Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology最新文献_第9页

Tumor microenvironment-regulating nanomedicine design to fight multi-drug resistant tumors. 肿瘤微环境调节纳米药物设计对抗多重耐药肿瘤。

IF 8.6 2区医学

Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology Pub Date : 2023-01-01 DOI: 10.1002/wnan.1842

Qinqin Xu, Xinyue Lan, Huimin Lin, Qiye Xi, Manchun Wang, Xiaolong Quan, Guangyu Yao, Zhiqiang Yu, Yongxia Wang, Meng Yu

{"title":"Tumor microenvironment-regulating nanomedicine design to fight multi-drug resistant tumors.","authors":"Qinqin Xu, Xinyue Lan, Huimin Lin, Qiye Xi, Manchun Wang, Xiaolong Quan, Guangyu Yao, Zhiqiang Yu, Yongxia Wang, Meng Yu","doi":"10.1002/wnan.1842","DOIUrl":"https://doi.org/10.1002/wnan.1842","url":null,"abstract":"The tumor microenvironment (TME) is a very cunning system that enables tumor cells to escape death post-traditional antitumor treatments through the comprehensive effect of different factors, thereby leading to drug resistance. Deep insights into TME characteristics and tumor resistance encourage the construction of nanomedicines that can remodel the TME against drug resistance. Tremendous interest in combining TME-regulation measurement with traditional tumor treatment to fight multidrug-resistant tumors has been inspired by the increasing understanding of the role of TME reconstruction in improving the antitumor efficiency of drug-resistant tumor therapy. This review focuses on the underlying relationships between specific TME characteristics (such as hypoxia, acidity, immunity, microorganisms, and metabolism) and drug resistance in tumor treatments. The exciting antitumor activities strengthened by TME regulation are also discussed in-depth, providing solutions from the perspective of nanomedicine design. This article is categorized under: Therapeutic Approaches and Drug Discovery > Emerging Technologies Therapeutic Approaches and Drug Discovery > Nanomedicine for Oncologic Disease Nanotechnology Approaches to Biology > Nanoscale Systems in Biology.","PeriodicalId":23697,"journal":{"name":"Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology","volume":"15 1","pages":"e1842"},"PeriodicalIF":8.6,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10637568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Nano-diagnostics as an emerging platform for oral cancer detection: Current and emerging trends. 纳米诊断作为口腔癌检测的新兴平台:当前和新兴趋势。

IF 8.6 2区医学

Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology Pub Date : 2023-01-01 DOI: 10.1002/wnan.1830

Debolina Chakraborty, Debayan Ghosh, Sanjit Kumar, David Jenkins, Natarajan Chandrasekaran, Amitava Mukherjee

{"title":"Nano-diagnostics as an emerging platform for oral cancer detection: Current and emerging trends.","authors":"Debolina Chakraborty, Debayan Ghosh, Sanjit Kumar, David Jenkins, Natarajan Chandrasekaran, Amitava Mukherjee","doi":"10.1002/wnan.1830","DOIUrl":"https://doi.org/10.1002/wnan.1830","url":null,"abstract":"Globally, oral cancer kills an estimated 150,000 individuals per year, with 300,000 new cases being diagnosed annually. The high incidence rate of oral cancer among the South-Asian and American populations is majorly due to overuse of tobacco, alcohol, and poor dental hygiene. Additionally, socio-economic issues and lack of general awareness delay the primary screening of the disease. The availability of early screening techniques for oral cancer can help in carving out a niche for accurate disease prognosis and also its prevention. However, conventional diagnostic approaches and therapeutics are still far from optimal. Thus, enhancing the analytical performance of diagnostic platforms in terms of specificity and precision can help in understanding the disease progression paradigm. Fabrication of efficient nanoprobes that are sensitive, noninvasive, cost-effective, and less labor-intensive can reduce the global cancer burden. Recent advances in optical, electrochemical, and spectroscopy-based nano biosensors that employ noble and superparamagnetic nanoparticles, have been proven to be extremely efficient. Further, these sensitive nanoprobes can also be employed for predicting disease relapse after chemotherapy, when the majority of the biomarker load is eliminated. Herein, we provide the readers with a brief summary of conventional and new-age oral cancer detection techniques. A comprehensive understanding of the inherent challenges associated with conventional oral cancer detection techniques is discussed. We also elaborate on how nanoparticles have shown tremendous promise and effectiveness in radically transforming the approach toward oral cancer detection. This article is categorized under: Diagnostic Tools > Biosensing Diagnostic Tools > Diagnostic Nanodevices Diagnostic Tools > In Vitro Nanoparticle-Based Sensing.","PeriodicalId":23697,"journal":{"name":"Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology","volume":"15 1","pages":"e1830"},"PeriodicalIF":8.6,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10629247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

