical features and outcomes of non-syndromic pituitary gigantism: experience of a single center from Sao Paulo, Brazil 非综合征性垂体巨人症的遗传学、临床特征和预后:来自巴西圣保罗单一中心的经验

Yearbook of Paediatric Endocrinology Pub Date : 2022-09-12 DOI: 10.1530/ey.19.1.10

Trarbach Eb, Trivellin G, Grande Ipp, Duarte Fhg, Jorge Aal, do Nascimento Fbp, Garmes Hm, Nery M, Mendonça Bb, Stratakis Ca, B. Md, Jallad Rs

引用次数: 0

Obesity class impacts adverse maternal and neonatal outcomes independent of diabetes 肥胖类别影响与糖尿病无关的孕产妇和新生儿的不良结局

Yearbook of Paediatric Endocrinology Pub Date : 2022-09-12 DOI: 10.1530/ey.19.2.20

Neal K, U. S, Glastras Sj

引用次数: 0

Characterization and risk factors of hyperglycaemia during treatment of childhood hematologic malignancies 儿童恶性血液病治疗期间高血糖的特点及危险因素

Yearbook of Paediatric Endocrinology Pub Date : 2022-09-12 DOI: 10.1530/ey.19.9.3

Welsch S, S. K., Brichard B, D. Ville, A. Damme, Boulanger C, Lysy P

引用次数: 0