Electrospun fibers as carriers for topical drug delivery and release in skin bandages and patches for atopic dermatitis treatment. 电纺丝纤维作为治疗特应性皮炎的皮肤绷带和贴剂中局部药物递送和释放的载体。

IF 8.6 2区医学

Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology Pub Date : 2023-01-01 DOI: 10.1002/wnan.1829

Zuzanna J Krysiak, Urszula Stachewicz

{"title":"Electrospun fibers as carriers for topical drug delivery and release in skin bandages and patches for atopic dermatitis treatment.","authors":"Zuzanna J Krysiak, Urszula Stachewicz","doi":"10.1002/wnan.1829","DOIUrl":"https://doi.org/10.1002/wnan.1829","url":null,"abstract":"The skin is a complex layer system and the most important barrier between the environment and the organism. In this review, we describe some widespread skin problems, with a focus on eczema, which are affecting more and more people all over the world. Most of treatment methods for atopic dermatitis (AD) are focused on increasing skin moisture and protecting from bacterial infection and external irritation. Topical and transdermal treatments have specific requirements for drug delivery. Breathability, flexibility, good mechanical properties, biocompatibility, and efficacy are important for the patches used for skin. Up to today, electrospun fibers are mostly used for wound dressing. Their properties, however, meet the requirements for skin patches for the treatment of AD. Active agents can be incorporated into fibers by blending, coaxial or side-by-side electrospinning, and also by physical absorption post-processing. Drug release from the electrospun membranes is affected by drug and polymer properties and the technique used to combine them into the patch. We describe in detail the in vitro release mechanisms, parameters affecting the drug transport, and their kinetics, including theoretical approaches. In addition, we present the current research on skin patch design. This review summarizes the current extensive know-how on electrospun fibers as skin drug delivery systems, while underlining the advantages in their prospective use as patches for atopic dermatitis. This article is categorized under: Implantable Materials and Surgical Technologies > Nanomaterials and Implants Implantable Materials and Surgical Technologies > Nanotechnology in Tissue Repair and Replacement Therapeutic Approaches and Drug Discovery > Emerging Technologies.","PeriodicalId":23697,"journal":{"name":"Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology","volume":"15 1","pages":"e1829"},"PeriodicalIF":8.6,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10629684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 28

Nano-embedded medical devices and delivery systems in interventional radiology. 介入放射学中的纳米嵌入式医疗设备和传输系统。

IF 8.6 2区医学

Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology Pub Date : 2023-01-01 Epub Date: 2022-08-10 DOI: 10.1002/wnan.1841

Erin Marie D San Valentin, Allan John R Barcena, Carleigh Klusman, Benjamin Martin, Marites P Melancon

{"title":"Nano-embedded medical devices and delivery systems in interventional radiology.","authors":"Erin Marie D San Valentin, Allan John R Barcena, Carleigh Klusman, Benjamin Martin, Marites P Melancon","doi":"10.1002/wnan.1841","DOIUrl":"10.1002/wnan.1841","url":null,"abstract":"Nanomaterials research has significantly accelerated the development of the field of vascular and interventional radiology. The incorporation of nanoparticles with unique and functional properties into medical devices and delivery systems has paved the way for the creation of novel diagnostic and therapeutic procedures for various clinical disorders. In this review, we discuss the advancements in the field of interventional radiology and the role of nanotechnology in maximizing the benefits and mitigating the disadvantages of interventional radiology theranostic procedures. Several nanomaterials have been studied to improve the efficacy of interventional radiology interventions, reduce the complications associated with medical devices, improve the accuracy and efficiency of drug delivery systems, and develop innovative imaging modalities. Here, we summarize the recent progress in the development of medical devices and delivery systems that link nanotechnology in vascular and interventional radiology. This article is categorized under: Diagnostic Tools > Diagnostic Nanodevices Diagnostic Tools > In Vivo Nanodiagnostics and Imaging Therapeutic Approaches and Drug Discovery > Nanomedicine for Cardiovascular Disease.","PeriodicalId":23697,"journal":{"name":"Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology","volume":"15 1","pages":"e1841"},"PeriodicalIF":8.6,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9840652/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10637111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

Immunomodulation in age-related disorders and nanotechnology interventions. 年龄相关疾病的免疫调节和纳米技术干预。

IF 6.9 2区医学

Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology Pub Date : 2023-01-01 Epub Date: 2022-08-10 DOI: 10.1002/wnan.1840

Uday Chintapula, Tanmayee Chikate, Deepsundar Sahoo, Amie Kieu, Ingrid D Guerrero Rodriguez, Kytai T Nguyen, Daniel Trott

{"title":"Immunomodulation in age-related disorders and nanotechnology interventions.","authors":"Uday Chintapula, Tanmayee Chikate, Deepsundar Sahoo, Amie Kieu, Ingrid D Guerrero Rodriguez, Kytai T Nguyen, Daniel Trott","doi":"10.1002/wnan.1840","DOIUrl":"10.1002/wnan.1840","url":null,"abstract":"Recently, the aging population has increased exponentially around the globe bringing more challenges to improve quality of life in those populations while reducing the economic burden on healthcare systems. Aging is associated with changes in the immune system culminating in detrimental effects such as immune dysfunction, immunosenescence, and chronic inflammation. Age-related decline of immune functions is associated with various pathologies including cardiovascular, autoimmune, neurodegenerative, and infectious diseases to name a few. Conventional treatment addresses the onset of age-related diseases by early detection of risk factors, administration of vaccines as preventive care, immunomodulatory treatment, and other dietary supplements. However, these approaches often come with systemic side-effects, low bioavailability of therapeutic agents, and poor outcomes seen in the elderly. Recent innovations in nanotechnology have led to the development of novel biomaterials/nanomaterials, which explore targeted drug delivery and immunomodulatory interactions in vivo. Current nanotechnology-based immunomodulatory approaches that have the potential to be used as therapeutic interventions for some prominent age-related diseases are discussed here. Finally, we explore challenges and future aspects of nanotechnology in the treatments of age-related disorders to improve quality of life in the elderly. This article is categorized under: Therapeutic Approaches and Drug Discovery > Nanomedicine for Cardiovascular Disease Therapeutic Approaches and Drug Discovery > Nanomedicine for Neurological Disease Therapeutic Approaches and Drug Discovery > Emerging Technologies.","PeriodicalId":23697,"journal":{"name":"Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology","volume":"15 1","pages":"e1840"},"PeriodicalIF":6.9,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9840662/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9650416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Engineering gold nanoparticles for molecular diagnostics and biosensing. 用于分子诊断和生物传感的工程金纳米颗粒。

IF 8.6 2区医学

Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology Pub Date : 2023-01-01 DOI: 10.1002/wnan.1836

Beatriz B Oliveira, Daniela Ferreira, Alexandra R Fernandes, Pedro Viana Baptista

{"title":"Engineering gold nanoparticles for molecular diagnostics and biosensing.","authors":"Beatriz B Oliveira, Daniela Ferreira, Alexandra R Fernandes, Pedro Viana Baptista","doi":"10.1002/wnan.1836","DOIUrl":"https://doi.org/10.1002/wnan.1836","url":null,"abstract":"Advances in nanotechnology and medical science have spurred the development of engineered nanomaterials and nanoparticles with particular focus on their applications in biomedicine. In particular, gold nanoparticles (AuNPs) have been the focus of great interest, due to their exquisite intrinsic properties, such as ease of synthesis and surface functionalization, tunable size and shape, lack of acute toxicity and favorable optical, electronic, and physicochemical features, which possess great value for application in biodetection and diagnostics purposes, including molecular sensing, photoimaging, and application under the form of portable and simple biosensors (e.g., lateral flow immunoassays that have been extensively exploited during the current COVID-19 pandemic). We shall discuss the main properties of AuNPs, their synthesis and conjugation to biorecognition moieties, and the current trends in sensing and detection in biomedicine and diagnostics. This article is categorized under: Diagnostic Tools > Biosensing Diagnostic Tools > In Vitro Nanoparticle-Based Sensing Diagnostic Tools > In Vivo Nanodiagnostics and Imaging.","PeriodicalId":23697,"journal":{"name":"Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology","volume":"15 1","pages":"e1836"},"PeriodicalIF":8.6,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9186737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

Recent developments in biosensing methods for extracellular vesicle protein characterization. 细胞外囊泡蛋白表征生物传感方法的最新进展。

IF 8.6 2区医学

Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology Pub Date : 2023-01-01 DOI: 10.1002/wnan.1839

Jugal Suthar, Marissa Taub, Randy P Carney, Gareth R Williams, Stefan Guldin

{"title":"Recent developments in biosensing methods for extracellular vesicle protein characterization.","authors":"Jugal Suthar, Marissa Taub, Randy P Carney, Gareth R Williams, Stefan Guldin","doi":"10.1002/wnan.1839","DOIUrl":"https://doi.org/10.1002/wnan.1839","url":null,"abstract":"Research into extracellular vesicles (EVs) has grown significantly over the last few decades with EVs being widely regarded as a source of biomarkers for human health and disease with massive clinical potential. Secreted by every cell type in the body, EVs report on the internal cellular conditions across all tissue types. Their presence in readily accessible biofluids makes the potential of EV biosensing highly attractive as a noninvasive diagnostic platform via liquid biopsies. However, their small size (50-250 nm), inherent heterogeneity, and the complexity of the native biofluids introduce challenges for effective characterization, thus, limiting their clinical utility. This has led to a surge in the development of various novel EV biosensing techniques, with capabilities beyond those of conventional methods that have been directly transferred from cell biology. In this review, key detection principles used for EV biosensing are summarized, with a focus on some of the most recent and fundamental developments in the field over the last 5 years. This article is categorized under: Diagnostic Tools > Biosensing Diagnostic Tools > In Vitro Nanoparticle-Based Sensing.","PeriodicalId":23697,"journal":{"name":"Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology","volume":"15 1","pages":"e1839"},"PeriodicalIF":8.6,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10078591/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9271942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Isolation and characterization of extracellular vesicles and future directions in diagnosis and therapy. 细胞外囊泡的分离和表征以及诊断和治疗的未来方向。

IF 6.9 2区医学

Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology Pub Date : 2023-01-01 Epub Date: 2022-07-27 DOI: 10.1002/wnan.1835

Karina P De Sousa, Izadora Rossi, Mahamed Abdullahi, Marcel Ivan Ramirez, Dan Stratton, Jameel Malhador Inal

{"title":"Isolation and characterization of extracellular vesicles and future directions in diagnosis and therapy.","authors":"Karina P De Sousa, Izadora Rossi, Mahamed Abdullahi, Marcel Ivan Ramirez, Dan Stratton, Jameel Malhador Inal","doi":"10.1002/wnan.1835","DOIUrl":"10.1002/wnan.1835","url":null,"abstract":"Extracellular vesicles (EVs) are a unique and heterogeneous class of lipid bilayer nanoparticles secreted by most cells. EVs are regarded as important mediators of intercellular communication in both prokaryotic and eukaryotic cells due to their ability to transfer proteins, lipids and nucleic acids to recipient cells. In addition to their physiological role, EVs are recognized as modulators in pathological processes such as cancer, infectious diseases, and neurodegenerative disorders, providing new potential targets for diagnosis and therapeutic intervention. For a complete understanding of EVs as a universal cellular biological system and its translational applications, optimal techniques for their isolation and characterization are required. Here, we review recent progress in those techniques, from isolation methods to characterization techniques. With interest in therapeutic applications of EVs growing, we address fundamental points of EV-related cell biology, such as cellular uptake mechanisms and their biodistribution in tissues as well as challenges to their application as drug carriers or biomarkers for less invasive diagnosis or as immunogens. This article is categorized under: Diagnostic Tools > Biosensing Therapeutic Approaches and Drug Discovery > Nanomedicine for Oncologic Disease Therapeutic Approaches and Drug Discovery > Nanomedicine for Infectious Disease.","PeriodicalId":23697,"journal":{"name":"Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology","volume":"15 1","pages":"e1835"},"PeriodicalIF":6.9,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10078256/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9620388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Rethinking nanoparticulate polymer-drug conjugates for cancer theranostics. 重新思考纳米聚合物-药物偶联物在癌症治疗中的应用。

IF 8.6 2区医学

Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology Pub Date : 2023-01-01 DOI: 10.1002/wnan.1828

Yaoqi Wang, Heming Xia, Binlong Chen, Yiguang Wang

{"title":"Rethinking nanoparticulate polymer-drug conjugates for cancer theranostics.","authors":"Yaoqi Wang, Heming Xia, Binlong Chen, Yiguang Wang","doi":"10.1002/wnan.1828","DOIUrl":"https://doi.org/10.1002/wnan.1828","url":null,"abstract":"Polymer-drug conjugates (PDCs) fabricated as nanoparticles have hogged the limelight in cancer theranostics in the past decade. Many researchers have devoted to developing novel and efficient polymeric drug delivery system since the first generation of poly(N-[2-hydroxypropyl]methacrylamide) copolymer-drug conjugates. However, none of them has been approved for chemotherapy in clinic. An ideal PDC nanoparticle for cancer theranostics should possess several properties, including prolonged circulation in blood, sufficient accumulation and internalization in tumors, and efficient drug release in target sites. To achieve these goals, it is important to rationally design the nanoparticulate PDCs based on circulation, accumulation, penetration, internalization, and drug release (CAPIR) cascade. Specifically, CAPIR cascades are divided into five steps: (1) circulation in the vascular compartment without burst release, (2) accumulation in tumors via enhanced permeability and retention effect, (3) subsequent penetration into the deep regions of tumors, (4) internalization into tumor cells, and (5) release of drugs as free molecules to exert their pharmacological effects. In this review, we focus on the development and novel approaches of nanoparticulate PDCs based on CAPIR cascade, and provide an outlook on future clinical application. This article is categorized under: Therapeutic Approaches and Drug Discovery > Nanomedicine for Oncologic Disease.","PeriodicalId":23697,"journal":{"name":"Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology","volume":"15 1","pages":"e1828"},"PeriodicalIF":8.6,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10629235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Nanoparticles for vaccine and gene therapy: Overcoming the barriers to nucleic acid delivery. 用于疫苗和基因治疗的纳米颗粒:克服核酸传递的障碍。

IF 8.6 2区医学

Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology Pub Date : 2022-11-01 DOI: 10.1002/wnan.1809

Lara M Mollé, Cameron H Smyth, Daniel Yuen, Angus P R Johnston

{"title":"Nanoparticles for vaccine and gene therapy: Overcoming the barriers to nucleic acid delivery.","authors":"Lara M Mollé, Cameron H Smyth, Daniel Yuen, Angus P R Johnston","doi":"10.1002/wnan.1809","DOIUrl":"https://doi.org/10.1002/wnan.1809","url":null,"abstract":"Nucleic acid therapeutics can be used to control virtually every aspect of cell behavior and therefore have significant potential to treat genetic disorders, infectious diseases, and cancer. However, while clinically approved to treat a small number of diseases, the full potential of nucleic acid therapeutics is hampered by inefficient delivery. Nucleic acids are large, highly charged biomolecules that are sensitive to degradation and so the approaches to deliver these molecules differ significantly from traditional small molecule drugs. Current studies suggest less than 1% of the injected nucleic acid dose is delivered to the target cell in an active form. This inefficient delivery increases costs and limits their use to applications where a small amount of nucleic acid is sufficient. In this review, we focus on two of the major barriers to efficient nucleic acid delivery: (1) delivery to the target cell and (2) transport to the subcellular compartment where the nucleic acids are therapeutically active. We explore how nanoparticles can be modified with targeting ligands to increase accumulation in specific cells, and how the composition of the nanoparticle can be engineered to manipulate or disrupt cellular membranes and facilitate delivery to the optimal subcellular compartments. Finally, we highlight how with intelligent material design, nanoparticle delivery systems have been developed to deliver nucleic acids that silence aberrant genes, correct genetic mutations, and act as both therapeutic and prophylactic vaccines. This article is categorized under: Nanotechnology Approaches to Biology > Cells at the Nanoscale Therapeutic Approaches and Drug Discovery > Nanomedicine for Infectious Disease Biology-Inspired Nanomaterials > Lipid-Based Structures.","PeriodicalId":23697,"journal":{"name":"Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology","volume":"14 6","pages":"e1809"},"PeriodicalIF":8.6,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/f3/85/WNAN-14-e1809.PMC9786906.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10814213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6